{"id":8423540195558,"title":"Naturally Pure Products Salvestrol Platinum","handle":"naturally-pure-products-salvestrol-platinum","description":"\u003ch2\u003eNaturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp\u003eSize: 90 Capsules\u003c\/p\u003e\n\u003cp\u003eNaturally Pure Products Salvestrol Platinum Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe natural way to boost immunity and defend against toxins\u003c\/li\u003e\n\u003cli\u003eWith plant-based ingredients\u003c\/li\u003e\n\u003cli\u003eEnhances overall wellness for a healthier you\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNaturally Pure Products Salvestrol Platinum\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRescue mechanism borrowed from plants\u003c\/li\u003e\n\u003cli\u003eAnti inflammatory\u003c\/li\u003e\n\u003cli\u003eAnti-fungal\u003c\/li\u003e\n\u003cli\u003eHealthy living\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWhy Salvesterols\u003c\/h5\u003e\n\u003ch2\u003eWhy Salvesterols: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003ch3\u003e“A natural rescue mechanism borrowed from plants”\u003c\/h3\u003e\n\u003cp\u003eSalvestrols are a class of natural plant derived compounds that support the body’s natural cell cycle to eliminate damaged cells while bypassing healthy functioning cells.\u003c\/p\u003e\n\u003cp\u003eSalvestrol is a blend of key extracts from everyday foods, which are now found in very low levels due to cropping and spraying, that help support our bodies, a protective and healthy support, for wellbeing and aging well.\u003c\/p\u003e\n\u003cp\u003eThese key extracts or nesems have been shown to have anti-fungal and anti-inflammatory properties as well as the activity of driving the elimination of DNA damaged or aberrant cells which overexpress the 1B1 protein or enzyme, thus helping modulate chronic disease\/inflammation.\u003c\/p\u003e\n\u003cp\u003eThese plant derived molecules or nesems provide a cell rescue mechanism and protection beyond antioxidant activities.\u003c\/p\u003e\n\u003cp\u003eChanges in cropping and how food is grown commercially have resulted in lower levels of these key phytonutrients in our daily diet. Going organic is helpful, trying to eat or choose foods that have been allowed to ripen on the plant\/in season is another step forward.\u003c\/p\u003e\n\u003cp\u003eTaking Salvestrol daily in the morning on an empty stomach, at a varying dose to suit your needs is a great addition to a healthy diet and lifestyle, especially when its so hard to find seasonal organic foods that have ripened on the plant naturally.\u003c\/p\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp\u003eTake the recommended number of capsule(s), at least 30 minutes before food, in the morning upon waking, as recommended by your health care practitioner.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor best results, we recommend the advice of a healthcare practitioner who can provide you with a personalised approach to dosing. Follow the instructions given to you by your qualified practitioner.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients:\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Vegetable Capsule (hydroxypropylmethylcellulose) Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCitrus Bioflavonoids (Citrus sinesis)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGrape seed (Vitis vinifera)\u003c\/td\u003e\n\u003ctd\u003e75mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePumpkin (Curcubita maxima)\u003c\/td\u003e\n\u003ctd\u003e75mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBulking agent (rice flour)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTotal: \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003e500mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eNO GRAPEFRUIT or extract from GRAPEFRUIT.\u003c\/p\u003e\n\u003cp\u003eContains extracts from Grape Seed but not grapes.\u003c\/p\u003e\n\u003ch5\u003eFree From\u003c\/h5\u003e\n\u003ch2\u003eFree From: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp\u003eNo artificial flavours, colours or preservatives.\u003c\/p\u003e\n\u003ch5\u003eFAQs\u003c\/h5\u003e\n\u003ch2\u003eFAQs: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003ch3\u003eQ1. Can I take Salvestrols with Chemotherapy or radiation?\u003c\/h3\u003e\n\u003cp\u003eSalvestrols are plant-derived compounds; there are no reported side effects or known interactions between Salvestrol and conventional treatments, including chemotherapy and radiotherapy.  We have many reports of patients having fewer side effects, (such as oral thrush), and recovering much quicker than those not having Salvestrols during their treatments.\u003c\/p\u003e\n\u003ch3\u003eQ2. Can I break open the capsules and take them as a powder?\u003c\/h3\u003e\n\u003cp\u003eYes, you can open the capsules and take them, they taste very bitter so try a small amount first to see if it is palatable to you.\u003c\/p\u003e\n\u003ch3\u003eQ3. Can I take other supplements between my two doses?\u003c\/h3\u003e\n\u003cp\u003eTaking a multivitamin and multi-mineral supplement can increase the effectiveness of Salvestrols. The specific cofactors are: Biotin, vitamin B3, vitamin B12, vitamin C, iron, and magnesium. These can be taken between the doses.\u003c\/p\u003e\n\u003ch3\u003eQ4. I will be using CBD and THC oils, can I use Salvestrols as well?\u003c\/h3\u003e\n\u003cp\u003eWe suggest taking the Salvestrols in the morning and the THC\/CBD as far away from the Salvestrols as possible. I.e. late afternoon\/evening as we do know there may be overlap.\u003c\/p\u003e\n\u003ch3\u003eQ5. Why do I have to take Salvestrol on an empty stomach?\u003c\/h3\u003e\n\u003cp\u003eThis is so the Salvestrols are not competing for absorption with other nutrients and give the Salvestrols the best chance of being fully utilized by the body.\u003c\/p\u003e\n\u003ch3\u003eQ6. Why do I have to take two doses of Salvestrols instead of one?\u003c\/h3\u003e\n\u003cp\u003eSalvestrols reach peak concentration after 3 hours after ingestion, the second dose boosts blood levels as the concentration of the 1st dose diminishes, allowing for peak levels to be reached in your body for a longer, lengthening the therapeutic window.\u003c\/p\u003e\n\u003ch3\u003eQ7. Why do you say to go for a walk 4 hours after taking the second dose of Salvestrols?\u003c\/h3\u003e\n\u003cp\u003eThe Salvestrols will reach a peak concentration in your blood three hours after taking them and to provide an oxygen-rich environment for this metabolism, take some form of exercise around four hours after taking your Salvestrols. This can be as simple as a brisk walk around your neighbourhood. When taking exercise is not possible engage in breathing exercises for about 10 minutes.\u003c\/p\u003e\n\u003ch3\u003eQ8. What do the 2000 points mean?\u003c\/h3\u003e\n\u003cp\u003eIn New Zealand, each capsule has “2000 points” which relates to the DNA-damaged cell selectivity of the proprietary blend of Salvestrols. No matter what fruit or vegetables are on the label, they will always make up the potency of 2000 active Salvestrols. Other countries like England and Europe have different amounts in their bottles, though ours are the highest.\u003c\/p\u003e\n\u003ch3\u003eQ9. Why do you say to take 1000mg of Vitamin C with the Salvestrols?\u003c\/h3\u003e\n\u003cp\u003eAscorbic acid provides the electron donation that supports the metabolism of Salvestrol by CYP1B1. This allows it to keep circulating in your body longer, optimizing its effectiveness.\u003c\/p\u003e\n\u003ch3\u003eQ10. If I forget to take them in the morning can I have them in the afternoon\/evening?\u003c\/h3\u003e\n\u003cp\u003eAlthough Salvestrols are metabolized in your body throughout the day, we recommend taking Salvestrols in the morning as this is when the CYP1B1 enzyme has the greatest activity.\u003c\/p\u003e\n\u003cp\u003eTip: Put them beside your bedside table or in the bathroom to help you remember to take them or put an alarm on your phone.\u003c\/p\u003e\n\u003ch5\u003eWhat is NESEM?\u003c\/h5\u003e\n\u003ch2\u003eWhat is NESEM?: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Tree.png?v=1726197012\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003ch3\u003e\"Let food be thy medicine and medicine be thy food\"  - Hippocrates\u003c\/h3\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003ch3\u003eNesem® represents over 25 years of dedicated research into understanding plant metabolites and employing cutting-edge extraction techniques to create food-based supplements of consistent performance and quality.\u003c\/h3\u003e\n\u003c\/blockquote\u003e\n\u003ch3\u003eNASEM - Naturally Elicited, Specifically Extracted, Molecules\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e'Naturally Elicited' \u003c\/strong\u003e- Produced naturally in plants as a protection mechanism during the 'ripening process' in response to challenges in the environment of the plant as it grows. That is, attack by bacteria, virus or pathogens when not sprayed or modified.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e'Specifically Extracted'\u003c\/strong\u003e - a targeted approach using supercritical fluid extraction to extract specific molecules from site of production, typically the skin and pith.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e'Molecules'\u003c\/strong\u003e - phytonutrients found in high volumes in the pith and skin of ripening fruit or vegetables when attacked by pathogens\/bacteria.\u003c\/p\u003e\n\u003ch3\u003eWhat does this mean?\u003c\/h3\u003e\n\u003cp\u003eWhen plants grow there are different phases of growth the plants undergo. The 1st phase is the growth of the plant while the 2nd Phase is when the plant flowers or fruits and ripens. It is at the end of this 2nd phase of growth when the fruit is ripening that it is attacked by several pathogens, viruses, fungi etc. It is at this site of attack that the plant will provide or over-produce molecules (phytonutrients) to protect itself against this attack.\u003c\/p\u003e\n\u003cp\u003eWe refer to these as molecules as secondary plant metabolites which occur at the site of  attack or challenge, it is the plants natural defence system.\u003c\/p\u003e\n\u003cp\u003eNatural supplements use some sort of extraction method to extract the plant molecules\/extracts. Typically, solvents are used with alcohol being one of the major solvents used in practice. NPP use a targeted approach to extract specific molecules using super critical or sub critical fluid extraction methods.\u003c\/p\u003e\n\u003cp\u003eMolecules are extracted from the pith and skin of the plants as this is where the concentration of the secondary plant metabolites are found, the site of attack.\u003c\/p\u003e\n\u003ch3\u003eCan we get enough nesems from food alone?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCommercial cropping\u003c\/strong\u003e has reduced nesem® extracts by:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCreation of new varieties\u003c\/li\u003e\n\u003cli\u003ePicking produce green then shipping across to markets\u003c\/li\u003e\n\u003cli\u003eSpraying of crops to reduce loss by disease etc\u003c\/li\u003e\n\u003cli\u003eThe use of fungicides or spraying in particular prelude the plant from having to produce these naturally protective compounds themselves as the chemicals used are providing the defence to the plant externally instead.\u003c\/li\u003e\n\u003cli\u003eGenetic modification to increase yields and reduce spoiling of crops\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eConsumer demands\u003c\/strong\u003e for sweeter perfect looking produce has impacted the amount of nesem® extract’s we consume in our foods by:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSweet taste\u003c\/li\u003e\n\u003cli\u003ePerfect produce – not quite ripe, no blemishes, storage methods,\u003c\/li\u003e\n\u003cli\u003eBright colors\u003c\/li\u003e\n\u003cli\u003eEasy peel\u003c\/li\u003e\n\u003cli\u003eBigger produce \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eRemember if the plants are not being attacked, they are not producing these healing molecules or secondary plant metabolites in high concentrations.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOrganically grown produce, is reported to contain higher amounts of these health-promoting compounds due to the exposure to naturally occurring challenges from plant pests to induce a defensive response and protective compounds, phytoalexins.  However, the amount of these phytoalexins being produced and consumed is still unknown.\u003c\/p\u003e\n\u003cp\u003eThere is clearly potential to re-optimise the levels of these molecules your intake from fruit and vegetable produce. The best way is to choose traditionally grown produce as these will increase the levels of secondary plant metabolites, phytoalexins\/phytonutrients, but the exact intake is unclear as many factors such as growing methods, harvesting, storage etc can influence these levels.\u003c\/p\u003e\n\u003cp\u003eUnfortunately, many of our modern-day foods are conventionally grown with the use of sprays and pesticides, which result in much lower levels of these secondary plant metabolites or phytonutrients.  \u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" height=\"451\" width=\"340\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Apples.png?v=1726197057\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eYou can increase your potential nesem® content from your daily foods by: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHaving a vegetable garden, growing your own produce.\u003c\/li\u003e\n\u003cli\u003eChoose organic wherever possible. Shop at markets wherever possible.\u003c\/li\u003e\n\u003cli\u003eChoose to eat in season as much as you are able.\u003c\/li\u003e\n\u003cli\u003eChoose produce that has ripened on the plant if possible, rather than the shelf\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eProperties of nesem® extracts\u003c\/h3\u003e\n\u003cp\u003enesem® as secondary plant metabolites, phytoalexins have been identified in many fruits, vegetables and herbs which are food sources around the world. They have been shown to benefit human health and have potent:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAnti-cancer activities\u003c\/li\u003e\n\u003cli\u003eNeurogenesis functions\u003c\/li\u003e\n\u003cli\u003eAnti-inflammatory activities\u003c\/li\u003e\n\u003cli\u003eAntioxidant activities\u003c\/li\u003e\n\u003cli\u003eCholesterol lowering ability\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cblockquote\u003e\n\u003cp\u003eIn every Salvestrol Capsule we guarantee you are getting a specific amount of phytoalexins, our support team can help you determine the amount needed to support your health.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch5\u003eCancer Support\u003c\/h5\u003e\n\u003ch2\u003eCancer Support:\u003c\/h2\u003e\n\u003ch3\u003eHow do Salvestrols provide support for those with cancer?\u003c\/h3\u003e\n\u003cp\u003eNesem extracted Salvestrols work beyond antioxidants, they are metabolized by the CYP1B1 enzyme or protein shown to be expressed in cancer cells. Salvestrols are metabolized by the CYP1B1 enzyme which then produces metabolites that are anti-cancer agents - modulating damaged cells, driving natural healthy cell cycle and apoptosis. 1\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Metabolite.png?v=1726127530\" style=\"display: block; margin-left: auto; margin-right: auto;\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Metabolite.png?v=1726127530\" data-mce-style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003ePotter, G. A., \u0026amp; Burke, M. D. (2006). Salvestrols–Natural Products with Tumour Selective Activity. Journal of Orthomolecular Medicine\u003c\/p\u003e\n\u003ch3\u003eUnderstanding CYP1B1 mRNA, versus CYP1B1 enzyme\u003c\/h3\u003e\n\u003cp\u003eAn important distinction to understand is the difference between the CYP1B1 messenger RNA and the CYP1B1 enzyme (protein). Both the mRNA and enzyme are involved in gene expression and function however, the:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eThe CYP1B1 protein performs metabolic functions in the body and is found in all cancer cells tested to date including all stages of cancer from precancerous dysplastic cells, primary cancer cells and metastases of the cancer cells. 1\u003c\/li\u003e\n\u003cli\u003eFor most CYP450 enzymes looking for and finding the mRNA will be predictive of the presence of the enzyme but this is not the case for the CYP1B1 enzyme. 1\u003c\/li\u003e\n\u003cli\u003eThe CYP1B1 enzyme is not found in healthy functioning cells, it has shown only to be found in damaged\/cancer cells but the mRNA CYP1B1 is found in both cancer and healthy cells. 1\u003c\/li\u003e\n\u003cli\u003eIf researching the CYP1B1 protein you need to ensure you are searching for the enzyme itself and not mRNA CYP1B1. 1\u003c\/li\u003e\n\u003cli\u003eThe CYP1B1 enzyme has a lifecycle of approximately three days, leading to the replacement of each enzyme with a new one within this time frame. 1\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3\u003eWhat is the recommended dose of Salvestrols for cancer support?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eInitial loading dose:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e6 capsules a day on an empty stomach in split dosing.\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e2 capsules, three hours later\u003c\/p\u003e\n\u003cp\u003eSalvestrols reach peak concentration in the body approximately 3-4 hours after taking the initial dose, second dose is recommended 3 hours after the initial dose, enabling therapeutic peak concentration to be maintained longer.\u003c\/p\u003e\n\u003cp\u003eTake Salvestrols before midday for greater effectiveness.\u003c\/p\u003e\n\u003cp\u003eTake Salvestrols on waking, empty stomach to allow for greater bioavailable, however, the Cytochrome P450 enzyme activity is highest in the morning and drops off after 3 pm, which further supports the recommendation for taking Salvestrols in the morning.\u003c\/p\u003e\n\u003cp\u003eAn example timeline for taking 6 capsules is:\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e6am \/ 7am – wake up and take 4 capsules **\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e6:30-7:30am – medications\/breakfast\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e9am \/ 10am – take 2 capsules **\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003eMidday onwards – supplements other medications\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e** take \u003ca rel=\"noopener\" title=\"Metagenics Meta Zinc With Vitamin C 10% off RRP | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/collections\/all\/meta-zinc-with-vitamin-c\" target=\"_blank\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/collections\/all\/meta-zinc-with-vitamin-c\"\u003eMetagenics Meta Zinc With Vitamin C \u003c\/a\u003e - add ½ metric teaspoon to 200 mL water twice daily with both doses of Salvestrol Platinum\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Target_Concentration.png?v=1726127531\" style=\"display: block; margin-left: auto; margin-right: auto;\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Target_Concentration.png?v=1726127531\" data-mce-style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003eFigure: Target Therapeutic Concentration of Salvestrols\u003c\/p\u003e\n\u003cp\u003eVitamin C supports the activity of Salvestrols, through its antioxidant and electron-donating ability, working synergistically with Salvestrols.1,29\u003c\/p\u003e\n\u003ch3\u003eUse with Chemotherapy \u0026amp; Radiotherapy\u003c\/h3\u003e\n\u003cp\u003eThere are no contraindications on using Salvestrols alongside conventional treatment – Chemotherapy or Radiotherapy. Also of note are Salvestrols are not antioxidants. 1,27,28\u003c\/p\u003e\n\u003cp\u003eIn one study patients taking Salvestrols alongside chemotherapy or radiotherapy reported improvements in overall survival and ECOG performance status indicating better health outcomes and quality of life.25,27,28\u003c\/p\u003e\n\u003cp\u003eSalvestrols in combination with chemotherapy can moderate cardiovascular risk, side effects due to salvestrols high affinity for the CYP1B1 enzyme preventing the metabolism of chemotherapy agents and their toxic metabolites which potentially cause cardiovascular complications and secondary cancers, improving quality of life.27,28\u003c\/p\u003e\n\u003ch3\u003eUse with pharmaceuticals\u003c\/h3\u003e\n\u003cp\u003eThere are no known contraindications with pharmaceuticals, if medications such as thyroxin need to be taken in the morning, we recommend having the first dose of Salvestrols, then have the medication 30 minutes later. Any medications that do not have to be taken in the morning can either be separated by 30 minutes or moved to be taken in the afternoon.\u003c\/p\u003e\n\u003cp\u003eThose with high Blood Pressure may notice a slight drop in BP, but this will normalize within a few days.\u003c\/p\u003e\n\u003ch3\u003eUse with supplements\u003c\/h3\u003e\n\u003cp\u003eIf taking additional supplements, we recommend taking these from lunchtime onwards or in the case of CYP1B1 inhibitors such as B17, CBD, resveratrol etc we recommend taking these late afternoon or evening when the concentration of Salvestrols are decreasing. 1,25\u003c\/p\u003e\n\u003cp\u003eSupporting excessive inflammatory response in cancer patients can lead to better health outcomes.\u003c\/p\u003e\n\u003ch3\u003eWhat is “all clear” mean?\u003c\/h3\u003e\n\u003cp\u003eWhen you have cancer and get the ‘’all clear’’ after undergoing treatment there is an increased concern for secondary cancer diagnosis. So what does ‘’all clear’’ really mean.\u003c\/p\u003e\n\u003cp\u003eWhen someone with cancer gets the “all clear” it is important that they maintain beneficial dietary changes and exercise to support continually clearance of damaged cells.\u003c\/p\u003e\n\u003cp\u003eWe also recommend a maintenance dose of Salvestrols, between 2-4 capsules a day depending on your underlying health.  If inflammation is an on-going concern consider adding Moderaflam to support their health, 2 capsules a day.\u003c\/p\u003e\n\u003cp\u003eWe recommend maintaining beneficial dietary changes and exercise to support your bodies continual clearance of damaged cells.\u003c\/p\u003e\n\u003cp\u003eIf you notice signs of inflammation, consider also adding Moderaflam into your regime to support the management of improved health outcomes. 24,25\u003c\/p\u003e\n\u003ch3\u003eReferences:\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003e\u003cspan\u003eSchaefer, B.A. (2012). Salvestrols, Natures Defence Against Cancer: Linking Diet \u0026amp; Cancer. Clinical Intelligence Corp, Canada.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMurray, G.I., Taylor, M.C., McFadyen, M.C., et al. Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res. (1997) 57: 3026- 3031.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMcFadyen, M.C., Breeman, S., Payne, S., et al. Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. J Histochem Cytochem. (1999) 47: 1457-1464.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMurray, G.I., Melvin, W.T., Greenlee, W.F., et al. Regulation, function and tissue-specific expression of cytochrome P450 CYP1B1. Ann Rev Pharmacol Toxicol. (2001) 41: 297-316.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStanley, L.A., Ball, M.T., Eaden, J., et al. Cytochrome P450 CYP1B1 in the early stages of colon tumour development. Drug Metabol Rev. (2001) 33: 77.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCarnell, D., Smith, R., Daley, F., et al. Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue. Int J Radiat Oncol Biol Phys. (2004) 58: 500-509.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBarnett, J.A., Urbauer, D.L., Murray, G.I., et al. Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target. Clin Cancer Res. (2007) 13: 3559-3567.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMcFadyen, M.C.E., Cruickshank, M.E., Miller, I.D., et al. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Br. J. Cancer. (2001) 85: 242-246.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTsuchiya, Y., Nakajima, M., Takagi, S., et al. MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. (2006) 66: 9090-9098.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eHoang, T.T.V., Burke, M.D., Butler, P.C., et al. Cytochrome P450 1B1 (CYP1B1) expression in human cervical intraepithelial neoplasia. Br J Cancer. (2001) 85: 78.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eChang, H., Su, J., Huang, C.C., et al. Using a combination of cytochrome P450 1B1 and b-catenin for early diagnosis and prevention of colorectal cancer. Cancer Detect Prevent. (2005) 29: 562–569.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSu, J., Lin, P., Wang, C., et al. Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target. Anticancer Res. (2009) 29: 509-515.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTokizane, T., Shiina, H., Igawa, M., et al. Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin Cancer Res. (2005) 11: 5793-5801\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMaecker, B., Sherr, D.H., Vonderheide, R.H., et al. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. (2003) 102: 3287-3294.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eChang, J.T., Chang, H., Chen, P., et al. Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas. Clin Cancer Res. (2007) 13: 38-45.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eKumarakulasingham, M., Rooney, P.H., Dundas, S.R., et al. Cytochrome P450 profile of colorectal cancer: identification of markers of prognosis. Clin Cancer Res. (2005) 11: 3758-3765.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eGreer, M.L., Richman, P.I., Barber, P.R., et al. Cytochrome P450 1B1 (CYP1B1) is expressed during the malignant progression of head and neck squamous cell carcinoma (HNSCC). Proc Am Cancer Res. (2004) 45: Abstract #3701.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFurukawa, M., Nishimura, M., Ogino, D., et al. Cytochrome P450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci. (2004) 95: 520-529.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMaecker, B., von Bergwelt-Baildon, M.S., Anderson, K.S., et al. Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients. Clin Exptl Immunol. (2005) 141: 558-562.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNedelkov, D., Kiernan, U.A., Niederkofler, E.E., et al. Population proteomics: the concept, attributes and potential for cancer biomarker research. Mol Cell Proteomics. (2006) 5: 1811-1818.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStoeckli, M., Chaurand, P., Halahan, D.E., et al. Imaging mass spectrometry; a new technology for the analysis of protein expression in mammalian tissues. Nature Med. (2001) 7: 493-496.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAlsubait, A., Aldossary, W., Rashid, M., Algamdi, A., Alrfaei, B.M. (2020). CYP1B1 gene: Implications in glaucoma and cancer. Journal of Cancer, 11(16), 4652-4661. https:\/\/doi.org\/10.7150\/jca.42669.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePotter, G. A., \u0026amp; Burke, M. D. (2006). Salvestrols–Natural Products with Tumour Selective Activity. Journal of Orthomolecular Medicine.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSchaefer, B. A. (2018). Salvestrols: Nature’s defense against cancer. Clinical Intelligence Inc.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNaturally Pure Products. (2023). Salvestrol Clinical Guidance Document.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/populationeducation.org\/a-timeline-of-the-three-major-agricultural-revolutions-in-history\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/maplespub.com\/article\/effect-of-nesem-s2013-in-indian-population-undergoing-conventional-treatment-for-the-malignancies-of-the-head-and-neck-git-ovary-breast-and-lung-as-an-adjunct\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNaturally Pure Products (2022), Salvestrols role in the utilization of CYP1B1 as a therapeutic target in cardio-oncology\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/isom.ca\/learning\/conference-proceedings\/48th-omt\/ascorbic-acid-as-a-novel-co-factor-for-cytochrome-p450-metabolism-and-cancer-cell-selectivity\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTsuchiya, Y. et al., Cancer Res. 66: 9090-98 (2006)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDevlin, A. et al., Mol. Carcin. 49: 190-99 (2010)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNakajima \u0026amp; Yokoi, Pharm. Ther. 131: 330-337 (2011)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.naturallypureproducts.com\/blogs\/news\/all-about-nesem%C2%AE-technology\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10334162\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.foodpackagingforum.org\/news\/two-studies-associate-microplastic-exposure-with-cancer\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK12712\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8964978\/#:~:text=Dysregulated%20IL%2D6%20promotes%20a,DKK%2D1%20(128).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/27260630\/\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings:\u003c\/h2\u003e\n\u003cp\u003eConsult your health care professional prior to use if pregnant or breastfeeding.\u003c\/p\u003e\n\u003cp\u003eColour may vary from batch to batch.\u003c\/p\u003e\n\u003cp\u003eKeep out of reach from children.\u003c\/p\u003e\n\u003cp\u003eDietary supplements should not be used as a substitute for a balanced diet and healthy lifestyle.\u003c\/p\u003e\n\u003cp\u003eSalvestrol® is a registered trademark licensed to Nature’s Defence Research Ltd\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage:\u003c\/h2\u003e\n\u003cp\u003eStore in a cool dry place below 25C.\u003c\/p\u003e","published_at":"2024-01-29T16:56:22+11:00","created_at":"2024-01-29T16:25:28+11:00","vendor":"Naturally Pure Products","type":"Naturally Pure Products 10-15% off RRP","tags":["Naturally Pure Products","Naturopathic","PB"],"price":15390,"price_min":15390,"price_max":15390,"available":true,"price_varies":false,"compare_at_price":17100,"compare_at_price_min":17100,"compare_at_price_max":17100,"compare_at_price_varies":false,"variants":[{"id":44253120233702,"title":"90 Capsules","option1":"90 Capsules","option2":null,"option3":null,"sku":"NPPSalvestrolPlatinum90C","requires_shipping":true,"taxable":true,"featured_image":{"id":40358947225830,"product_id":8423540195558,"position":1,"created_at":"2024-01-29T16:25:45+11:00","updated_at":"2024-01-29T16:26:47+11:00","alt":"Naturally Pure Products Salvestrol Platinum 90 Caps 10% off RRP HealthMasters Naturally Pure Products","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum90Caps10_offRRPHealthMastersNaturallyPureProducts.png?v=1706506007","variant_ids":[44253120233702]},"available":true,"name":"Naturally Pure Products Salvestrol Platinum - 90 Capsules","public_title":"90 Capsules","options":["90 Capsules"],"price":15390,"weight":0,"compare_at_price":17100,"inventory_quantity":5,"inventory_management":"shopify","inventory_policy":"continue","barcode":"","featured_media":{"alt":"Naturally Pure Products Salvestrol Platinum 90 Caps 10% off RRP HealthMasters Naturally Pure Products","id":32977086480614,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum90Caps10_offRRPHealthMastersNaturallyPureProducts.png?v=1706506007"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum90Caps10_offRRPHealthMastersNaturallyPureProducts.png?v=1706506007","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum10_offRRPHealthMastersNaturallyPureProductsInformation.png?v=1706506029"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum90Caps10_offRRPHealthMastersNaturallyPureProducts.png?v=1706506007","options":["Size"],"media":[{"alt":"Naturally Pure Products Salvestrol Platinum 90 Caps 10% off RRP HealthMasters Naturally Pure Products","id":32977086480614,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum90Caps10_offRRPHealthMastersNaturallyPureProducts.png?v=1706506007"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum90Caps10_offRRPHealthMastersNaturallyPureProducts.png?v=1706506007","width":1200},{"alt":"Naturally Pure Products Salvestrol Platinum 90 Caps 10% off RRP HealthMasters Naturally Pure Products Information","id":32977086415078,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum10_offRRPHealthMastersNaturallyPureProductsInformation.png?v=1706506029"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/NaturallyPureProductsSalvestrolPlatinum10_offRRPHealthMastersNaturallyPureProductsInformation.png?v=1706506029","width":1200}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eNaturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp\u003eSize: 90 Capsules\u003c\/p\u003e\n\u003cp\u003eNaturally Pure Products Salvestrol Platinum Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe natural way to boost immunity and defend against toxins\u003c\/li\u003e\n\u003cli\u003eWith plant-based ingredients\u003c\/li\u003e\n\u003cli\u003eEnhances overall wellness for a healthier you\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNaturally Pure Products Salvestrol Platinum\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRescue mechanism borrowed from plants\u003c\/li\u003e\n\u003cli\u003eAnti inflammatory\u003c\/li\u003e\n\u003cli\u003eAnti-fungal\u003c\/li\u003e\n\u003cli\u003eHealthy living\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWhy Salvesterols\u003c\/h5\u003e\n\u003ch2\u003eWhy Salvesterols: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003ch3\u003e“A natural rescue mechanism borrowed from plants”\u003c\/h3\u003e\n\u003cp\u003eSalvestrols are a class of natural plant derived compounds that support the body’s natural cell cycle to eliminate damaged cells while bypassing healthy functioning cells.\u003c\/p\u003e\n\u003cp\u003eSalvestrol is a blend of key extracts from everyday foods, which are now found in very low levels due to cropping and spraying, that help support our bodies, a protective and healthy support, for wellbeing and aging well.\u003c\/p\u003e\n\u003cp\u003eThese key extracts or nesems have been shown to have anti-fungal and anti-inflammatory properties as well as the activity of driving the elimination of DNA damaged or aberrant cells which overexpress the 1B1 protein or enzyme, thus helping modulate chronic disease\/inflammation.\u003c\/p\u003e\n\u003cp\u003eThese plant derived molecules or nesems provide a cell rescue mechanism and protection beyond antioxidant activities.\u003c\/p\u003e\n\u003cp\u003eChanges in cropping and how food is grown commercially have resulted in lower levels of these key phytonutrients in our daily diet. Going organic is helpful, trying to eat or choose foods that have been allowed to ripen on the plant\/in season is another step forward.\u003c\/p\u003e\n\u003cp\u003eTaking Salvestrol daily in the morning on an empty stomach, at a varying dose to suit your needs is a great addition to a healthy diet and lifestyle, especially when its so hard to find seasonal organic foods that have ripened on the plant naturally.\u003c\/p\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp\u003eTake the recommended number of capsule(s), at least 30 minutes before food, in the morning upon waking, as recommended by your health care practitioner.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor best results, we recommend the advice of a healthcare practitioner who can provide you with a personalised approach to dosing. Follow the instructions given to you by your qualified practitioner.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients:\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Vegetable Capsule (hydroxypropylmethylcellulose) Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCitrus Bioflavonoids (Citrus sinesis)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGrape seed (Vitis vinifera)\u003c\/td\u003e\n\u003ctd\u003e75mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePumpkin (Curcubita maxima)\u003c\/td\u003e\n\u003ctd\u003e75mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBulking agent (rice flour)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTotal: \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003e500mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eNO GRAPEFRUIT or extract from GRAPEFRUIT.\u003c\/p\u003e\n\u003cp\u003eContains extracts from Grape Seed but not grapes.\u003c\/p\u003e\n\u003ch5\u003eFree From\u003c\/h5\u003e\n\u003ch2\u003eFree From: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp\u003eNo artificial flavours, colours or preservatives.\u003c\/p\u003e\n\u003ch5\u003eFAQs\u003c\/h5\u003e\n\u003ch2\u003eFAQs: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003ch3\u003eQ1. Can I take Salvestrols with Chemotherapy or radiation?\u003c\/h3\u003e\n\u003cp\u003eSalvestrols are plant-derived compounds; there are no reported side effects or known interactions between Salvestrol and conventional treatments, including chemotherapy and radiotherapy.  We have many reports of patients having fewer side effects, (such as oral thrush), and recovering much quicker than those not having Salvestrols during their treatments.\u003c\/p\u003e\n\u003ch3\u003eQ2. Can I break open the capsules and take them as a powder?\u003c\/h3\u003e\n\u003cp\u003eYes, you can open the capsules and take them, they taste very bitter so try a small amount first to see if it is palatable to you.\u003c\/p\u003e\n\u003ch3\u003eQ3. Can I take other supplements between my two doses?\u003c\/h3\u003e\n\u003cp\u003eTaking a multivitamin and multi-mineral supplement can increase the effectiveness of Salvestrols. The specific cofactors are: Biotin, vitamin B3, vitamin B12, vitamin C, iron, and magnesium. These can be taken between the doses.\u003c\/p\u003e\n\u003ch3\u003eQ4. I will be using CBD and THC oils, can I use Salvestrols as well?\u003c\/h3\u003e\n\u003cp\u003eWe suggest taking the Salvestrols in the morning and the THC\/CBD as far away from the Salvestrols as possible. I.e. late afternoon\/evening as we do know there may be overlap.\u003c\/p\u003e\n\u003ch3\u003eQ5. Why do I have to take Salvestrol on an empty stomach?\u003c\/h3\u003e\n\u003cp\u003eThis is so the Salvestrols are not competing for absorption with other nutrients and give the Salvestrols the best chance of being fully utilized by the body.\u003c\/p\u003e\n\u003ch3\u003eQ6. Why do I have to take two doses of Salvestrols instead of one?\u003c\/h3\u003e\n\u003cp\u003eSalvestrols reach peak concentration after 3 hours after ingestion, the second dose boosts blood levels as the concentration of the 1st dose diminishes, allowing for peak levels to be reached in your body for a longer, lengthening the therapeutic window.\u003c\/p\u003e\n\u003ch3\u003eQ7. Why do you say to go for a walk 4 hours after taking the second dose of Salvestrols?\u003c\/h3\u003e\n\u003cp\u003eThe Salvestrols will reach a peak concentration in your blood three hours after taking them and to provide an oxygen-rich environment for this metabolism, take some form of exercise around four hours after taking your Salvestrols. This can be as simple as a brisk walk around your neighbourhood. When taking exercise is not possible engage in breathing exercises for about 10 minutes.\u003c\/p\u003e\n\u003ch3\u003eQ8. What do the 2000 points mean?\u003c\/h3\u003e\n\u003cp\u003eIn New Zealand, each capsule has “2000 points” which relates to the DNA-damaged cell selectivity of the proprietary blend of Salvestrols. No matter what fruit or vegetables are on the label, they will always make up the potency of 2000 active Salvestrols. Other countries like England and Europe have different amounts in their bottles, though ours are the highest.\u003c\/p\u003e\n\u003ch3\u003eQ9. Why do you say to take 1000mg of Vitamin C with the Salvestrols?\u003c\/h3\u003e\n\u003cp\u003eAscorbic acid provides the electron donation that supports the metabolism of Salvestrol by CYP1B1. This allows it to keep circulating in your body longer, optimizing its effectiveness.\u003c\/p\u003e\n\u003ch3\u003eQ10. If I forget to take them in the morning can I have them in the afternoon\/evening?\u003c\/h3\u003e\n\u003cp\u003eAlthough Salvestrols are metabolized in your body throughout the day, we recommend taking Salvestrols in the morning as this is when the CYP1B1 enzyme has the greatest activity.\u003c\/p\u003e\n\u003cp\u003eTip: Put them beside your bedside table or in the bathroom to help you remember to take them or put an alarm on your phone.\u003c\/p\u003e\n\u003ch5\u003eWhat is NESEM?\u003c\/h5\u003e\n\u003ch2\u003eWhat is NESEM?: Naturally Pure Products Salvestrol Platinum\u003c\/h2\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Tree.png?v=1726197012\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003ch3\u003e\"Let food be thy medicine and medicine be thy food\"  - Hippocrates\u003c\/h3\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003ch3\u003eNesem® represents over 25 years of dedicated research into understanding plant metabolites and employing cutting-edge extraction techniques to create food-based supplements of consistent performance and quality.\u003c\/h3\u003e\n\u003c\/blockquote\u003e\n\u003ch3\u003eNASEM - Naturally Elicited, Specifically Extracted, Molecules\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e'Naturally Elicited' \u003c\/strong\u003e- Produced naturally in plants as a protection mechanism during the 'ripening process' in response to challenges in the environment of the plant as it grows. That is, attack by bacteria, virus or pathogens when not sprayed or modified.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e'Specifically Extracted'\u003c\/strong\u003e - a targeted approach using supercritical fluid extraction to extract specific molecules from site of production, typically the skin and pith.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e'Molecules'\u003c\/strong\u003e - phytonutrients found in high volumes in the pith and skin of ripening fruit or vegetables when attacked by pathogens\/bacteria.\u003c\/p\u003e\n\u003ch3\u003eWhat does this mean?\u003c\/h3\u003e\n\u003cp\u003eWhen plants grow there are different phases of growth the plants undergo. The 1st phase is the growth of the plant while the 2nd Phase is when the plant flowers or fruits and ripens. It is at the end of this 2nd phase of growth when the fruit is ripening that it is attacked by several pathogens, viruses, fungi etc. It is at this site of attack that the plant will provide or over-produce molecules (phytonutrients) to protect itself against this attack.\u003c\/p\u003e\n\u003cp\u003eWe refer to these as molecules as secondary plant metabolites which occur at the site of  attack or challenge, it is the plants natural defence system.\u003c\/p\u003e\n\u003cp\u003eNatural supplements use some sort of extraction method to extract the plant molecules\/extracts. Typically, solvents are used with alcohol being one of the major solvents used in practice. NPP use a targeted approach to extract specific molecules using super critical or sub critical fluid extraction methods.\u003c\/p\u003e\n\u003cp\u003eMolecules are extracted from the pith and skin of the plants as this is where the concentration of the secondary plant metabolites are found, the site of attack.\u003c\/p\u003e\n\u003ch3\u003eCan we get enough nesems from food alone?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCommercial cropping\u003c\/strong\u003e has reduced nesem® extracts by:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCreation of new varieties\u003c\/li\u003e\n\u003cli\u003ePicking produce green then shipping across to markets\u003c\/li\u003e\n\u003cli\u003eSpraying of crops to reduce loss by disease etc\u003c\/li\u003e\n\u003cli\u003eThe use of fungicides or spraying in particular prelude the plant from having to produce these naturally protective compounds themselves as the chemicals used are providing the defence to the plant externally instead.\u003c\/li\u003e\n\u003cli\u003eGenetic modification to increase yields and reduce spoiling of crops\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eConsumer demands\u003c\/strong\u003e for sweeter perfect looking produce has impacted the amount of nesem® extract’s we consume in our foods by:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSweet taste\u003c\/li\u003e\n\u003cli\u003ePerfect produce – not quite ripe, no blemishes, storage methods,\u003c\/li\u003e\n\u003cli\u003eBright colors\u003c\/li\u003e\n\u003cli\u003eEasy peel\u003c\/li\u003e\n\u003cli\u003eBigger produce \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eRemember if the plants are not being attacked, they are not producing these healing molecules or secondary plant metabolites in high concentrations.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOrganically grown produce, is reported to contain higher amounts of these health-promoting compounds due to the exposure to naturally occurring challenges from plant pests to induce a defensive response and protective compounds, phytoalexins.  However, the amount of these phytoalexins being produced and consumed is still unknown.\u003c\/p\u003e\n\u003cp\u003eThere is clearly potential to re-optimise the levels of these molecules your intake from fruit and vegetable produce. The best way is to choose traditionally grown produce as these will increase the levels of secondary plant metabolites, phytoalexins\/phytonutrients, but the exact intake is unclear as many factors such as growing methods, harvesting, storage etc can influence these levels.\u003c\/p\u003e\n\u003cp\u003eUnfortunately, many of our modern-day foods are conventionally grown with the use of sprays and pesticides, which result in much lower levels of these secondary plant metabolites or phytonutrients.  \u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" height=\"451\" width=\"340\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Apples.png?v=1726197057\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eYou can increase your potential nesem® content from your daily foods by: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHaving a vegetable garden, growing your own produce.\u003c\/li\u003e\n\u003cli\u003eChoose organic wherever possible. Shop at markets wherever possible.\u003c\/li\u003e\n\u003cli\u003eChoose to eat in season as much as you are able.\u003c\/li\u003e\n\u003cli\u003eChoose produce that has ripened on the plant if possible, rather than the shelf\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eProperties of nesem® extracts\u003c\/h3\u003e\n\u003cp\u003enesem® as secondary plant metabolites, phytoalexins have been identified in many fruits, vegetables and herbs which are food sources around the world. They have been shown to benefit human health and have potent:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAnti-cancer activities\u003c\/li\u003e\n\u003cli\u003eNeurogenesis functions\u003c\/li\u003e\n\u003cli\u003eAnti-inflammatory activities\u003c\/li\u003e\n\u003cli\u003eAntioxidant activities\u003c\/li\u003e\n\u003cli\u003eCholesterol lowering ability\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cblockquote\u003e\n\u003cp\u003eIn every Salvestrol Capsule we guarantee you are getting a specific amount of phytoalexins, our support team can help you determine the amount needed to support your health.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch5\u003eCancer Support\u003c\/h5\u003e\n\u003ch2\u003eCancer Support:\u003c\/h2\u003e\n\u003ch3\u003eHow do Salvestrols provide support for those with cancer?\u003c\/h3\u003e\n\u003cp\u003eNesem extracted Salvestrols work beyond antioxidants, they are metabolized by the CYP1B1 enzyme or protein shown to be expressed in cancer cells. Salvestrols are metabolized by the CYP1B1 enzyme which then produces metabolites that are anti-cancer agents - modulating damaged cells, driving natural healthy cell cycle and apoptosis. 1\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Metabolite.png?v=1726127530\" style=\"display: block; margin-left: auto; margin-right: auto;\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Metabolite.png?v=1726127530\" data-mce-style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003ePotter, G. A., \u0026amp; Burke, M. D. (2006). Salvestrols–Natural Products with Tumour Selective Activity. Journal of Orthomolecular Medicine\u003c\/p\u003e\n\u003ch3\u003eUnderstanding CYP1B1 mRNA, versus CYP1B1 enzyme\u003c\/h3\u003e\n\u003cp\u003eAn important distinction to understand is the difference between the CYP1B1 messenger RNA and the CYP1B1 enzyme (protein). Both the mRNA and enzyme are involved in gene expression and function however, the:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eThe CYP1B1 protein performs metabolic functions in the body and is found in all cancer cells tested to date including all stages of cancer from precancerous dysplastic cells, primary cancer cells and metastases of the cancer cells. 1\u003c\/li\u003e\n\u003cli\u003eFor most CYP450 enzymes looking for and finding the mRNA will be predictive of the presence of the enzyme but this is not the case for the CYP1B1 enzyme. 1\u003c\/li\u003e\n\u003cli\u003eThe CYP1B1 enzyme is not found in healthy functioning cells, it has shown only to be found in damaged\/cancer cells but the mRNA CYP1B1 is found in both cancer and healthy cells. 1\u003c\/li\u003e\n\u003cli\u003eIf researching the CYP1B1 protein you need to ensure you are searching for the enzyme itself and not mRNA CYP1B1. 1\u003c\/li\u003e\n\u003cli\u003eThe CYP1B1 enzyme has a lifecycle of approximately three days, leading to the replacement of each enzyme with a new one within this time frame. 1\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3\u003eWhat is the recommended dose of Salvestrols for cancer support?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eInitial loading dose:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e6 capsules a day on an empty stomach in split dosing.\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e2 capsules, three hours later\u003c\/p\u003e\n\u003cp\u003eSalvestrols reach peak concentration in the body approximately 3-4 hours after taking the initial dose, second dose is recommended 3 hours after the initial dose, enabling therapeutic peak concentration to be maintained longer.\u003c\/p\u003e\n\u003cp\u003eTake Salvestrols before midday for greater effectiveness.\u003c\/p\u003e\n\u003cp\u003eTake Salvestrols on waking, empty stomach to allow for greater bioavailable, however, the Cytochrome P450 enzyme activity is highest in the morning and drops off after 3 pm, which further supports the recommendation for taking Salvestrols in the morning.\u003c\/p\u003e\n\u003cp\u003eAn example timeline for taking 6 capsules is:\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e6am \/ 7am – wake up and take 4 capsules **\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e6:30-7:30am – medications\/breakfast\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e9am \/ 10am – take 2 capsules **\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003eMidday onwards – supplements other medications\u003c\/p\u003e\n\u003cp style=\"padding-left: 40px;\" data-mce-style=\"padding-left: 40px;\"\u003e** take \u003ca rel=\"noopener\" title=\"Metagenics Meta Zinc With Vitamin C 10% off RRP | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/collections\/all\/meta-zinc-with-vitamin-c\" target=\"_blank\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/collections\/all\/meta-zinc-with-vitamin-c\"\u003eMetagenics Meta Zinc With Vitamin C \u003c\/a\u003e - add ½ metric teaspoon to 200 mL water twice daily with both doses of Salvestrol Platinum\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Target_Concentration.png?v=1726127531\" style=\"display: block; margin-left: auto; margin-right: auto;\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Naturally_Pure_Products_Salvestrol_Platinum_10_off_RRP_at_HealthMasters_Naturally_Pure_Products_Target_Concentration.png?v=1726127531\" data-mce-style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003eFigure: Target Therapeutic Concentration of Salvestrols\u003c\/p\u003e\n\u003cp\u003eVitamin C supports the activity of Salvestrols, through its antioxidant and electron-donating ability, working synergistically with Salvestrols.1,29\u003c\/p\u003e\n\u003ch3\u003eUse with Chemotherapy \u0026amp; Radiotherapy\u003c\/h3\u003e\n\u003cp\u003eThere are no contraindications on using Salvestrols alongside conventional treatment – Chemotherapy or Radiotherapy. Also of note are Salvestrols are not antioxidants. 1,27,28\u003c\/p\u003e\n\u003cp\u003eIn one study patients taking Salvestrols alongside chemotherapy or radiotherapy reported improvements in overall survival and ECOG performance status indicating better health outcomes and quality of life.25,27,28\u003c\/p\u003e\n\u003cp\u003eSalvestrols in combination with chemotherapy can moderate cardiovascular risk, side effects due to salvestrols high affinity for the CYP1B1 enzyme preventing the metabolism of chemotherapy agents and their toxic metabolites which potentially cause cardiovascular complications and secondary cancers, improving quality of life.27,28\u003c\/p\u003e\n\u003ch3\u003eUse with pharmaceuticals\u003c\/h3\u003e\n\u003cp\u003eThere are no known contraindications with pharmaceuticals, if medications such as thyroxin need to be taken in the morning, we recommend having the first dose of Salvestrols, then have the medication 30 minutes later. Any medications that do not have to be taken in the morning can either be separated by 30 minutes or moved to be taken in the afternoon.\u003c\/p\u003e\n\u003cp\u003eThose with high Blood Pressure may notice a slight drop in BP, but this will normalize within a few days.\u003c\/p\u003e\n\u003ch3\u003eUse with supplements\u003c\/h3\u003e\n\u003cp\u003eIf taking additional supplements, we recommend taking these from lunchtime onwards or in the case of CYP1B1 inhibitors such as B17, CBD, resveratrol etc we recommend taking these late afternoon or evening when the concentration of Salvestrols are decreasing. 1,25\u003c\/p\u003e\n\u003cp\u003eSupporting excessive inflammatory response in cancer patients can lead to better health outcomes.\u003c\/p\u003e\n\u003ch3\u003eWhat is “all clear” mean?\u003c\/h3\u003e\n\u003cp\u003eWhen you have cancer and get the ‘’all clear’’ after undergoing treatment there is an increased concern for secondary cancer diagnosis. So what does ‘’all clear’’ really mean.\u003c\/p\u003e\n\u003cp\u003eWhen someone with cancer gets the “all clear” it is important that they maintain beneficial dietary changes and exercise to support continually clearance of damaged cells.\u003c\/p\u003e\n\u003cp\u003eWe also recommend a maintenance dose of Salvestrols, between 2-4 capsules a day depending on your underlying health.  If inflammation is an on-going concern consider adding Moderaflam to support their health, 2 capsules a day.\u003c\/p\u003e\n\u003cp\u003eWe recommend maintaining beneficial dietary changes and exercise to support your bodies continual clearance of damaged cells.\u003c\/p\u003e\n\u003cp\u003eIf you notice signs of inflammation, consider also adding Moderaflam into your regime to support the management of improved health outcomes. 24,25\u003c\/p\u003e\n\u003ch3\u003eReferences:\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003e\u003cspan\u003eSchaefer, B.A. (2012). Salvestrols, Natures Defence Against Cancer: Linking Diet \u0026amp; Cancer. Clinical Intelligence Corp, Canada.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMurray, G.I., Taylor, M.C., McFadyen, M.C., et al. Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res. (1997) 57: 3026- 3031.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMcFadyen, M.C., Breeman, S., Payne, S., et al. Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. J Histochem Cytochem. (1999) 47: 1457-1464.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMurray, G.I., Melvin, W.T., Greenlee, W.F., et al. Regulation, function and tissue-specific expression of cytochrome P450 CYP1B1. Ann Rev Pharmacol Toxicol. (2001) 41: 297-316.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStanley, L.A., Ball, M.T., Eaden, J., et al. Cytochrome P450 CYP1B1 in the early stages of colon tumour development. Drug Metabol Rev. (2001) 33: 77.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCarnell, D., Smith, R., Daley, F., et al. Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue. Int J Radiat Oncol Biol Phys. (2004) 58: 500-509.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBarnett, J.A., Urbauer, D.L., Murray, G.I., et al. Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target. Clin Cancer Res. (2007) 13: 3559-3567.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMcFadyen, M.C.E., Cruickshank, M.E., Miller, I.D., et al. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Br. J. Cancer. (2001) 85: 242-246.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTsuchiya, Y., Nakajima, M., Takagi, S., et al. MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. (2006) 66: 9090-9098.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eHoang, T.T.V., Burke, M.D., Butler, P.C., et al. Cytochrome P450 1B1 (CYP1B1) expression in human cervical intraepithelial neoplasia. Br J Cancer. (2001) 85: 78.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eChang, H., Su, J., Huang, C.C., et al. Using a combination of cytochrome P450 1B1 and b-catenin for early diagnosis and prevention of colorectal cancer. Cancer Detect Prevent. (2005) 29: 562–569.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSu, J., Lin, P., Wang, C., et al. Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target. Anticancer Res. (2009) 29: 509-515.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTokizane, T., Shiina, H., Igawa, M., et al. Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin Cancer Res. (2005) 11: 5793-5801\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMaecker, B., Sherr, D.H., Vonderheide, R.H., et al. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. (2003) 102: 3287-3294.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eChang, J.T., Chang, H., Chen, P., et al. Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas. Clin Cancer Res. (2007) 13: 38-45.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eKumarakulasingham, M., Rooney, P.H., Dundas, S.R., et al. Cytochrome P450 profile of colorectal cancer: identification of markers of prognosis. Clin Cancer Res. (2005) 11: 3758-3765.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eGreer, M.L., Richman, P.I., Barber, P.R., et al. Cytochrome P450 1B1 (CYP1B1) is expressed during the malignant progression of head and neck squamous cell carcinoma (HNSCC). Proc Am Cancer Res. (2004) 45: Abstract #3701.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFurukawa, M., Nishimura, M., Ogino, D., et al. Cytochrome P450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci. (2004) 95: 520-529.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMaecker, B., von Bergwelt-Baildon, M.S., Anderson, K.S., et al. Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients. Clin Exptl Immunol. (2005) 141: 558-562.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNedelkov, D., Kiernan, U.A., Niederkofler, E.E., et al. Population proteomics: the concept, attributes and potential for cancer biomarker research. Mol Cell Proteomics. (2006) 5: 1811-1818.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStoeckli, M., Chaurand, P., Halahan, D.E., et al. Imaging mass spectrometry; a new technology for the analysis of protein expression in mammalian tissues. Nature Med. (2001) 7: 493-496.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAlsubait, A., Aldossary, W., Rashid, M., Algamdi, A., Alrfaei, B.M. (2020). CYP1B1 gene: Implications in glaucoma and cancer. Journal of Cancer, 11(16), 4652-4661. https:\/\/doi.org\/10.7150\/jca.42669.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePotter, G. A., \u0026amp; Burke, M. D. (2006). Salvestrols–Natural Products with Tumour Selective Activity. Journal of Orthomolecular Medicine.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSchaefer, B. A. (2018). Salvestrols: Nature’s defense against cancer. Clinical Intelligence Inc.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNaturally Pure Products. (2023). Salvestrol Clinical Guidance Document.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/populationeducation.org\/a-timeline-of-the-three-major-agricultural-revolutions-in-history\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/maplespub.com\/article\/effect-of-nesem-s2013-in-indian-population-undergoing-conventional-treatment-for-the-malignancies-of-the-head-and-neck-git-ovary-breast-and-lung-as-an-adjunct\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNaturally Pure Products (2022), Salvestrols role in the utilization of CYP1B1 as a therapeutic target in cardio-oncology\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/isom.ca\/learning\/conference-proceedings\/48th-omt\/ascorbic-acid-as-a-novel-co-factor-for-cytochrome-p450-metabolism-and-cancer-cell-selectivity\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTsuchiya, Y. et al., Cancer Res. 66: 9090-98 (2006)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDevlin, A. et al., Mol. Carcin. 49: 190-99 (2010)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNakajima \u0026amp; Yokoi, Pharm. Ther. 131: 330-337 (2011)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.naturallypureproducts.com\/blogs\/news\/all-about-nesem%C2%AE-technology\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10334162\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.foodpackagingforum.org\/news\/two-studies-associate-microplastic-exposure-with-cancer\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK12712\/\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8964978\/#:~:text=Dysregulated%20IL%2D6%20promotes%20a,DKK%2D1%20(128).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/27260630\/\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings:\u003c\/h2\u003e\n\u003cp\u003eConsult your health care professional prior to use if pregnant or breastfeeding.\u003c\/p\u003e\n\u003cp\u003eColour may vary from batch to batch.\u003c\/p\u003e\n\u003cp\u003eKeep out of reach from children.\u003c\/p\u003e\n\u003cp\u003eDietary supplements should not be used as a substitute for a balanced diet and healthy lifestyle.\u003c\/p\u003e\n\u003cp\u003eSalvestrol® is a registered trademark licensed to Nature’s Defence Research Ltd\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage:\u003c\/h2\u003e\n\u003cp\u003eStore in a cool dry place below 25C.\u003c\/p\u003e"}