Metagenics MetaRelax Powder (CalmX)

Product Video

Description

• Metagenics MetaRelax Powder (CalmX) is a great tasting magnesium combination that helps to relieve the symptoms of stress while supporting a healthy stress response and neuroendocrine function. The formula also contains taurine, potassium citrate, vitamin B6 and vitamin C.

• Metagenics MetaRelax Powder (CalmX) helps nervous system function by assisting synthesis of some neurotransmitters, which are chemical messengers in the brain and central nervous system and are involved in the body’s stress response.

• Metagenics MetaRelax Powder (CalmX) features MagActive®, an exclusive Magnesium bisglycinate blend with enhanced absorption magnesium.

Clinical Benefits

• Metagenics MetaRelax Powder (CalmX) is a magnesium formula specifically designed for times of stress with ingredients that play a critical role in building stress resilience and supporting the nervous system. Stress can deplete many nutrients, particularly magnesium as it causes this essential mineral to shift to the extracellular space, increasing urinary excretion and depleting body magnesium stores. This adversely affects key neurotransmitters like serotonin and acetylcholine, exacerbating stress.

• A double-blind, placebo-controlled trial demonstrated that a daily intake of 6g of taurine effectively inhibits the stress-induced release of adrenaline, highlighting taurine’s role in stress management. The synergy of magnesium, B vitamins, vitamin C, and zinc is crucial for regulating the stress response, acting as cofactors in neurotransmitter synthesis.

• Zinc is vital for modulating the stress response and has been linked to feelings of anxiety. Acute stress elevates serum glucocorticoids and induces metallothionein synthesis, reducing serum zinc levels.

• By addressing these nutrient deficiencies, this formulation enhances the body’s ability to manage stress, leading to improved clinical outcomes for patients experiencing stress and anxiety, resulting in better stress resilience and overall mental wellbeing.

Directions

Warnings

Contains 100mg of potassium per 12.7 g dose.

Vitamin and mineral supplements should not replace a balanced diet.

Stop taking this medication if you experience tingling, burning or numbness and see your healthcare practitioner as soon as possible. [Contains vitamin B6].

This product is sold by weight not volume. Some settling may occur.

If symptoms persist consult your healthcare professional.

Storage

Store below 30°C.

Key Ingredients

Active Ingredients

Free from

Animal products, Dairy protein, Lactose, Eggs, Gluten, Wheat, Nuts, Yeast, Soy protein, Artificial colours, Artificial sweeteners, Artificial flavours, Artificial preservatives.

Excipients

Citric acid, Colour, Flavour, Glycine hypromellose, Malic acid, Maltodextrin, Silicon dioxide, Steviol glycosides, Tartaric acid.

Frequently asked questions

How does MetaRelax™ help during stress?

When we’re under stress, our bodies need additional nutrients—especially magnesium and B vitamins—to support the neuroendocrine system, which plays a key role in maintaining both mental and physical wellbeing¹. MetaRelax™ delivers a targeted blend of brain-supportive nutrients designed to promote a healthy stress response by nourishing the nervous system. These nutrients also help enhance the production of neurotransmitters—chemical messengers that regulate how the brain and body respond to stress.¹⁻⁶

References

1. Pouteau E, et al. PLoS One. 2018;13(12):e0208454.
2. Tarleton EK, et al. PLoS One. 2017;12(6):e0180067.
3. Ranjbar E, et al. Iran J Psychiatry. 2013;8(2):73-79.
4. Al-fahham AA. J of Phys: Conference Series 2019 Sep; 1294(6).
5. Sarris J, et al. Nutr Hosp. 2021;38(6):1277-1286.

How long does it take to see results from using MetaRelax™?

You may notice the benefits of MetaRelax™ within a few days. Clinical studies have shown these nutrients at the provided dosages to support stress reduction, mood balance, concentration, and stamina within 2 to 4 weeks.⁴,⁵

Additional benefits observed over 6 to 12 weeks include: * 42.4% reduction in stress. * 24% to 50% improvement in mood scores.¹⁻³

References:

1. Pouteau E, et al. PLoS One. 2018;13(12):e0208454.
2. Tarleton EK, et al. PLoS One. 2017;12(6):e0180067.
3. Ranjbar E, et al. Iran J Psychiatry. 2013;8(2):73-79.
4. Al-fahham AA. J of Phys: Conference Series 2019 Sep; 1294(6).
5. Sarris J, et al. Nutr Hosp. 2021;38(6):1277-1286.

What makes MetaRelax™ different to other magnesium-based products?

MetaRelax™ is a comprehensive formula designed with synergistic ingredients to support the nervous system. It features a highly absorbable form of magnesium (magnesium bisglycinate) along with supporting nutrients: taurine, potassium citrate, vitamin B6, and vitamin C. It is available in two delicious-tasting varieties.

When should I take MetaRelax™?

MetaRelax™ is ideal for daily use. It should be taken once or twice daily, preferably in the morning and afternoon, with meals.

Is MetaRelax™ safe to use during pregnancy or while breastfeeding?

MetaRelax™ contains nutrients commonly found in food, though some are present in higher amounts than what is found in a typical daily intake. While it contains taurine (naturally found in seafood), there is currently insufficient reliable information regarding taurine supplementation during pregnancy and lactation.

We suggest using Metagenics Pregnancy Care Advanced tablets as a specialised alternative to MetaRelax™ during this time.

Is MetaRelax™ suitable for vegans and vegetarians?

Yes. There are no animal-derived products in MetaRelax™, making it suitable for both vegans and vegetarians.

I experience soft stools or diarrhea when taking magnesium. Should I stop?

Metagenics use magnesium bisglycinate. This form is bound to the amino acid glycine, which improves bioavailability and is significantly gentler on the stomach, making it less likely to cause gastrointestinal upset.

If you still experience loose stools: * Reduce your dose by half (e.g., take one serve per day instead of two). * Gradually increase the dose over 1 to 2 weeks to find your optimal tolerance level.

Magnesium Bisglycinate

MAGNESIUM BISGLYCINATE

Metagenics CalmX contains evidenced-based ingredients to support the natural metabolic pathways for gamma-aminobutyric acid (GABA) production and activity, indicated to promote relaxation during times of stress. MetaMag Magnesium bisglycinate is scientifically designed to provide a highly bioavailable form of magnesium. Magnesium may act as a GABA receptor agonist and also has a binding site on the glutamate receptors helping to regulate the activity of this main excitatory neurotransmitter.1 Glycine functions as an inhibitory neurotransmitter in the nervous system while glutamine is a precursor to GABA production.2 Pyridoxal (vitamin B6) is a cofactor for the enzyme Glutamate decarboxylase that synthesises GABA from glutamate.4 Zinc also has a binding site on the glutamate receptor and may act as a modulator for both excitatory and inhibitory neurotransmission.5

Magnesium

Magnesium is predominantly located intra-cellular in bone, muscles and non-muscular soft tissues while only 1% of total magnesium is found in serum and red blood cells. Magnesium needs to be consumed in the diet regularly to prevent the risk of magnesium deficiency and due to the increased consumption of processed foods; magnesium intake in the western world is decreasing. Magnesium is a cofactor in more than 300 enzymatic reactions, critically stabilising enzymes, including many ATP-generating reactions. ATP metabolism, muscle contraction and relaxation, normal neurological function and release of neurotransmitters are all magnesium dependent.6 While evidence generally does not support the use of magnesium for skeletal muscle cramps with many studies producing null effect7,8, there is evidence to suggest oral magnesium supplementation can improve anaerobic metabolism in athletes, decreasing lactate production9 and improving physical performance in healthy elderly women involved in an exercise program.10

Magnesium may function as a GABA receptor agonist promoting the effects of GABA. Further, in the central nervous system (CNS), magnesium ions block NMDAR channels at resting membrane potentials. The binding site for magnesium ions is deep within the channel. This block is voltage-dependent but ion flux occurs when the membrane potential is depolarized. NMDAR receptors are glutamate-binding sites, being the major excitatory neurotransmitter in the CNS.11 See Figure 1.

Figure 1. Neurotransmitter signalling12

Glycine

Glycine functions as one of the major inhibitory neurotransmitters in the CNS with a high density of glycine containing neurons being found in spinal cord and brain stem. When glycine binds to its receptor it opens the anion channel allowing an influx of chloride ions into the postsynaptic neuron causing hyperpolarization that raises the threshold for neuronal firing and thereby inhibits the postsynaptic neuron.2,13

Glutamine

Glutamine and glutamate are amino acids. Several studies show that concentrations of serum glutamine in the body are diminished during times of physical or psychological stress and further that patients presenting with exhaustion, anxiety, sleeplessness and lack of concentration have low serum glutamate concentration. Glutamine and glutamate synthesis occur interchangeably (see figure 2). Glutamine converts to glutamate using NADPH as a cofactor and glutamate is a precursor for GABA production using vitamin B6 as a cofactor.15-19

Figure 2. GABA is synthesized from Glutamine and Glutamate20

Pyridoxal 5-Phosphate (Vitamin B6)

Pyridoxine is the cofactor required by Glutamate decarboxylase to convert glutamate to GABA in the CNS.4 See Figure 2.

Zinc

Approximately 10% of total zinc in the brain is located in synaptic vesicles of certain glutamatergic neurons.5 Zinc may modulate neurotransmission mediated via both excitatory and inhibitory amino acid receptors at specific synapses for example the NMDA glutamate receptor is directly inhibited by zinc whereas GABA release from the presynapse can be potentiated (see Figure 1).28

Clinical Summary:

• To naturally increase GABA production to induce relaxation
• Helps relieve symptoms of nervous tension, stress and mild anxiety
• For the symptomatic relief of stress disorders.
• Herbal blend which helps relieve stress of study or work
• May help reduce the frequency of migraines.

Who will benefit:

• Those with symptoms of anxiety and nervous tension
• Those who are experiencing mild stress and associated disorders
• Those who are experiencing stress associated with work and/or study
• Those with magnesium deficiency
• Those who are experiencing frequent migraines
• Those who wish to improve their cognitive performance and mood.

References:

1. Held K, Antonijevic IA, Künzel H, et al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry 2002;35(4):135-143
2. Legendre P. The glycinergic inhibitory synapse. Cell. Mol. Life Sci 2001;58:760–793
3. Kimura K1, Ozeki M, Juneja LR, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol 2007;74(1):39-45
4. Qu K, Martin DL, Lawrence C. Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase. Protein Sci 1998;7:1092-1105.
5. Takeda A, Minami A, Seki Y, et al. Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. J Neurosci Res 2004; 15;75(2):225-9.
6. Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J 2012;5 (1);i3–i14.
7. Nygaard IH, Valbo A, Oethick SV, et al. Does oral magnesium substitution relieve pregnancy-inducede leg cramps? Eur J Obstet Gynecol Reprod Biol 2008;141:23-6.
8. Garrison SR, Birmingham CL, Koehler BE, et al. The effect of magnesium infusion on rest cramps: a randomized controlled trial. J Gerontol A Biol Sci Med Sci 2011;66:661-6.
9. Setaro L, Santos-Silva PR, Nakano EY, et al. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation. J Sports Sci 2014;32:438-45.
10. Veronese N, Berton L, Carraro S, et al. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Nutr 2014;100:974-81.
11. Monaghan DT, Jane DE. Pharmacology of NMDA receptors. In: Van Dongen AM, editor. Biology of the NMDA receptor. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 12.
12. Gecz, J. Glutamate receptors and learning and memory. Nat. Genet 2010;42:925
13. Berger AJ, Dieudonne S, Ascher P. Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol 1998;80: 3336–3340.
14. Hubner CA, Stein V, Hermans-Borgmeyer I, et al. Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron 2001;30:515–524.
15. Chen SW, Kong WX, Zhang YJ, et al. Possible anxiolytic effects of taurine in the mouse elevated plus-maze. Life Sci 2004;75(12):1503-1511.
16. Hertz L, Kvamme E, McGeer, EG, et al. Glutamine, Glutamate, and Gaba in the Central Nervous System. Alan R Liss Inc. New York; 1983.
17. Bowtell JL, Gelly K, Jackman ML, et al. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. J.Appl Physiol 1999:1770-1777.
18. Welbourne TC. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr 1995;61(5):1058-1061.
19. Hasler G, Van der Veen JW, Tumonis, T, et al. Reduced Prefrontal Glutamate/Glutamine and Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy. Arch Gen Psych 2007;64 (2):193-200.
20. Owens DF, Krieg Stein AR. Is there more to GABA than synaptic inhibition? Nat. Rev. Neurosci 2002;3:715
21. Kakuda T, Nozawa A, Sugimoto A, et al. Inhibition by Theanine of binding of [3H]AMPA, [3H]Kainate and [3H]MDL 105,519 to glutamate receptors. Biosci Biotechnol Biochem 2002;66:2683-86.
22. Kimura R, Murata T. Influence of alkylamides of glutamic acid and related compounds on the central nervous system I. Central depressant effect of theanine. Chem Pharm Bull 1971;19:1257–1261.
23. Nathan PJ, Lu K, Gray M, et al.; The neuropharmacology of L-theanine (N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother 2006;6(2):21-30.
24. Heese T, Jenkinson J, Love C, et al.& Anxiolytic effects of L-theanine - a component of green tea - when combined with midazolam, in the male Sprague-Dawley rat. AANA J 2009;77(6):445-449.
25. Ito K, Nagato Y, Aoi N, et al. Effects of L-theanine on the release of alpha brain waves in human volunteers. Nippon Nogeikagaku Kaishi 1998;72:153-157.
26. Lu K., Gray MA, Oliver C, et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol 2004;19(7):457-465.
27. Lardner AL. Neurobiological effects of the green tea constituent Theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutr Neurosci 2014;17:145-55.
28. Smart TG, Hosie AM, Miller PS. Zn2+ ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist 2004;10(5):432-42.
29. Gröber U. Magnesium. In: Gröber U., editor. Micronutrients: Metabolic Tuning-Prevention-Therapy. 1st ed. MedPharm Scientific Publishers; Stuttgart, Germany: 2009:159–166.
30. Foca FJ. Motor and sensory neuropathy secondary to excessive pyridoxine ingestion. Arch Phys Med Rehabil 1985;66(9):634-6.
31. Dalton K, Dalton MJ. Characteristics of pyridoxine overdose neuropathy syndrome. Acta Neurol Scand 1987;76(1):8-11.

Technical Information

Metagenics CalmX Technical Information - Click Here

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