Bioclinic Naturals Oregano Oil 60 Softgels

Benefits

• Contains 180 mg of oregano (Origanum vulgare) oil, which is extracted from hand-picked leaves using steam distillation, ensuring that the oil is chemical free
• Contains a minimum of 80% carvacrol
• Oregano (Origanum vulgare) oil supports healthy gastrointestinal function

Recommended Use

Adults: 1–4 softgels per day or as directed by a health care practitioner.

Medicinal Ingredients

*Derived from wild-crafted Mediterranean oregano. The oil is extracted from the hand-picked leaves using steam distillation, ensuring that the oil is chemical free.

Technical Information

Oregano Oil

Oregano oil is a herbal remedy used for its potent antioxidant and antimicrobial effects. Oregano oil can be used orally to fight systemic infection, topically for fungal infection or daily for the maintenance of good health.

Bioclinic Natural’s organic, wild-crafted oregano oil is hand harvested from the Origanum vulgare plant.

To maintain the purity and concentration of the active ingredients, the leaf is gently steam-distilled without the use of chemicals, to deliver the strongest antimicrobial properties and the highest phenolic content.1

The pure oil is then blended with an antioxidant carrier of vitamin E from non-GMO sunflower oil and organic cold pressed virgin olive oil.

Bioclinic Natural’s Oregano Oil is standardised to contain a minimum of 80% of carvacrol making it ideal for providing extra antimicrobial action. Oregano Oil is available in convenient softgels to avoid compliance issues arising from concentrated oregano oil.

Oregano oil’s main active constituents include the phenolic compounds carvacrol, thymol, and rosmaric acid. Rosmarinic acid in particular, and other related phenolic constituents, account for the powerful antioxidant action of oregano oil.2 Rosmarinic acid also accounts for much of the anti-inflammatory action associated with oregano oil and has been shown to provide beneficial anti-inflammatory control over allergic rhinitis in humans.3,4

The natural anti-inflammatory actions of oregano oil account for its many oral herbal uses including respiratory tract disorders such as coughs, asthma, croup, and bronchitis. It is also thought that oregano oil possesses antispasmodic and mucolytic properties.5 One of the benefits associated with the oil of Origanum vulgare is its potent antimicrobial action, produced by the phenolic constituents carvacrol and thymol. Numerous scientific studies demonstrate that oregano oil can inhibit the growth of, or kill many of, the harmful bacteria that adversely affect humans, including some of those which have already become resistant to treatment.6-12 Additionally, a study has found that the oil of Origanum vulgare had the highest and broadest antimicrobial activity when compared with other essential oils, with carvacrol showing the highest antimicrobial action of the tested constituents.13

The whole essential oil has also shown in vitro activity against a number of gram positive and negative organisms, including Acinetobacter calcoaceticus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella species, Serratia marcescens, Staphylococcus aureus, and the yeast Candida albicans.7,8,9,12

Carvacrol and thymol also inhibit bacterial growth, with carvacrol demonstrating bacteriocidal effect against Bacillus cereus.14

Oregano oil has also been found to arrest the growth of intestinal parasites in vivo.15

Cautions

Initial topical application to genital areas should proceed cautiously in smaller amounts to learn individual sensitivity.

Avoid contact with the eyes, and flush immediately with water if eye contact occurs.

Caution is required for childhood use. Childhood use of oregano essential oil should be guided by a health care practitioner. The label dose for this product is an adult dose.

In bleeding disorders and perioperatively, oregano essential oil may act as a thrombin inhibitor increasing the risk for bleeding.1 Use caution in those on anticoagulant therapy. This product supplies 1–2 mg per day of vitamin E, which is not expected to compromise anticoagulation therapy through warfarin, or other drugs that inhibit vitamin K recycling. The mechanism for increased bleeding and decreased vitamin K status accompanying vitamin E supplementation is unknown3, but compromised coagulation control is usually associated with doses of 300 mg/day of vitamin E, rather than 1–2 mg per day.4 Furthermore, the oregano essential oil content may enhance the effects of anticoagulation drugs.1

References

1. Teixeira, B., Marques, A., Ramos, C., et al. (2013). Chemical composition and bioactivity of different oregano (Origanum vulgare) extracts and essential oils. Journal of the Science of Food and Agriculture, 93(11), 2707-14.
2. Exarchou, V., Nenadis, N., Tsimidou, M., et al. (2002). Antioxidant activities andphenolic composition of extracts from Greek oregano, Greek sage, and summer savory. Journal of Agriculture and Food Chemistry, 50(19), 5294-9.
3. Takano, H., Osakabe, N., Sanbongi, C., et al. (2004). Extract of perilla frutescens enriched for rosmarinic acid inhibits seasonal allergic rhinoconjunctivitis in humans. Experimental Biology and Medicine (Maywood), 229(3), 247-54.
4. Osakabe, N., Takano, H., Sanbongi, C., et al. (2004). Anti-inflammatory and anti-allergy effects of rosmarinic acid (RA). Inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. Biofactors, 21(1-4), 127-131.
5. Jellin, J.M., Gregoty, P.J., Batz, F., Hitchens, K., et al. (Eds.). (2013). Melatonin. Retrieved December 2013, Therapeutic Research Faculty: http//www. naturaldatabase.therapeuticresearch.com.
6. Hammer, K.A., Carson, C.F. & Riley, T.V. (1999). Antimicrobial activity of essential oils and other plant extracts. Journal of Applied Microbiology, 86(6), 985-90.
7. Rodriguez, M., Alvarez, M. & Zayas, M. (1991). [Microbiological quality of spices consumed in Cuba]. [Article in Spanish]. Revista Lantinoamericana de Microbiologia, 33(2-3), 149-51.
8. Kivanc, M., Akgul, A., Dogan, A. (1991). Inhibitory and stimulatory effects of cumin, oregano and their essential oils on growth and acid production of Lactobacillus plantarum and Leuconostoc mesenteroides. International Journal of Food Microbiology, 13(1), 81-5.
9. Akgul, A. & Kivanc, M. (1988). Inhibitory effects of selected Turkish spices and oregano components on some foodborne fungi. International Journal of Food Microbiology, 6(3), 263-8.
10. Burt, S.A. & Reidner, R.D. (2003). Antibacterial activity of selected plant essential oils against Escherichia coli O157:H7. Letters in Applied Microbiology, 36(3), 162-7.
11. Nostro, A. & Papalia, T. (2012). Antimicrobial activity of carvacrol. Current progress and future prospectives. Recent Patents on Anti-infective Drug Discovery, 7(1), 28-35
12. Sokovic, M., Glamoclija, J., Marin, P.D., Brkic, D. & van Griensven, L.J. (2010). Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model. Molecules, 15(11), 7532-46.
13. Ultee, A., Kets, E.P. & Smid, E.J. (1999). Mechanisms of action of carvacrol on the food-borne pathogen Bacillus cereus. Applied and Environmental Microbiology, 65(10), 4606-10.