Activated Probiotics Biome Daily Kids

Indications

• Helps enhance immune system function
• Helps reduce the occurrence and duration of common colds
• Supports good gut bacteria during antibiotic use

Directions For Use

Children over 2 years:

Take one sachet daily, or as directed by a healthcare practitioner.

Add to water or milk, or mix with yoghurt.

Not to be used in children under 2 years of age without medical advice.

If symptoms persist, talk to your health professional.

Formulation

*BLB = Billion Live Bacteria"No Refrigeration Required

No Added

GMOs, wheat, gluten, dairy, lactose, fructose, sugar, yeast, nuts, seeds, peanut, soy, egg, fish, shellfish, or animal derivatives.

No artificial sweeteners, colours, flavours, or preservatives.

Contains polyols and natural vanilla flavour.

Storage Conditions

Fridge Free

Technical Information

Probiotics help to support children?s general health and wellbeing in a number of ways, including keeping their digestive system healthy, and enhancing the function of the immune system1

ANTIBIOTIC USE IN CHILDREN

Antibiotics are the most widely prescribed class of medication for Australian children2. In order to target a number of different pathogens, most antibiotics have broad-spectrum antimicrobial activity. An unintended consequence of this is that related members of the gut microbiome are often adversely affected3. Numerous studies have demonstrated that antibiotics can significantly reduce microbial abundance and diversity4,5 and induce a state of microbial imbalance, known as intestinal dysbiosis6. Intestinal dysbiosis results in the loss of the ability of the gut microbiota to ward off pathogens, which increases susceptibility to infections7

ANTIBIOTIC-ASSOCIATED DIARRHOEA

A common side effect of antibiotics is antibiotic-associated diarrhea (AAD), which affects around 11% of children in an outpatient setting8, and can begin any time from initiation of antibiotic therapy until up to two months after the course is finished9. A recent position paper published by a working group of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) found that probiotic supplements are generally effective in reducing the risk of AAD by 52% (RR 0.48; 95% CI 0.37-0.61), with the strongest evidence being for the use of Lactobacillus rhamnosus GG10.

ACUTE RESPIRATORY TRACT INFECTIONS IN CHILDREN

Acute respiratory tract infections (RTIs) - such as the common cold and acute tonsillitis - are particularly prevalent among young children, especially when they attend childcare centres11. These illnesses present a significant economic burden, causing parental absenteeism from work, visits to GPs and emergency departments, and antibiotic prescriptions, which are ineffective if the infection is viral12. The probiotic strain Lactobacillus rhamnosus GG has been shown to significantly reduce the risk of UTRIs in children by 38% (RR 0.62, 95% CI 0.50-0.78) compared to placebo13, and significantly reduce their duration12.

RECURRENT ABDOMINAL PAIN IN CHILDREN

Recurrent abdominal pain is an umbrella term to describe a number of functional gastrointestinal disorders, including Irritable Bowel Syndrome (IBS), functional dyspepsia, functional abdominal pain, and abdominal migraine. Recurrent abdominal pain is a common problem managed in general practice, affecting between 4% and 25% of schoolaged children14. A recent systematic review found that children treated with probiotics were more likely to experience improvement in their pain (0-3 months) than those who received placebo (odds ratio 1.63, 95% CI 1.07-2.47; 722 children)14.

References

1. Hojsak I. Probiotics in Children: What Is the Evidence? Pediatr Gastroenterol Hepatol Nutr. 2017 Sep;20(3):139?46.
2. Gadzhanova S, Roughead E. Prescribed antibiotic use in Australian children aged 0?12 years. Aust Fam Physician. 2016;45(3):5.
3. Willing BP, Russell SL, Finlay BB. Shifting the balance: antibiotic effects on host?microbiota mutualism. Nat Rev Microbiol. 2011 Apr;9(4):233?43.
4. Clemente JC, Ursell LK, Parfrey LW, Knight R. The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell. 2012 Mar 16;148(6):1258?70.
5. Antonopoulos DA, Huse SM, Morrison HG, Schmidt TM, Sogin ML, Young VB. Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation. Infect Immun. 2009 Jun;77(6):2367?75.
6. Weiss GA, Hennet T. Mechanisms and consequences of intestinal dysbiosis. Cell Mol Life Sci. 2017 Aug 1;74(16):2959?77.
7. Langdon A, Crook N, Dantas G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med [Internet]. 2016 Apr 13 [cited 2019 Jun 13];8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831151/
8. Turck D, Bernet J-P, Marx J, Kempf H, Giard P, Walbaum O, et al. Incidence and risk factors of oral antibiotic-associated diarrhea in an outpatient pediatric population. J Pediatr Gastroenterol Nutr. 2003 Jul;37(1):22?6.
9. McFarland LV. Epidemiology, risk factors and treatments for antibiotic-associated diarrhea. Dig Dis Basel Switz. 1998 Oct;16(5):292?307.
10. Szajewska H, Canani RB, Guarino A, Hojsak I, Indrio F, Kolacek S, et al. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children. J Pediatr Gastroenterol Nutr. 2016 Mar;62(3):495?506.
11. Biezen R, Pollack AJ, Harrison C, Brijnath B, Grando D, Britt HC, et al. Respiratory tract infections among children younger than 5 years: current management in Australian general practice. Med J Aust. 2015 Mar 16;202(5):262?5.
12. Laursen RP, Hojsak I. Probiotics for respiratory tract infections in children attending day care centers?a systematic review. Eur J Pediatr. 2018 Jul;177(7):979?94.
13. Liu S, Hu P, Du X, Zhou T, Pei X. Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: a meta-analysis of randomized, placebo-controlled trials. Indian Pediatr. 2013 Apr;50(4):377?81.
14. Newlove-Delgado TV, Martin AE, Abbott RA, Bethel A, Thompson-Coon J, Whear R, et al. Dietary interventions for recurrent abdominal pain in childhood. Cochrane Database Syst Rev [Internet]. 2017 Mar 23 [cited 2019 Aug 29];2017(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464236/