(Discontinued) Metagenics D-Ribose 300g

Directions

1¼ metric teaspoons (5.0 g) is equal to 5.0 g of D-Ribose 

• For fatigue – 5g (1¼ tsp) once daily
• For fibromyalgia and chronic fatigue syndrome – 5g (1¼ tsp) three times daily
• For exercise and sports performance – 5g (1¼ tsp) once to twice daily
• For heart health – 5g (1¼ tsp) three times daily

Benefits

KEY ACTIONS:

• Production of ATP (via AMP and ADP synthesis)
• Protects cardiac muscle from ischaemia
• Improves muscle recovery
• Improves exercise tolerance
• Reduces oxidative stress

KEY APPLICATIONS:

• Fatigue
• Fibromyalgia
• Chronic fatigue syndrome
• Exercise and sporting performance
• Cardiac health

Ingredients

D-Ribose is made from glucose and corn. Our own body makes Ribose from glucose.

Excipients

Nil Excipients

Warnings

CONTRAINDICATIONS:

Nil

CAUTIONS:

• Antidiabetic drugs: Ribose may increase the hypoglycaemic effect of oral antihyperglycaemic agents such as the sulfonylureas, biguanides, alfa-glucosidase inhibitors, thiazolidinediones, and meglitinides.3 While additional hypoglycaemic effects may be clinically desirable, blood glucose levels should be monitored.
• Insulin: Ribose may increase the hypoglycaemic effect of insulin.3 While additional hypoglycaemic effects may be clinically desirable, blood glucose levels should be monitored.

Pregnancy and Lactation

• There are no human clinical studies in this area to date, however animal evidence suggests there are no teratogenic effects.3 Use with caution when there is a clear clinical benefit.

Storage

Store below 30° C

References

1. http://chemwiki.ucdavis.edu/Physical_Chemistry/Thermodynamics/Case_Studies/Case_Study%3A_Thermodynamics_of_ATP?hig hlight=chemiosmosis date accessed 9/9/13
2. Pasque MK & Wechsler AS. Metabolic intervention to affect myocardial recovery following ischaemia. Annals of Surgery 1984;1(200): 1-12
3. Díaz-Flores M, et al. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol. 2013 Oct;91(10):855-60
4. Seifert JG, Subudhi AW, Fu MX, Riska KL, John JC, Shecterle LM, St Cyr JA. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food. 2009 Jun;12(3):690-3.
5. Elvin A, Siösteen AK, Nilsson A, Kosek E. Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: a contrast media enhanced colour Doppler study. Eur J Pain. 2006 Feb;10(2):137-44.
6. Lee JH, et al. Arterial stiffness in female patients with fibromyalgia and its relationship to chronic emotional and physical stress. Korean Circ J. 2011 Oct;41(10):596-602.
7. Zarzeczny R et al. Influence of ribose on adenine salvage after intense muscle contractions. J Appl Physiol 2001; 91:1775-1781.
8. Myhill S, Booth NE, McLaren-Howard J. Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit. Int J Clin Exp Med. 2013;6(1):1-15.
9. Bengtsson A, Henriksson KG, Larsson J. Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia. Arthritis Rheum. 1986 Jul;29(7):817-21.
10. Casro-Marrero J, et al. Mitochondrial Dysfunction Be a Differentiating Marker Between Chronic Fatigue Syndrome and Fibromyalgia? Antioxid Redox Signal. 2013 May 29. [Epub ahead of print]
11. Addis P, et al. Cellular Protection during Oxidative stress: a potential role for Ribose and Antioxidants. Journal of Dietary Supplements 2012;9(3):178-182.
12. Dodd SL, et al. The role of ribose in human skeletal muscle metabolism. Medical Hypotheses 2004;62:819-824.
13. Dodd SL, et al. The role of ribose in human skeletal muscle metabolism. Medical Hypotheses 2004;62:819-824.
14. Hellsten Y, Skadhauge L & Bangsbo J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am J Physiol Regul Integr Comp Physiol 2004;286:R182-R188.
15. http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=&s=ND&pt=100&id=827&ds=&name=RIBOSE&searchi d=40637790 date accessed 05/04/13.
16. Zarzeczny R et al. Influence of ribose on adenine salvage after intense muscle contractions. J Appl Physiol 2001; 91:1775-1781.
17. Seifert JG et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food 2009;12(3):690-693.
18. Flanigan R, MacCarter D, Shecterle LM, St Cyr JA. D-ribose aids fatigue in aging adults. J Altern Complement Med. 2010 May;16(5):529-30.
19. Teitelbaum JE et al. The use of Ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Alt and Complement Med 2006; 12(9):857-862.
20. Teitelbaum J ect al. Treatment of chronic fatigue syndrome and fibromyalgia with Ribose – an open–label multicentre study. The Open Pain Journal 2012;5:32-37.
21. Teitelbaum J ect al. Treatment of chronic fatigue syndrome and fibromyalgia with Ribose – an open–label multicentre study. The Open Pain Journal 2012;5:32-37.
22. http://naturalstandard.com/databases/herbssupplements/ribose.asp?#undefined date accessed 10/9/13
23. Pliml W et al. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. The Lancet 1992;340:507-510.
24. MacCarter D et al. Ribose aids advanced ischaemic heart failure patients. Int J Cardiol 2009;137(1):79-80.
25. Pliml W et al. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. The Lancet 1992;340:507-510.
26. Dodd SL, et al. The role of ribose in human skeletal muscle metabolism. Medical Hypotheses 2004;62:819-824.
27. Seifert JG et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food 2009;12(3):690-693.
28. Seifert JG et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food 2009;12(3):690-693.
29. Dodd SL, et al. The role of ribose in human skeletal muscle metabolism. Medical Hypotheses 2004;62:819-824.
30. Addis P, et al. Cellular Protection during Oxidative stress: a potential role for Ribose and Antioxidants. Journal of Dietary Supplements 2012;9(3):178-182
31. Hellsten Y, Skadhauge L & Bangsbo J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am J Physiol Regul Integr Comp Physiol 2004;286:R182-R188.
32. Seifert JG et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food 2009;12(3):690-693.
33. Hellsten Y, Skadhauge L & Bangsbo J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am J Physiol Regul Integr Comp Physiol 2004;286:R182-R188.
34. Van Gammeren D, Falk D and Antonio J. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo-controlled trial. Current Therapeutic Research 2002; 63(8):486-495
35. http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=&s=ND&pt=100&id=827&ds=&name=RIBOSE&searchi d=40637790 date accessed 05/04/13.
36. http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=&s=ND&pt=100&id=827&ds=&name=RIBOSE&searchi d=40637790 date accessed 05/04/13.
37. Griffiths JC, Borzelleca JF, St Cyr J. Lack of oral embryotoxicity/teratogenicity with D-ribose in Wistar rats. Food Chem Toxicol. 2007 Mar;45(3):388-95.