{"id":8350879121638,"title":"Bioclinic Naturals HM-Clear","handle":"bioclinic-naturals-hm-clear","description":"\u003ch2\u003eBioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eWith Glutathione, Alpha Lipoic Acid, Selenium, Zinc and Vitamin C\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 49g Powder Pineapple Flavour\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioclinic Naturals HM-Clear is a nutritional and antioxidant formula to help support natural body detoxification and cognitive function.\u003c\/li\u003e\n\u003cli\u003eBioclinic Naturals HM-Clear has a unique combination of lipoic acid, selenium, zinc and vitamin C for antioxidant support.\u003c\/li\u003e\n\u003cli\u003eToxin overload may result in impaired cognitive function.\u003c\/li\u003e\n\u003cli\u003eVitamin C, zinc and folate also support immune system function.\u003c\/li\u003e\n\u003cli\u003eVitamin C helps support healthy cognitive function and relieves weariness and fatigue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear AUST L 371983\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eTargeted, concentrated formula containing herbs and nutrients including garlic as GarlicRich extract, glutathione as Opitac, selenium as SelenoExcell and levomefolic acid as the highly bioavailable Quatrefolic.\u003c\/li\u003e\n\u003cli\u003eSupports natural body detoxification processes.\u003c\/li\u003e\n\u003cli\u003eSupports healthy immune system function.\u003c\/li\u003e\n\u003cli\u003eRich in antioxidants to help reduce free radical damage to body cells.\u003c\/li\u003e\n\u003cli\u003eFormulated to maintain body levels of key nutrients such as folate, selenium, vitamin C, zinc and manganese, which may be depleted as a result of heavy metal exposure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eRecommended Use\u003c\/h5\u003e\n\u003ch2\u003eRecommended Use: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003cp\u003eAdults: Mix 3.5 g powder (approximately one metric 5 mL teaspoon) with 250 mL water per day or as directed by a health care practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Per 3.5g Serve Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAlpha lipoic acid\u003c\/td\u003e\n\u003ctd\u003e400mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGarlic powder concentrate (Allium sativum) (GarlicRich)\u003c\/td\u003e\n\u003ctd\u003e400mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv. fresh bulb\u003c\/td\u003e\n\u003ctd\u003e4g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandardised to allicin\u003c\/td\u003e\n\u003ctd\u003e2.4mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlutathione (Opitac)\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (high selenium yeast) (SelenoExcell)\u003c\/td\u003e\n\u003ctd\u003e140micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (vitamin C)\u003c\/td\u003e\n\u003ctd\u003e1000mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLevomefolate glucosamine (Quatrefolic)\u003c\/td\u003e\n\u003ctd\u003e712micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv. levomefolic acid\u003c\/td\u003e\n\u003ctd\u003e400micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (citrate dihydrate)\u003c\/td\u003e\n\u003ctd\u003e20mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eManganese (sulfate monohydrate)\u003c\/td\u003e\n\u003ctd\u003e800micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eKey Features and Benefits\u003c\/h5\u003e\n\u003ch2\u003eKey Features and Benefits: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ch3\u003eHeavy metals\u003c\/h3\u003e\n\u003cp\u003eSome heavy metals are highly toxic to us and the environment.1 These metals, including arsenic, cadmium, chromium, lead and mercury, significantly contribute to environmental pollution. Humans can be exposed through ingestion, inhalation and dermal contact and they can cause a number of effects that are time and dosedependent and are specific to the type of metal. Effects can include specific organ dysfunctions, metabolic abnormalities, altered hormones, congenital disorders and immune system dysfunction.2,3,4 Several studies have confirmed that exposure to certain heavy metals may cause long-term human health issues. The toxicities from these metals may be either acute or chronic and some more recent studies have shown that these toxic elements may interact with some physiologically important metals such as iron, calcium and zinc, to potentially impair their normal metabolic function.5\u003c\/p\u003e\n\u003ch3\u003eHeavy metals and ROS:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHeavy metal toxicity generates reactive oxygen and nitrogen species. Many of the toxic manifestations of heavy metals are attributed to oxidative stress and an imbalance between pro-oxidant and antioxidant homeostasis.6-11\u003c\/li\u003e\n\u003cli\u003eHeavy metals can also bind to sulfhydryl groups of proteins and deplete glutathione.\u003c\/li\u003e\n\u003cli\u003eAntioxidants are considered to be key for the management of heavy metal detoxification, and to reduce the damaging effects of these heavy metals.6-11\u003c\/li\u003e\n\u003cli\u003eStudies also show that supplementation of antioxidants along-with a chelating agent provides better outcomes than monotherapy with chelating agents.9,10\u003c\/li\u003e\n\u003cli\u003eSupports the body’s natural detoxification processes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSupports the body’s natural detoxification processes\u003c\/h2\u003e\n\u003ch3\u003eSelenium\u003c\/h3\u003e\n\u003cp\u003eThis formula contains SelenoExcell selenium which is a high selenium yeast that provides 140 micrograms of selenium. Organically bound forms of selenium are high selenium yeast or selenomethionine. High selenium yeast contains three organic selenium compounds (selenomethionine, selenocysteine and methylselenocysteine), whereas selenomethionine is a single amino acid (methionine) with a selenium molecule attached to it. A recent study showed that 100% organically bound selenium yeast is most effective for reducing oxidative stress as compared to selenomethionine.12 Selenium is one of the few minerals that is intrinsic to mercury detoxification. The evidence now points to the fact that the selenium is actually the pathophysiological target of mercury and that mercury has a higher affinity for selenium than thiol\/sulfhydryl groups. In fact, recent work has provided convincing evidence that the primary cellular targets are the selenoproteins of the thioredoxin system (thioredoxin reductase 1 and thioredoxin reductase 2) and the glutathione-glutaredoxin system (glutathione peroxidase). Mercury binds to the selenium site on these proteins and permanently inhibits their function, disrupting the intracellular redox environment.13,14\u003c\/p\u003e\n\u003cp\u003eA number of other important possible target selenoproteins have been identified, including selenoprotein P, K, and T. Selenium therefore acts as a mercury magnet with a very strong binding affinity for the mercury. This strong attraction allows selenium to mix and neutralise their reaction characteristics. This new Hg – Se substance that is produced is not absorbed by the body and gets flushed out of the system. This beneficial interaction removes mercury from the body before it can lodge in fatty tissue and cause damage.13,14\u003c\/p\u003e\n\u003cp\u003eImpairment of the thioredoxin and glutaredoxin systems allows for proliferation of intracellular reactive oxygen species which leads to glutamate excitosis, calcium dyshomeostasis, mitochondrial injury\/loss, lipid peroxidation, impairment of protein repair, and apoptosis. Methylmercury is a more potent inhibitor of the thioredoxin system, partially explaining its increased neurotoxicity. A second important mechanism is due to the high affinity of mercury for selenium and the subsequent depletion of selenium stores needed for insertion into de novo generation of replacement selenoproteins. This mercuryinduced selenium deficiency state inhibits regeneration of the selenoproteins to restore the cellular redox environment.13,15-27\u003c\/p\u003e\n\u003cp\u003eTherefore supplementing with additional selenium when faced with excess mercury may support the body’s natural detoxification of mercury, as well as to reduce mercury induced ROS. \u003c\/p\u003e\n\u003ch2\u003eAntioxidant support \u003c\/h2\u003e\n\u003ch3\u003eAlpha lipoic acid\u003c\/h3\u003e\n\u003cp\u003eAlpha lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g. vitamins E and C, and reduced glutathione) and has metal-chelating activity. Both fat and water soluble, it is readily absorbed from the gut and crosses cellular and blood-brain membrane barriers.28,29 Animal studies have shown that alpha lipoic acid may attenuate the oxidative stress caused by arsenic (along with vitamin C) and lead. There is also a clinical trial that demonstrates its possible preventive effect in the development of age-related macular degeneration (AMD) through an antioxidant mechanism.30,31\u003c\/p\u003e\n\u003ch3\u003eVitamin C \u003c\/h3\u003e\n\u003cp\u003eAs an electron donor, vitamin C is a potent water-soluble antioxidant in humans. Antioxidant effects of vitamin C have been demonstrated during in vitro experiments. Oxidation of lipids, proteins and DNA results in specific oxidation products that can be measured in the laboratory. In plasma, vitamin C is thought to be the most effective antioxidant in part due to its water solubility and to the wide range of ROS that it can scavenge.31,33\u003c\/p\u003e\n\u003cp\u003eIn addition, due to its antioxidant activity, there is a large body of evidence demonstrating that maintaining healthy vitamin C levels can have a protective function against age-related cognitive decline.32, 33\u003c\/p\u003e\n\u003cp\u003eAs an antioxidant vitamin C has also been demonstrated to support the detoxification of the oxidant effects of some heavy metals including lead and arsenic.34-36\u003c\/p\u003e\n\u003ch3\u003eGlutathione\u003c\/h3\u003e\n\u003cp\u003eOpitac is a L-glutathione product in its reduced (GSH) form. It is known as a simple tripeptide and consists of glutamic acid, cysteine and glycine, which exists in every cell of the human body. This form has been shown to significantly increase the protein-bound form of glutathione in human blood after oral administration.37\u003c\/p\u003e\n\u003cp\u003eGlutathione plays a role in protecting cellular macromolecules against endogenous and exogenous reactive oxygen and nitrogen species. It directly quenches free radicals, and it deals directly with the causes of oxidative stress such as mercury and POPs.38\u003c\/p\u003e\n\u003cp\u003eGlutathione is involved in the detoxification of both xenobiotic and endogenous compounds. It facilitates excretion from cells (Hg), facilitates excretion from body (POPs, Hg) and directly neutralises (POPs) many oxidative chemicals. Glutathione facilitates the plasma membrane transport of toxins by at least 4 different mechanisms, the most important of which is formation of glutathione S-conjugates. Low levels of glutathione and\/or transferase activity are also associated with chronic exposure to chemical toxins and alcohol, cadmium exposure, macular degeneration, and neurodegenerative disorders.\u003c\/p\u003e\n\u003cp\u003eGlutathione directly scavenges a diverse array of oxidants: superoxide anion, hydroxyl radical, nitric oxide and carbon radicals. Glutathione catalytically detoxifies: hydroperoxides, peroxynitrites, and lipid peroxides.39 Another way glutathione protects cells from oxidants is through recycling of vitamins C and E.40 \u003c\/p\u003e\n\u003cp\u003eIn summary, glutathione is an important physiological chelator, and the reduced form of glutathione protects cells from reactive oxygen species associated with heavy metals.41-44\u003c\/p\u003e\n\u003ch3\u003eZinc\u003c\/h3\u003e\n\u003cp\u003eZinc is an essential component of numerous proteins involved in protection against oxidative stress.9 Zinc has been shown to reduce oxidative stress caused by exposure to lead and cadmium, due to its role as a cofactor of the antioxidant enzyme copper zinc-superoxide dismutase.45\u003c\/p\u003e\n\u003cp\u003eStudies in both humans and animals have also reported that zinc deficiency can lead to greater absorption and toxicity of both lead and cadmium.45 Zinc has similar physical and chemical properties to lead and cadmium and competes for the binding sites of metal absorptive and enzymatic proteins.\u003c\/p\u003e\n\u003cp\u003eZinc intake also induces the synthesis of metallothionein, a low molecular weight protein that has a high affinity for cadmium and leads to its detoxification by binding to cadmium. In addition, zinc supplementation effectively protects the activity of the zinc dependent enzyme that is very sensitive to lead toxicity in the blood.45\u003c\/p\u003e\n\u003ch2\u003eImmune and digestive function support\u003c\/h2\u003e\n\u003ch3\u003eGarlic\u003c\/h3\u003e\n\u003cp\u003eHeavy metals have been shown to cause immune and lung disorders as well as GI dysfunction and discomfort. In particular mercury, chromium, arsenic and lead.8\u003c\/p\u003e\n\u003cp\u003eGarlic has traditionally been used in Western herbal medicine to help promote bile flow and support healthy digestive function.47 Garlic is also traditionally used to relieve symptoms of mild upper respiratory tract infections.47-53\u003c\/p\u003e\n\u003cp\u003eGarlicRich, a potent and odourless 10:1 concentrate, is made from the whole bulb of garlic to ensure its synergistic complexity. The garlic is grown without pesticides and the bulbs are hand-picked and stored in cool temperatures away from light and air to preserve the enzymes and other compounds that make garlic so beneficial. The bulbs are then gently processed without alcohol or other solvents.\u003c\/p\u003e\n\u003ch2\u003eTable 1: Specific nutrients for HM toxicity and clearance\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eNutrient\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eHeavy metal\/s\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eMechanisms of action\/effects\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eMinimum clinical dosage\/day\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc 54-58\u003c\/td\u003e\n\u003ctd\u003eCadmium, lead, aluminium\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eAffinity with metallothionein – a cysteine-rich heavy protein that binds to heavy metals\u003c\/li\u003e\n\u003cli\u003eReduced body, including kidney and liver, accumulation and HM levels\u003c\/li\u003e\n\u003cli\u003eReduce oxidative stress and increased antioxidant capacity\u003c\/li\u003e\n\u003cli\u003eReduced HM toxicity and damage\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e11-15mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eGlutathione\u003c\/p\u003e\n\u003cp\u003e59-64\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003eAll heavy metals\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eMain cellular antioxidant and regenerator of other antioxidants\u003c\/li\u003e\n\u003cli\u003ePotent HM chelator\u003c\/li\u003e\n\u003cli\u003eRequired for detoxification systems\u003c\/li\u003e\n\u003cli\u003eIncreases glutathione body levels\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAlpha lipoic acid 59, 61,63-68\u003c\/td\u003e\n\u003ctd\u003eArsenic, cadmium, mercury\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eWater and lipid-soluble antioxidant\u003c\/li\u003e\n\u003cli\u003eHM chelator with reduction in HM body load\u003c\/li\u003e\n\u003cli\u003eImproves mitochondrial activity and reduces oxidative damage\u003c\/li\u003e\n\u003cli\u003eActivates Nrf2 pathway leading to synthesis and recycling of glutathione\u003c\/li\u003e\n\u003cli\u003eVitamin C and vitamin E regeneration\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003eMostly preclinical trials\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eVitamin C\u003c\/p\u003e\n\u003cp\u003e70, 74\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003eMercury, lead, arsenic\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eAntioxidant\u003c\/li\u003e\n\u003cli\u003eAmeliorates HM toxicity potential\u003c\/li\u003e\n\u003cli\u003eReduces HM body load by increasing excretion\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e1000mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eSelenium\u003c\/p\u003e\n\u003cp\u003e26, 56, 57\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003eMercury\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eRestores selenium depletion caused by mercury\u003c\/li\u003e\n\u003cli\u003eMitigates mercury toxicity\u003c\/li\u003e\n\u003cli\u003eRedistributes mercury to less sensitive target organs\u003c\/li\u003e\n\u003cli\u003eBinds and chelates inorganic mercury\u003c\/li\u003e\n\u003cli\u003eReduces mercury absorption\u003c\/li\u003e\n\u003cli\u003eIncreases mercury excretion and decreases oxidative stress\u003c\/li\u003e\n\u003cli\u003eReduced hair mercury levels by 34%\u003c\/li\u003e\n\u003cli\u003eRestores antioxidant capacity\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e100 mcg selenium enriched yeast\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eWarnings\u003cbr\u003e\n\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ch3\u003eWarnings\u003c\/h3\u003e\n\u003cp\u003eAdults only.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear contains selenium which is toxic in high doses. A daily dose of 150 micrograms for adults of selenium from dietary supplements should not be exceeded.\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear is not recommended for use by pregnant and lactating women.\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist, talk to your healthcare practitioner.\u003cbr\u003e\u003c\/p\u003e\n\u003ch3\u003ePrecautions and contraindications\u003c\/h3\u003e\n\u003cp\u003eHigh dose vitamin C supplements in excess of 500 mg daily, should be used with caution in patients with a history of kidney stones due to concerns that vitamin C may theoretically increase oxalate excretion.\u003c\/p\u003e\n\u003cp\u003eVitamin C enhances iron absorption.\u003c\/p\u003e\n\u003cp\u003eCaution is advised with high dose vitamin C intake in individuals with iron metabolism disorders such as hereditary haemochromatosis, sideroblastic anaemia or thalassaemia.\u003cbr\u003e\u003c\/p\u003e\n\u003ch3\u003eAdverse effects\u003c\/h3\u003e\n\u003cp\u003eThe ingredients in this product are generally well-tolerated.\u003c\/p\u003e\n\u003cp\u003eSome ingredients such as garlic, alpha-lipoic acid, vitamin C and zinc have been associated with mild gastrointestinal adverse effects. These may include abdominal cramps, bloating, loose stools, flatulence, dyspepsia, nausea and vomiting.\u003c\/p\u003e\n\u003cp\u003ePregnancy and lactation Use of this product during pregnancy and lactation is not recommended.\u003c\/p\u003e\n\n\u003c!-- \/TABS --\u003e","published_at":"2023-11-13T13:13:22+11:00","created_at":"2023-11-13T11:34:13+11:00","vendor":"Bioclinic Naturals","type":"Bioclinic Naturals Naturopathic Medicines","tags":["Bioclinic Naturals","Naturopathic","PB","SOOS"],"price":4496,"price_min":4496,"price_max":4496,"available":true,"price_varies":false,"compare_at_price":4995,"compare_at_price_min":4995,"compare_at_price_max":4995,"compare_at_price_varies":false,"variants":[{"id":44046335869158,"title":"49g Powder Pineapple Flavour","option1":"49g Powder Pineapple 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","id":32644937580774,"position":2,"preview_image":{"aspect_ratio":3.4,"height":120,"width":408,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioclinicNaturals10_offRRPHealthMastersBioclinicNaturals_9735e6a2-b12a-4989-8a46-40a5cfd0e7cc.png?v=1699835776"},"aspect_ratio":3.4,"height":120,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioclinicNaturals10_offRRPHealthMastersBioclinicNaturals_9735e6a2-b12a-4989-8a46-40a5cfd0e7cc.png?v=1699835776","width":408}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eBioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eWith Glutathione, Alpha Lipoic Acid, Selenium, Zinc and Vitamin C\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 49g Powder Pineapple Flavour\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioclinic Naturals HM-Clear is a nutritional and antioxidant formula to help support natural body detoxification and cognitive function.\u003c\/li\u003e\n\u003cli\u003eBioclinic Naturals HM-Clear has a unique combination of lipoic acid, selenium, zinc and vitamin C for antioxidant support.\u003c\/li\u003e\n\u003cli\u003eToxin overload may result in impaired cognitive function.\u003c\/li\u003e\n\u003cli\u003eVitamin C, zinc and folate also support immune system function.\u003c\/li\u003e\n\u003cli\u003eVitamin C helps support healthy cognitive function and relieves weariness and fatigue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear AUST L 371983\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eTargeted, concentrated formula containing herbs and nutrients including garlic as GarlicRich extract, glutathione as Opitac, selenium as SelenoExcell and levomefolic acid as the highly bioavailable Quatrefolic.\u003c\/li\u003e\n\u003cli\u003eSupports natural body detoxification processes.\u003c\/li\u003e\n\u003cli\u003eSupports healthy immune system function.\u003c\/li\u003e\n\u003cli\u003eRich in antioxidants to help reduce free radical damage to body cells.\u003c\/li\u003e\n\u003cli\u003eFormulated to maintain body levels of key nutrients such as folate, selenium, vitamin C, zinc and manganese, which may be depleted as a result of heavy metal exposure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eRecommended Use\u003c\/h5\u003e\n\u003ch2\u003eRecommended Use: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003cp\u003eAdults: Mix 3.5 g powder (approximately one metric 5 mL teaspoon) with 250 mL water per day or as directed by a health care practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Per 3.5g Serve Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAlpha lipoic acid\u003c\/td\u003e\n\u003ctd\u003e400mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGarlic powder concentrate (Allium sativum) (GarlicRich)\u003c\/td\u003e\n\u003ctd\u003e400mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv. fresh bulb\u003c\/td\u003e\n\u003ctd\u003e4g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandardised to allicin\u003c\/td\u003e\n\u003ctd\u003e2.4mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlutathione (Opitac)\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (high selenium yeast) (SelenoExcell)\u003c\/td\u003e\n\u003ctd\u003e140micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (vitamin C)\u003c\/td\u003e\n\u003ctd\u003e1000mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLevomefolate glucosamine (Quatrefolic)\u003c\/td\u003e\n\u003ctd\u003e712micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv. levomefolic acid\u003c\/td\u003e\n\u003ctd\u003e400micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (citrate dihydrate)\u003c\/td\u003e\n\u003ctd\u003e20mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eManganese (sulfate monohydrate)\u003c\/td\u003e\n\u003ctd\u003e800micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eKey Features and Benefits\u003c\/h5\u003e\n\u003ch2\u003eKey Features and Benefits: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ch3\u003eHeavy metals\u003c\/h3\u003e\n\u003cp\u003eSome heavy metals are highly toxic to us and the environment.1 These metals, including arsenic, cadmium, chromium, lead and mercury, significantly contribute to environmental pollution. Humans can be exposed through ingestion, inhalation and dermal contact and they can cause a number of effects that are time and dosedependent and are specific to the type of metal. Effects can include specific organ dysfunctions, metabolic abnormalities, altered hormones, congenital disorders and immune system dysfunction.2,3,4 Several studies have confirmed that exposure to certain heavy metals may cause long-term human health issues. The toxicities from these metals may be either acute or chronic and some more recent studies have shown that these toxic elements may interact with some physiologically important metals such as iron, calcium and zinc, to potentially impair their normal metabolic function.5\u003c\/p\u003e\n\u003ch3\u003eHeavy metals and ROS:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHeavy metal toxicity generates reactive oxygen and nitrogen species. Many of the toxic manifestations of heavy metals are attributed to oxidative stress and an imbalance between pro-oxidant and antioxidant homeostasis.6-11\u003c\/li\u003e\n\u003cli\u003eHeavy metals can also bind to sulfhydryl groups of proteins and deplete glutathione.\u003c\/li\u003e\n\u003cli\u003eAntioxidants are considered to be key for the management of heavy metal detoxification, and to reduce the damaging effects of these heavy metals.6-11\u003c\/li\u003e\n\u003cli\u003eStudies also show that supplementation of antioxidants along-with a chelating agent provides better outcomes than monotherapy with chelating agents.9,10\u003c\/li\u003e\n\u003cli\u003eSupports the body’s natural detoxification processes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSupports the body’s natural detoxification processes\u003c\/h2\u003e\n\u003ch3\u003eSelenium\u003c\/h3\u003e\n\u003cp\u003eThis formula contains SelenoExcell selenium which is a high selenium yeast that provides 140 micrograms of selenium. Organically bound forms of selenium are high selenium yeast or selenomethionine. High selenium yeast contains three organic selenium compounds (selenomethionine, selenocysteine and methylselenocysteine), whereas selenomethionine is a single amino acid (methionine) with a selenium molecule attached to it. A recent study showed that 100% organically bound selenium yeast is most effective for reducing oxidative stress as compared to selenomethionine.12 Selenium is one of the few minerals that is intrinsic to mercury detoxification. The evidence now points to the fact that the selenium is actually the pathophysiological target of mercury and that mercury has a higher affinity for selenium than thiol\/sulfhydryl groups. In fact, recent work has provided convincing evidence that the primary cellular targets are the selenoproteins of the thioredoxin system (thioredoxin reductase 1 and thioredoxin reductase 2) and the glutathione-glutaredoxin system (glutathione peroxidase). Mercury binds to the selenium site on these proteins and permanently inhibits their function, disrupting the intracellular redox environment.13,14\u003c\/p\u003e\n\u003cp\u003eA number of other important possible target selenoproteins have been identified, including selenoprotein P, K, and T. Selenium therefore acts as a mercury magnet with a very strong binding affinity for the mercury. This strong attraction allows selenium to mix and neutralise their reaction characteristics. This new Hg – Se substance that is produced is not absorbed by the body and gets flushed out of the system. This beneficial interaction removes mercury from the body before it can lodge in fatty tissue and cause damage.13,14\u003c\/p\u003e\n\u003cp\u003eImpairment of the thioredoxin and glutaredoxin systems allows for proliferation of intracellular reactive oxygen species which leads to glutamate excitosis, calcium dyshomeostasis, mitochondrial injury\/loss, lipid peroxidation, impairment of protein repair, and apoptosis. Methylmercury is a more potent inhibitor of the thioredoxin system, partially explaining its increased neurotoxicity. A second important mechanism is due to the high affinity of mercury for selenium and the subsequent depletion of selenium stores needed for insertion into de novo generation of replacement selenoproteins. This mercuryinduced selenium deficiency state inhibits regeneration of the selenoproteins to restore the cellular redox environment.13,15-27\u003c\/p\u003e\n\u003cp\u003eTherefore supplementing with additional selenium when faced with excess mercury may support the body’s natural detoxification of mercury, as well as to reduce mercury induced ROS. \u003c\/p\u003e\n\u003ch2\u003eAntioxidant support \u003c\/h2\u003e\n\u003ch3\u003eAlpha lipoic acid\u003c\/h3\u003e\n\u003cp\u003eAlpha lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g. vitamins E and C, and reduced glutathione) and has metal-chelating activity. Both fat and water soluble, it is readily absorbed from the gut and crosses cellular and blood-brain membrane barriers.28,29 Animal studies have shown that alpha lipoic acid may attenuate the oxidative stress caused by arsenic (along with vitamin C) and lead. There is also a clinical trial that demonstrates its possible preventive effect in the development of age-related macular degeneration (AMD) through an antioxidant mechanism.30,31\u003c\/p\u003e\n\u003ch3\u003eVitamin C \u003c\/h3\u003e\n\u003cp\u003eAs an electron donor, vitamin C is a potent water-soluble antioxidant in humans. Antioxidant effects of vitamin C have been demonstrated during in vitro experiments. Oxidation of lipids, proteins and DNA results in specific oxidation products that can be measured in the laboratory. In plasma, vitamin C is thought to be the most effective antioxidant in part due to its water solubility and to the wide range of ROS that it can scavenge.31,33\u003c\/p\u003e\n\u003cp\u003eIn addition, due to its antioxidant activity, there is a large body of evidence demonstrating that maintaining healthy vitamin C levels can have a protective function against age-related cognitive decline.32, 33\u003c\/p\u003e\n\u003cp\u003eAs an antioxidant vitamin C has also been demonstrated to support the detoxification of the oxidant effects of some heavy metals including lead and arsenic.34-36\u003c\/p\u003e\n\u003ch3\u003eGlutathione\u003c\/h3\u003e\n\u003cp\u003eOpitac is a L-glutathione product in its reduced (GSH) form. It is known as a simple tripeptide and consists of glutamic acid, cysteine and glycine, which exists in every cell of the human body. This form has been shown to significantly increase the protein-bound form of glutathione in human blood after oral administration.37\u003c\/p\u003e\n\u003cp\u003eGlutathione plays a role in protecting cellular macromolecules against endogenous and exogenous reactive oxygen and nitrogen species. It directly quenches free radicals, and it deals directly with the causes of oxidative stress such as mercury and POPs.38\u003c\/p\u003e\n\u003cp\u003eGlutathione is involved in the detoxification of both xenobiotic and endogenous compounds. It facilitates excretion from cells (Hg), facilitates excretion from body (POPs, Hg) and directly neutralises (POPs) many oxidative chemicals. Glutathione facilitates the plasma membrane transport of toxins by at least 4 different mechanisms, the most important of which is formation of glutathione S-conjugates. Low levels of glutathione and\/or transferase activity are also associated with chronic exposure to chemical toxins and alcohol, cadmium exposure, macular degeneration, and neurodegenerative disorders.\u003c\/p\u003e\n\u003cp\u003eGlutathione directly scavenges a diverse array of oxidants: superoxide anion, hydroxyl radical, nitric oxide and carbon radicals. Glutathione catalytically detoxifies: hydroperoxides, peroxynitrites, and lipid peroxides.39 Another way glutathione protects cells from oxidants is through recycling of vitamins C and E.40 \u003c\/p\u003e\n\u003cp\u003eIn summary, glutathione is an important physiological chelator, and the reduced form of glutathione protects cells from reactive oxygen species associated with heavy metals.41-44\u003c\/p\u003e\n\u003ch3\u003eZinc\u003c\/h3\u003e\n\u003cp\u003eZinc is an essential component of numerous proteins involved in protection against oxidative stress.9 Zinc has been shown to reduce oxidative stress caused by exposure to lead and cadmium, due to its role as a cofactor of the antioxidant enzyme copper zinc-superoxide dismutase.45\u003c\/p\u003e\n\u003cp\u003eStudies in both humans and animals have also reported that zinc deficiency can lead to greater absorption and toxicity of both lead and cadmium.45 Zinc has similar physical and chemical properties to lead and cadmium and competes for the binding sites of metal absorptive and enzymatic proteins.\u003c\/p\u003e\n\u003cp\u003eZinc intake also induces the synthesis of metallothionein, a low molecular weight protein that has a high affinity for cadmium and leads to its detoxification by binding to cadmium. In addition, zinc supplementation effectively protects the activity of the zinc dependent enzyme that is very sensitive to lead toxicity in the blood.45\u003c\/p\u003e\n\u003ch2\u003eImmune and digestive function support\u003c\/h2\u003e\n\u003ch3\u003eGarlic\u003c\/h3\u003e\n\u003cp\u003eHeavy metals have been shown to cause immune and lung disorders as well as GI dysfunction and discomfort. In particular mercury, chromium, arsenic and lead.8\u003c\/p\u003e\n\u003cp\u003eGarlic has traditionally been used in Western herbal medicine to help promote bile flow and support healthy digestive function.47 Garlic is also traditionally used to relieve symptoms of mild upper respiratory tract infections.47-53\u003c\/p\u003e\n\u003cp\u003eGarlicRich, a potent and odourless 10:1 concentrate, is made from the whole bulb of garlic to ensure its synergistic complexity. The garlic is grown without pesticides and the bulbs are hand-picked and stored in cool temperatures away from light and air to preserve the enzymes and other compounds that make garlic so beneficial. The bulbs are then gently processed without alcohol or other solvents.\u003c\/p\u003e\n\u003ch2\u003eTable 1: Specific nutrients for HM toxicity and clearance\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eNutrient\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eHeavy metal\/s\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eMechanisms of action\/effects\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eMinimum clinical dosage\/day\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc 54-58\u003c\/td\u003e\n\u003ctd\u003eCadmium, lead, aluminium\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eAffinity with metallothionein – a cysteine-rich heavy protein that binds to heavy metals\u003c\/li\u003e\n\u003cli\u003eReduced body, including kidney and liver, accumulation and HM levels\u003c\/li\u003e\n\u003cli\u003eReduce oxidative stress and increased antioxidant capacity\u003c\/li\u003e\n\u003cli\u003eReduced HM toxicity and damage\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e11-15mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eGlutathione\u003c\/p\u003e\n\u003cp\u003e59-64\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003eAll heavy metals\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eMain cellular antioxidant and regenerator of other antioxidants\u003c\/li\u003e\n\u003cli\u003ePotent HM chelator\u003c\/li\u003e\n\u003cli\u003eRequired for detoxification systems\u003c\/li\u003e\n\u003cli\u003eIncreases glutathione body levels\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAlpha lipoic acid 59, 61,63-68\u003c\/td\u003e\n\u003ctd\u003eArsenic, cadmium, mercury\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eWater and lipid-soluble antioxidant\u003c\/li\u003e\n\u003cli\u003eHM chelator with reduction in HM body load\u003c\/li\u003e\n\u003cli\u003eImproves mitochondrial activity and reduces oxidative damage\u003c\/li\u003e\n\u003cli\u003eActivates Nrf2 pathway leading to synthesis and recycling of glutathione\u003c\/li\u003e\n\u003cli\u003eVitamin C and vitamin E regeneration\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003eMostly preclinical trials\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eVitamin C\u003c\/p\u003e\n\u003cp\u003e70, 74\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003eMercury, lead, arsenic\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eAntioxidant\u003c\/li\u003e\n\u003cli\u003eAmeliorates HM toxicity potential\u003c\/li\u003e\n\u003cli\u003eReduces HM body load by increasing excretion\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e1000mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eSelenium\u003c\/p\u003e\n\u003cp\u003e26, 56, 57\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003eMercury\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eRestores selenium depletion caused by mercury\u003c\/li\u003e\n\u003cli\u003eMitigates mercury toxicity\u003c\/li\u003e\n\u003cli\u003eRedistributes mercury to less sensitive target organs\u003c\/li\u003e\n\u003cli\u003eBinds and chelates inorganic mercury\u003c\/li\u003e\n\u003cli\u003eReduces mercury absorption\u003c\/li\u003e\n\u003cli\u003eIncreases mercury excretion and decreases oxidative stress\u003c\/li\u003e\n\u003cli\u003eReduced hair mercury levels by 34%\u003c\/li\u003e\n\u003cli\u003eRestores antioxidant capacity\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003ctd\u003e100 mcg selenium enriched yeast\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eWarnings\u003cbr\u003e\n\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Bioclinic Naturals HM-Clear\u003c\/h2\u003e\n\u003ch3\u003eWarnings\u003c\/h3\u003e\n\u003cp\u003eAdults only.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear contains selenium which is toxic in high doses. A daily dose of 150 micrograms for adults of selenium from dietary supplements should not be exceeded.\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals HM-Clear is not recommended for use by pregnant and lactating women.\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist, talk to your healthcare practitioner.\u003cbr\u003e\u003c\/p\u003e\n\u003ch3\u003ePrecautions and contraindications\u003c\/h3\u003e\n\u003cp\u003eHigh dose vitamin C supplements in excess of 500 mg daily, should be used with caution in patients with a history of kidney stones due to concerns that vitamin C may theoretically increase oxalate excretion.\u003c\/p\u003e\n\u003cp\u003eVitamin C enhances iron absorption.\u003c\/p\u003e\n\u003cp\u003eCaution is advised with high dose vitamin C intake in individuals with iron metabolism disorders such as hereditary haemochromatosis, sideroblastic anaemia or thalassaemia.\u003cbr\u003e\u003c\/p\u003e\n\u003ch3\u003eAdverse effects\u003c\/h3\u003e\n\u003cp\u003eThe ingredients in this product are generally well-tolerated.\u003c\/p\u003e\n\u003cp\u003eSome ingredients such as garlic, alpha-lipoic acid, vitamin C and zinc have been associated with mild gastrointestinal adverse effects. These may include abdominal cramps, bloating, loose stools, flatulence, dyspepsia, nausea and vomiting.\u003c\/p\u003e\n\u003cp\u003ePregnancy and lactation Use of this product during pregnancy and lactation is not recommended.\u003c\/p\u003e\n\n\u003c!-- \/TABS --\u003e"}