Activated Probiotics Biome Advanced Probiotic

Ailments

• Supports beneficial gut bacteria during antibiotic use
• Helps restore beneficial gut bacteria after antibiotic use
• Promotes healthy digestion and bowel regularity

Instructions For Use

Adults and children over 12 years:

take 1 capsule daily (with or without food), or as directed by your healthcare practitioner.

Activated Probiotics Biome Advanced Probiotic is recommended daily during antibiotic use, starting on the first day of the course. Continue taking Activated Probiotics Biome Advanced Probiotic daily for at least two weeks after completing the course of antibiotics.

Ingredients

*BLB = Billion Live Bacteria"

No Refrigeration Required

No Added

No added: GMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanut, soy, egg, fish, shellfish, or animal derivatives.

No artificial colours, flavours, sweeteners, or preservatives.

Suitable for vegetarians and vegans.

Warnings and Cautions

If symptoms persist, consult your healthcare practitioner.

Drink plenty of water.

Do not use when abdominal pain, nausea or vomiting are present, or if you develop diarrhoea.

If you are pregnant or breastfeeding seek the advice of a healthcare practitioner before using.

Resources

Storage Conditions

Refrigeration Not Required

Technical Information

EFFECT OF ANTIBIOTIC USE ON THE GUT MICROBIOME

The use of antibiotics in the Australian community is high, with more than 30 million courses prescribed in 2015 [1]. In order to target a number of different pathogens, most antibiotics have broad-spectrum antimicrobial activity. An unintended consequence of this is that susceptible beneficial (non-pathogenic) strains in the gut microbiome are often adversely affected [2]. While the composition of the gut microbiome generally remains stable within individuals over time, the composition can be disrupted by a number of external factors, in particular, treatment with antibiotics. [3]

Numerous studies have demonstrated that antibiotics can significantly reduce microbial abundance and diversity [3, 4] and induce a state of microbial imbalance, known as intestinal dysbiosis [5]. Intestinal dysbiosis results in the loss of the ability of the gut microbiota to ward off pathogens, which increases susceptibility to infections [6]. Intestinal pathogens weaken gut barrier function and trigger inflammation, which generally results in diarrhoea [7]. As such, a common side effect of antibiotics is antibiotic-associated diarrhea (AAD), which affects 5-39% of patients treated (depending on the type of antibiotic used), and can persist for up to two months after the end of treatment [8].

BENEFIT OF PROBIOTIC SUPPLEMENTATION

Probiotics have numerous beneficial effects on the gut microbiome, including inhibiting the growth and proliferation of pathogenic microorganisms, known as colonisation resistance [9]. This is achieved through a number of mechanisms, including the production of acids, which lowers the pH intestinal lumen, suppressing the growth of pathogenic bacteria; the production of hydrogen peroxide, bacteriocins and other substances that are toxic to pathogens; and competitive inhibition of adhesion of the pathogen to the intestinal epithelium9. Probiotics are also able to enhance the gut barrier function (reducing intestinal permeability), and modulate the local immune system [10].

Following a course of antibiotics, probiotics may help to restore the abundance and diversity of beneficial gut microbes after the course of antibiotics is completed [11,12] (Figure 1). A recent systematic review investigating the efficacy of probiotics for the restoration of the gut microbiome following a disruptive event (such as a course of antibiotics) found that the probiotic product partially or fully restored the gut microbiota in 83% of the studies included [11].

PROBIOTICS AND ANTIBIOTIC-ASSOCIATED DIARRHOEA (AAD)

A recent meta-analysis found that the use of a probiotic may reduce the risk of AAD by 51% (RR 0.49; 95% CI 0.36-0.66; I2=58%) [13]. Lactobacillus rhamnosus GG was found to be the most effective probiotic strain, which demonstrated a 71% reduction in risk of AAD (RR 0.29; 95% CI: 0.150.57)13. The authors concluded that supplementation with probiotics is considered a safe and simple method of AAD prophylaxis [13].

References

1. Australian Commission on Safety & Quality in Health Care (ACSQHC). AURA 2016: first Australian report on antimicrobial use and resistance in human health. Sydney; 2016.

2. Willing BP, Russell SL, Finlay BB. Shifting the balance: antibiotic effects on host–microbiota mutualism. Nat Rev Microbiol. 2011 Apr;9(4):233–43.

3. Clemente JC, Ursell LK, Parfrey LW, Knight R. The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell. 2012 Mar 16;148(6):1258–70.

4. Antonopoulos DA, Huse SM, Morrison HG, Schmidt TM, Sogin ML, Young VB. Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation. Infect Immun. 2009 Jun;77(6):2367–75.

5. Weiss GA, Hennet T. Mechanisms and consequences of intestinal dysbiosis. Cell Mol Life Sci. 2017 Aug 1;74(16):2959–77.

6. Langdon A, Crook N, Dantas G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med [Internet]. 2016 Apr 13 [cited 2019 Jun 13];8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831151/

7. Lawley TD, Walker AW. Intestinal colonization resistance. Immunology. 2013 Jan;138(1):1–11.

8. McFarland LV. Epidemiology, risk factors and treatments for antibiotic-associated diarrhea. Dig Dis Basel Switz. 1998 Oct;16(5):292–307.

9. Williams NT. Probiotics. Am J Health Syst Pharm. 2010 Mar 15;67(6):449–58.

10. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506–14.

11. McFarland LV. Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review. BMJ Open. 2014 Aug 25;4(8):e005047–e005047.

12. Engelbrektson A, Korzenik JR, Pittler A, Sanders ME, Klaenhammer TR, Leyer G, et al. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol. 2009 May 1;58(5):663–70.

13. Blaabjerg S, Artzi D, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. Antibiotics. 2017 Oct 12;6(4):21.