{"id":9296350603,"title":"Metagenics PainX","handle":"metagenics-painx-120g","description":"\u003ch3\u003e\u003cem\u003eFor Neuromuscular Function and Pain Relief\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics PainX\u003c\/h2\u003e\n\u003cp\u003eSize: 120g powder (12 days) Raspberry Flavour\u003c\/p\u003e\n\u003cp\u003eMetagenics PainX Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduces and relieves nerve pain and persistent muscular pain, cramps, and spasm.\u003c\/li\u003e\n\u003cli\u003eFor neuromuscular pain, such as shoulder and back pain, head and neck pain, sciatic pain, and fibromyalgia pain.\u003c\/li\u003e\n\u003cli\u003ePEA is analgesic and anti-inflammatory, exerts endocannabinoid activity and reduces pain amplification and muscle pain.\u003c\/li\u003e\n\u003cli\u003eContains highly bioavailable PEA and exclusive Meta Mag Magnesium.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics PainX is Free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics PainX AUST L 376652\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicines you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"Metagenics Fibroplex MagActive 10% off RRP | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/search?q=Fibroples+Mag+Active\" target=\"_blank\"\u003eMetagenics Fibroplex MagActive Raspberry\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003eand\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-bio-absorb-pea-advanced\" title=\"Metagenics Bio Absorb PEA Advanced 10% off RRP | HealthMasters Metagenics\" target=\"_blank\"\u003eMetagenics Bio Absorb PEA Advanced\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate naturopathic medicines, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003eAdults: Add 1 scoop (5 g) to 200 mL water twice daily.\u003c\/p\u003e\n\u003cp\u003eDosing – The daily dosage of PEA in clinical trials has ranged from 300mg–1200mg daily for chronic pain and up to 1800mg daily for acute colds and flu. Clinical trial data would suggest that a loading dose of 600–1200mg for 3–4 weeks followed by a maintenance dose of 300–600mg may be the most appropriate dosing strategy for chronic pain conditions. Individual requirements will vary.\u003c\/p\u003e\n\u003cp\u003eTiming – Considering that PEA is a fat soluble compound, consumption with a fat-containing meal may enhance absorption.\u003c\/p\u003e\n\u003cp\u003eContraindications and adverse effects – There are no known contraindications. PEA has been clinically studied across a broad population group and has been found to be highly tolerable, with aside effect profile similar to placebo.\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNumerous other studies exist which used PEA over three months without negative effects.\u003c\/strong\u003e See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eKey Clinical Applications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLow back pain\u003c\/li\u003e\n\u003cli\u003eMuscle cramps and spasms\u003c\/li\u003e\n\u003cli\u003eChronic jaw pain\u003c\/li\u003e\n\u003cli\u003eMigraine\/headache\u003c\/li\u003e\n\u003cli\u003eFibromyalgia\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eRelieves neuromuscular pain:\u003c\/strong\u003e Magnesium exerts muscle-relaxing actions (and prevents muscle spasms) via multiple mechanisms and is a natural glutamate antagonist.1 Glutamate is involved in central sensitisation and pain amplification.2 Magnesium regulates neuromuscular transmission by blocking the entry of calcium ions in synaptic nerve terminals,3  as well as inhibiting presynaptic acetylcholine release, which propagates impulses between motor nerves and muscles.4\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigher magnesium intake has found to be protective against chronic pain.\u003c\/strong\u003e5 However, one third of Australian adults fail to meet their requirements for adequate magnesium intake.6 PainX contains 420 mg\/d to support adults to meet the recommended intake of 310 to 320 mg\/d in women and 400 to 420 mg\/d in \u003cem\u003emen\u003c\/em\u003e.7\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_1_600x600.png?v=1644472335\" alt=\"Metagenics PainX 10% off RRP at HealthMasters Metagenics Figure 1\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e \u003cstrong\u003eFigure 1: Magnesium and PEA Address Multiple Drivers of Pain Amplification.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePalmitoylethanolamide (PEA) promotes endogenous cannabinoid system (ECS) activity through its ability to augment the activity of cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).\u003c\/strong\u003e8 \u003c\/p\u003e\n\u003cp\u003eThese receptors are expressed in nerve tissue and immune cells and are involved in modulating the inflammatory response by suppressing immune cell activation, which can reduce pain perception.9 PEA proves to be effective and safe in nerve compression syndromes. In one pivotal, double blind, placebo-controlled trial in 636 sciatic pain patients, subjective pain scores were reduced from 6.5\/10 to 3.6\/10 in the 300 mg\/d group, while in the 600 mg\/d group scores were reduced from 7.1\/10 to 2.1\/10 compared to placebo, which decreased from 6.6\/10 to 4.6 (Figure 2).10\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_2_600x600.png?v=1644472404\" alt=\"Metagenics PainX 10% off RRP at HealthMasters Metagenics Figure 2\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: Outcomes of 600 mg\/d of PEA on Sciatic Pain.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMeta Mag and Levagen+ are both exclusive types of magnesium and PEA, respectively, that show enhanced bioavailability.\u003c\/strong\u003e11 Meta Mag is different to magnesium salts and other magnesium chelates because it is covalently bound to two glycine molecules.12 Levagen+ is a highly bioavailable PEA using LipiSperse technology for enhanced absorption.13 The Levagen+ absorption studies show that Levagen+ is 1.7 times better absorbed and that it stays in the plasma for a longer period of time compared to a standard PEA (Levagen) (Figure 3). Clinically, 600 mg\/d of Levagen+ PEA is likely to equate to consuming 1,000 mg\/d of a standard micronised PEA (Levagen). A Practitioner can expect Levagen+ to produce greater efficacy and to last longer in the body.14\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_3_600x600.png?v=1644472452\" alt=\"Metagenics PainX 10% off RRP at HealthMasters Metagenics Figure 3\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 3: Levagen+ PEA vs Standard PEA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLevagen+ is owned by Gencor Pacific Limited.\u003c\/p\u003e\n\u003cp\u003eMeta Mag is a registered trademark of Balchem Corp\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics PainX\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach dose (5 g) of  PainX contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium glycinate dihydrate\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e(Meta Mag - Magnesium bisglycinate)\u003c\/td\u003e\n\u003ctd\u003e2.1g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequivalent Magnesium\u003c\/td\u003e\n\u003ctd\u003e210mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmidrol (Palmitoylethanolamide) (Levagen+)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003ePainX contains 750 mg of malic acid per dose.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003ePainX contains 750 mg of malic acid per dose.\u003c\/p\u003e\n\u003ch5\u003eAllergen Advice\u003c\/h5\u003e\n\u003ch2\u003eAllergen Advice: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003e\u003cspan\u003eFree from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003eThis medicine is not to be used for more than 21 consecutive days, and may interact with other prescription analgesic medicines.\u003c\/p\u003e\n\u003cp\u003ePlease consult your healthcare Practitioner before use. \u003c\/p\u003e\n\u003cp\u003eSuitable for individuals 18 years and over.\u003c\/p\u003e\n\u003cp\u003eMineral supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eNot all cautions and contraindications are listed. For full details, references or more information contact HealthMasters in Australia by email: reception@healthmasters.com.au.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNumerous other studies exist which used PEA over three months without negative effects.\u003c\/strong\u003e See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003ch5\u003eMore Information \u0026amp; References\u003c\/h5\u003e\n\u003ch2\u003eMore Information \u0026amp; References: PEA\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound\" target=\"_blank\"\u003ePEA: A novel anti-neuroinflammatory compound\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound#Additional-References\" title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters\" target=\"_blank\"\u003ePEA: Additional References and Resources\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T14:18:09+11:00","created_at":"2017-06-29T17:41:23+10:00","vendor":"Metagenics","type":"Metagenics Naturopathic Medicines","tags":["1200px","Essential Minerals \u0026 Multivitamins","Magnesium","Metagenics","Naturopathic","Pain and Inflammation","PB","PEA"],"price":5846,"price_min":5846,"price_max":5846,"available":true,"price_varies":false,"compare_at_price":6495,"compare_at_price_min":6495,"compare_at_price_max":6495,"compare_at_price_varies":false,"variants":[{"id":42545825349862,"title":"120g Powder","option1":"120g Powder","option2":null,"option3":null,"sku":"PainX120g","requires_shipping":true,"taxable":true,"featured_image":{"id":36950585671910,"product_id":9296350603,"position":1,"created_at":"2022-03-04T17:34:20+11:00","updated_at":"2022-03-04T17:36:29+11:00","alt":"Metagenics PainX 120g 10% off RRP at HealthMasters Metagenics","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g10_offRRPatHealthMastersMetagenics.jpg?v=1646375789","variant_ids":[42545825349862]},"available":true,"name":"Metagenics PainX - 120g Powder","public_title":"120g Powder","options":["120g Powder"],"price":5846,"weight":130,"compare_at_price":6495,"inventory_quantity":9941,"inventory_management":"shopify","inventory_policy":"continue","barcode":"9315771011928","featured_media":{"alt":"Metagenics PainX 120g 10% off RRP at HealthMasters Metagenics","id":29508745199846,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g10_offRRPatHealthMastersMetagenics.jpg?v=1646375789"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g10_offRRPatHealthMastersMetagenics.jpg?v=1646375789","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g-2_3d20bd56-a7b7-43dd-b8ec-73c8e0c0171f.jpg?v=1646375828","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g-3_3f6ad46d-cbc9-4f28-acf3-25e2ad6faa02.jpg?v=1646375792","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_PainX_Tropical_275_g_10_off_RRP_at_HealthMasters.jpg?v=1646375792"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g10_offRRPatHealthMastersMetagenics.jpg?v=1646375789","options":["Size:"],"media":[{"alt":"Metagenics PainX 120g 10% off RRP at HealthMasters Metagenics","id":29508745199846,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g10_offRRPatHealthMastersMetagenics.jpg?v=1646375789"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g10_offRRPatHealthMastersMetagenics.jpg?v=1646375789","width":1200},{"alt":"Metagenics PainX 120g 10% off RRP at HealthMasters Metagenics Informmation","id":29508745265382,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g-2_3d20bd56-a7b7-43dd-b8ec-73c8e0c0171f.jpg?v=1646375828"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g-2_3d20bd56-a7b7-43dd-b8ec-73c8e0c0171f.jpg?v=1646375828","width":1200},{"alt":"Metagenics PainX 120g 10% off RRP at HealthMasters Metagenics Directions","id":29508745232614,"position":3,"preview_image":{"aspect_ratio":1.0,"height":2400,"width":2400,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g-3_3f6ad46d-cbc9-4f28-acf3-25e2ad6faa02.jpg?v=1646375792"},"aspect_ratio":1.0,"height":2400,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsPainXRaspberry120g-3_3f6ad46d-cbc9-4f28-acf3-25e2ad6faa02.jpg?v=1646375792","width":2400},{"alt":"Metagenics PainX 10% off RRP at HealthMasters Metagenics Logo","id":2550152626235,"position":4,"preview_image":{"aspect_ratio":1.0,"height":1000,"width":1000,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_PainX_Tropical_275_g_10_off_RRP_at_HealthMasters.jpg?v=1646375792"},"aspect_ratio":1.0,"height":1000,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_PainX_Tropical_275_g_10_off_RRP_at_HealthMasters.jpg?v=1646375792","width":1000}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch3\u003e\u003cem\u003eFor Neuromuscular Function and Pain Relief\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics PainX\u003c\/h2\u003e\n\u003cp\u003eSize: 120g powder (12 days) Raspberry Flavour\u003c\/p\u003e\n\u003cp\u003eMetagenics PainX Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduces and relieves nerve pain and persistent muscular pain, cramps, and spasm.\u003c\/li\u003e\n\u003cli\u003eFor neuromuscular pain, such as shoulder and back pain, head and neck pain, sciatic pain, and fibromyalgia pain.\u003c\/li\u003e\n\u003cli\u003ePEA is analgesic and anti-inflammatory, exerts endocannabinoid activity and reduces pain amplification and muscle pain.\u003c\/li\u003e\n\u003cli\u003eContains highly bioavailable PEA and exclusive Meta Mag Magnesium.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics PainX is Free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics PainX AUST L 376652\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicines you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"Metagenics Fibroplex MagActive 10% off RRP | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/search?q=Fibroples+Mag+Active\" target=\"_blank\"\u003eMetagenics Fibroplex MagActive Raspberry\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003eand\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-bio-absorb-pea-advanced\" title=\"Metagenics Bio Absorb PEA Advanced 10% off RRP | HealthMasters Metagenics\" target=\"_blank\"\u003eMetagenics Bio Absorb PEA Advanced\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate naturopathic medicines, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003eAdults: Add 1 scoop (5 g) to 200 mL water twice daily.\u003c\/p\u003e\n\u003cp\u003eDosing – The daily dosage of PEA in clinical trials has ranged from 300mg–1200mg daily for chronic pain and up to 1800mg daily for acute colds and flu. Clinical trial data would suggest that a loading dose of 600–1200mg for 3–4 weeks followed by a maintenance dose of 300–600mg may be the most appropriate dosing strategy for chronic pain conditions. Individual requirements will vary.\u003c\/p\u003e\n\u003cp\u003eTiming – Considering that PEA is a fat soluble compound, consumption with a fat-containing meal may enhance absorption.\u003c\/p\u003e\n\u003cp\u003eContraindications and adverse effects – There are no known contraindications. PEA has been clinically studied across a broad population group and has been found to be highly tolerable, with aside effect profile similar to placebo.\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNumerous other studies exist which used PEA over three months without negative effects.\u003c\/strong\u003e See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eKey Clinical Applications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLow back pain\u003c\/li\u003e\n\u003cli\u003eMuscle cramps and spasms\u003c\/li\u003e\n\u003cli\u003eChronic jaw pain\u003c\/li\u003e\n\u003cli\u003eMigraine\/headache\u003c\/li\u003e\n\u003cli\u003eFibromyalgia\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eRelieves neuromuscular pain:\u003c\/strong\u003e Magnesium exerts muscle-relaxing actions (and prevents muscle spasms) via multiple mechanisms and is a natural glutamate antagonist.1 Glutamate is involved in central sensitisation and pain amplification.2 Magnesium regulates neuromuscular transmission by blocking the entry of calcium ions in synaptic nerve terminals,3  as well as inhibiting presynaptic acetylcholine release, which propagates impulses between motor nerves and muscles.4\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigher magnesium intake has found to be protective against chronic pain.\u003c\/strong\u003e5 However, one third of Australian adults fail to meet their requirements for adequate magnesium intake.6 PainX contains 420 mg\/d to support adults to meet the recommended intake of 310 to 320 mg\/d in women and 400 to 420 mg\/d in \u003cem\u003emen\u003c\/em\u003e.7\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_1_600x600.png?v=1644472335\" alt=\"Metagenics PainX 10% off RRP at HealthMasters Metagenics Figure 1\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e \u003cstrong\u003eFigure 1: Magnesium and PEA Address Multiple Drivers of Pain Amplification.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePalmitoylethanolamide (PEA) promotes endogenous cannabinoid system (ECS) activity through its ability to augment the activity of cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).\u003c\/strong\u003e8 \u003c\/p\u003e\n\u003cp\u003eThese receptors are expressed in nerve tissue and immune cells and are involved in modulating the inflammatory response by suppressing immune cell activation, which can reduce pain perception.9 PEA proves to be effective and safe in nerve compression syndromes. In one pivotal, double blind, placebo-controlled trial in 636 sciatic pain patients, subjective pain scores were reduced from 6.5\/10 to 3.6\/10 in the 300 mg\/d group, while in the 600 mg\/d group scores were reduced from 7.1\/10 to 2.1\/10 compared to placebo, which decreased from 6.6\/10 to 4.6 (Figure 2).10\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_2_600x600.png?v=1644472404\" alt=\"Metagenics PainX 10% off RRP at HealthMasters Metagenics Figure 2\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: Outcomes of 600 mg\/d of PEA on Sciatic Pain.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMeta Mag and Levagen+ are both exclusive types of magnesium and PEA, respectively, that show enhanced bioavailability.\u003c\/strong\u003e11 Meta Mag is different to magnesium salts and other magnesium chelates because it is covalently bound to two glycine molecules.12 Levagen+ is a highly bioavailable PEA using LipiSperse technology for enhanced absorption.13 The Levagen+ absorption studies show that Levagen+ is 1.7 times better absorbed and that it stays in the plasma for a longer period of time compared to a standard PEA (Levagen) (Figure 3). Clinically, 600 mg\/d of Levagen+ PEA is likely to equate to consuming 1,000 mg\/d of a standard micronised PEA (Levagen). A Practitioner can expect Levagen+ to produce greater efficacy and to last longer in the body.14\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_3_600x600.png?v=1644472452\" alt=\"Metagenics PainX 10% off RRP at HealthMasters Metagenics Figure 3\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 3: Levagen+ PEA vs Standard PEA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLevagen+ is owned by Gencor Pacific Limited.\u003c\/p\u003e\n\u003cp\u003eMeta Mag is a registered trademark of Balchem Corp\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics PainX\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach dose (5 g) of  PainX contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium glycinate dihydrate\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e(Meta Mag - Magnesium bisglycinate)\u003c\/td\u003e\n\u003ctd\u003e2.1g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequivalent Magnesium\u003c\/td\u003e\n\u003ctd\u003e210mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmidrol (Palmitoylethanolamide) (Levagen+)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003ePainX contains 750 mg of malic acid per dose.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003ePainX contains 750 mg of malic acid per dose.\u003c\/p\u003e\n\u003ch5\u003eAllergen Advice\u003c\/h5\u003e\n\u003ch2\u003eAllergen Advice: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003e\u003cspan\u003eFree from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003eThis medicine is not to be used for more than 21 consecutive days, and may interact with other prescription analgesic medicines.\u003c\/p\u003e\n\u003cp\u003ePlease consult your healthcare Practitioner before use. \u003c\/p\u003e\n\u003cp\u003eSuitable for individuals 18 years and over.\u003c\/p\u003e\n\u003cp\u003eMineral supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eNot all cautions and contraindications are listed. For full details, references or more information contact HealthMasters in Australia by email: reception@healthmasters.com.au.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNumerous other studies exist which used PEA over three months without negative effects.\u003c\/strong\u003e See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics PainX\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003ch5\u003eMore Information \u0026amp; References\u003c\/h5\u003e\n\u003ch2\u003eMore Information \u0026amp; References: PEA\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound\" target=\"_blank\"\u003ePEA: A novel anti-neuroinflammatory compound\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound#Additional-References\" title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters\" target=\"_blank\"\u003ePEA: Additional References and Resources\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}