{"id":4450252259387,"title":"Metagenics Bio Absorb PEA Advanced 42 caps","handle":"metagenics-bio-absorb-pea-advanced","description":"\u003ch3 style=\"text-align: left;\"\u003e\n\u003cem\u003eHigh Strength, Enhanced Absorption PEA For Nerve Pain Combined With Saffron\u003c\/em\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003ch2\u003eMetagenics Bio Absorb PEA Advanced 42 caps\u003c\/h2\u003e\n\u003cp\u003eSize: 42 capsules (VegeCaps) (21 days)\u003c\/p\u003e\n\u003cp\u003eMetagenics Bio Absorb PEA Advanced summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor the relief of nerve pain, neuralgia, and compression neuropathy.\u003c\/li\u003e\n\u003cli\u003eBreaks the pain cycle by targeting drivers of pain amplification, is analgesic and enhances endocannabinoid activity.\u003c\/li\u003e\n\u003cli\u003eA highly bioavailable form of PEA using the Levagen+ (LipiSperse) delivery system, with affron and vitamin B1.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics Bio Absorb PEA Advanced is Free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics Bio Absorb PEA Advanced AUST L 376653\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule twice daily.\u003c\/p\u003e\n\u003cp\u003eThis medicine is not to be used for more than 21 consecutive days and may interact with other prescription analgesic medicines. Suitable for individuals 18 years and over.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003eNumerous other studies exist which used PEA over three months without negative effects. See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eBio Absorb PEA Advanced relieves neuropathic pain, such as sciatica, neuropathies and neuralgia.\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eClinical Research of PEA\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eStudy Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eDose of PEA\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eDuration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eOutcome\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA large scale, pivotal randomised, doubleblind, placebocontrolled trial in 636 participants with lumbosciatica pain.\u003c\/td\u003e\n\u003ctd\u003e300 mg\/d or 600 mg\/d\u003c\/td\u003e\n\u003ctd\u003e3 weeks\u003c\/td\u003e\n\u003ctd\u003eThe group receiving 600 mg\/d of PEA reported a significant improvement in quality of life (p\u0026lt;0.001). Pain was reduced by greater than 50% compared with the 300 mg\/d and placebo group.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOpen label study in 30 participants with diabetic-induced peripheral neuropathy.2\u003c\/td\u003e\n\u003ctd\u003e600 mg\/d\u003c\/td\u003e\n\u003ctd\u003e8 weeks\u003c\/td\u003e\n\u003ctd\u003eSignificant reduction in intensity and presence of pain from baseline (p\u0026lt;0.0001). No serious adverse events reported.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eClinical trial of 20 patients with chemotherapy induced neuropathic pain.3\u003c\/td\u003e\n\u003ctd\u003e600 mg\/d\u003c\/td\u003e\n\u003ctd\u003e8 weeks\u003c\/td\u003e\n\u003ctd\u003ePain and all neurophysiological measures assessing Aα, Aß, and Aδ fibres significantly improved (p\u0026lt;0.05) with PEA administration.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePalmitoylethanolamide (PEA) is neuroprotective, anti-inflammatory, and analgesic4 due to its endocannabinoid (eCB) action.\u003c\/strong\u003e5 PEA affects eCB signalling through peroxisome proliferator-activated receptor alpha (PPAR-α)  activation6and is capable of exerting antiallodynic and anti-hyperalgesia effects by downmodulating both microglial and mast cell activity which has led to its use for neuropathic pain.7Both TRPA1 (transient receptor potential ankyrin 1) and TRPV1 (transient receptor potential vanilloid type 1) are co-expressed in sensory neurons and are implicated in neuropathic pain, hyperalgesia and neural amplification.8 Animal studies have shown that a main phytoconstitutent of saffron, safranal, desensitises TRPA1 and PEA desensitises TRPV1.9 In addition, vitamin B1 deficiency results in neuropathic pain10 and vitamin B1 was found to significantly reduce dorsal root ganglia neuron excitability in vitro, a provocating factor in central sensitisation of pain.11\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1 in 5 of chronic pain sufferers have neuropathic pain.\u003c\/strong\u003e12 Patients presenting an inadequate response to drug treatment13 can partly be explained by the hyperalgesia that is associated with long-term opioid use.14 PEA and saffron have been found to be safe to use alongside common pain medication in certain individuals*.15,16,17,18,91,20,21,22,23\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Bio_Absorb_PEA_Advanced_42_caps_10_off_RRP_at_HealthMasters_Metagenics_Figure_1_600x600.png?v=1644544796\" alt=\"Bio Absorb PEA Advanced 42 caps 10% off RRP at HealthMasters Metagenics Figure 1\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: PEA, Saffron and Vitamin B1 in the Pain Cycle\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLevagen+ uses LipiSperse technology for enhanced absorption24 and is 70% better absorbed (Figure 2) leading to greater plasma levels over time compared to a standard PEA.\u003c\/strong\u003e 600 mg\/d of Levagen+ PEA is likely to equate to consuming 1,000 mg of a standard micronized PEA. Practitioners can expect Levagen+ to produce greater efficacy and to last longer in the body.25\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_3_600x600.png?v=1644472452\" alt=\"Bio Absorb PEA Advanced 42 caps 10% off RRP at HealthMasters Metagenics Figure 2\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: Levagen+ PEA vs Standard PEA.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLevagen+ is owned by Gencor Pacific Limited.\u003c\/p\u003e\n\u003cp\u003eaffron is a registered trademark of Pharmactive Biotech Products, S.L.\u003c\/p\u003e\n\u003cp\u003e*Always check patient medications for interactions and safety.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmidrol\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmitoylethanolamide) (Levagen+)\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThiamine hydrochloride (Vitamin B1)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDry herbal extract:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCrocus sativus (affron), stigma\u003c\/td\u003e\n\u003ctd\u003e7.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDerived from dry stigma\u003c\/td\u003e\n\u003ctd\u003e22.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eAllergen Advice\u003c\/h5\u003e\n\u003ch2\u003eAllergen Advice: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eFree from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eThis medicine is not to be used for more than 21 consecutive days and may interact with other prescription analgesic medicines. Suitable for individuals 18 years and over.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003eNumerous other studies exist which used PEA over three months without negative effects. See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C.\u003c\/p\u003e\n\u003ch5\u003eMore Information \u0026amp; References\u003c\/h5\u003e\n\u003ch2\u003eMore Information \u0026amp; References: Metagenics Bio Absorb PEA\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound\" target=\"_blank\"\u003ePEA: A novel anti-neuroinflammatory compound\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound#Additional-References\" title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters Metagenics\" target=\"_blank\"\u003ePEA: Additional References and Resources\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-02-11T16:27:27+11:00","created_at":"2020-01-19T12:14:03+11:00","vendor":"Metagenics","type":"Metagenics Naturopathic Medicines","tags":["1200px","Metagenics","Naturopathic","Pain and Inflammation","PEA"],"price":6296,"price_min":6296,"price_max":6296,"available":true,"price_varies":false,"compare_at_price":6995,"compare_at_price_min":6995,"compare_at_price_max":6995,"compare_at_price_varies":false,"variants":[{"id":31665681956923,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"BioAbsorbPEAAdvanced42caps","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Metagenics Bio Absorb PEA Advanced 42 caps","public_title":null,"options":["Default Title"],"price":6296,"weight":0,"compare_at_price":6995,"inventory_quantity":19995,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9315771011935"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Caps10_offRRPatHealthMastersMetagenics.jpg?v=1644555552","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Capsules-3.jpg?v=1644555552","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Capsules-2.jpg?v=1644555552","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics10_offRRPatHealthMasters_12bd9e2a-31da-4015-8f3f-6b924baca7a9.jpg?v=1644555552"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Caps10_offRRPatHealthMastersMetagenics.jpg?v=1644555552","options":["Title"],"media":[{"alt":"Metagenics Bio Absorb PEA Advanced 42 Caps 10% off RRP at HealthMasters Metagenics","id":29315353706726,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Caps10_offRRPatHealthMastersMetagenics.jpg?v=1644555552"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Caps10_offRRPatHealthMastersMetagenics.jpg?v=1644555552","width":1200},{"alt":"Metagenics Bio Absorb PEA Advanced 42 Caps 10% off RRP at HealthMasters Metagenics Ingredients","id":29315353772262,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Capsules-3.jpg?v=1644555552"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Capsules-3.jpg?v=1644555552","width":1200},{"alt":"Metagenics Bio Absorb PEA Advanced 42 Caps 10% off RRP at HealthMasters Metagenics Information","id":29315353739494,"position":3,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Capsules-2.jpg?v=1644555552"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsBioAbsorbPEAAdvanced42Capsules-2.jpg?v=1644555552","width":1200},{"alt":"Metagenics Bio Absorb PEA Advanced 42 Caps 10% off RRP at HealthMasters Metagenics Logo","id":8159917080635,"position":4,"preview_image":{"aspect_ratio":0.944,"height":500,"width":472,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics10_offRRPatHealthMasters_12bd9e2a-31da-4015-8f3f-6b924baca7a9.jpg?v=1644555552"},"aspect_ratio":0.944,"height":500,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics10_offRRPatHealthMasters_12bd9e2a-31da-4015-8f3f-6b924baca7a9.jpg?v=1644555552","width":472}],"content":"\u003ch3 style=\"text-align: left;\"\u003e\n\u003cem\u003eHigh Strength, Enhanced Absorption PEA For Nerve Pain Combined With Saffron\u003c\/em\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003ch2\u003eMetagenics Bio Absorb PEA Advanced 42 caps\u003c\/h2\u003e\n\u003cp\u003eSize: 42 capsules (VegeCaps) (21 days)\u003c\/p\u003e\n\u003cp\u003eMetagenics Bio Absorb PEA Advanced summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor the relief of nerve pain, neuralgia, and compression neuropathy.\u003c\/li\u003e\n\u003cli\u003eBreaks the pain cycle by targeting drivers of pain amplification, is analgesic and enhances endocannabinoid activity.\u003c\/li\u003e\n\u003cli\u003eA highly bioavailable form of PEA using the Levagen+ (LipiSperse) delivery system, with affron and vitamin B1.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics Bio Absorb PEA Advanced is Free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics Bio Absorb PEA Advanced AUST L 376653\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule twice daily.\u003c\/p\u003e\n\u003cp\u003eThis medicine is not to be used for more than 21 consecutive days and may interact with other prescription analgesic medicines. Suitable for individuals 18 years and over.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003eNumerous other studies exist which used PEA over three months without negative effects. See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eBio Absorb PEA Advanced relieves neuropathic pain, such as sciatica, neuropathies and neuralgia.\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eClinical Research of PEA\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eStudy Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eDose of PEA\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eDuration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eOutcome\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA large scale, pivotal randomised, doubleblind, placebocontrolled trial in 636 participants with lumbosciatica pain.\u003c\/td\u003e\n\u003ctd\u003e300 mg\/d or 600 mg\/d\u003c\/td\u003e\n\u003ctd\u003e3 weeks\u003c\/td\u003e\n\u003ctd\u003eThe group receiving 600 mg\/d of PEA reported a significant improvement in quality of life (p\u0026lt;0.001). Pain was reduced by greater than 50% compared with the 300 mg\/d and placebo group.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOpen label study in 30 participants with diabetic-induced peripheral neuropathy.2\u003c\/td\u003e\n\u003ctd\u003e600 mg\/d\u003c\/td\u003e\n\u003ctd\u003e8 weeks\u003c\/td\u003e\n\u003ctd\u003eSignificant reduction in intensity and presence of pain from baseline (p\u0026lt;0.0001). No serious adverse events reported.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eClinical trial of 20 patients with chemotherapy induced neuropathic pain.3\u003c\/td\u003e\n\u003ctd\u003e600 mg\/d\u003c\/td\u003e\n\u003ctd\u003e8 weeks\u003c\/td\u003e\n\u003ctd\u003ePain and all neurophysiological measures assessing Aα, Aß, and Aδ fibres significantly improved (p\u0026lt;0.05) with PEA administration.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePalmitoylethanolamide (PEA) is neuroprotective, anti-inflammatory, and analgesic4 due to its endocannabinoid (eCB) action.\u003c\/strong\u003e5 PEA affects eCB signalling through peroxisome proliferator-activated receptor alpha (PPAR-α)  activation6and is capable of exerting antiallodynic and anti-hyperalgesia effects by downmodulating both microglial and mast cell activity which has led to its use for neuropathic pain.7Both TRPA1 (transient receptor potential ankyrin 1) and TRPV1 (transient receptor potential vanilloid type 1) are co-expressed in sensory neurons and are implicated in neuropathic pain, hyperalgesia and neural amplification.8 Animal studies have shown that a main phytoconstitutent of saffron, safranal, desensitises TRPA1 and PEA desensitises TRPV1.9 In addition, vitamin B1 deficiency results in neuropathic pain10 and vitamin B1 was found to significantly reduce dorsal root ganglia neuron excitability in vitro, a provocating factor in central sensitisation of pain.11\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1 in 5 of chronic pain sufferers have neuropathic pain.\u003c\/strong\u003e12 Patients presenting an inadequate response to drug treatment13 can partly be explained by the hyperalgesia that is associated with long-term opioid use.14 PEA and saffron have been found to be safe to use alongside common pain medication in certain individuals*.15,16,17,18,91,20,21,22,23\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Bio_Absorb_PEA_Advanced_42_caps_10_off_RRP_at_HealthMasters_Metagenics_Figure_1_600x600.png?v=1644544796\" alt=\"Bio Absorb PEA Advanced 42 caps 10% off RRP at HealthMasters Metagenics Figure 1\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: PEA, Saffron and Vitamin B1 in the Pain Cycle\u003c\/strong\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLevagen+ uses LipiSperse technology for enhanced absorption24 and is 70% better absorbed (Figure 2) leading to greater plasma levels over time compared to a standard PEA.\u003c\/strong\u003e 600 mg\/d of Levagen+ PEA is likely to equate to consuming 1,000 mg of a standard micronized PEA. Practitioners can expect Levagen+ to produce greater efficacy and to last longer in the body.25\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_PainX_10_off_RRP_at_HealthMasters_Metagenics_Figure_3_600x600.png?v=1644472452\" alt=\"Bio Absorb PEA Advanced 42 caps 10% off RRP at HealthMasters Metagenics Figure 2\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: Levagen+ PEA vs Standard PEA.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLevagen+ is owned by Gencor Pacific Limited.\u003c\/p\u003e\n\u003cp\u003eaffron is a registered trademark of Pharmactive Biotech Products, S.L.\u003c\/p\u003e\n\u003cp\u003e*Always check patient medications for interactions and safety.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmidrol\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmitoylethanolamide) (Levagen+)\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThiamine hydrochloride (Vitamin B1)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDry herbal extract:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCrocus sativus (affron), stigma\u003c\/td\u003e\n\u003ctd\u003e7.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDerived from dry stigma\u003c\/td\u003e\n\u003ctd\u003e22.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eAllergen Advice\u003c\/h5\u003e\n\u003ch2\u003eAllergen Advice: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eFree from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eThis medicine is not to be used for more than 21 consecutive days and may interact with other prescription analgesic medicines. Suitable for individuals 18 years and over.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.\u003c\/p\u003e\n\u003cp\u003eNumerous other studies exist which used PEA over three months without negative effects. See references Tab for 256 references relating to PEA.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics Bio Absorb PEA Advanced\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C.\u003c\/p\u003e\n\u003ch5\u003eMore Information \u0026amp; References\u003c\/h5\u003e\n\u003ch2\u003eMore Information \u0026amp; References: Metagenics Bio Absorb PEA\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound\" target=\"_blank\"\u003ePEA: A novel anti-neuroinflammatory compound\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/pea-a-novel-anti-neuroinflammatory-compound#Additional-References\" title=\"PEA: A novel anti-neuroinflammatory compound | HealthMasters Metagenics\" target=\"_blank\"\u003ePEA: Additional References and Resources\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}

Metagenics Bio Absorb PEA Advanced 42 caps

Product Details

High Strength, Enhanced Absorption PEA For Nerve Pain Combined With Saffron

Metagenics Bio Absorb PEA Advanced 42 caps

Size: 42 capsules (VegeCaps) (21 days)

Metagenics Bio Absorb PEA Advanced summary:

  • For the relief of nerve pain, neuralgia, and compression neuropathy.
  • Breaks the pain cycle by targeting drivers of pain amplification, is analgesic and enhances endocannabinoid activity.
  • A highly bioavailable form of PEA using the Levagen+ (LipiSperse) delivery system, with affron and vitamin B1.

Metagenics Bio Absorb PEA Advanced is Free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.

Metagenics Bio Absorb PEA Advanced AUST L 376653

Directions: Metagenics Bio Absorb PEA Advanced

Adults: Take 1 capsule twice daily.

This medicine is not to be used for more than 21 consecutive days and may interact with other prescription analgesic medicines. Suitable for individuals 18 years and over.

Why is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?

The Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.

Numerous other studies exist which used PEA over three months without negative effects. See references Tab for 256 references relating to PEA.

Benefits: Metagenics Bio Absorb PEA Advanced

Bio Absorb PEA Advanced relieves neuropathic pain, such as sciatica, neuropathies and neuralgia.

Clinical Research of PEA

Study Type Dose of PEA Duration Outcome
A large scale, pivotal randomised, doubleblind, placebocontrolled trial in 636 participants with lumbosciatica pain. 300 mg/d or 600 mg/d 3 weeks The group receiving 600 mg/d of PEA reported a significant improvement in quality of life (p<0.001). Pain was reduced by greater than 50% compared with the 300 mg/d and placebo group.
Open label study in 30 participants with diabetic-induced peripheral neuropathy.2 600 mg/d 8 weeks Significant reduction in intensity and presence of pain from baseline (p<0.0001). No serious adverse events reported.
Clinical trial of 20 patients with chemotherapy induced neuropathic pain.3 600 mg/d 8 weeks Pain and all neurophysiological measures assessing Aα, Aß, and Aδ fibres significantly improved (p<0.05) with PEA administration.

 

Palmitoylethanolamide (PEA) is neuroprotective, anti-inflammatory, and analgesic4 due to its endocannabinoid (eCB) action.5 PEA affects eCB signalling through peroxisome proliferator-activated receptor alpha (PPAR-α)  activation6and is capable of exerting antiallodynic and anti-hyperalgesia effects by downmodulating both microglial and mast cell activity which has led to its use for neuropathic pain.7Both TRPA1 (transient receptor potential ankyrin 1) and TRPV1 (transient receptor potential vanilloid type 1) are co-expressed in sensory neurons and are implicated in neuropathic pain, hyperalgesia and neural amplification.8 Animal studies have shown that a main phytoconstitutent of saffron, safranal, desensitises TRPA1 and PEA desensitises TRPV1.9 In addition, vitamin B1 deficiency results in neuropathic pain10 and vitamin B1 was found to significantly reduce dorsal root ganglia neuron excitability in vitro, a provocating factor in central sensitisation of pain.11

1 in 5 of chronic pain sufferers have neuropathic pain.12 Patients presenting an inadequate response to drug treatment13 can partly be explained by the hyperalgesia that is associated with long-term opioid use.14 PEA and saffron have been found to be safe to use alongside common pain medication in certain individuals*.15,16,17,18,91,20,21,22,23

Bio Absorb PEA Advanced 42 caps 10% off RRP at HealthMasters Metagenics Figure 1

Figure 1: PEA, Saffron and Vitamin B1 in the Pain Cycle 

Levagen+ uses LipiSperse technology for enhanced absorption24 and is 70% better absorbed (Figure 2) leading to greater plasma levels over time compared to a standard PEA. 600 mg/d of Levagen+ PEA is likely to equate to consuming 1,000 mg of a standard micronized PEA. Practitioners can expect Levagen+ to produce greater efficacy and to last longer in the body.25

Bio Absorb PEA Advanced 42 caps 10% off RRP at HealthMasters Metagenics Figure 2

Figure 2: Levagen+ PEA vs Standard PEA.

Levagen+ is owned by Gencor Pacific Limited.

affron is a registered trademark of Pharmactive Biotech Products, S.L.

*Always check patient medications for interactions and safety.

Ingredients: Metagenics Bio Absorb PEA Advanced

Each capsule contains:
Palmidrol 300mg
Palmitoylethanolamide) (Levagen+)
Thiamine hydrochloride (Vitamin B1) 50mg
Dry herbal extract:
Crocus sativus (affron), stigma 7.5mg
Derived from dry stigma 22.5mg

Allergen Advice: Metagenics Bio Absorb PEA Advanced

Free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.

Warnings: Metagenics Bio Absorb PEA Advanced

This medicine is not to be used for more than 21 consecutive days and may interact with other prescription analgesic medicines. Suitable for individuals 18 years and over.

Why is there a 21-Day Warning for Bio Absorb PEA? Is it safe to take long term?

The Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA.

Numerous other studies exist which used PEA over three months without negative effects. See references Tab for 256 references relating to PEA.

Always read the label. Use only as directed. If symptoms persist consult your healthcare professional.

Storage: Metagenics Bio Absorb PEA Advanced

Store below 30°C.

More Information & References: Metagenics Bio Absorb PEA

PEA: A novel anti-neuroinflammatory compound

PEA: Additional References and Resources

Related products  

x