(Discontinued) Metagenics PainX Headache & Migraine formerly Bio Absorb PEA

Product Video

Directions

Take 1 capsule twice daily

or as directed by your healthcare professional.

Benefits

Metagenics Bio Absorb PEA uses Levagen+ based PEA for improved bioavailability of PEA with human clinical research confirming 70% greater absorption compared to standard PEA (Figure 1). Figure 2 outlines how Levagen+ water dispersion technology overcomes the poor water solubility nature of PEA to improve absorption in the gastrointestinal system. Even with micronisation* (which reduces particle size) PEA is still lipohilic, causing aggregation and absorption at the hydrophilic gastrointestinal mucosal layer. Levagen+ prevents aggregation, while increasing hydrophilic capabilities of PEA molecules, thus improving absorption, making Bio Absorb PEA a clinically effective solution for patients requiring greater efficacy for pain relief and longer lasting benefits in the body. Figure 3 outlines key difference between Levagen+ PEA to micronised forms.

Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator influencing a variety of receptors and immune cells to provide antineuroinflammatory, analgesic and neuroprotective actions. PEA is found in certain foods and is endogenously produced in the body,1 with levels declining during chronic disease, tissue damage, inflammation, pain syndromes and ageing.2 PEA is associated with the endocannabinoid system (ECS) and key bioactive endocannabinoids, anandamide (AEA) and 2- arachidonoylglycerol (2-AG).3 The ECS regulates and balances an array of physiological functions in the body4 and imbalances may contribute to the development of several pathological  conditions.5,6,7 PEA supports the ECS directly by modulating endocannabinoid signalling and indirectly by activating (known as the entourage effect) cannabinoid receptors.8,9,10

PEA is extensively researched, with over 35 published human clinical trials to date. Given the current crises in pain management, including side effects and poor response to treatment, Bio Absorb PEA offers a clinically relevant and safe solution for patients in managing a variety of issues.11 Key clinical applications include acute pain issues and chronic neuropathic pain conditions,12 as well as nervous system disorders, nerve damage or injury that may be contributing to pinched or compressed nerves (i.e. sciatica and carpal tunnel syndrome), nerve pressure and/or heightened sensitivity and reactivity to pain.13,14,15,16,17 

Ingredients

Bio Absorb PEA is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, and soy protein. Bio Absorb PEA is free from artificial colours, flavours and preservatives. RSPO (Roundtable on Sustainable Palm Oil) certified.

Levagen+ is a trademark of Gencor.

Metagenics products use sustainable produced palm oil, which does not harm local animals in its production. It encompasses criteria for legal, economically viable, environmentally appropriate and socially beneficial management and operations of palm oil plantations (RSPO certified).

Palm oil is derived from the inner flesh of the fruit of the oil palm Elgeis guineensis, and is not the same as palm kernel oil which is derived from the outer coat of the palm fruit from the same tree. Palm oil contains less saturated fat than butter and contains no trans-fat, therefore the literature surrounding the use of palm oil is quite mixed. 

With respect to the palm oil used in Metagenics Bio Absorb PEA - the manufacturing process and purification of the product does not result in the same mechanistic action of palm oil on its own, thus it does not potentiate a negative effect on the body.

Excipients

00 green V-caps contain:

Hypromellose, sodium edetate and copper complex of chlorophyllins. Anhydrous colloidal silica, Calcium hydrogen phosphate, Celulose microcrystalline, Cold pressed lime oil, Fractionated coconut oil, Magnesium stearate, PEG-35 Castor oil, Silicon dioxide, Sunflower/Oat lecithin and Vitamin E acetate.

For more information about excipients used in this product, see our full excipient list here.

Warnings

This medicine is not to be used for more than 21 consecutive days, and may interact with other prescription analgesic medicines. Suitable for individuals 18 years and over.

Why is there a 21-Day Warning for Bio Absorb PEA? Is it safe for me to take long term?

The Therapeutic Goods Association (TGA) mandates a 21-day warning be placed on all listed PEA product labels. In listing this medicine, 17 clinical studies were provided to the TGA, of these, only three were conducted in ‘healthy participants’ with the maximum duration of these studies being 21 days, hence these three studies were considered by the TGA. 

Numerous other studies exist which used PEA over three months without negative effects. See References Tab or CLICK HERE for 256 references relating to PEA.

Always read the label. Use only as directed. If symptoms persist consult your healthcare professional.

Storage

Store below 25°C

More Information & References

PEA: A novel anti-neuroinflammatory compound

PEA: Additional References and Resources

TruQuality

Metagenics has stringent testing policies and practices means that Practitioners can prescribe products with complete confidence to deliver an exceptional patient product experience that provides health outcomes. When Metagenics say "check us", they mean it. It's easy to say we care about quality - let us show you. TruQuality grants full visibility to product ingredients and testing information for every single product we make.

For more information about product testing, click HERE.

To learn about excipients used in this product, see our full excipient list HERE.

The naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicines you are looking for is unavailable.

• Metagenics Bio Absorb PEA Advanced

Can't see an appropriate naturopathic medicines, or have any other questions?

You can contact HealthMasters for assistance HERE