Metagenics Calcitite Osteo

Hydroxyapatite and Soy for Osteoporosis

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To support bone health:

Dosage: Take 2 tablets twice daily with food OR Add 1 scoop (3.9 g) to 200 mL of water twice daily with food. Stir well and take immediately.

A clinically effective combination of soy isoflavones, hydroxyapatite calcium, vitamin D and trace minerals to improve bone formation and density and slow the progression of osteoporosis.

Mechanism of Action/Clinical Research:

  • Microcrystalline hydroxyapatite (MCHA) contains all the natural elements of healthy bone in a protein-mineral complex, providing calcium and phosphorus in the ideal 2:1 physiological ratio for bone mineralisation.[150]

In women with osteoporosis, MCHA providing 712 mg/d elemental calcium vs. 1000 mg/d of elemental calcium from calcium carbonate in addition to a vitamin D (266 µg/d) lowered the rate of bone mineral density (BMD) loss over three years more significantly in the MCHA group (p<0.05).[151]

  • Glycine max (Soy Isoflav-One) extract is a non-genetically modified soybean extract containing a minimum of 40% isoflavones that act as SERMs through their phytoestrogenic actions.

Isoflavones have been shown to inhibit osteoclast proliferation and decrease bone resorption by osteoclasts.[152]

A meta-analysis including data from 1,240 menopausal women demonstrated ingestion of 82 mg/d of soy isoflavones for 6 to 12 months significantly increased spine BMD by an average of 2.38% (p<0.001) compared to controls.[153]

  • 800 IU/d of vitamin D in combination with calcium may decrease the incidence of non-vertebral fractures by 10% to 20%, especially in persons in the older age groups with lower baseline vitamin D.[154]
  • Boron plays a role in calcium balance through a number of different mechanisms, in particular, helping to reduce urinary calcium excretion and enhance calcium absorption.[155]
  • Zinc may modulate the anabolic effect of insulin-like growth factor I (IGF-1) in osteoblasts, and may enhance the proliferative effect of oestrogen on these cells.[156]

Metagenics Calcitite Osteo

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