{"id":4625553915963,"title":"Vera's Formulations 5-HTP 60caps","handle":"veras-formulations-5-htp-60caps","description":"\u003ch2\u003eVera's Formulations 5-HTP 60caps\u003cbr\u003e\n\u003c\/h2\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"Vera's Formulations 10% off RRP | HealthMasters\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003eVera's Formulations 10% off RRP\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\u003cimg alt=\"Vera's Formulations 10% off RRP at HealthMasters Vera's Formulations\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Vera_s_Formulations_10_off_RRP_at_HealthMasters_Vera_s_Formulations_480x480.png?v=1652413854\"\u003e\u003c\/div\u003e\n\u003ch2\u003eVera's Formulations are Qld only products\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"text-decoration: underline; color: #ff2a00;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters\" style=\"color: #ff2a00; text-decoration: underline;\"\u003e\u003cbig\u003eContact HealthMasters\u003c\/big\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicine you are looking for is unavailable.\u003c\/p\u003e\n\u003cp\u003eVera's Formulations 5-HTP 1 capsule contains 5-HTP 100mg\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-5-htp-powder-25g\" title=\"RN Labs 5-HTP Powder 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs 5-HTP Powder 25g\u003c\/a\u003e\u003c\/span\u003e - 1.5 scoops contains 5-HTP 97.5mg\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate naturopathic medicine, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca title=\"Contact HealthMasters For Assistance\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDescription\u003c\/h5\u003e\n\u003ch2\u003eDescription: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e5-Hydroxytryptophan (5-HTP) is the precursor of serotonin. Supplementation may improve symptoms associated with low levels of serotonin.\u003c\/li\u003e\n\u003cli\u003eSerotonin levels are important for the regulation of sleep, mood disorders, anxiety, aggression, appetite, temperature, sexual behaviour, and pain sensation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"\/pages\/what-is-5-hydroxytryptophan-5-htp?_pos=1\u0026amp;_sid=39d99d97e\u0026amp;_ss=r\" title=\"What is 5-Hydroxytryptophan (5-HTP)? | HealthMasters Naturopath Kevin Tresize ND\" target=\"_blank\"\u003eFor more on 5-Hydroxytryptophan (5-HTP) see 'What is 5-Hydroxytryptophan (5-HTP)?'\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003ePack Size\u003c\/h5\u003e\n\u003ch2\u003ePack Size: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003ePack Size: 60 capsules\u003c\/p\u003e\n\u003ch5\u003eRecommended Dose\u003c\/h5\u003e\n\u003ch2\u003eRecommended Dose: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003e1 capsule per day on an empty stomach, with juice, or as recommended by your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eMay help to support serotonin levels\u003c\/li\u003e\n\u003cli\u003eMay help to support sleep\u003c\/li\u003e\n\u003cli\u003eMay help to support appetite control\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eInteractions\u003c\/h5\u003e\n\u003ch2\u003eInteractions: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003eCaution with serotonin agonists including prescription medicines such as SSRI’s, Tricyclic antidepressants, SNRI’s, MAOI’s, St John’s Wort and other antidepressants. 5-HTP may theoretically enhance the actions of these drugs\u003c\/p\u003e\n\u003ch5\u003eContraindications\u003c\/h5\u003e\n\u003ch2\u003eContraindications: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003eAvoid during pregnancy and lactation\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Vera's 5-HTP capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e5-Hydroxytryptophan (5-HTP)\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyridoxal 5-phosphate (B6)\u003c\/td\u003e\n\u003ctd\u003e5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding-left: 30px;\"\u003eequiv. Pyridoxine\u003c\/td\u003e\n\u003ctd\u003e3.43mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eFree From's\u003c\/h5\u003e\n\u003ch2\u003eFree From's: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003eGluten Free, Vegan, Vegetarian, Sugar Free\u003c\/p\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003e5-Hydroxytryptophan (5-HTP) is an endogenous amino acid, formed from tryptophan as an intermediate in the production of serotonin. Serotonin levels are important for the regulation of sleep, mood disorders, anxiety, aggression, appetite, temperature, sexual behaviour, and pain sensation.(1) The amount of synaptic serotonin available largely depends on the availability of substrates essential for serotonin synthesis. 5-HTP acts to increase levels of serotonin within the central nervous system (CNS), but, unlike tryptophan, is not shunted down additional biochemical pathways.\u003c\/p\u003e\n\u003cp\u003eTryptophan can be metabolised to either serotonin or, in cases of vitamin B3 deficiency, to niacin via the kynurenine pathway. It also plays a role in protein formation, as well as kynurenic and quinolinic acids that can affect neurotransmitters in the brain. The conversion of tryptophan to 5-HTP is an irreversible step and, therefore, 5-HTP cannot be used as a precursor for niacin or other tryptophan metabolites. Thus, supplementation with 5-HTP can be of greater benefit than tryptophan to support serotonin levels.(2) \u003c\/p\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Dr_Vera_s_5-HTP_10__off_RRP_Figure_1_1024x1024.jpg?v=1583809494\" alt=\"Figure 1: Serotonin Pathway | HealthMasters\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003ch2\u003eSerotonin Pathway\u003c\/h2\u003e\n\u003cp\u003eTryptophan requires a carrier molecule to be transported through the blood brain barrier, and tryptophan itself is difficult to absorb from dietary sources. Conversely, approximately 70% of an oral dose of 5-HTP is absorbed from the blood stream and is easily transported across the blood brain barrier without the need for a carrier protein. Serotonin itself, however, when used by the nervous system, must be produced there, since it cannot cross the blood brain barrier.(2)\u003c\/p\u003e\n\u003ch2\u003eMay Help to Support Serotonin Levels\u003c\/h2\u003e\n\u003cp\u003eOne of the most common uses of 5-HTP relates to its effects on mood disorders,(3) thought to be linked with serotonergic mechanisms. It is suggested that the regulation of normal mood largely depends on normal serotonin stores, (4) which can be impacted through the provision of adequate precursor nutrients.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eResearch Review:\u003c\/p\u003e\n\u003cp\u003eAn analysis of 15 separate studies, encompassing a total of 511 patients with different types of mood disorders, showed that 285 (56%) of these patients demonstrated significant improvement of symptoms while taking 5-HTP. (5)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2\u003eMay Help to Support Sleep\u003c\/h2\u003e\n\u003cp\u003eSerotonin is involved in both sleep and wakefulness through its actions in different areas of the CNS and on different serotonin receptors. Serotonin has been shown to increase both REM (6) and NREM (7) sleep, stimulate wake promoting neurons, (8) and acts as a precursor to melatonin. In fact, the actions of both serotonin and melatonin help to maintain circadian rhythms and sleep maintenance. (10) Thus, supplementing with 5-HTP to support serotonin levels may be beneficial in supporting circadian rhythms and better quality sleep. (9)\u003c\/p\u003e\n\u003ch2\u003eMay Help to Support Appetite Control\u003c\/h2\u003e\n\u003cp\u003eUp to 90% of the body’s serotonin is found in the gastrointestinal tract (GIT) and stored in enterochromaffin cells. (10) Secretion of serotonin in the GIT stimulates both mucosal secretory and peristaltic reflexes. (11) It has a role in intestinal motility, and is released into the blood postprandially and in response to changes in pressure across the gut wall. As such, supplementation with 5-HTP may be supportive in cases of reduced bowel motility. (12)\u003c\/p\u003e\n\u003cp\u003eIn the CNS, serotonin plays a role in satiation – believed to be through regulation of leptin and neuropeptide Y (NPY). The release of NPY, which stimulates hunger and appetite, is decreased by serotonin. Leptin, which is released by adipose tissue, plays a role in end of meal satiation. Serotonin release stimulates leptin release which signals feelings of satiety. Leptin release in turn down regulates serotonin release. (13) In the CNS, serotonin release is increased by consumption of carbohydrates, while carbohydrate or sugar cravings are linked to serotonin deficiency. (14)\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eClinical Study:\u003c\/p\u003e\n\u003cp\u003eA study into the effects of 5-HTP on food intake, mood and weight loss in obese subjects (BMI of 30-40) determined that an oral dose of 5-HTP (8 mg\/kg\/day) was associated with a decrease in food intake and subsequent weight loss after five weeks of treatment. (15)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2\u003eSerotonin and Pain\u003c\/h2\u003e\n\u003cp\u003eSerotonin is involved in both pain recognition and pain control, including chronic pain. The effect of serotonin is dependent on both the area of the body and the receptor subtype. (16) It is released from platelets and mast cells after tissue injury, and after nerve injury serotonin levels in the affective nerve increases. This suggests a role for serotonin in inflammation and pain sensitization. (16)\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eClinical Study:\u003c\/p\u003e\n\u003cp\u003eA study into whether serotonin displays a nociceptive or antinociceptive role in experimental pain evaluation in healthy volunteers found a lower pain threshold associated with higher serotonin levels. No association with pain tolerance was found. (17)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T15:56:30+11:00","created_at":"2020-03-09T17:47:44+11:00","vendor":"Vera's Formulations","type":"Naturopathic Medicines 10% off RRP","tags":["Discontinued","Naturopathic","PB","Veras Formulations"],"price":8414,"price_min":8414,"price_max":8414,"available":false,"price_varies":false,"compare_at_price":9350,"compare_at_price_min":9350,"compare_at_price_max":9350,"compare_at_price_varies":false,"variants":[{"id":32612366483515,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"VeF5-HTP60C","requires_shipping":true,"taxable":true,"featured_image":null,"available":false,"name":"Vera's Formulations 5-HTP 60caps","public_title":null,"options":["Default Title"],"price":8414,"weight":0,"compare_at_price":9350,"inventory_quantity":0,"inventory_management":"shopify","inventory_policy":"deny","barcode":null,"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations10_offRRPatHealthMastersVera_sFormulations_906cd5e6-631d-4635-be55-5c5fbf20bf76.jpg?v=1652418902","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_s5-HTP60caps10_offRRPatHealthMasters.jpg?v=1652418902","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations10_ofRRPatHealthMastersVera_sLogo_157bb82f-b4cb-4f57-95f3-34605593d82b.png?v=1652418902","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations5-HTP10_offRRPFigure1atHealthMasters.jpg?v=1652418899"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations10_offRRPatHealthMastersVera_sFormulations_906cd5e6-631d-4635-be55-5c5fbf20bf76.jpg?v=1652418902","options":["Title"],"media":[{"alt":"Vera's Formulations 10% off RRP at HealthMasters Vera's Formulations","id":30121322283238,"position":1,"preview_image":{"aspect_ratio":1.034,"height":500,"width":517,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations10_offRRPatHealthMastersVera_sFormulations_906cd5e6-631d-4635-be55-5c5fbf20bf76.jpg?v=1652418902"},"aspect_ratio":1.034,"height":500,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations10_offRRPatHealthMastersVera_sFormulations_906cd5e6-631d-4635-be55-5c5fbf20bf76.jpg?v=1652418902","width":517},{"alt":"Vera's 5-HTP 60caps 10% off RRP | HealthMasters Vera's Fromulations","id":7127931715643,"position":2,"preview_image":{"aspect_ratio":0.531,"height":260,"width":138,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_s5-HTP60caps10_offRRPatHealthMasters.jpg?v=1652418902"},"aspect_ratio":0.531,"height":260,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_s5-HTP60caps10_offRRPatHealthMasters.jpg?v=1652418902","width":138},{"alt":"Vera's Formulations 5-HTP 60caps 10% off RRP | HealthMasters Vera's","id":29429427405030,"position":3,"preview_image":{"aspect_ratio":2.279,"height":244,"width":556,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations10_ofRRPatHealthMastersVera_sLogo_157bb82f-b4cb-4f57-95f3-34605593d82b.png?v=1652418902"},"aspect_ratio":2.279,"height":244,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations10_ofRRPatHealthMastersVera_sLogo_157bb82f-b4cb-4f57-95f3-34605593d82b.png?v=1652418902","width":556},{"alt":"Vera's Formulations 5-HTP 10% off RRP Figure 1 at HealthMasters Vera's","id":7686087835707,"position":4,"preview_image":{"aspect_ratio":1.26,"height":480,"width":605,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations5-HTP10_offRRPFigure1atHealthMasters.jpg?v=1652418899"},"aspect_ratio":1.26,"height":480,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Vera_sFormulations5-HTP10_offRRPFigure1atHealthMasters.jpg?v=1652418899","width":605}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eVera's Formulations 5-HTP 60caps\u003cbr\u003e\n\u003c\/h2\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"Vera's Formulations 10% off RRP | HealthMasters\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003eVera's Formulations 10% off RRP\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\u003cimg alt=\"Vera's Formulations 10% off RRP at HealthMasters Vera's Formulations\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Vera_s_Formulations_10_off_RRP_at_HealthMasters_Vera_s_Formulations_480x480.png?v=1652413854\"\u003e\u003c\/div\u003e\n\u003ch2\u003eVera's Formulations are Qld only products\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"text-decoration: underline; color: #ff2a00;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters\" style=\"color: #ff2a00; text-decoration: underline;\"\u003e\u003cbig\u003eContact HealthMasters\u003c\/big\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicine you are looking for is unavailable.\u003c\/p\u003e\n\u003cp\u003eVera's Formulations 5-HTP 1 capsule contains 5-HTP 100mg\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-5-htp-powder-25g\" title=\"RN Labs 5-HTP Powder 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs 5-HTP Powder 25g\u003c\/a\u003e\u003c\/span\u003e - 1.5 scoops contains 5-HTP 97.5mg\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate naturopathic medicine, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca title=\"Contact HealthMasters For Assistance\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDescription\u003c\/h5\u003e\n\u003ch2\u003eDescription: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e5-Hydroxytryptophan (5-HTP) is the precursor of serotonin. Supplementation may improve symptoms associated with low levels of serotonin.\u003c\/li\u003e\n\u003cli\u003eSerotonin levels are important for the regulation of sleep, mood disorders, anxiety, aggression, appetite, temperature, sexual behaviour, and pain sensation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca href=\"\/pages\/what-is-5-hydroxytryptophan-5-htp?_pos=1\u0026amp;_sid=39d99d97e\u0026amp;_ss=r\" title=\"What is 5-Hydroxytryptophan (5-HTP)? | HealthMasters Naturopath Kevin Tresize ND\" target=\"_blank\"\u003eFor more on 5-Hydroxytryptophan (5-HTP) see 'What is 5-Hydroxytryptophan (5-HTP)?'\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003ePack Size\u003c\/h5\u003e\n\u003ch2\u003ePack Size: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003ePack Size: 60 capsules\u003c\/p\u003e\n\u003ch5\u003eRecommended Dose\u003c\/h5\u003e\n\u003ch2\u003eRecommended Dose: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003e1 capsule per day on an empty stomach, with juice, or as recommended by your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eMay help to support serotonin levels\u003c\/li\u003e\n\u003cli\u003eMay help to support sleep\u003c\/li\u003e\n\u003cli\u003eMay help to support appetite control\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eInteractions\u003c\/h5\u003e\n\u003ch2\u003eInteractions: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003eCaution with serotonin agonists including prescription medicines such as SSRI’s, Tricyclic antidepressants, SNRI’s, MAOI’s, St John’s Wort and other antidepressants. 5-HTP may theoretically enhance the actions of these drugs\u003c\/p\u003e\n\u003ch5\u003eContraindications\u003c\/h5\u003e\n\u003ch2\u003eContraindications: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003eAvoid during pregnancy and lactation\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Vera's 5-HTP capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e5-Hydroxytryptophan (5-HTP)\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyridoxal 5-phosphate (B6)\u003c\/td\u003e\n\u003ctd\u003e5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding-left: 30px;\"\u003eequiv. Pyridoxine\u003c\/td\u003e\n\u003ctd\u003e3.43mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eFree From's\u003c\/h5\u003e\n\u003ch2\u003eFree From's: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003eGluten Free, Vegan, Vegetarian, Sugar Free\u003c\/p\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: Vera's Formulations 5-HTP\u003c\/h2\u003e\n\u003cp\u003e5-Hydroxytryptophan (5-HTP) is an endogenous amino acid, formed from tryptophan as an intermediate in the production of serotonin. Serotonin levels are important for the regulation of sleep, mood disorders, anxiety, aggression, appetite, temperature, sexual behaviour, and pain sensation.(1) The amount of synaptic serotonin available largely depends on the availability of substrates essential for serotonin synthesis. 5-HTP acts to increase levels of serotonin within the central nervous system (CNS), but, unlike tryptophan, is not shunted down additional biochemical pathways.\u003c\/p\u003e\n\u003cp\u003eTryptophan can be metabolised to either serotonin or, in cases of vitamin B3 deficiency, to niacin via the kynurenine pathway. It also plays a role in protein formation, as well as kynurenic and quinolinic acids that can affect neurotransmitters in the brain. The conversion of tryptophan to 5-HTP is an irreversible step and, therefore, 5-HTP cannot be used as a precursor for niacin or other tryptophan metabolites. Thus, supplementation with 5-HTP can be of greater benefit than tryptophan to support serotonin levels.(2) \u003c\/p\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Dr_Vera_s_5-HTP_10__off_RRP_Figure_1_1024x1024.jpg?v=1583809494\" alt=\"Figure 1: Serotonin Pathway | HealthMasters\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003ch2\u003eSerotonin Pathway\u003c\/h2\u003e\n\u003cp\u003eTryptophan requires a carrier molecule to be transported through the blood brain barrier, and tryptophan itself is difficult to absorb from dietary sources. Conversely, approximately 70% of an oral dose of 5-HTP is absorbed from the blood stream and is easily transported across the blood brain barrier without the need for a carrier protein. Serotonin itself, however, when used by the nervous system, must be produced there, since it cannot cross the blood brain barrier.(2)\u003c\/p\u003e\n\u003ch2\u003eMay Help to Support Serotonin Levels\u003c\/h2\u003e\n\u003cp\u003eOne of the most common uses of 5-HTP relates to its effects on mood disorders,(3) thought to be linked with serotonergic mechanisms. It is suggested that the regulation of normal mood largely depends on normal serotonin stores, (4) which can be impacted through the provision of adequate precursor nutrients.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eResearch Review:\u003c\/p\u003e\n\u003cp\u003eAn analysis of 15 separate studies, encompassing a total of 511 patients with different types of mood disorders, showed that 285 (56%) of these patients demonstrated significant improvement of symptoms while taking 5-HTP. (5)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2\u003eMay Help to Support Sleep\u003c\/h2\u003e\n\u003cp\u003eSerotonin is involved in both sleep and wakefulness through its actions in different areas of the CNS and on different serotonin receptors. Serotonin has been shown to increase both REM (6) and NREM (7) sleep, stimulate wake promoting neurons, (8) and acts as a precursor to melatonin. In fact, the actions of both serotonin and melatonin help to maintain circadian rhythms and sleep maintenance. (10) Thus, supplementing with 5-HTP to support serotonin levels may be beneficial in supporting circadian rhythms and better quality sleep. (9)\u003c\/p\u003e\n\u003ch2\u003eMay Help to Support Appetite Control\u003c\/h2\u003e\n\u003cp\u003eUp to 90% of the body’s serotonin is found in the gastrointestinal tract (GIT) and stored in enterochromaffin cells. (10) Secretion of serotonin in the GIT stimulates both mucosal secretory and peristaltic reflexes. (11) It has a role in intestinal motility, and is released into the blood postprandially and in response to changes in pressure across the gut wall. As such, supplementation with 5-HTP may be supportive in cases of reduced bowel motility. (12)\u003c\/p\u003e\n\u003cp\u003eIn the CNS, serotonin plays a role in satiation – believed to be through regulation of leptin and neuropeptide Y (NPY). The release of NPY, which stimulates hunger and appetite, is decreased by serotonin. Leptin, which is released by adipose tissue, plays a role in end of meal satiation. Serotonin release stimulates leptin release which signals feelings of satiety. Leptin release in turn down regulates serotonin release. (13) In the CNS, serotonin release is increased by consumption of carbohydrates, while carbohydrate or sugar cravings are linked to serotonin deficiency. (14)\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eClinical Study:\u003c\/p\u003e\n\u003cp\u003eA study into the effects of 5-HTP on food intake, mood and weight loss in obese subjects (BMI of 30-40) determined that an oral dose of 5-HTP (8 mg\/kg\/day) was associated with a decrease in food intake and subsequent weight loss after five weeks of treatment. (15)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2\u003eSerotonin and Pain\u003c\/h2\u003e\n\u003cp\u003eSerotonin is involved in both pain recognition and pain control, including chronic pain. The effect of serotonin is dependent on both the area of the body and the receptor subtype. (16) It is released from platelets and mast cells after tissue injury, and after nerve injury serotonin levels in the affective nerve increases. This suggests a role for serotonin in inflammation and pain sensitization. (16)\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eClinical Study:\u003c\/p\u003e\n\u003cp\u003eA study into whether serotonin displays a nociceptive or antinociceptive role in experimental pain evaluation in healthy volunteers found a lower pain threshold associated with higher serotonin levels. No association with pain tolerance was found. (17)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c!-- \/TABS --\u003e"}