{"id":8457326067942,"title":"BioCeuticals Clinical SaffroPEA","handle":"bioceuticals-clinical-saffropea","description":"\u003ch2\u003eBioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003ch3\u003eWith highly bioavailable PEA, clinically trialled Saffron extract and supportive Vitamin D3\u003c\/h3\u003e\n\u003cp\u003eSizes: 42 Capsules\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical SaffroPEA SaffroPEA features a unique formulation of highly bioavailable PEA, combined with saffron extract, affron® at the studied daily dose, and supportive vitamin D3.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRelieves pain including mild joint pain and soreness with highly bioavailable PEA, Levagen+.\u003c\/li\u003e\n\u003cli\u003eSupports a healthy mood balance and improves sleep quality with affron® saffron extract.\u003c\/li\u003e\n\u003cli\u003eDaily dose of SaffroPEA aligns with the studied dose of 28 mg of affron® a day.\u003c\/li\u003e\n\u003cli\u003eSupports the function of the immune system, muscles, and nervous system with vitamin D3.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eBioCeuticals Clinical SaffroPEA is  Dairy Free, FODMAP Friendly, Lactose Free, Soy Free\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical SaffroPEA AUST L 394691\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule two times a day, or as professionally prescribed.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRelieves pain including mild joint pain and soreness with highly bioavailable PEA, Levagen®+.\u003c\/li\u003e\n\u003cli\u003eSupports a healthy mood balance and improves sleep quality with affron® saffron extract.\u003c\/li\u003e\n\u003cli\u003eDaily dose of SaffroPEA aligns with the studied dose of 28 mg of affron® a day.\u003c\/li\u003e\n\u003cli\u003eSupports the function of the immune system, muscles, and nervous system with vitamin D3.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cimg style=\"float: left;\" alt=\"BioCeuticals Clinical SaffroPEA 10% off RRP | HealthMasters BioCeuticals Clinical\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/chrome_Wf7fOe4ym9_600x600.png?v=1709093543\"\u003e\u003c\/p\u003e\n\u003cstyle\u003e.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/819709218?h=afcdce9a3e\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003eConditions associated with pain can cause sleep disturbance1,2. Inflammation and the immune dysregulation play into this complex bidirectional relationship.3\u003c\/p\u003e\n\u003ch3\u003ePain relief via bioavailable PEA, Levagen®+\u003c\/h3\u003e\n\u003cp\u003ePalmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator, N-acyl-ethanolamine fatty acid amide. It is synthesised on demand in the lipid bilayer, acts locally, and is in all tissues including the brain. It is produced as a pro-homeostatic protective response to cellular injury. PEA has analgesic benefits via its anti-inflammatory, immunomodulatory, and neuroprotective effects.4 Endogenous PEA is generally insufficient to counter the allostatic load seen in some conditions.4\u003c\/p\u003e\n\u003ch3\u003ePEA works on multiple mechanisms to relieve pain\u003c\/h3\u003e\n\u003cp\u003ePEA targets the nuclear receptor peroxisome proliferator-activated alpha (PPAR-a), acts on cannabinoid receptors on G protein-coupled receptor 55 (GPR55) and G protein-coupled receptor 119 (GPR119), and indirectly activates cannabinoid receptors 1 and 2 (CB1 and CB2) through inhibiting the degradation of the endocannabinoid, anandamide (AEA), a phenomenon known as the ‘entourage effect’.4 Also, PEA activates and desensitises the transient receptor potential vanilloid receptor 1 (TRPV1) channels, contributing to a significant anti-nociceptive effect.4 Trials have shown PEA can have therapeutic benefits in pain conditions, including relieving mild joint pain.5 PEA is generally well tolerated.4,5,6\u003c\/p\u003e\n\u003ch3\u003eaffron® supports healthy mood balance and improves sleep quality\u003c\/h3\u003e\n\u003cp\u003eThe therapeutic actives from the dried stigmas from saffron, Crocus sativus L., are safranal and crocin isomers and crocetin.8 SaffroPEA contains affron®, a premium, clinically trialled saffron extract, that utilises a patented AFF on COOL-Tech extraction technology. The result is a standardised extract containing 3% Lepticrosalides, a term that refers to the sum of bioactive compounds, including safranal and crocin isomers.9\u003c\/p\u003e\n\u003cp\u003eSaffron’s action is likely to be multifactorial including an influence on neurotransmitters, inflammation, hypothalamic-pituitary-adrenal axis, oxidative stress, mitochondria, and neuroplasticity.10 Crocins act as reuptake inhibitors of dopamine and norepinephrine while safranol acts primarily on serotonin reuptake.11 Antioxidants in saffron extracts protect against oxidative stress in the central nervous system.11 It is suggested that saffron’s sleep-enhancing effects may be due to its influence on the circadian hormone melatonin.12\u003c\/p\u003e\n\u003ch3\u003eaffron® key clinical research\u003c\/h3\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStudy - double-blind randomised placebo-controlled\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eaffron® dose versus placebo\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eResults \u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eMood and sleep \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e4 wks, n= 128, healthy adults.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e22 mg or 28 mg day.\u003c\/td\u003e\n\u003ctd\u003e28 mg affron® group performed better when compared to placebo.11\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eMood \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e8 wks, n= 80, 12–16-yr-olds.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 mg twice daily.\u003c\/td\u003e\n\u003ctd\u003eaffron® group performed better against placebo, based on self-reports.13\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eMood \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e12 wks, n= 86 perimenopausal women\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 mg twice daily.\u003c\/td\u003e\n\u003ctd\u003eaffron® group performed better than placebo.14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eSleep \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e28 days, n= 120, healthy adults.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 or 28 mg 1 hour before bedtime.\u003c\/td\u003e\n\u003ctd\u003eGreater improvements in sleep quality ratings after awakening.12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eSleep \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e28-day, n= 63, healthy adults.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 mg twice daily.\u003c\/td\u003e\n\u003ctd\u003eAssociated with improvements in sleep quality.9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eSupportive Vitamin D3\u003c\/h3\u003e\n\u003cp\u003eVitamin D3 modulates the innate and adaptive immune response.17 Vitamin D also supports a healthy nervous system and studies have suggested its action on different biological mechanisms such as nociceptive sensitivity and nervous system modulation including serotonin and melatonin regulation.15,16\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCrocus sativus (saffron) extract dry conc. (affron®)\u003c\/td\u003e\n\u003ctd\u003e12.6mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. dry stigma\u003c\/td\u003e\n\u003ctd\u003e42mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmidrol (Levagen®+)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eColecalciferol (vitamin D3 500 IU)\u003c\/td\u003e\n\u003ctd\u003e12.5micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003eDo not use during pregnancy or breastfeeding.\u003c\/p\u003e\n\u003cp\u003eAdults only.\u003c\/p\u003e\n\u003cp\u003eNot to be used for more than 21 consecutive days.\u003c\/p\u003e\n\u003cp\u003eThe medicine may interact with other prescription analgesic medicines, please consult your healthcare practitioner before use. If symptoms persist talk to your health professional.\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003e1. Mayo Clinic. Insomnia. https:\/\/www.mayoclinic.org\/diseases-conditions\/ insomnia\/symptoms-causes\/syc-20355167. Downloaded 22\/02\/23.\u003c\/p\u003e\n\u003cp\u003e2. Turner J. Emotional dimensions of chronic disease. Culture and Medicine. WJM. Feb 2000. 125, Volume 172.\u003c\/p\u003e\n\u003cp\u003e3. Beurel E, Toups M, Nemeroff C. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 2020. 107(2): 234-256.\u003c\/p\u003e\n\u003cp\u003e4. Clayton P, Hill M, Bogoda N et al. Palmitoylemthanolamide: A natural compound for health management. Int. J. Mol. Sci. 2021, 22, 5305.\u003c\/p\u003e\n\u003cp\u003e5. Keppel Hesselink J, de Boer T, Witkamp R. Palmitoylethanolamide: A natural body-own anti-inflammatory agent, effective and safe against influenza and common cold. Int. J. Inflamm. 2013.\u003c\/p\u003e\n\u003cp\u003e6. Gabrielson L, Mattsson S, Fowler C. Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. Br J Clin Pharmacol. 2016, 82 932-942.\u003c\/p\u003e\n\u003cp\u003e7. Briskey D, Roche G and Rao A. The effect of a dispersable Palmitolylethanolamide (Levagen+) compared to a placebo for reducing joint pain in an adult population – a randomised, double-blind study. Int J Food Sci Nutr. 2021; 10(1):9-13.\u003c\/p\u003e\n\u003cp\u003e8. Orio L, Alen F, Balesta A et al. Antihedonic and antidepressant effect of affron® a standardised saffron (Crocus Sativus L.) extract. Molecules, 2020, 25, 3207.\u003c\/p\u003e\n\u003cp\u003e9. Lopresit A, Smith S, Metse A et al. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomised, double-blind, placebo-controlled trial. JCSM, 2020, Vol 16, 6, 937-946.\u003c\/p\u003e\n\u003cp\u003e10. Lopresti A, Drummond P. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Pyscholpharmacol Clin Exp. 2014; 29:517-527.\u003c\/p\u003e\n\u003cp\u003e11. Kell G, Rao A, Beccaria G et al. A novel saffron extract (Crocus sativus L.) improves mood and sleep quality in healthy adults in over 4 weeks in a double-blind, parallel, randomised, placebo-controlled clinical trial. Comp Ther Med. 2017, Aug;33-58-64.\u003c\/p\u003e\n\u003cp\u003e12. Lopresti A, Smith S, Drummond P. An investigation into an evening intake of saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study. Sleep Med. 2021. Oct;86:7-18.\u003c\/p\u003e\n\u003cp\u003e13. Lopresti A, Drummond P, Inarejos-Garcia M et al. affron® a standardised extract from saffron (Croccus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebocontrolled study. J. Affect. Disord. 2018 May; 232:349-357\u003c\/p\u003e\n\u003cp\u003e14. Lopresti A, Smith S. The effects of a saffron extract (affron®) on menopausal symptoms in women during perimenopause: a randomised, double-blind, placebo-controlled study. J Menopausal Med. 2021;27:66-78\u003c\/p\u003e\n\u003cp\u003e15. De Oliveria D, Hirotsu C, Tufik S et al. The interfaces between vitamin D, sleep and pain. J Endocrinol. 2017 Jul;234(1):R23-R36\u003c\/p\u003e\n\u003cp\u003e16. Huiberts L, Smolders K. Effects of vitamin D on mood and sleep in the healthy population: interpretations from the serotonergic pathway. Sleep Med Review. 2021, 55, 101379.\u003c\/p\u003e\n\u003cp\u003e17. Natural medicines database. Vitamin D monograph. Downloaded 1\/03\/2023.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2024-02-28T15:24:16+11:00","created_at":"2024-02-28T13:21:48+11:00","vendor":"BioCeuticals","type":"BioCeuticals Clinical Naturopathic Medicines","tags":["BioCeuticals Clinical","Musculoskeletal","Naturopathic","PEA"],"price":6116,"price_min":6116,"price_max":6116,"available":true,"price_varies":false,"compare_at_price":6795,"compare_at_price_min":6795,"compare_at_price_max":6795,"compare_at_price_varies":false,"variants":[{"id":44340160069862,"title":"42 Capsules","option1":"42 Capsules","option2":null,"option3":null,"sku":"BiCClSaffroPEA42c","requires_shipping":true,"taxable":true,"featured_image":{"id":40528217997542,"product_id":8457326067942,"position":1,"created_at":"2024-02-28T13:23:01+11:00","updated_at":"2024-02-28T13:25:48+11:00","alt":"BioCeuticals Clinical SaffroPEA 42 caps 10% off RRP at HealthMasters BioCeuticals 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Logo","id":33149390979302,"position":2,"preview_image":{"aspect_ratio":4.656,"height":302,"width":1406,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bioceuticals-logo_0c279f19-79d6-40f4-8cda-2cf05fb99e3d.jpg?v=1709087148"},"aspect_ratio":4.656,"height":302,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bioceuticals-logo_0c279f19-79d6-40f4-8cda-2cf05fb99e3d.jpg?v=1709087148","width":1406}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eBioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003ch3\u003eWith highly bioavailable PEA, clinically trialled Saffron extract and supportive Vitamin D3\u003c\/h3\u003e\n\u003cp\u003eSizes: 42 Capsules\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical SaffroPEA SaffroPEA features a unique formulation of highly bioavailable PEA, combined with saffron extract, affron® at the studied daily dose, and supportive vitamin D3.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRelieves pain including mild joint pain and soreness with highly bioavailable PEA, Levagen+.\u003c\/li\u003e\n\u003cli\u003eSupports a healthy mood balance and improves sleep quality with affron® saffron extract.\u003c\/li\u003e\n\u003cli\u003eDaily dose of SaffroPEA aligns with the studied dose of 28 mg of affron® a day.\u003c\/li\u003e\n\u003cli\u003eSupports the function of the immune system, muscles, and nervous system with vitamin D3.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eBioCeuticals Clinical SaffroPEA is  Dairy Free, FODMAP Friendly, Lactose Free, Soy Free\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical SaffroPEA AUST L 394691\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule two times a day, or as professionally prescribed.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRelieves pain including mild joint pain and soreness with highly bioavailable PEA, Levagen®+.\u003c\/li\u003e\n\u003cli\u003eSupports a healthy mood balance and improves sleep quality with affron® saffron extract.\u003c\/li\u003e\n\u003cli\u003eDaily dose of SaffroPEA aligns with the studied dose of 28 mg of affron® a day.\u003c\/li\u003e\n\u003cli\u003eSupports the function of the immune system, muscles, and nervous system with vitamin D3.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cimg style=\"float: left;\" alt=\"BioCeuticals Clinical SaffroPEA 10% off RRP | HealthMasters BioCeuticals Clinical\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/chrome_Wf7fOe4ym9_600x600.png?v=1709093543\"\u003e\u003c\/p\u003e\n\u003cstyle\u003e.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/819709218?h=afcdce9a3e\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003eConditions associated with pain can cause sleep disturbance1,2. Inflammation and the immune dysregulation play into this complex bidirectional relationship.3\u003c\/p\u003e\n\u003ch3\u003ePain relief via bioavailable PEA, Levagen®+\u003c\/h3\u003e\n\u003cp\u003ePalmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator, N-acyl-ethanolamine fatty acid amide. It is synthesised on demand in the lipid bilayer, acts locally, and is in all tissues including the brain. It is produced as a pro-homeostatic protective response to cellular injury. PEA has analgesic benefits via its anti-inflammatory, immunomodulatory, and neuroprotective effects.4 Endogenous PEA is generally insufficient to counter the allostatic load seen in some conditions.4\u003c\/p\u003e\n\u003ch3\u003ePEA works on multiple mechanisms to relieve pain\u003c\/h3\u003e\n\u003cp\u003ePEA targets the nuclear receptor peroxisome proliferator-activated alpha (PPAR-a), acts on cannabinoid receptors on G protein-coupled receptor 55 (GPR55) and G protein-coupled receptor 119 (GPR119), and indirectly activates cannabinoid receptors 1 and 2 (CB1 and CB2) through inhibiting the degradation of the endocannabinoid, anandamide (AEA), a phenomenon known as the ‘entourage effect’.4 Also, PEA activates and desensitises the transient receptor potential vanilloid receptor 1 (TRPV1) channels, contributing to a significant anti-nociceptive effect.4 Trials have shown PEA can have therapeutic benefits in pain conditions, including relieving mild joint pain.5 PEA is generally well tolerated.4,5,6\u003c\/p\u003e\n\u003ch3\u003eaffron® supports healthy mood balance and improves sleep quality\u003c\/h3\u003e\n\u003cp\u003eThe therapeutic actives from the dried stigmas from saffron, Crocus sativus L., are safranal and crocin isomers and crocetin.8 SaffroPEA contains affron®, a premium, clinically trialled saffron extract, that utilises a patented AFF on COOL-Tech extraction technology. The result is a standardised extract containing 3% Lepticrosalides, a term that refers to the sum of bioactive compounds, including safranal and crocin isomers.9\u003c\/p\u003e\n\u003cp\u003eSaffron’s action is likely to be multifactorial including an influence on neurotransmitters, inflammation, hypothalamic-pituitary-adrenal axis, oxidative stress, mitochondria, and neuroplasticity.10 Crocins act as reuptake inhibitors of dopamine and norepinephrine while safranol acts primarily on serotonin reuptake.11 Antioxidants in saffron extracts protect against oxidative stress in the central nervous system.11 It is suggested that saffron’s sleep-enhancing effects may be due to its influence on the circadian hormone melatonin.12\u003c\/p\u003e\n\u003ch3\u003eaffron® key clinical research\u003c\/h3\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStudy - double-blind randomised placebo-controlled\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eaffron® dose versus placebo\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eResults \u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eMood and sleep \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e4 wks, n= 128, healthy adults.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e22 mg or 28 mg day.\u003c\/td\u003e\n\u003ctd\u003e28 mg affron® group performed better when compared to placebo.11\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eMood \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e8 wks, n= 80, 12–16-yr-olds.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 mg twice daily.\u003c\/td\u003e\n\u003ctd\u003eaffron® group performed better against placebo, based on self-reports.13\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eMood \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e12 wks, n= 86 perimenopausal women\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 mg twice daily.\u003c\/td\u003e\n\u003ctd\u003eaffron® group performed better than placebo.14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eSleep \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e28 days, n= 120, healthy adults.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 or 28 mg 1 hour before bedtime.\u003c\/td\u003e\n\u003ctd\u003eGreater improvements in sleep quality ratings after awakening.12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cstrong\u003eSleep \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e28-day, n= 63, healthy adults.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e14 mg twice daily.\u003c\/td\u003e\n\u003ctd\u003eAssociated with improvements in sleep quality.9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eSupportive Vitamin D3\u003c\/h3\u003e\n\u003cp\u003eVitamin D3 modulates the innate and adaptive immune response.17 Vitamin D also supports a healthy nervous system and studies have suggested its action on different biological mechanisms such as nociceptive sensitivity and nervous system modulation including serotonin and melatonin regulation.15,16\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCrocus sativus (saffron) extract dry conc. (affron®)\u003c\/td\u003e\n\u003ctd\u003e12.6mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. dry stigma\u003c\/td\u003e\n\u003ctd\u003e42mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePalmidrol (Levagen®+)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eColecalciferol (vitamin D3 500 IU)\u003c\/td\u003e\n\u003ctd\u003e12.5micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003eDo not use during pregnancy or breastfeeding.\u003c\/p\u003e\n\u003cp\u003eAdults only.\u003c\/p\u003e\n\u003cp\u003eNot to be used for more than 21 consecutive days.\u003c\/p\u003e\n\u003cp\u003eThe medicine may interact with other prescription analgesic medicines, please consult your healthcare practitioner before use. If symptoms persist talk to your health professional.\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Clinical SaffroPEA\u003c\/h2\u003e\n\u003cp\u003e1. Mayo Clinic. Insomnia. https:\/\/www.mayoclinic.org\/diseases-conditions\/ insomnia\/symptoms-causes\/syc-20355167. Downloaded 22\/02\/23.\u003c\/p\u003e\n\u003cp\u003e2. Turner J. Emotional dimensions of chronic disease. Culture and Medicine. WJM. Feb 2000. 125, Volume 172.\u003c\/p\u003e\n\u003cp\u003e3. Beurel E, Toups M, Nemeroff C. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 2020. 107(2): 234-256.\u003c\/p\u003e\n\u003cp\u003e4. Clayton P, Hill M, Bogoda N et al. Palmitoylemthanolamide: A natural compound for health management. Int. J. Mol. Sci. 2021, 22, 5305.\u003c\/p\u003e\n\u003cp\u003e5. Keppel Hesselink J, de Boer T, Witkamp R. Palmitoylethanolamide: A natural body-own anti-inflammatory agent, effective and safe against influenza and common cold. Int. J. Inflamm. 2013.\u003c\/p\u003e\n\u003cp\u003e6. Gabrielson L, Mattsson S, Fowler C. Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. Br J Clin Pharmacol. 2016, 82 932-942.\u003c\/p\u003e\n\u003cp\u003e7. Briskey D, Roche G and Rao A. The effect of a dispersable Palmitolylethanolamide (Levagen+) compared to a placebo for reducing joint pain in an adult population – a randomised, double-blind study. Int J Food Sci Nutr. 2021; 10(1):9-13.\u003c\/p\u003e\n\u003cp\u003e8. Orio L, Alen F, Balesta A et al. Antihedonic and antidepressant effect of affron® a standardised saffron (Crocus Sativus L.) extract. Molecules, 2020, 25, 3207.\u003c\/p\u003e\n\u003cp\u003e9. Lopresit A, Smith S, Metse A et al. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomised, double-blind, placebo-controlled trial. JCSM, 2020, Vol 16, 6, 937-946.\u003c\/p\u003e\n\u003cp\u003e10. Lopresti A, Drummond P. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Pyscholpharmacol Clin Exp. 2014; 29:517-527.\u003c\/p\u003e\n\u003cp\u003e11. Kell G, Rao A, Beccaria G et al. A novel saffron extract (Crocus sativus L.) improves mood and sleep quality in healthy adults in over 4 weeks in a double-blind, parallel, randomised, placebo-controlled clinical trial. Comp Ther Med. 2017, Aug;33-58-64.\u003c\/p\u003e\n\u003cp\u003e12. Lopresti A, Smith S, Drummond P. An investigation into an evening intake of saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study. Sleep Med. 2021. Oct;86:7-18.\u003c\/p\u003e\n\u003cp\u003e13. Lopresti A, Drummond P, Inarejos-Garcia M et al. affron® a standardised extract from saffron (Croccus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebocontrolled study. J. Affect. Disord. 2018 May; 232:349-357\u003c\/p\u003e\n\u003cp\u003e14. Lopresti A, Smith S. The effects of a saffron extract (affron®) on menopausal symptoms in women during perimenopause: a randomised, double-blind, placebo-controlled study. J Menopausal Med. 2021;27:66-78\u003c\/p\u003e\n\u003cp\u003e15. De Oliveria D, Hirotsu C, Tufik S et al. The interfaces between vitamin D, sleep and pain. J Endocrinol. 2017 Jul;234(1):R23-R36\u003c\/p\u003e\n\u003cp\u003e16. Huiberts L, Smolders K. Effects of vitamin D on mood and sleep in the healthy population: interpretations from the serotonergic pathway. Sleep Med Review. 2021, 55, 101379.\u003c\/p\u003e\n\u003cp\u003e17. Natural medicines database. Vitamin D monograph. Downloaded 1\/03\/2023.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}