{"id":7819741036774,"title":"RN Labs Methyl Fortify","handle":"rn-labs-methyl-fortify","description":"\u003ch2\u003eRN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eBalanced Methyl Cofactors\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60 Capsules\u003c\/p\u003e\n\u003cp\u003eRN Labs Methyl Fortify Summary:\u003c\/p\u003e\n\u003cp\u003eRN Labs Methyl Fortify is part of the RN Labs Range of Practitioner Brand quality naturopathic medicines available for patients under the care of a practitioner.\u003c\/p\u003e\n\u003cp\u003eRN Labs was formerly named Research Nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eTo access RN Labs Methyl Fortify select the \u003ca title=\"How To Access RN Labs Naturopathic Medicines 10% off RRP | HealthMasters RN Labs\" href=\"#how-to-access\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eHow To Access tab\u003c\/span\u003e\u003c\/a\u003e for more information.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eRN Labs Methyl Fortify AUST L 270112\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\n\u003ch2\u003eSummary: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRN Labs Methyl Fortify contains a balanced and synergistic blend of methylfolate (L-5MTHF), methyl-B12, and choline each serving as an external source of methyl (CH3) groups to the body.\u003c\/li\u003e\n\u003cli\u003eActivated vitamin B2 and B6 provide additional cofactor support for optimum metabolism.\u003c\/li\u003e\n\u003cli\u003eInvaluable for delivering highly focused clinical methylation support, and the optimisation of cardiovascular, neurological and detoxification function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eBalanced Methyl Cofactors\u003c\/em\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eA balanced and synergistic blend of methylation-supportive B vitamins\u003c\/li\u003e\n\u003cli\u003eProvides the externally methylated forms of folate and vitamin B12\u003c\/li\u003e\n\u003cli\u003eActivated forms of vitamin B2 and B6 provide crucial co-factor support for the proper metabolism of folate, B12 and methylation\u003c\/li\u003e\n\u003cli\u003eProvides a therapeutic dose of choline for support of the alternate BHMT homocysteine methylation pathway\u003c\/li\u003e\n\u003cli\u003eMay help to support the maintenance of normal, healthy homocysteine levels via remethylation back to methionine\u003c\/li\u003e\n\u003cli\u003eProvides vitamin B6 for conversion of homocysteine to cysteine via the transulfation pathway\u003c\/li\u003e\n\u003cli\u003eSupports the synthesis of glutathione\u003c\/li\u003e\n\u003cli\u003eVitamin B2 is a component of glutathione reductase and a crucial cofactor in the activity of MTHFR\u003c\/li\u003e\n\u003cli\u003eCholine may support normal lipid metabolism\u003c\/li\u003e\n\u003cli\u003eCholine assists in the synthesis of SAMe\u003c\/li\u003e\n\u003cli\u003eCholine serves as a valuable precursor for the synthesis of acetylcholine and phosphatidylcholine\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eVideo\u003c\/h5\u003e\n\u003ch2\u003eVideo: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/378455361\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eSuggested Use:\u003c\/p\u003e\n\u003cp\u003eAdults take 1 capsule daily or as prescribed by your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach vegetarian capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRiboflavin-5-phosphate sodium\u003c\/td\u003e\n\u003ctd\u003e31.7mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to Riboflavin\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyridoxal-5-phosphate\u003c\/td\u003e\n\u003ctd\u003e39.2mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to Pyridoxine\u003c\/td\u003e\n\u003ctd\u003e20mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium L-5-methyltetrahydrofolate\u003c\/td\u003e\n\u003ctd\u003e550mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Levomefolic acid (L-5MTHF)\u003c\/td\u003e\n\u003ctd\u003e500mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMethylcobalamin\u003c\/td\u003e\n\u003ctd\u003e1 000mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCholine Dihydrogen Citrate\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eExcipients: Leucine, Microcrystalline Cellulose, Tapioca Starch, Colloidal Anhydrous Silica\u003c\/p\u003e\n\u003ch5\u003eFAQs\u003c\/h5\u003e\n\u003ch2\u003eFAQs: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eWhy does the formula not include serine?\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eAny protein sufficient diet should supply sufficient serine for overall metabolic support, which then ensures the available room in the capsule can be devoted to delivering the maximum amount of active vitamin nutrients for optimum potency and targeted efficacy of the product.\u003c\/p\u003e\n\u003ch5\u003eArticles\u003c\/h5\u003e\n\u003ch2\u003eArticles: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch2\u003eHomocysteine and 5-MTHF\u003c\/h2\u003e\n\u003cp\u003eA study examined the effect of oral treatment with 15mg per day of 5-methyltetrahydrofolate (5-MTHF) for 12 weeks, on homocysteinaemia and endothelial function in 19 patients undergoing peritoneal dialysis and compared them, for the same period of time, to a control group of patients on peritoneal dialysis.\u003c\/p\u003e\n\u003cp\u003ePlasma homocysteine concentrations fell by 30% after oral treatment with 5-MTHF. Endothelial function improved significantly after oral 5-MTHF treatment. A worsening of basal values was observed in the control group. These results confirm a positive outcome in reducing atherosclerosis via these independent mechanisms.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eBaragetti I, Raselli S, Stucchi A, Terraneo V, Furiani S, Buzzi L, Garlaschelli K, Alberghini E, Catapano AL, Buccianti G, 2007, Improvement of endothelial function in uraemic patients on peritoneal dialysis- a possible role for 5-MTHF administration, Molecular Genetics \u0026amp; Metabolism, vol. 84, no. 4, pp.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eThe Power of Choline for Methylation\u003c\/h2\u003e\n\u003ch3\u003eMany practitioners are aware that Betaine (aka Trimethylglycine, TMG) is the methyl donor in the BHMT pathway and as it’s alternate name suggests, possesses three chemically reactive methyl groups linked to a nitrogen atom.1 \u003c\/h3\u003e\n\u003cp\u003eWithin the BHMT pathway, Betaine is converted into Dimethylglycine (DMG) after donating one of its three methyl groups to homocysteine, to convert it to methionine and ultimately SAMe as an alternate and important route of methylation production to the well known Folate\/B12 requiring MTR pathway.\u003c\/p\u003e\n\u003cp\u003eWhat many practitioners may not be aware of, is that \u003cstrong\u003eBetaine can be readily produced in the body through the oxidation of Choline\u003c\/strong\u003e via the choline dehydrogenase and betaine aldehyde dehydrogenase enzymes, particularly in the liver and muscles.2\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eFor this reason, Choline has also been shown to indirectly support homocysteine methylation.3\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eOne study of postmenopausal women showed that Choline supplementation increased plasma Betaine levels and slightly lowered plasma levels of total homocysteine (tHcy) after six weeks.4\u003c\/p\u003e\n\u003cp\u003eThe upper tolerable limit for Choline in adults is 3.5 g\/day. Beyond the diet and supplements, the only other source of choline is via de novo synthesis from phosphatidylcholine which requires significant amounts of SAMe via the PEMT pathway (3 mole SAM to produce 1 mole choline) and produces homocysteine.\u003c\/p\u003e\n\u003cp\u003eA deficiency of Choline will therefore put an increased additional burden on potentially already strained SAMe\/Methylation levels, in those exhibiting insufficient methylation capacity.\u003c\/p\u003e\n\u003cp\u003eAvailable evidence suggests that Folate deficiency can be partly compensated for when more Choline is available, and vice versa.\u003c\/p\u003e\n\u003cp\u003eFor example, Choline and Phosphatidylcholine were depleted in the livers of rats fed a Folate-deficient diet.5 In turn, consumption of a Choline-deficient diet decreased hepatic Folate stores6 and lowered Methionine formation in animal livers by 20%–25%,7 due to less Choline being available for conversion into Betaine. The effects of Choline deficiency on reducing liver SAMe (by 60%) and increasing liver SAH (by 50%) were pronounced.7\u003c\/p\u003e\n\u003cp\u003eSupplementation with Choline can therefore prove to be an invaluable if not essential co-prescription with any methylated B vitamins in the clinical treatment of methylation insufficiencies.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eSupplements that include the preferable form ‘Choline Dihydrogen Citrate’ in combination with methylated Folate and B12, such as Research Nutrition’s Methyl Fortify, may provide maximum utility in patients requiring comprehensive methylation support.\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eAlternatively, if you just want to use Methyl Folate on its own Research Nutrition’s L-5MTHF provides 500 mcg per capsule.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat about how to quench excess methyl groups?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNiacinamide B3 represents an invaluable clinical tool for balancing methylation protocols.\u003c\/p\u003e\n\u003cp\u003eThe mechanism of action is attributed to the conversion of Niacinamide into 1-Methyl-Niacinamide after receiving a methyl group via the Niacinamide n-methyltransferase (NNMT) enzyme. NNMT shunts Niacinamide away from NAD+ formation, using S-adenosylmethionine (SAMe) as its methyl donor. Clinical observations indicate a dose of 150mg Niacinamide appears to begin quenching excess methyl groups, with 500mg or more being required to make a noticeable impact in most individuals.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eObeid R. The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway. Nutrients 2013; 5: 3481–3495.\u003c\/li\u003e\n\u003cli\u003eRogers J.D., Sanchez-Saffon A., Frol A.B., Diaz-Arrastia R. Elevated plasma homocysteine levels in patients treated with levodopa: Association with vascular disease. Arch. Neurol. 2003;60:59–64.\u003c\/li\u003e\n\u003cli\u003eWallace J.M., McCormack J.M., McNulty H., Walsh P.M., Robson P.J., Bonham M.P., Duffy M.E., Ward M., Molloy A.M., Scott J.M., et al. Choline supplementation and measures of choline and betaine status: A randomised, controlled trial in postmenopausal women. Br. J. Nutr. 2012;108:1264–1271.\u003c\/li\u003e\n\u003cli\u003eHolm P.I., Ueland P.M., Vollset S.E., Midttun O., Blom H.J., Keijzer M.B., den Heijer M. Betaine and folate status as cooperative determinants of plasma homocysteine in humans. Arterioscler. Thromb. Vasc. Biol. 2005;25:379–385.\u003c\/li\u003e\n\u003cli\u003eKim Y.I., Miller J.W., da Costa K.A., Nadeau M., Smith D., Selhub J., Zeisel S.H., Mason J.B. Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver. J. Nutr.1994;124:2197–2203.\u003c\/li\u003e\n\u003cli\u003eHorne D.W., Cook R.J., Wagner C. Effect of dietary methyl group deficiency on folate metabolism in rats. J. Nutr. 1989;119:618–621.\u003c\/li\u003e\n\u003cli\u003e7. Zeisel S.H., Zola T., da Costa K.A., Pomfret E.A. Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. Biochem. J. 1989;259:725–729.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch5\u003eCautions\u003c\/h5\u003e\n\u003ch2\u003eCautions: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eThis product contains Pyridoxal-5-Phosphate which may be dangerous when used in large amounts or for a long time.\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eKnown Side Effects\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eIn doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.\u003c\/p\u003e\n\u003cp\u003eWhilst some concern exists that supplementation with high doses of folic acid could mask a vitamin B12 deficiency, supplementation with 5-MTHF appears to sidestep this potential problem. Since 5-MTHF can only be converted to 5,10-methylenetetrahydrofolate (involved in DNA synthesis) after participating in homocysteine recycling with vitamin B12, 5-MTHF will not mask a B12 deficiency.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMedication Interactions\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe activity of various B vitamins may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.\u003c\/p\u003e\n\u003ch5\u003eQuality \u0026amp; Purity\u003c\/h5\u003e\n\u003ch2\u003eQuality \u0026amp; Purity: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003eRN Labs use only the highest grade ingredients and materials available. RN Labs purity standards for manufacturing and sourcing are extensively researched and verified.\u003c\/h3\u003e\n\u003cp\u003eMethyl Fortify is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003ePure \u0026amp; Free From\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThis product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.\u003c\/p\u003e\n\u003ch5\u003eThe RN Difference\u003c\/h5\u003e\n\u003ch2\u003eThe RN Difference: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/325810732\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eStore below 25°C in a cool, dry, dark place.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T15:58:34+11:00","created_at":"2022-06-08T10:43:35+10:00","vendor":"RN Labs","type":"RN Labs Naturopathic Mediciness","tags":["Methylation","MTHFR","Naturopathic","PB","RN Labs"],"price":3762,"price_min":3762,"price_max":3762,"available":true,"price_varies":false,"compare_at_price":4180,"compare_at_price_min":4180,"compare_at_price_max":4180,"compare_at_price_varies":false,"variants":[{"id":42988649775334,"title":"60 Capsules","option1":"60 Capsules","option2":null,"option3":null,"sku":"RNLMethylFortify60C","requires_shipping":true,"taxable":true,"featured_image":{"id":37698122252518,"product_id":7819741036774,"position":2,"created_at":"2022-06-08T17:37:16+10:00","updated_at":"2022-07-06T13:47:59+10:00","alt":"RN Labs Methyl Fortify 10% off RRP at HealthMasters RN 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Logo","id":30477229752550,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_58e1ff2f-a57f-427c-a1d9-238c69d393d6.png?v=1657079279"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_58e1ff2f-a57f-427c-a1d9-238c69d393d6.png?v=1657079279","width":1200},{"alt":"RN Labs Methyl Fortify 10% off RRP at HealthMasters RN Labs","id":30266992918758,"position":2,"preview_image":{"aspect_ratio":0.553,"height":723,"width":400,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsMethylFortify10_offRRPatHealthMastersRNLabs.png?v=1657079279"},"aspect_ratio":0.553,"height":723,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsMethylFortify10_offRRPatHealthMastersRNLabs.png?v=1657079279","width":400},{"alt":"RN Labs Methyl Fortify 10% off RRP at HealthMasters RN Labs Logo","id":30265386172646,"position":3,"preview_image":{"aspect_ratio":3.0,"height":100,"width":300,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_e5e5464b-acbe-4b29-bee8-970e6b107bd0.jpg?v=1657079279"},"aspect_ratio":3.0,"height":100,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_e5e5464b-acbe-4b29-bee8-970e6b107bd0.jpg?v=1657079279","width":300}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eRN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eBalanced Methyl Cofactors\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60 Capsules\u003c\/p\u003e\n\u003cp\u003eRN Labs Methyl Fortify Summary:\u003c\/p\u003e\n\u003cp\u003eRN Labs Methyl Fortify is part of the RN Labs Range of Practitioner Brand quality naturopathic medicines available for patients under the care of a practitioner.\u003c\/p\u003e\n\u003cp\u003eRN Labs was formerly named Research Nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eTo access RN Labs Methyl Fortify select the \u003ca title=\"How To Access RN Labs Naturopathic Medicines 10% off RRP | HealthMasters RN Labs\" href=\"#how-to-access\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eHow To Access tab\u003c\/span\u003e\u003c\/a\u003e for more information.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eRN Labs Methyl Fortify AUST L 270112\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\n\u003ch2\u003eSummary: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRN Labs Methyl Fortify contains a balanced and synergistic blend of methylfolate (L-5MTHF), methyl-B12, and choline each serving as an external source of methyl (CH3) groups to the body.\u003c\/li\u003e\n\u003cli\u003eActivated vitamin B2 and B6 provide additional cofactor support for optimum metabolism.\u003c\/li\u003e\n\u003cli\u003eInvaluable for delivering highly focused clinical methylation support, and the optimisation of cardiovascular, neurological and detoxification function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eBalanced Methyl Cofactors\u003c\/em\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eA balanced and synergistic blend of methylation-supportive B vitamins\u003c\/li\u003e\n\u003cli\u003eProvides the externally methylated forms of folate and vitamin B12\u003c\/li\u003e\n\u003cli\u003eActivated forms of vitamin B2 and B6 provide crucial co-factor support for the proper metabolism of folate, B12 and methylation\u003c\/li\u003e\n\u003cli\u003eProvides a therapeutic dose of choline for support of the alternate BHMT homocysteine methylation pathway\u003c\/li\u003e\n\u003cli\u003eMay help to support the maintenance of normal, healthy homocysteine levels via remethylation back to methionine\u003c\/li\u003e\n\u003cli\u003eProvides vitamin B6 for conversion of homocysteine to cysteine via the transulfation pathway\u003c\/li\u003e\n\u003cli\u003eSupports the synthesis of glutathione\u003c\/li\u003e\n\u003cli\u003eVitamin B2 is a component of glutathione reductase and a crucial cofactor in the activity of MTHFR\u003c\/li\u003e\n\u003cli\u003eCholine may support normal lipid metabolism\u003c\/li\u003e\n\u003cli\u003eCholine assists in the synthesis of SAMe\u003c\/li\u003e\n\u003cli\u003eCholine serves as a valuable precursor for the synthesis of acetylcholine and phosphatidylcholine\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eVideo\u003c\/h5\u003e\n\u003ch2\u003eVideo: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/378455361\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eSuggested Use:\u003c\/p\u003e\n\u003cp\u003eAdults take 1 capsule daily or as prescribed by your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach vegetarian capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRiboflavin-5-phosphate sodium\u003c\/td\u003e\n\u003ctd\u003e31.7mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to Riboflavin\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyridoxal-5-phosphate\u003c\/td\u003e\n\u003ctd\u003e39.2mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to Pyridoxine\u003c\/td\u003e\n\u003ctd\u003e20mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium L-5-methyltetrahydrofolate\u003c\/td\u003e\n\u003ctd\u003e550mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Levomefolic acid (L-5MTHF)\u003c\/td\u003e\n\u003ctd\u003e500mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMethylcobalamin\u003c\/td\u003e\n\u003ctd\u003e1 000mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCholine Dihydrogen Citrate\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eExcipients: Leucine, Microcrystalline Cellulose, Tapioca Starch, Colloidal Anhydrous Silica\u003c\/p\u003e\n\u003ch5\u003eFAQs\u003c\/h5\u003e\n\u003ch2\u003eFAQs: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eWhy does the formula not include serine?\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eAny protein sufficient diet should supply sufficient serine for overall metabolic support, which then ensures the available room in the capsule can be devoted to delivering the maximum amount of active vitamin nutrients for optimum potency and targeted efficacy of the product.\u003c\/p\u003e\n\u003ch5\u003eArticles\u003c\/h5\u003e\n\u003ch2\u003eArticles: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch2\u003eHomocysteine and 5-MTHF\u003c\/h2\u003e\n\u003cp\u003eA study examined the effect of oral treatment with 15mg per day of 5-methyltetrahydrofolate (5-MTHF) for 12 weeks, on homocysteinaemia and endothelial function in 19 patients undergoing peritoneal dialysis and compared them, for the same period of time, to a control group of patients on peritoneal dialysis.\u003c\/p\u003e\n\u003cp\u003ePlasma homocysteine concentrations fell by 30% after oral treatment with 5-MTHF. Endothelial function improved significantly after oral 5-MTHF treatment. A worsening of basal values was observed in the control group. These results confirm a positive outcome in reducing atherosclerosis via these independent mechanisms.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eBaragetti I, Raselli S, Stucchi A, Terraneo V, Furiani S, Buzzi L, Garlaschelli K, Alberghini E, Catapano AL, Buccianti G, 2007, Improvement of endothelial function in uraemic patients on peritoneal dialysis- a possible role for 5-MTHF administration, Molecular Genetics \u0026amp; Metabolism, vol. 84, no. 4, pp.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eThe Power of Choline for Methylation\u003c\/h2\u003e\n\u003ch3\u003eMany practitioners are aware that Betaine (aka Trimethylglycine, TMG) is the methyl donor in the BHMT pathway and as it’s alternate name suggests, possesses three chemically reactive methyl groups linked to a nitrogen atom.1 \u003c\/h3\u003e\n\u003cp\u003eWithin the BHMT pathway, Betaine is converted into Dimethylglycine (DMG) after donating one of its three methyl groups to homocysteine, to convert it to methionine and ultimately SAMe as an alternate and important route of methylation production to the well known Folate\/B12 requiring MTR pathway.\u003c\/p\u003e\n\u003cp\u003eWhat many practitioners may not be aware of, is that \u003cstrong\u003eBetaine can be readily produced in the body through the oxidation of Choline\u003c\/strong\u003e via the choline dehydrogenase and betaine aldehyde dehydrogenase enzymes, particularly in the liver and muscles.2\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eFor this reason, Choline has also been shown to indirectly support homocysteine methylation.3\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eOne study of postmenopausal women showed that Choline supplementation increased plasma Betaine levels and slightly lowered plasma levels of total homocysteine (tHcy) after six weeks.4\u003c\/p\u003e\n\u003cp\u003eThe upper tolerable limit for Choline in adults is 3.5 g\/day. Beyond the diet and supplements, the only other source of choline is via de novo synthesis from phosphatidylcholine which requires significant amounts of SAMe via the PEMT pathway (3 mole SAM to produce 1 mole choline) and produces homocysteine.\u003c\/p\u003e\n\u003cp\u003eA deficiency of Choline will therefore put an increased additional burden on potentially already strained SAMe\/Methylation levels, in those exhibiting insufficient methylation capacity.\u003c\/p\u003e\n\u003cp\u003eAvailable evidence suggests that Folate deficiency can be partly compensated for when more Choline is available, and vice versa.\u003c\/p\u003e\n\u003cp\u003eFor example, Choline and Phosphatidylcholine were depleted in the livers of rats fed a Folate-deficient diet.5 In turn, consumption of a Choline-deficient diet decreased hepatic Folate stores6 and lowered Methionine formation in animal livers by 20%–25%,7 due to less Choline being available for conversion into Betaine. The effects of Choline deficiency on reducing liver SAMe (by 60%) and increasing liver SAH (by 50%) were pronounced.7\u003c\/p\u003e\n\u003cp\u003eSupplementation with Choline can therefore prove to be an invaluable if not essential co-prescription with any methylated B vitamins in the clinical treatment of methylation insufficiencies.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eSupplements that include the preferable form ‘Choline Dihydrogen Citrate’ in combination with methylated Folate and B12, such as Research Nutrition’s Methyl Fortify, may provide maximum utility in patients requiring comprehensive methylation support.\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eAlternatively, if you just want to use Methyl Folate on its own Research Nutrition’s L-5MTHF provides 500 mcg per capsule.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat about how to quench excess methyl groups?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNiacinamide B3 represents an invaluable clinical tool for balancing methylation protocols.\u003c\/p\u003e\n\u003cp\u003eThe mechanism of action is attributed to the conversion of Niacinamide into 1-Methyl-Niacinamide after receiving a methyl group via the Niacinamide n-methyltransferase (NNMT) enzyme. NNMT shunts Niacinamide away from NAD+ formation, using S-adenosylmethionine (SAMe) as its methyl donor. Clinical observations indicate a dose of 150mg Niacinamide appears to begin quenching excess methyl groups, with 500mg or more being required to make a noticeable impact in most individuals.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eObeid R. The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway. Nutrients 2013; 5: 3481–3495.\u003c\/li\u003e\n\u003cli\u003eRogers J.D., Sanchez-Saffon A., Frol A.B., Diaz-Arrastia R. Elevated plasma homocysteine levels in patients treated with levodopa: Association with vascular disease. Arch. Neurol. 2003;60:59–64.\u003c\/li\u003e\n\u003cli\u003eWallace J.M., McCormack J.M., McNulty H., Walsh P.M., Robson P.J., Bonham M.P., Duffy M.E., Ward M., Molloy A.M., Scott J.M., et al. Choline supplementation and measures of choline and betaine status: A randomised, controlled trial in postmenopausal women. Br. J. Nutr. 2012;108:1264–1271.\u003c\/li\u003e\n\u003cli\u003eHolm P.I., Ueland P.M., Vollset S.E., Midttun O., Blom H.J., Keijzer M.B., den Heijer M. Betaine and folate status as cooperative determinants of plasma homocysteine in humans. Arterioscler. Thromb. Vasc. Biol. 2005;25:379–385.\u003c\/li\u003e\n\u003cli\u003eKim Y.I., Miller J.W., da Costa K.A., Nadeau M., Smith D., Selhub J., Zeisel S.H., Mason J.B. Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver. J. Nutr.1994;124:2197–2203.\u003c\/li\u003e\n\u003cli\u003eHorne D.W., Cook R.J., Wagner C. Effect of dietary methyl group deficiency on folate metabolism in rats. J. Nutr. 1989;119:618–621.\u003c\/li\u003e\n\u003cli\u003e7. Zeisel S.H., Zola T., da Costa K.A., Pomfret E.A. Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. Biochem. J. 1989;259:725–729.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch5\u003eCautions\u003c\/h5\u003e\n\u003ch2\u003eCautions: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eThis product contains Pyridoxal-5-Phosphate which may be dangerous when used in large amounts or for a long time.\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eKnown Side Effects\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eIn doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.\u003c\/p\u003e\n\u003cp\u003eWhilst some concern exists that supplementation with high doses of folic acid could mask a vitamin B12 deficiency, supplementation with 5-MTHF appears to sidestep this potential problem. Since 5-MTHF can only be converted to 5,10-methylenetetrahydrofolate (involved in DNA synthesis) after participating in homocysteine recycling with vitamin B12, 5-MTHF will not mask a B12 deficiency.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMedication Interactions\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe activity of various B vitamins may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.\u003c\/p\u003e\n\u003ch5\u003eQuality \u0026amp; Purity\u003c\/h5\u003e\n\u003ch2\u003eQuality \u0026amp; Purity: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003ch3\u003eRN Labs use only the highest grade ingredients and materials available. RN Labs purity standards for manufacturing and sourcing are extensively researched and verified.\u003c\/h3\u003e\n\u003cp\u003eMethyl Fortify is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003ePure \u0026amp; Free From\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThis product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.\u003c\/p\u003e\n\u003ch5\u003eThe RN Difference\u003c\/h5\u003e\n\u003ch2\u003eThe RN Difference: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/325810732\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: RN Labs Methyl Fortify\u003c\/h2\u003e\n\u003cp\u003eStore below 25°C in a cool, dry, dark place.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}