{"id":9249547083,"title":"Metagenics AdrenoTone 60 tablets","handle":"metagenics-adrenotone-60-tablets","description":"\u003ch3\u003e\u003cem\u003eFor Stress Management And Adrenal Support\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics AdrenoTone 60 tablets\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e Size:\u003c\/strong\u003e 60 tablets (20 days)\u003c\/p\u003e\n\u003cp\u003eMetagenics AdrenoTone For Stress Management and Adrenal Support:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMetagenics AdrenoTone contains herbs that may be of benefit during times of stress, according to traditional and scientific evidence.\u003c\/li\u003e\n\u003cli\u003eRhodiola has been shown to reduce physical and mental fatigue caused by stress.\u003c\/li\u003e\n\u003cli\u003eThe herbs in Metagenics AdrenoTone are used to support the nervous system, and for their tonic effect on adrenal function in traditional Ayurvedic and Western herbal medicine.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics AdrenoTone is free from dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein. Metagenics AdrenoTone is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003cp\u003eMetagenics AdrenoTone AUST L158604\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eProduct Summary\u003c\/h5\u003e\n\u003ch2\u003eProduct Summary: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003eHerbs in Metagenics AdrenoTone have been clinically shown to or traditionally used to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupport patients feeling flat and exhausted.\u003csup style=\"box-sizing: border-box; position: relative; font-size: 11.25px; line-height: 0; vertical-align: baseline; top: -0.5em;\"\u003e1\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eReduce stress-induced physical and mental fatigue.\u003csup style=\"box-sizing: border-box; position: relative; font-size: 11.25px; line-height: 0; vertical-align: baseline; top: -0.5em;\"\u003e2\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupport adrenal and nervous exhaustion.\u003csup style=\"box-sizing: border-box; position: relative; font-size: 11.25px; line-height: 0; vertical-align: baseline; top: -0.5em;\"\u003e3,4\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdults:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTake 1 tablet three times daily with food.\u003c\/p\u003e\n\u003cp\u003eOr as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWithania has been shown to reduce plasma cortisol levels\u003c\/strong\u003e via its effects on the adrenal glands, potentially protecting against the negative effects of elevated cortisol levels in chronic stress.\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSiberian ginseng assists in the management of stress\u003c\/strong\u003e by altering the levels of hormones involved in the stress response and HPA axis.\u003csup\u003e6 \u003c\/sup\u003eAs a result, catecholamine levels are preserved and the release of excess catecholamines is reduced.\u003csup\u003e7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRhodiola has been shown to improve mental performance in physically stressed and fatigued individuals.\u003c\/strong\u003e\u003csup\u003e8\u003c\/sup\u003e A double blind, cross-over study examined the effects of rhodiola on fatigue during night shift.\u003csup\u003e9\u003c\/sup\u003e The study observed levels of mental fatigue, involving complex perceptive and cognitive cerebral functions.\u003csup\u003e10 \u003c\/sup\u003eSignificant improvements were noted in all treatment groups within just two weeks (Figure One).\u003csup\u003e11, 12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach tablet contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eExtracts equivalent to:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWithania somnifera, root dry (Ashwagandha)\u003c\/td\u003e\n\u003ctd\u003e3.8g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEleutherococcus senticosus, root dry (Siberian ginseng)\u003c\/td\u003e\n\u003ctd\u003e2.8g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlycyrrhiza glabra, root dry (Liquorice)\u003c\/td\u003e\n\u003ctd\u003e1.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRhodiola rosea, root dry (Rhodiola)\u003c\/td\u003e\n\u003ctd\u003e1.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanax ginseng, root dry (Korean ginseng)\u003c\/td\u003e\n\u003ctd\u003e281.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTyrosine\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eMetagenics AdrenoTone is free from dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein. Metagenics AdrenoTone is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003ch5\u003eCautions\/Contraindications\u003c\/h5\u003e\n\u003ch2\u003eCautions\/Contraindications: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBipolar depression\u003c\/strong\u003e (rhodiola).39\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCongestive heart failure\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSevere renal insufficiency\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypokalaemia\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypertonia:\u003c\/strong\u003e Mineralocorticoid effects of liquorice can cause hypokalaemia, which can worsen hypertonia.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatic cirrhosis\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholestatic liver disease\u003c\/strong\u003e (liquorice)41\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eTraditional contraindications:\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- Siberian ginseng – in acute infection or fever.4\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- Panax ginseng – in fever, excessive menstruation, nose bleeds, acute infections, and acute asthma.11\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eCAUTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eAnticoagulant\/antiplatelet drugs:\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- \u003cstrong\u003eWarfarin\u003c\/strong\u003e - Liquorice seems to increase metabolism and decrease levels of warfarin in animal models.40 Avoid, or use with medical supervision.\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- Uncertainty exists about whether Panax ginseng may decrease platelet aggregation or have effects on warfarin metabolism.42\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- A constituent of Siberian ginseng may inhibit platelet aggregation.43\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntidiabetes drugs:\u003c\/strong\u003e Korean ginseng42 and Siberian ginseng43 may theoretically lower blood glucose. Monitor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCorticosteroids:\u003c\/strong\u003e Theoretically, liquorice may potentiate the effects. Monitor.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigoxin:\u003c\/strong\u003e Potential toxicity with high dose liquorice. Caution.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiuretics:\u003c\/strong\u003e Potential increased risk for hypokalaemia with liquorice. Monitor.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypertension:\u003c\/strong\u003e Monitor blood pressure when taking high dose liquorice for greater than 2 weeks.44\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHyperthyroidism:\u003c\/strong\u003e Withania may enhance T4. Monitor.45 Tyrosine is a precursor to thyroid hormone and may increase levels. Monitor.47\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunosuppressants:\u003c\/strong\u003e Theoretically, withania46 and Korean ginseng42 may reduce the effectiveness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLevodopa:\u003c\/strong\u003e Tyrosine may theoretically decrease the effectiveness through competition for absorption. Separate doses by 2 hours.47\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonoamine oxidase inhibitors (MAOIs):\u003c\/strong\u003e Theoretically, ginsengs may interfere with MAOI therapy. There is one case report of insomnia, headache and tremors, and a second case report of hypomania, with concomitant phenelzine and unspecified ginseng use.11\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrogens:\u003c\/strong\u003e Liquorice may interfere with oestrogen therapy due to oestrogenic and anti-oestrogenic effects.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrogen-sensitive cancers or conditions:\u003c\/strong\u003e Because of the potential oestrogenic effects of liquorice and Korean\/Siberian ginsengs, women with hormone sensitive conditions, such as breast cancer, uterine cancer, ovarian cancer, endometriosis, and uterine fibroids, should avoid.40,42,43\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptic ulcer disease:\u003c\/strong\u003e Withania may cause gastric irritation. Monitor.46\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSedatives:\u003c\/strong\u003e Withania46 and Siberian ginseng43 may have theoretical additive effects. Monitor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSensitivity to solanaceae family:\u003c\/strong\u003e (Withania) caution.48\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStimulants:\u003c\/strong\u003e Avoid concurrent use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroxine:\u003c\/strong\u003e Withania may enhance T4. Monitor.49 Tyrosine is a precursor to thyroid hormone and may increase levels. Monitor.47\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eDrugs metabolised by the following cytochrome enzymes:\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\n\u003cstrong\u003e- CYP2D6:\u003c\/strong\u003e Panax ginseng may inhibit activity of these enzymes, although evidence is conflicting. Theoretical risk of unknown clinical significance. Monitor.42\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\n\u003cstrong\u003e- CYP2B6, CYP2C9, CYP3A4:\u003c\/strong\u003e Conflicting evidence exists for the effects of liquorice on these enzymes. Caution if using medications metabolised by these enzymes.40\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\n\u003cstrong\u003e- CYP1A2, CYP2C9, CYP2D6, CYP3A4:\u003c\/strong\u003e In vitro and animal data suggest Siberian ginseng may inhibit these enzymes, although there is no evidence of effects in humans.43\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery\u003c\/strong\u003e: Suspend use 1 week prior to major surgery.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePREGNANCY AND LACTATION:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy\u003c\/strong\u003e: Not safe. Rhodiola in contraindicated in pregnancy.50 Ginsenoside Rb1 has a significant effect on the morphogenesis of rat embryos. Exposure to ginsenoside Rb1 at very high concentrations (\u0026gt;30 mg\/ml) resulted in a significant reduction of total morphological score and scores for some individual features. The importance of this concentration in human pregnancies is uncertain. Before more information in humans becomes available, use of ginseng during pregnancy should be with caution.51\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLactation\u003c\/strong\u003e: Likely safe.\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003eStore below 30° C\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003e1 Pole S. Ayurvedic Medicine: The Principles of Traditional Practice. Philadelphia; Elsevier, Churchill Livingstone, 2006: pp133-4.\u003c\/p\u003e\n\u003cp\u003e2 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri; Churchill Livingstone, 2005: pp 631-4.\u003c\/p\u003e\n\u003cp\u003e3 Bone K. Clinical Applications of Ayurvedic and Chinese Herbs. Monographs for the Western Herbal Practitioner. Warwick;  Phytotherapy Press, 1996: pp137-41.\u003c\/p\u003e\n\u003cp\u003e4 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri; Churchill Livingstone, 2005: pp 578-80.\u003c\/p\u003e\n\u003cp\u003e5 Mills S, Bone K. Principles and Practice of Phytotherapy. Modern Herbal Medicine. Edinburgh; Churchill Livingstone, 2000: pp534-41.\u003c\/p\u003e\n\u003cp\u003e6 Gruenwald J, Brendler T, Jaenicke C (Eds). PDR for Herbal Medicines. 4th Ed. Montvale, NJ; Thomson, 2004: pp703-5.\u003c\/p\u003e\n\u003cp\u003e7 Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001 Jun;6(3):293-302.\u003c\/p\u003e\n\u003cp\u003e8 Rhodiola rosea. 2003. http:\/\/www.plant-identification.co.uk\/skye\/crassulaceae\/rhodiola-rosea.htm (date accessed: Dec 23, 2008)\u003c\/p\u003e\n\u003cp\u003e9 Pole S. Ayurvedic Medicine: The Principles of Traditional Practice. Philadelphia; Elsevier, Churchill Livingstone, 2006: pp220-1.\u003c\/p\u003e\n\u003cp\u003e10 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri, Churchill Livingstone, 2005: pp498-502.\u003c\/p\u003e\n\u003cp\u003e11 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri; Churchill Livingstone, 2005: pp 433-6.\u003c\/p\u003e\n\u003cp\u003e12 Mills S, Bone K. Principles and Practice of Phytotherapy. Modern Herbal Medicine. Edinburgh; Churchill Livingstone, 2000: pp418-31.\u003c\/p\u003e\n\u003cp\u003e13 Bensky D, Clavey S, Stöger E, Gamble A. Chinese Herbal Medicine Materia Medica. 3rd edition. Seattle, Washington; Eastland Press, 2004: pp701-4.\u003c\/p\u003e\n\u003cp\u003e14 Rai D, Bhatia G, Sen T, Palit G. Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study. J Pharmacol Sci 2003 Dec;93(4):458-64.\u003c\/p\u003e\n\u003cp\u003e15 Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav 2003;75(3):547-55.\u003c\/p\u003e\n\u003cp\u003e16 Kumar A, Kalonia H. Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method). Indian J Exp Biol 2007;45(6):524-8.\u003c\/p\u003e\n\u003cp\u003e17 Sankar SR, Manivasagam T, Krishnamurti A, Ramanathan M. The neuroprotective effect of Withania somnifera root extract in MPTPintoxicated mice: An analysis of behavioral and biochemical variables. Cell Mol Biol Lett 2007;12(4):473-81.\u003c\/p\u003e\n\u003cp\u003e18 Bhatnagar M, Sisodia SS, Bhatnagar R. Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats. Ann N Y Acad Sci 2005;1056:261-78.\u003c\/p\u003e\n\u003cp\u003e19 Lee SH, Jung BH, Kim SY, Lee EH, Chung BC. The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress. Pharmacol Res 2006;54(1):46-9.\u003c\/p\u003e\n\u003cp\u003e20 Mattioli L, Funari C, Perfumi M. Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. J Psychopharmacol. 2008 May 30. [Epub ahead of print]\u003c\/p\u003e\n\u003cp\u003e21 Mattioli L, Perfumi M. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J Psychopharmacol. 2007 Sep;21(7):742-50.\u003c\/p\u003e\n\u003cp\u003e22 Reay JL, Kennedy DO, Scholey AB. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol 2006;20(6):771-81.\u003c\/p\u003e\n\u003cp\u003e23 Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 2005;19(4):357-65.\u003c\/p\u003e\n\u003cp\u003e24 Banerjee U, Izquierdo JA. Antistress and antifatigue properties of Panax ginseng: comparison with piracetam. Acta Physiol Lat Am 1982;32(4):277-85.\u003c\/p\u003e\n\u003cp\u003e25 Hartz AJ, Bentler S, Noyes R, Hoehns J, Logemann C, Sinift S, Butani Y, Wang W, Brake K, Ernst M, Kautzman H. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34(1):51-61.\u003c\/p\u003e\n\u003cp\u003e26 Kimura Y, Sumiyoshi M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J Ethnopharmacol 2004;95(2-3):447-53.\u003c\/p\u003e\n\u003cp\u003e27 Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999;64(1):91-3.\u003c\/p\u003e\n\u003cp\u003e28 Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacological investigation of Ashwagandha and Ginseng. J Ethnopharmacol 1994;44(3):131-5.\u003c\/p\u003e\n\u003cp\u003e29 Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000;7(2):85-9.\u003c\/p\u003e\n\u003cp\u003e30 Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7(5):365-71.\u003c\/p\u003e\n\u003cp\u003e31 Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull. 1989 Apr;22(4):759-62.\u003c\/p\u003e\n\u003cp\u003e32 Deijen JB, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. 1994;33(3):319-23.\u003c\/p\u003e\n\u003cp\u003e33 Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999 Jan 15;48(2):203-9.\u003c\/p\u003e\n\u003cp\u003e34 Lee YJ, Chung E, Lee KY, Lee YH, Huh B, Lee SK. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol Cell Endocrinol 1997;133(2):135-40.\u003c\/p\u003e\n\u003cp\u003e35 Kim DH, Moon YS, Jung JS, Min SK, Son BK, Suh HW, Song DK. Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice. Neurosci Lett. 2003 May 29;343(1):62-6.\u003c\/p\u003e\n\u003cp\u003e36 Tachikawa E, Kudo K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: suppression of adrenal medullary function in vitro by ginseng. J Pharmacol Sci 2004;95(2):140-4.\u003c\/p\u003e\n\u003cp\u003e37 Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343-8.\u003c\/p\u003e\n\u003cp\u003e38 Panossian A, Nikoyan N, Ohanyan N, Hovhannisyan A, Abrahamyan H, Gabrielyan E, Wikman G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008 Jan;15(1-2):84-91.\u003c\/p\u003e\n\u003cp\u003e39 Braun L and Cohen M. Herbs and Natural Supplements: An evidence-based guide. 3rd Ed. Sydney; Elsevier, 2010:pp794-801.\u003c\/p\u003e\n\u003cp\u003e40 Jellin JM, Ed. Natural Medicines Comprehensive Database, Liquorice. Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=881\u0026amp;fs=ND\u0026amp;searchid=126596\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=881\u0026amp;fs=ND\u0026amp;searchid=126596\u003c\/a\u003e 67 (date accessed: Dec 24, 2008).\u003c\/p\u003e\n\u003cp\u003e41 Blumenthal M, Senior Editor. The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. Texas; American Botanical Council, 1998: pp161-2.\u003c\/p\u003e\n\u003cp\u003e42 Jellin JM, Ed. Natural Medicines Comprehensive Database; Ginseng, Panax. Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1000\u0026amp;fs=ND\u0026amp;searchid=12660\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1000\u0026amp;fs=ND\u0026amp;searchid=12660\u003c\/a\u003e 107 (date accessed: Dec 24, 2008).\u003c\/p\u003e\n\u003cp\u003e43 Jellin JM, Ed. Natural Medicines Comprehensive Database; Ginseng, Siberian. Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=985\u0026amp;fs=ND\u0026amp;searchid=126603\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=985\u0026amp;fs=ND\u0026amp;searchid=126603\u003c\/a\u003e 31 (date accessed: Dec 24, 2008).\u003c\/p\u003e\n\u003cp\u003e44 Braun L and Cohen M. Herbs and Natural Supplements: An evidence-based guide. 2nd Ed. Sydney; Elsevier, 2007:pp455-64.\u003c\/p\u003e\n\u003cp\u003e45 Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67(2):233-9.\u003c\/p\u003e\n\u003cp\u003e46 Jellin JM, Ed. Natural Medicines Comprehensive Database, Ashwagandha. Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=881\u0026amp;fs=ND\u0026amp;searchid=126596\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=881\u0026amp;fs=ND\u0026amp;searchid=126596\u003c\/a\u003e 67 (date accessed: Dec 24, 2008).\u003c\/p\u003e\n\u003cp\u003e47 Jellin JM, Ed. Natural Medicines Comprehensive Database, Tyrosine. Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1037\u0026amp;fs=ND\u0026amp;searchid=12660\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1037\u0026amp;fs=ND\u0026amp;searchid=12660\u003c\/a\u003e 670 (date accessed: Dec 24, 2008)\u003c\/p\u003e\n\u003cp\u003e48 Braun L and Cohen M. Herbs and Natural Supplements: An evidence-based guide. 2nd Ed. Sydney; Elsevier, 2007:pp696-700.\u003c\/p\u003e\n\u003cp\u003e49 Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67(2):233-9.\u003c\/p\u003e\n\u003cp\u003e50 Braun L and Cohen M. Herbs and Natural Supplements: An evidence-based guide. 3rd Ed. Sydney; Elsevier, 2010:pp794-801.\u003c\/p\u003e\n\u003cp\u003e51 Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb1-induced teratogenicity using a whole rat embryo culture model. Hum Reprod. 2003 Oct;18(10):2166-8.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T14:10:49+11:00","created_at":"2017-06-26T16:24:14+10:00","vendor":"Metagenics","type":"Metagenics Naturopathic Medicines","tags":["Dairy protein free","Fatigue","Free from Nuts and Seeds","Free from Soy protein","Gluten free","Lactose free","Metagenics","Naturopathic","PB","Stress-Anxiety-Mood"],"price":4856,"price_min":4856,"price_max":4856,"available":true,"price_varies":false,"compare_at_price":5395,"compare_at_price_min":5395,"compare_at_price_max":5395,"compare_at_price_varies":false,"variants":[{"id":33229316427,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"AdrenoTone60T","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Metagenics AdrenoTone 60 tablets","public_title":null,"options":["Default Title"],"price":4856,"weight":252,"compare_at_price":5395,"inventory_quantity":9937,"inventory_management":"shopify","inventory_policy":"continue","barcode":"9315771004562","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-110_offRRPatHealthMasters.jpg?v=1621858092","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-210_offRRPatHealthMasters.jpg?v=1621858139","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-310_offRRPatHealthMasters.jpg?v=1621858177","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_AdrenoTone_60_tabs_10_off_RRP_-_HealthMasters.jpg?v=1596756912"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-110_offRRPatHealthMasters.jpg?v=1621858092","options":["Title"],"media":[{"alt":"Metagenics AdrenoTone 60 Tabs 10% off RRP | HealthMasters Metagenics","id":9591997333662,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-110_offRRPatHealthMasters.jpg?v=1621858092"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-110_offRRPatHealthMasters.jpg?v=1621858092","width":1200},{"alt":"Metagenics AdrenoTone 60 Tabs 10% off RRP | HealthMasters Metagenics Ingredients","id":9591997300894,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-210_offRRPatHealthMasters.jpg?v=1621858139"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-210_offRRPatHealthMasters.jpg?v=1621858139","width":1200},{"alt":"Metagenics AdrenoTone 60 Tabs 10% off RRP | HealthMasters Metagenics Ingredients","id":9592034033822,"position":3,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-310_offRRPatHealthMasters.jpg?v=1621858177"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsAdrenoTone60Tablets-310_offRRPatHealthMasters.jpg?v=1621858177","width":1200},{"alt":"Metagenics AdrenoTone 60 tabs | HealthMasters","id":2843691221051,"position":4,"preview_image":{"aspect_ratio":1.0,"height":500,"width":500,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_AdrenoTone_60_tabs_10_off_RRP_-_HealthMasters.jpg?v=1596756912"},"aspect_ratio":1.0,"height":500,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_AdrenoTone_60_tabs_10_off_RRP_-_HealthMasters.jpg?v=1596756912","width":500}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch3\u003e\u003cem\u003eFor Stress Management And Adrenal Support\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics AdrenoTone 60 tablets\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e Size:\u003c\/strong\u003e 60 tablets (20 days)\u003c\/p\u003e\n\u003cp\u003eMetagenics AdrenoTone For Stress Management and Adrenal Support:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMetagenics AdrenoTone contains herbs that may be of benefit during times of stress, according to traditional and scientific evidence.\u003c\/li\u003e\n\u003cli\u003eRhodiola has been shown to reduce physical and mental fatigue caused by stress.\u003c\/li\u003e\n\u003cli\u003eThe herbs in Metagenics AdrenoTone are used to support the nervous system, and for their tonic effect on adrenal function in traditional Ayurvedic and Western herbal medicine.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics AdrenoTone is free from dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein. Metagenics AdrenoTone is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003cp\u003eMetagenics AdrenoTone AUST L158604\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eProduct Summary\u003c\/h5\u003e\n\u003ch2\u003eProduct Summary: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003eHerbs in Metagenics AdrenoTone have been clinically shown to or traditionally used to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupport patients feeling flat and exhausted.\u003csup style=\"box-sizing: border-box; position: relative; font-size: 11.25px; line-height: 0; vertical-align: baseline; top: -0.5em;\"\u003e1\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eReduce stress-induced physical and mental fatigue.\u003csup style=\"box-sizing: border-box; position: relative; font-size: 11.25px; line-height: 0; vertical-align: baseline; top: -0.5em;\"\u003e2\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupport adrenal and nervous exhaustion.\u003csup style=\"box-sizing: border-box; position: relative; font-size: 11.25px; line-height: 0; vertical-align: baseline; top: -0.5em;\"\u003e3,4\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdults:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTake 1 tablet three times daily with food.\u003c\/p\u003e\n\u003cp\u003eOr as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWithania has been shown to reduce plasma cortisol levels\u003c\/strong\u003e via its effects on the adrenal glands, potentially protecting against the negative effects of elevated cortisol levels in chronic stress.\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSiberian ginseng assists in the management of stress\u003c\/strong\u003e by altering the levels of hormones involved in the stress response and HPA axis.\u003csup\u003e6 \u003c\/sup\u003eAs a result, catecholamine levels are preserved and the release of excess catecholamines is reduced.\u003csup\u003e7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRhodiola has been shown to improve mental performance in physically stressed and fatigued individuals.\u003c\/strong\u003e\u003csup\u003e8\u003c\/sup\u003e A double blind, cross-over study examined the effects of rhodiola on fatigue during night shift.\u003csup\u003e9\u003c\/sup\u003e The study observed levels of mental fatigue, involving complex perceptive and cognitive cerebral functions.\u003csup\u003e10 \u003c\/sup\u003eSignificant improvements were noted in all treatment groups within just two weeks (Figure One).\u003csup\u003e11, 12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach tablet contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eExtracts equivalent to:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWithania somnifera, root dry (Ashwagandha)\u003c\/td\u003e\n\u003ctd\u003e3.8g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEleutherococcus senticosus, root dry (Siberian ginseng)\u003c\/td\u003e\n\u003ctd\u003e2.8g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlycyrrhiza glabra, root dry (Liquorice)\u003c\/td\u003e\n\u003ctd\u003e1.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRhodiola rosea, root dry (Rhodiola)\u003c\/td\u003e\n\u003ctd\u003e1.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanax ginseng, root dry (Korean ginseng)\u003c\/td\u003e\n\u003ctd\u003e281.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTyrosine\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eMetagenics AdrenoTone is free from dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein. Metagenics AdrenoTone is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003ch5\u003eCautions\/Contraindications\u003c\/h5\u003e\n\u003ch2\u003eCautions\/Contraindications: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBipolar depression\u003c\/strong\u003e (rhodiola).39\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCongestive heart failure\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSevere renal insufficiency\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypokalaemia\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypertonia:\u003c\/strong\u003e Mineralocorticoid effects of liquorice can cause hypokalaemia, which can worsen hypertonia.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatic cirrhosis\u003c\/strong\u003e (liquorice)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholestatic liver disease\u003c\/strong\u003e (liquorice)41\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eTraditional contraindications:\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- Siberian ginseng – in acute infection or fever.4\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- Panax ginseng – in fever, excessive menstruation, nose bleeds, acute infections, and acute asthma.11\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eCAUTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eAnticoagulant\/antiplatelet drugs:\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- \u003cstrong\u003eWarfarin\u003c\/strong\u003e - Liquorice seems to increase metabolism and decrease levels of warfarin in animal models.40 Avoid, or use with medical supervision.\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- Uncertainty exists about whether Panax ginseng may decrease platelet aggregation or have effects on warfarin metabolism.42\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- A constituent of Siberian ginseng may inhibit platelet aggregation.43\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntidiabetes drugs:\u003c\/strong\u003e Korean ginseng42 and Siberian ginseng43 may theoretically lower blood glucose. Monitor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCorticosteroids:\u003c\/strong\u003e Theoretically, liquorice may potentiate the effects. Monitor.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigoxin:\u003c\/strong\u003e Potential toxicity with high dose liquorice. Caution.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiuretics:\u003c\/strong\u003e Potential increased risk for hypokalaemia with liquorice. Monitor.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypertension:\u003c\/strong\u003e Monitor blood pressure when taking high dose liquorice for greater than 2 weeks.44\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHyperthyroidism:\u003c\/strong\u003e Withania may enhance T4. Monitor.45 Tyrosine is a precursor to thyroid hormone and may increase levels. Monitor.47\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunosuppressants:\u003c\/strong\u003e Theoretically, withania46 and Korean ginseng42 may reduce the effectiveness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLevodopa:\u003c\/strong\u003e Tyrosine may theoretically decrease the effectiveness through competition for absorption. Separate doses by 2 hours.47\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonoamine oxidase inhibitors (MAOIs):\u003c\/strong\u003e Theoretically, ginsengs may interfere with MAOI therapy. There is one case report of insomnia, headache and tremors, and a second case report of hypomania, with concomitant phenelzine and unspecified ginseng use.11\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrogens:\u003c\/strong\u003e Liquorice may interfere with oestrogen therapy due to oestrogenic and anti-oestrogenic effects.40\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrogen-sensitive cancers or conditions:\u003c\/strong\u003e Because of the potential oestrogenic effects of liquorice and Korean\/Siberian ginsengs, women with hormone sensitive conditions, such as breast cancer, uterine cancer, ovarian cancer, endometriosis, and uterine fibroids, should avoid.40,42,43\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptic ulcer disease:\u003c\/strong\u003e Withania may cause gastric irritation. Monitor.46\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSedatives:\u003c\/strong\u003e Withania46 and Siberian ginseng43 may have theoretical additive effects. Monitor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSensitivity to solanaceae family:\u003c\/strong\u003e (Withania) caution.48\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStimulants:\u003c\/strong\u003e Avoid concurrent use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroxine:\u003c\/strong\u003e Withania may enhance T4. Monitor.49 Tyrosine is a precursor to thyroid hormone and may increase levels. Monitor.47\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eDrugs metabolised by the following cytochrome enzymes:\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\n\u003cstrong\u003e- CYP2D6:\u003c\/strong\u003e Panax ginseng may inhibit activity of these enzymes, although evidence is conflicting. Theoretical risk of unknown clinical significance. Monitor.42\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\n\u003cstrong\u003e- CYP2B6, CYP2C9, CYP3A4:\u003c\/strong\u003e Conflicting evidence exists for the effects of liquorice on these enzymes. Caution if using medications metabolised by these enzymes.40\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e\n\u003cstrong\u003e- CYP1A2, CYP2C9, CYP2D6, CYP3A4:\u003c\/strong\u003e In vitro and animal data suggest Siberian ginseng may inhibit these enzymes, although there is no evidence of effects in humans.43\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery\u003c\/strong\u003e: Suspend use 1 week prior to major surgery.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePREGNANCY AND LACTATION:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy\u003c\/strong\u003e: Not safe. Rhodiola in contraindicated in pregnancy.50 Ginsenoside Rb1 has a significant effect on the morphogenesis of rat embryos. Exposure to ginsenoside Rb1 at very high concentrations (\u0026gt;30 mg\/ml) resulted in a significant reduction of total morphological score and scores for some individual features. The importance of this concentration in human pregnancies is uncertain. Before more information in humans becomes available, use of ginseng during pregnancy should be with caution.51\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLactation\u003c\/strong\u003e: Likely safe.\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003eStore below 30° C\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics AdrenoTone\u003c\/h2\u003e\n\u003cp\u003e1 Pole S. Ayurvedic Medicine: The Principles of Traditional Practice. Philadelphia; Elsevier, Churchill Livingstone, 2006: pp133-4.\u003c\/p\u003e\n\u003cp\u003e2 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri; Churchill Livingstone, 2005: pp 631-4.\u003c\/p\u003e\n\u003cp\u003e3 Bone K. Clinical Applications of Ayurvedic and Chinese Herbs. Monographs for the Western Herbal Practitioner. Warwick;  Phytotherapy Press, 1996: pp137-41.\u003c\/p\u003e\n\u003cp\u003e4 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri; Churchill Livingstone, 2005: pp 578-80.\u003c\/p\u003e\n\u003cp\u003e5 Mills S, Bone K. Principles and Practice of Phytotherapy. Modern Herbal Medicine. Edinburgh; Churchill Livingstone, 2000: pp534-41.\u003c\/p\u003e\n\u003cp\u003e6 Gruenwald J, Brendler T, Jaenicke C (Eds). PDR for Herbal Medicines. 4th Ed. Montvale, NJ; Thomson, 2004: pp703-5.\u003c\/p\u003e\n\u003cp\u003e7 Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001 Jun;6(3):293-302.\u003c\/p\u003e\n\u003cp\u003e8 Rhodiola rosea. 2003. http:\/\/www.plant-identification.co.uk\/skye\/crassulaceae\/rhodiola-rosea.htm (date accessed: Dec 23, 2008)\u003c\/p\u003e\n\u003cp\u003e9 Pole S. Ayurvedic Medicine: The Principles of Traditional Practice. Philadelphia; Elsevier, Churchill Livingstone, 2006: pp220-1.\u003c\/p\u003e\n\u003cp\u003e10 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri, Churchill Livingstone, 2005: pp498-502.\u003c\/p\u003e\n\u003cp\u003e11 Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis, Missouri; Churchill Livingstone, 2005: pp 433-6.\u003c\/p\u003e\n\u003cp\u003e12 Mills S, Bone K. Principles and Practice of Phytotherapy. Modern Herbal Medicine. Edinburgh; Churchill Livingstone, 2000: pp418-31.\u003c\/p\u003e\n\u003cp\u003e13 Bensky D, Clavey S, Stöger E, Gamble A. Chinese Herbal Medicine Materia Medica. 3rd edition. Seattle, Washington; Eastland Press, 2004: pp701-4.\u003c\/p\u003e\n\u003cp\u003e14 Rai D, Bhatia G, Sen T, Palit G. Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study. J Pharmacol Sci 2003 Dec;93(4):458-64.\u003c\/p\u003e\n\u003cp\u003e15 Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav 2003;75(3):547-55.\u003c\/p\u003e\n\u003cp\u003e16 Kumar A, Kalonia H. Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method). Indian J Exp Biol 2007;45(6):524-8.\u003c\/p\u003e\n\u003cp\u003e17 Sankar SR, Manivasagam T, Krishnamurti A, Ramanathan M. The neuroprotective effect of Withania somnifera root extract in MPTPintoxicated mice: An analysis of behavioral and biochemical variables. Cell Mol Biol Lett 2007;12(4):473-81.\u003c\/p\u003e\n\u003cp\u003e18 Bhatnagar M, Sisodia SS, Bhatnagar R. Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats. Ann N Y Acad Sci 2005;1056:261-78.\u003c\/p\u003e\n\u003cp\u003e19 Lee SH, Jung BH, Kim SY, Lee EH, Chung BC. The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress. Pharmacol Res 2006;54(1):46-9.\u003c\/p\u003e\n\u003cp\u003e20 Mattioli L, Funari C, Perfumi M. Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. J Psychopharmacol. 2008 May 30. [Epub ahead of print]\u003c\/p\u003e\n\u003cp\u003e21 Mattioli L, Perfumi M. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J Psychopharmacol. 2007 Sep;21(7):742-50.\u003c\/p\u003e\n\u003cp\u003e22 Reay JL, Kennedy DO, Scholey AB. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol 2006;20(6):771-81.\u003c\/p\u003e\n\u003cp\u003e23 Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 2005;19(4):357-65.\u003c\/p\u003e\n\u003cp\u003e24 Banerjee U, Izquierdo JA. Antistress and antifatigue properties of Panax ginseng: comparison with piracetam. Acta Physiol Lat Am 1982;32(4):277-85.\u003c\/p\u003e\n\u003cp\u003e25 Hartz AJ, Bentler S, Noyes R, Hoehns J, Logemann C, Sinift S, Butani Y, Wang W, Brake K, Ernst M, Kautzman H. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34(1):51-61.\u003c\/p\u003e\n\u003cp\u003e26 Kimura Y, Sumiyoshi M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J Ethnopharmacol 2004;95(2-3):447-53.\u003c\/p\u003e\n\u003cp\u003e27 Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999;64(1):91-3.\u003c\/p\u003e\n\u003cp\u003e28 Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacological investigation of Ashwagandha and Ginseng. J Ethnopharmacol 1994;44(3):131-5.\u003c\/p\u003e\n\u003cp\u003e29 Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000;7(2):85-9.\u003c\/p\u003e\n\u003cp\u003e30 Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7(5):365-71.\u003c\/p\u003e\n\u003cp\u003e31 Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull. 1989 Apr;22(4):759-62.\u003c\/p\u003e\n\u003cp\u003e32 Deijen JB, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. 1994;33(3):319-23.\u003c\/p\u003e\n\u003cp\u003e33 Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999 Jan 15;48(2):203-9.\u003c\/p\u003e\n\u003cp\u003e34 Lee YJ, Chung E, Lee KY, Lee YH, Huh B, Lee SK. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol Cell Endocrinol 1997;133(2):135-40.\u003c\/p\u003e\n\u003cp\u003e35 Kim DH, Moon YS, Jung JS, Min SK, Son BK, Suh HW, Song DK. Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice. Neurosci Lett. 2003 May 29;343(1):62-6.\u003c\/p\u003e\n\u003cp\u003e36 Tachikawa E, Kudo K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: suppression of adrenal medullary function in vitro by ginseng. J Pharmacol Sci 2004;95(2):140-4.\u003c\/p\u003e\n\u003cp\u003e37 Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343-8.\u003c\/p\u003e\n\u003cp\u003e38 Panossian A, Nikoyan N, Ohanyan N, Hovhannisyan A, Abrahamyan H, Gabrielyan E, Wikman G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008 Jan;15(1-2):84-91.\u003c\/p\u003e\n\u003cp\u003e39 Braun L and Cohen M. Herbs and Natural Supplements: An evidence-based guide. 3rd Ed. Sydney; Elsevier, 2010:pp794-801.\u003c\/p\u003e\n\u003cp\u003e40 Jellin JM, Ed. Natural Medicines Comprehensive Database, Liquorice. Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=881\u0026amp;fs=ND\u0026amp;searchid=126596\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=881\u0026amp;fs=ND\u0026amp;searchid=126596\u003c\/a\u003e 67 (date accessed: Dec 24, 2008).\u003c\/p\u003e\n\u003cp\u003e41 Blumenthal M, Senior Editor. The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. Texas; American Botanical Council, 1998: pp161-2.\u003c\/p\u003e\n\u003cp\u003e42 Jellin JM, Ed. Natural Medicines Comprehensive Database; Ginseng, Panax. Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1000\u0026amp;fs=ND\u0026amp;searchid=12660\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1000\u0026amp;fs=ND\u0026amp;searchid=12660\u003c\/a\u003e 107 (date accessed: Dec 24, 2008).\u003c\/p\u003e\n\u003cp\u003e43 Jellin JM, Ed. Natural Medicines Comprehensive Database; Ginseng, Siberian. 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Therapeutic Research Faculty 2008; [webpage] \u003ca href=\"http:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1037\u0026amp;fs=ND\u0026amp;searchid=12660\"\u003ehttp:\/\/www.naturaldatabase.com\/(S(iahu0c45lsflzf55fayeaeb2))\/nd\/Search.aspx?cs=\u0026amp;s=ND\u0026amp;pt=100\u0026amp;id=1037\u0026amp;fs=ND\u0026amp;searchid=12660\u003c\/a\u003e 670 (date accessed: Dec 24, 2008)\u003c\/p\u003e\n\u003cp\u003e48 Braun L and Cohen M. Herbs and Natural Supplements: An evidence-based guide. 2nd Ed. Sydney; Elsevier, 2007:pp696-700.\u003c\/p\u003e\n\u003cp\u003e49 Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67(2):233-9.\u003c\/p\u003e\n\u003cp\u003e50 Braun L and Cohen M. Herbs and Natural Supplements: An evidence-based guide. 3rd Ed. Sydney; Elsevier, 2010:pp794-801.\u003c\/p\u003e\n\u003cp\u003e51 Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb1-induced teratogenicity using a whole rat embryo culture model. Hum Reprod. 2003 Oct;18(10):2166-8.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}