{"id":8061484728550,"title":"Designs For Health NR Supreme","handle":"designs-for-health-nr-supreme","description":"\u003ch2\u003eDesigns For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003e100% \u003cspan data-mce-fragment=\"1\"\u003eNicotinamide riboside\u003c\/span\u003e\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eAssists with NAD+ production and enhances NAD+ levels in the body\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 30 Vegetarian Capsules   Servings Per Pack: 30 serves\u003c\/p\u003e\n\u003cp\u003eDesigns For Health NR Supreme Summary:\u003c\/p\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e100% Nicotinamide Riboside Chloride\u003c\/li\u003e\n\u003cli\u003eContains 300 mg Nicotinamide Riboside Chloride per capsule\u003c\/li\u003e\n\u003cli\u003eAssists with NAD+ Production\u003c\/li\u003e\n\u003cli\u003eEnhances NAD+ levels in the body\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health NR Supreme AUST L 394330\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e \u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioactiv-healthcare-10-off-rrp\/products\/bioactiv-healthcare-nmn\" title=\"BioActiv HealthCare NMN 10% off RRP | HealthMasters BioActiv HealthCare\" target=\"_blank\"\u003eBioActiv HealthCare NMN\u003c\/a\u003e\u003c\/span\u003e - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"Designs For Health NR Supreme 10% off RRP | HealthMasters Designs For Health\" target=\"_blank\"\u003eDesigns For Health NR Supreme\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"RN Labs Nicotinamide Riboside NR 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs Nicotinamide Riboside NR\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNote:\u003c\/p\u003e\n\u003cp\u003eIn the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eAdults: Take one capsule daily\u003c\/p\u003e\n\u003cp\u003eor as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases NAD+ status and replenishes the body’s NAD+ pool\u003c\/li\u003e\n\u003cli\u003eProvides nutritional support for NAD+ replenishment which can:\u003c\/li\u003e\n\u003cul\u003e\n\u003cli\u003eSupport energy production\u003c\/li\u003e\n\u003cli\u003eSupport healthy aging\u003c\/li\u003e\n\u003cli\u003eProvide antioxidant support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients (per vegetarian hard capsule) \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide Riboside Chloride\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. ribose\u003c\/td\u003e\n\u003ctd\u003e154.8mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eHydrated silica, Hypromellose, Purified water\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNo Added: Soy, Dairy, Nuts, Eggs, Yeast, Sesame.\u003c\/p\u003e\n\u003cp\u003eFree From: Colours, Flavours, Benzoates, Sulfites, Sorbates.\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNot to be taken by children under 12 years old.\u003c\/p\u003e\n\u003cp\u003eNot recommended for use during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eContains ribose which is a sugar.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eNicotinamide (NAM) is required for the synthesis of NAD+, an essential coenzyme involved in several metabolic pathways. In fact, an estimated 200 enzymes – including dehydrogenases – require NAD and NADP as coenzymes. As an electron carrier, NAD+ is necessary for oxidative reactions that occur in the cytosol and mitochondria. Due to its capacity to extract energy from substrates, NAD+ is fundamental to cellular health. NAD+ is also required for carbohydrate oxidation during adenosine triphosphate (ATP) production.\u003c\/p\u003e\n\u003ch3\u003ePharmacokinetics\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAbsorption:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNicotinamide is absorbed predominantly in the small intestine via facilitated diffusion. Once in the bloodstream, nicotinamide moves across cell membranes via passive diffusion.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMetabolism to NAD+:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNR acts as a precursor in producing NAD+ via two pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe NRK1\/2 Pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR is phosphorylated to nicotinamide mononucleotide (NMN) by the enzyme NR kinase Nrk1. The resulting MNM is then converted to NAD+ by NMN adenylyltransferase.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe salvage pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR, Nicotinic acid (NA) or NAM is converted to NMN under the influence of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NMN is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT aka NMN transferase).\u003c\/p\u003e\n\u003cp\u003eNR has the ability to maintain intracellular levels of NAD+ in the body.4 In the first human clinical trial conducted with NR, results found that blood NAD+ levels can increase up to 2.7 fold with a single oral dose of NR.\u003c\/p\u003e\n\u003cp\u003eA randomised, double-blind, placebo-controlled trial consisting of 113 people receiving NR in combination with pterostilbene (NRPT) found that the group receiving NRPT at 250mg per day had significantly increased NAD+ levels to 40% over baseline.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eElimination:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe enzyme glycohydrolase transforms NAD into adenosine diphosphate-ribose and nicotinamide. The resulting nicotinamide is then released from cells for processing by the liver. Nicotinamide undergoes methylation and oxidation in the liver – its metabolites are then excreted in the urine. Much of the free nicotinamide is reabsorbed into the body via glomerular filtrate \u003c\/p\u003e\n\u003cp\u003e\u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 1 The Salvage Pathway\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: The salvage pathway\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eIn the salvage pathway, the precursors are converted into an intermediate called nicotinamide mononucleotide (NMN) through nicotinamide phosphoribosyltransferase (NAMPT). Then NMN is converted into NAD+ via nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD+ generated by this pathway is consumed by multiple enzymes including sirtuins, PARPs, and cADPR synthases.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure2TheNRK1-2Pathway_600x600.png?v=1674101380\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 2 The NRK1-2 Pathway\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: The NRK1\/2 Pathway.4\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eNRK 1\/2 mediated NAD+ biosynthesis pathway. Nicotinamide riboside (NR) is metabolised by nicotinamide riboside kinase (NRK 1\/2) to nicotinamide mononucleotide (NMN) and subsequently converted to NAD+ by NMN-adenylyltransferase (NMNAT) activity).\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2023-01-18T18:26:46+11:00","created_at":"2022-11-19T14:51:54+11:00","vendor":"Designs For Health","type":"Designs For Health Naturopathic Medicines","tags":["Designs For Health","Naturopathic","Nicotinamide riboside","PB"],"price":3776,"price_min":3776,"price_max":3776,"available":true,"price_varies":false,"compare_at_price":4195,"compare_at_price_min":4195,"compare_at_price_max":4195,"compare_at_price_varies":false,"variants":[{"id":43539694026982,"title":"30 capsules","option1":"30 capsules","option2":null,"option3":null,"sku":"DFHNRSupreme30C","requires_shipping":true,"taxable":true,"featured_image":{"id":39097033064678,"product_id":8061484728550,"position":1,"created_at":"2023-01-18T18:14:53+11:00","updated_at":"2023-01-18T18:15:34+11:00","alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","variant_ids":[43539694026982]},"available":true,"name":"Designs For Health NR Supreme - 30 capsules","public_title":"30 capsules","options":["30 capsules"],"price":3776,"weight":0,"compare_at_price":4195,"inventory_quantity":19997,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9353993000580","featured_media":{"alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health","id":31690153722086,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthLogo_81184dda-d8aa-4287-b79d-4506562caafe.jpg?v=1674026099"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","options":["Size"],"media":[{"alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health","id":31690153722086,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","width":1200},{"alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Logo","id":31344425337062,"position":2,"preview_image":{"aspect_ratio":2.5,"height":142,"width":355,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthLogo_81184dda-d8aa-4287-b79d-4506562caafe.jpg?v=1674026099"},"aspect_ratio":2.5,"height":142,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthLogo_81184dda-d8aa-4287-b79d-4506562caafe.jpg?v=1674026099","width":355}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eDesigns For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003e100% \u003cspan data-mce-fragment=\"1\"\u003eNicotinamide riboside\u003c\/span\u003e\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eAssists with NAD+ production and enhances NAD+ levels in the body\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 30 Vegetarian Capsules   Servings Per Pack: 30 serves\u003c\/p\u003e\n\u003cp\u003eDesigns For Health NR Supreme Summary:\u003c\/p\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e100% Nicotinamide Riboside Chloride\u003c\/li\u003e\n\u003cli\u003eContains 300 mg Nicotinamide Riboside Chloride per capsule\u003c\/li\u003e\n\u003cli\u003eAssists with NAD+ Production\u003c\/li\u003e\n\u003cli\u003eEnhances NAD+ levels in the body\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health NR Supreme AUST L 394330\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e \u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioactiv-healthcare-10-off-rrp\/products\/bioactiv-healthcare-nmn\" title=\"BioActiv HealthCare NMN 10% off RRP | HealthMasters BioActiv HealthCare\" target=\"_blank\"\u003eBioActiv HealthCare NMN\u003c\/a\u003e\u003c\/span\u003e - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"Designs For Health NR Supreme 10% off RRP | HealthMasters Designs For Health\" target=\"_blank\"\u003eDesigns For Health NR Supreme\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"RN Labs Nicotinamide Riboside NR 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs Nicotinamide Riboside NR\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNote:\u003c\/p\u003e\n\u003cp\u003eIn the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eAdults: Take one capsule daily\u003c\/p\u003e\n\u003cp\u003eor as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases NAD+ status and replenishes the body’s NAD+ pool\u003c\/li\u003e\n\u003cli\u003eProvides nutritional support for NAD+ replenishment which can:\u003c\/li\u003e\n\u003cul\u003e\n\u003cli\u003eSupport energy production\u003c\/li\u003e\n\u003cli\u003eSupport healthy aging\u003c\/li\u003e\n\u003cli\u003eProvide antioxidant support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients (per vegetarian hard capsule) \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide Riboside Chloride\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. ribose\u003c\/td\u003e\n\u003ctd\u003e154.8mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eHydrated silica, Hypromellose, Purified water\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNo Added: Soy, Dairy, Nuts, Eggs, Yeast, Sesame.\u003c\/p\u003e\n\u003cp\u003eFree From: Colours, Flavours, Benzoates, Sulfites, Sorbates.\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNot to be taken by children under 12 years old.\u003c\/p\u003e\n\u003cp\u003eNot recommended for use during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eContains ribose which is a sugar.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eNicotinamide (NAM) is required for the synthesis of NAD+, an essential coenzyme involved in several metabolic pathways. In fact, an estimated 200 enzymes – including dehydrogenases – require NAD and NADP as coenzymes. As an electron carrier, NAD+ is necessary for oxidative reactions that occur in the cytosol and mitochondria. Due to its capacity to extract energy from substrates, NAD+ is fundamental to cellular health. NAD+ is also required for carbohydrate oxidation during adenosine triphosphate (ATP) production.\u003c\/p\u003e\n\u003ch3\u003ePharmacokinetics\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAbsorption:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNicotinamide is absorbed predominantly in the small intestine via facilitated diffusion. Once in the bloodstream, nicotinamide moves across cell membranes via passive diffusion.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMetabolism to NAD+:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNR acts as a precursor in producing NAD+ via two pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe NRK1\/2 Pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR is phosphorylated to nicotinamide mononucleotide (NMN) by the enzyme NR kinase Nrk1. The resulting MNM is then converted to NAD+ by NMN adenylyltransferase.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe salvage pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR, Nicotinic acid (NA) or NAM is converted to NMN under the influence of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NMN is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT aka NMN transferase).\u003c\/p\u003e\n\u003cp\u003eNR has the ability to maintain intracellular levels of NAD+ in the body.4 In the first human clinical trial conducted with NR, results found that blood NAD+ levels can increase up to 2.7 fold with a single oral dose of NR.\u003c\/p\u003e\n\u003cp\u003eA randomised, double-blind, placebo-controlled trial consisting of 113 people receiving NR in combination with pterostilbene (NRPT) found that the group receiving NRPT at 250mg per day had significantly increased NAD+ levels to 40% over baseline.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eElimination:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe enzyme glycohydrolase transforms NAD into adenosine diphosphate-ribose and nicotinamide. The resulting nicotinamide is then released from cells for processing by the liver. Nicotinamide undergoes methylation and oxidation in the liver – its metabolites are then excreted in the urine. Much of the free nicotinamide is reabsorbed into the body via glomerular filtrate \u003c\/p\u003e\n\u003cp\u003e\u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 1 The Salvage Pathway\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: The salvage pathway\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eIn the salvage pathway, the precursors are converted into an intermediate called nicotinamide mononucleotide (NMN) through nicotinamide phosphoribosyltransferase (NAMPT). Then NMN is converted into NAD+ via nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD+ generated by this pathway is consumed by multiple enzymes including sirtuins, PARPs, and cADPR synthases.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure2TheNRK1-2Pathway_600x600.png?v=1674101380\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 2 The NRK1-2 Pathway\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: The NRK1\/2 Pathway.4\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eNRK 1\/2 mediated NAD+ biosynthesis pathway. Nicotinamide riboside (NR) is metabolised by nicotinamide riboside kinase (NRK 1\/2) to nicotinamide mononucleotide (NMN) and subsequently converted to NAD+ by NMN-adenylyltransferase (NMNAT) activity).\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c!-- \/TABS --\u003e"}