{"id":8061412114662,"title":"RN Labs Nicotinamide Riboside NR","handle":"rn-labs-nicotinamide-riboside-nr","description":"\u003ch2\u003eRN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eNicotinamide Riboside 300mg\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60 Capsules\u003c\/p\u003e\n\u003cp\u003eRN Labs Nicotinamide Riboside NR AUST L 395455\u003c\/p\u003e\n\u003cp\u003eRN Labs Nicotinamide Riboside NR is part of the RN Labs Range of Practitioner Brand quality naturopathic medicines available for patients under the care of a practitioner.\u003c\/p\u003e\n\u003cp\u003eRN Labs was formerly named Research Nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eTo access RN Labs Nicotinamide Riboside NR select the \u003ca href=\"#how-to-access\" title=\"How To Access RN Labs Naturopathic Medicines 10% off RRP | HealthMasters RN Labs\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eHow To Access tab\u003c\/span\u003e\u003c\/a\u003e for more information.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e \u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioactiv-healthcare-10-off-rrp\/products\/bioactiv-healthcare-nmn\" title=\"BioActiv HealthCare NMN 10% off RRP | HealthMasters BioActiv HealthCare\" target=\"_blank\"\u003eBioActiv HealthCare NMN\u003c\/a\u003e\u003c\/span\u003e - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"Designs For Health NR Supreme 10% off RRP | HealthMasters Designs For Health\" target=\"_blank\"\u003eDesigns For Health NR Supreme\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"RN Labs Nicotinamide Riboside NR 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs Nicotinamide Riboside NR\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNote:\u003c\/p\u003e\n\u003cp\u003eIn the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\n\u003ch2\u003eSummary: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRN Labs Nicotinamide Riboside delivers a highly bioavailable, well tolerated, non-flushing form of Vitamin B3, that serves as an active precursor to NAD+ in the body.\u003c\/li\u003e\n\u003cli\u003eNicotinamide Riboside has been shown to support numerous metabolic pathways including energy production, cognition, cardiovascular health, and more.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports systemic NAD+ metabolism\u003c\/li\u003e\n\u003cli\u003eWell tolerated at high doses\u003c\/li\u003e\n\u003cli\u003eEnhanced bioavailability\u003c\/li\u003e\n\u003cli\u003eReduces inflammatory cytokines\u003c\/li\u003e\n\u003cli\u003eEncourages healthy cognitive and neuromuscular function\u003c\/li\u003e\n\u003cli\u003eSupports cardiovascular and arterial health\u003c\/li\u003e\n\u003cli\u003eMay support healthy ageing\u003c\/li\u003e\n\u003cli\u003eMay support energy production\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eResearch highlights\u003c\/h5\u003e\n\u003ch2\u003eResearch Highlights: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003ch3\u003eENHANCED TOLERANCE AND BIOAVAILABILITY\u003c\/h3\u003e\n\u003cp\u003eMultiple human and animal studies have confirmed the safety and effective use of Nicotinamide Riboside (NR) at high doses for extended periods of time, with minimal side effects. Conze et al (2019) demonstrated the use of NR at 100mg, 300mg, and 1000mg daily for 8 weeks in both men and women.\u003c\/p\u003e\n\u003cp\u003eNo adverse effects were reported during the trial including no incidence of flushing, no elevation of LDL cholesterol, nor any disturbances to methylation metabolism. Another study used two 250mg capsules, twice daily (total of 1000mg\/day) for 21 days in a group of elderly men (median age 75 years), with no adverse effects reported.\u003c\/p\u003e\n\u003ch3\u003eIMPROVED BODY COMPOSITION\u003c\/h3\u003e\n\u003cp\u003eMany animal studies show promising evidence to support the use of NR in ameliorating metabolic disease and optimising body composition.\u003c\/p\u003e\n\u003cp\u003eOne human trial conducted by Remie et al (2020) used NR 1000mg\/day for 6 weeks in overweight but otherwise healthy men. At completion, there was a significant increase in NAD+ metabolites followed by increased acetylcarnitine metabolites. This resulted in favourable changes in body composition (1.33% reduction in body fat mass in 6 weeks, with an equal improvement in lean mass) and sleeping metabolic rate, even without exercise.\u003c\/p\u003e\n\u003ch3\u003eIMPROVED COGNITIVE \/ NEUROMUSCULAR FUNCTION\u003c\/h3\u003e\n\u003cp\u003eNeurodegenerative diseases are associated with oxidative stress leading to DNA damage, often associated with ageing.\u003c\/p\u003e\n\u003cp\u003eThe development of Alzheimer’s and Parkinson’s Disease (PD) as well as Amyotrophic Lateral Sclerosis (ALS) and in some instances Autism Spectrum Disorder (ASD) are also correlated with NAD+ depletion and neuroinflammation. NR has been shown to increase NAD+ levels in brain tissue resulting in improved cognition, reduced inflammation in serum and cerebrospinal fluid (CSF) and therefore a reduction in symptoms and progression of cognitive and neuromuscular diseases.\u003c\/p\u003e\n\u003cp\u003eOne study involved twenty-four patients with Ataxia Telangiectasia (AT) who were given NR dosed at 24mg\/kg body weight for four months. Scores for both the Scale for the Assessment and Rating of Ataxia (SARA) and International Cooperative Ataxia Rating Scale (ICARS) improved during the trial period and showed a decline once NR treatment was discontinued indicating a transient improvement in symptoms.\u003c\/p\u003e\n\u003cp\u003eAnother study by Brakedal et al (2022) saw a variable yet significant increase in cerebral NAD levels (90%) in patients recently diagnosed with Parkinsons Diseases (PD). Patients were given 1000mg NR per day or placebo for 30 days. The NR treatment group also had increased expression of genes related to mitochondrial energy production, lysosomal, and proteasomal antioxidant function in blood and muscle and decreased the levels of inflammatory cytokines.\u003c\/p\u003e\n\u003ch3\u003eCARDIOVASCULAR HEALTH\u003c\/h3\u003e\n\u003cp\u003eIn a randomised, placebo-controlled, cross-over trial patients were treated with 500mg twice daily for 6 weeks. Results revealed a reduction in carotid-femoral pulse wave velocity and an average of 10mmHg reduction in mildly elevated systolic blood pressure. Therefore, indicating a potential therapeutic use for NR in the prevention of aortic stiffness and its potential for comorbidities associated with cardiovascular disease. The mechanism of action is believed to be via activation of Sirtuin 1 (SIRT-1) pathway as a result of increased NAD+.\u003c\/p\u003e\n\u003cp\u003e \u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"RN Labs Nicotinamide Riboside NR 10% off RRP at HealthMasters RN Labs Figure 1\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabsFigure1_600x600.png?v=1668827218\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabsFigure1_600x600.png?v=1668827218\"\u003e\u003c\/p\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eTake 1 capsule daily, or as prescribed by a healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Vegetarian Capsule Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide Riboside Chloride\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Ribose\u003c\/td\u003e\n\u003ctd\u003e155mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eLeucine, Hypromellose (Capsule), Microcrystalline Celluose, Colloidal Anhydrous Silica.\u003c\/p\u003e\n\u003ch5\u003eAllergen Advice\u003c\/h5\u003e\n\u003ch2\u003eAllergen Advice: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eSuitable for vegans.\u003c\/p\u003e\n\u003cp\u003eThis product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours.\u003c\/p\u003e\n\u003cp\u003eThis product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.\u003c\/p\u003e\n\u003ch5\u003eStatements\u003c\/h5\u003e\n\u003ch2\u003eStatements: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eFOR PRACTITIONER DISPENSING ONLY.\u003c\/p\u003e\n\u003cp\u003eSafety has not been confirmed during pregnancy \u0026amp; lactation.\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKnown Side Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGenerally well tolerated.\u003c\/p\u003e\n\u003ch5\u003eQuality \u0026amp; Purity\u003c\/h5\u003e\n\u003ch2\u003eQuality \u0026amp; Purity: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eRN Labs use only the highest grade ingredients and materials available. Research Nutrition purity standards for manufacturing and sourcing are extensively researched and verified.\u003c\/p\u003e\n\u003cp\u003eNicotinamide Ribosire NR is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.\u003c\/p\u003e\n\u003ch5\u003eThe RN Difference\u003c\/h5\u003e\n\u003ch2\u003eThe RN Difference: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/325810732\" allowfullscreen=\"\" mozallowfullscreen=\"\" webkitallowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-11-19T14:40:45+11:00","created_at":"2022-11-19T12:06:03+11:00","vendor":"RN Labs","type":"RN Labs Naturopathic Medicines","tags":["Naturopathic","Nicotinamide riboside","PB","RN Labs"],"price":6015,"price_min":6015,"price_max":6015,"available":true,"price_varies":false,"compare_at_price":6683,"compare_at_price_min":6683,"compare_at_price_max":6683,"compare_at_price_varies":false,"variants":[{"id":43539613319398,"title":"60 Capsules","option1":"60 Capsules","option2":null,"option3":null,"sku":"RNLNicotinamideRibosideNR60C","requires_shipping":true,"taxable":true,"featured_image":{"id":38754605891814,"product_id":8061412114662,"position":2,"created_at":"2022-11-19T14:08:31+11:00","updated_at":"2022-11-19T14:09:04+11:00","alt":"RN Labs Nicotinamide Riboside NR 10% off RRP at HealthMasters RN Labs","width":664,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabs.png?v=1668827344","variant_ids":[43539613319398]},"available":true,"name":"RN Labs Nicotinamide Riboside NR - 60 Capsules","public_title":"60 Capsules","options":["60 Capsules"],"price":6015,"weight":0,"compare_at_price":6683,"inventory_quantity":20001,"inventory_management":"shopify","inventory_policy":"deny","barcode":null,"featured_media":{"alt":"RN Labs Nicotinamide Riboside NR 10% off RRP at HealthMasters RN Labs","id":31344323657958,"position":2,"preview_image":{"aspect_ratio":0.553,"height":1200,"width":664,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabs.png?v=1668827344"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_44748034-94a4-479b-87d6-59cad404f907.png?v=1668819966","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabs.png?v=1668827344","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_70e357a2-3df0-4299-b2f6-b783121d45ad.jpg?v=1668827317"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_44748034-94a4-479b-87d6-59cad404f907.png?v=1668819966","options":["Size"],"media":[{"alt":"RN Labs Nicotinamide Riboside NR 10% off RRP at HealthMasters RN Labs Logo2","id":31343931261158,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_44748034-94a4-479b-87d6-59cad404f907.png?v=1668819966"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_44748034-94a4-479b-87d6-59cad404f907.png?v=1668819966","width":1200},{"alt":"RN Labs Nicotinamide Riboside NR 10% off RRP at HealthMasters RN Labs","id":31344323657958,"position":2,"preview_image":{"aspect_ratio":0.553,"height":1200,"width":664,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabs.png?v=1668827344"},"aspect_ratio":0.553,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabs.png?v=1668827344","width":664},{"alt":"RN Labs Nicotinamide Riboside NR 10% off RRP at HealthMasters RN Labs Logo1","id":31343931293926,"position":3,"preview_image":{"aspect_ratio":3.0,"height":100,"width":300,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_70e357a2-3df0-4299-b2f6-b783121d45ad.jpg?v=1668827317"},"aspect_ratio":3.0,"height":100,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_70e357a2-3df0-4299-b2f6-b783121d45ad.jpg?v=1668827317","width":300}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eRN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eNicotinamide Riboside 300mg\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60 Capsules\u003c\/p\u003e\n\u003cp\u003eRN Labs Nicotinamide Riboside NR AUST L 395455\u003c\/p\u003e\n\u003cp\u003eRN Labs Nicotinamide Riboside NR is part of the RN Labs Range of Practitioner Brand quality naturopathic medicines available for patients under the care of a practitioner.\u003c\/p\u003e\n\u003cp\u003eRN Labs was formerly named Research Nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eTo access RN Labs Nicotinamide Riboside NR select the \u003ca href=\"#how-to-access\" title=\"How To Access RN Labs Naturopathic Medicines 10% off RRP | HealthMasters RN Labs\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eHow To Access tab\u003c\/span\u003e\u003c\/a\u003e for more information.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e \u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioactiv-healthcare-10-off-rrp\/products\/bioactiv-healthcare-nmn\" title=\"BioActiv HealthCare NMN 10% off RRP | HealthMasters BioActiv HealthCare\" target=\"_blank\"\u003eBioActiv HealthCare NMN\u003c\/a\u003e\u003c\/span\u003e - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"Designs For Health NR Supreme 10% off RRP | HealthMasters Designs For Health\" target=\"_blank\"\u003eDesigns For Health NR Supreme\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"RN Labs Nicotinamide Riboside NR 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs Nicotinamide Riboside NR\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNote:\u003c\/p\u003e\n\u003cp\u003eIn the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\n\u003ch2\u003eSummary: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRN Labs Nicotinamide Riboside delivers a highly bioavailable, well tolerated, non-flushing form of Vitamin B3, that serves as an active precursor to NAD+ in the body.\u003c\/li\u003e\n\u003cli\u003eNicotinamide Riboside has been shown to support numerous metabolic pathways including energy production, cognition, cardiovascular health, and more.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports systemic NAD+ metabolism\u003c\/li\u003e\n\u003cli\u003eWell tolerated at high doses\u003c\/li\u003e\n\u003cli\u003eEnhanced bioavailability\u003c\/li\u003e\n\u003cli\u003eReduces inflammatory cytokines\u003c\/li\u003e\n\u003cli\u003eEncourages healthy cognitive and neuromuscular function\u003c\/li\u003e\n\u003cli\u003eSupports cardiovascular and arterial health\u003c\/li\u003e\n\u003cli\u003eMay support healthy ageing\u003c\/li\u003e\n\u003cli\u003eMay support energy production\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eResearch highlights\u003c\/h5\u003e\n\u003ch2\u003eResearch Highlights: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003ch3\u003eENHANCED TOLERANCE AND BIOAVAILABILITY\u003c\/h3\u003e\n\u003cp\u003eMultiple human and animal studies have confirmed the safety and effective use of Nicotinamide Riboside (NR) at high doses for extended periods of time, with minimal side effects. Conze et al (2019) demonstrated the use of NR at 100mg, 300mg, and 1000mg daily for 8 weeks in both men and women.\u003c\/p\u003e\n\u003cp\u003eNo adverse effects were reported during the trial including no incidence of flushing, no elevation of LDL cholesterol, nor any disturbances to methylation metabolism. Another study used two 250mg capsules, twice daily (total of 1000mg\/day) for 21 days in a group of elderly men (median age 75 years), with no adverse effects reported.\u003c\/p\u003e\n\u003ch3\u003eIMPROVED BODY COMPOSITION\u003c\/h3\u003e\n\u003cp\u003eMany animal studies show promising evidence to support the use of NR in ameliorating metabolic disease and optimising body composition.\u003c\/p\u003e\n\u003cp\u003eOne human trial conducted by Remie et al (2020) used NR 1000mg\/day for 6 weeks in overweight but otherwise healthy men. At completion, there was a significant increase in NAD+ metabolites followed by increased acetylcarnitine metabolites. This resulted in favourable changes in body composition (1.33% reduction in body fat mass in 6 weeks, with an equal improvement in lean mass) and sleeping metabolic rate, even without exercise.\u003c\/p\u003e\n\u003ch3\u003eIMPROVED COGNITIVE \/ NEUROMUSCULAR FUNCTION\u003c\/h3\u003e\n\u003cp\u003eNeurodegenerative diseases are associated with oxidative stress leading to DNA damage, often associated with ageing.\u003c\/p\u003e\n\u003cp\u003eThe development of Alzheimer’s and Parkinson’s Disease (PD) as well as Amyotrophic Lateral Sclerosis (ALS) and in some instances Autism Spectrum Disorder (ASD) are also correlated with NAD+ depletion and neuroinflammation. NR has been shown to increase NAD+ levels in brain tissue resulting in improved cognition, reduced inflammation in serum and cerebrospinal fluid (CSF) and therefore a reduction in symptoms and progression of cognitive and neuromuscular diseases.\u003c\/p\u003e\n\u003cp\u003eOne study involved twenty-four patients with Ataxia Telangiectasia (AT) who were given NR dosed at 24mg\/kg body weight for four months. Scores for both the Scale for the Assessment and Rating of Ataxia (SARA) and International Cooperative Ataxia Rating Scale (ICARS) improved during the trial period and showed a decline once NR treatment was discontinued indicating a transient improvement in symptoms.\u003c\/p\u003e\n\u003cp\u003eAnother study by Brakedal et al (2022) saw a variable yet significant increase in cerebral NAD levels (90%) in patients recently diagnosed with Parkinsons Diseases (PD). Patients were given 1000mg NR per day or placebo for 30 days. The NR treatment group also had increased expression of genes related to mitochondrial energy production, lysosomal, and proteasomal antioxidant function in blood and muscle and decreased the levels of inflammatory cytokines.\u003c\/p\u003e\n\u003ch3\u003eCARDIOVASCULAR HEALTH\u003c\/h3\u003e\n\u003cp\u003eIn a randomised, placebo-controlled, cross-over trial patients were treated with 500mg twice daily for 6 weeks. Results revealed a reduction in carotid-femoral pulse wave velocity and an average of 10mmHg reduction in mildly elevated systolic blood pressure. Therefore, indicating a potential therapeutic use for NR in the prevention of aortic stiffness and its potential for comorbidities associated with cardiovascular disease. The mechanism of action is believed to be via activation of Sirtuin 1 (SIRT-1) pathway as a result of increased NAD+.\u003c\/p\u003e\n\u003cp\u003e \u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"RN Labs Nicotinamide Riboside NR 10% off RRP at HealthMasters RN Labs Figure 1\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabsFigure1_600x600.png?v=1668827218\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/RNLabsNicotinamideRibosideNR10_offRRPatHealthMastersRNLabsFigure1_600x600.png?v=1668827218\"\u003e\u003c\/p\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eTake 1 capsule daily, or as prescribed by a healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Vegetarian Capsule Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide Riboside Chloride\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Ribose\u003c\/td\u003e\n\u003ctd\u003e155mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eLeucine, Hypromellose (Capsule), Microcrystalline Celluose, Colloidal Anhydrous Silica.\u003c\/p\u003e\n\u003ch5\u003eAllergen Advice\u003c\/h5\u003e\n\u003ch2\u003eAllergen Advice: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eSuitable for vegans.\u003c\/p\u003e\n\u003cp\u003eThis product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours.\u003c\/p\u003e\n\u003cp\u003eThis product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.\u003c\/p\u003e\n\u003ch5\u003eStatements\u003c\/h5\u003e\n\u003ch2\u003eStatements: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eFOR PRACTITIONER DISPENSING ONLY.\u003c\/p\u003e\n\u003cp\u003eSafety has not been confirmed during pregnancy \u0026amp; lactation.\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKnown Side Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGenerally well tolerated.\u003c\/p\u003e\n\u003ch5\u003eQuality \u0026amp; Purity\u003c\/h5\u003e\n\u003ch2\u003eQuality \u0026amp; Purity: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cp\u003eRN Labs use only the highest grade ingredients and materials available. Research Nutrition purity standards for manufacturing and sourcing are extensively researched and verified.\u003c\/p\u003e\n\u003cp\u003eNicotinamide Ribosire NR is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.\u003c\/p\u003e\n\u003ch5\u003eThe RN Difference\u003c\/h5\u003e\n\u003ch2\u003eThe RN Difference: RN Labs Nicotinamide Riboside NR\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/325810732\" allowfullscreen=\"\" mozallowfullscreen=\"\" webkitallowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003c!-- \/TABS --\u003e"}