{"id":8858882867430,"title":"Designs For Health LV-GB Complex","handle":"designs-for-health-lv-gb-complex","description":"\u003ch2\u003eDesigns For Health LV-GB Complex\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eA Standardised Herbal and Nutritional Liver \u0026amp; Gall Bladder Support Formula\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 120 Capsules\u003c\/p\u003e\n\u003cp\u003eDesigns For Health LV-GB Complex Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA unique formula aimed at maintaining the health and function of the liver and gall bladder.\u003c\/li\u003e\n\u003cli\u003eSupports bile production and secretion.\u003c\/li\u003e\n\u003cli\u003eStandardised extracts of both St. Mary’s Thistle and Globe Artichoke at therapeutic dose.\u003c\/li\u003e\n\u003cli\u003eGlobe Artichoke, beetroot and taurine are involved in bile production and secretion. \u003c\/li\u003e\n\u003cli\u003eSchisandra chinensis, Rosmarinus officinalis, Beta vulgaris, Taurine and Inositol support the health and function of the liver.\u003c\/li\u003e\n\u003cli\u003eCalcium saccharate (calcium d-glucarate) as an excipient ingredient to support liver function via phase 2 glucuronidation pathways.\u003c\/li\u003e\n\u003cli\u003eThe unique blend of herbs and nutrients supports liver function by maintaining phase one, two and three detox pathways.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health LV-GB Complex has No added gluten, dairy, soy, lactose, nuts.\u003c\/p\u003e\n\u003cp\u003eDesigns For Health LV-GB Complex AUST L 422244\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 4 capsules daily with a large glass of water,  or as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eThe liver is a complex and vital organ that makes up around 2% of our body weight and receives nutrient-rich blood from the stomach, intestines, pancreas and spleen via the portal vein and oxygenated blood from the aorta via the hepatic artery. It holds around 13% of the body’s total blood volume at any given time. It functions in several critical physiological processes, including detoxification, digestion, metabolism \u0026amp; energy production, immunity, macro and micronutrient storage and metabolism, endocrine signalling, lipid and cholesterol maintenance, glycogen production and storage, blood coagulation homeostasis, heme breakdown and the synthesis of bile, hormones, amino acids and other compounds vital for cellular functioning and the sustenance of life.\u003c\/p\u003e\n\u003cp\u003eThe most well-known function of the liver is that of detoxification, which occurs in three phases – two of them biochemical and one mechanical.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase one (functionalisation):\u003c\/strong\u003e The addition of a reactive oxygen group, such as a hydroxyl, carboxyl, or amino group, to form a reactive site on the toxic compound in readiness for phase two. \u003cspan style=\"font-size: 0.875rem;\"\u003eThe addition of this group can render the compound highly reactive and contribute to tissue damage and subsequent disease or adverse drug events if phase two doesn’t begin immediately or is dysfunctional.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase two (conjugation):\u003c\/strong\u003e The addition of a water-soluble group to the reactive site created in phase one. The water-soluble group can include glucuronic acid, sulfate, glutathione, amino acids, or an acetyl or methyl group. This increases the hydrophilicity, enabling it to be safely excreted via the bile or urine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase three (elimination):\u003c\/strong\u003e Includes the excretion of the end product either via the bowel under the influence of peristalsis, healthy microbiota and adequate stool bulk or the kidneys (in urine)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eA fine balance between phases one and two needs to be maintained as the metabolites produced during phase one can be more toxic and reactive than the starting compound. If phase two isn’t initiated immediately or is initiated poorly or dysfunctionally, tissue damage and disease can ensue.\u003c\/p\u003e\n\u003ch3\u003eSilybum marianum\u003c\/h3\u003e\n\u003cp\u003eTraditionally used in Western Herbal Medicine as a hepatoprotective, St Mary’s Thistle now enjoys a reputation as one of the most well-used and loved herbs to support the health and function of the liver.\u003c\/p\u003e\n\u003cp\u003eThe therapeutic activity of St Mary’s Thistle can be attributed to the flavonolignan compound silymarin. Research has suggested that standardisation to between 70-80% of this component is best to achieve therapeutic effects.\u003c\/p\u003e\n\u003cp\u003eThe term “silymarin” actually refers to 7 flavonolignan compounds: silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, and silydianin. Some extracts may also contain the flavonoid taxifolin.\u003c\/p\u003e\n\u003cp\u003eSt Mary’s Thistle supports the healthy functioning of the liver via the induction of both phase one and two detoxification pathways, therefore keeping the two vital phases balanced. Research into this herb is extensive and has identified the following functions that contribute to its activity in supporting liver health.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePrevents uptake of toxins and pathogens by stabilisation of cell membranes. Silybinin and silymarin are incorporated into the outer cell membrane thereby altering its structure. In doing so, these compounds stabilise the membranes and regulate their permeability and subsequent intracellular contents. They prevent the penetration of toxins into the hepatocytes, providing a “toxin blockade”\u003c\/li\u003e\n\u003cli\u003eAids hepatic repair and regeneration by enhancing ribosomal RNA synthesis (via stimulating nucleolar polymerase A) and cellular proliferation.\u003c\/li\u003e\n\u003cli\u003eImproves intracellular glutathione concentration.\u003c\/li\u003e\n\u003cli\u003eIncreases the proliferation of Kupffer cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eCynara scolymus\u003c\/h3\u003e\n\u003cp\u003eThe chlorogenic acids (cynarin and caffeoylquinic acid) found in Globe Artichoke also support the healthy functioning of both phase one and two detoxification pathways in the liver. In addition to this, Globe Artichoke is seen as the herb of choice in protocols targeting bile production and the gall bladder, as Globe Artichoke is seen as one of the most paramount choleretic and cholagogue herbs available to practitioners. Effects on bile secretion occurs an hour after the administration of a single dose. The excretion of cholesterol and other solids, as well as increases in faecal bile salts, have been shown in both pre-clinical and clinical studies. As a result of this, conditions requiring either the maintenance or increase of choleresis may benefit from the administration of globe artichoke.\u003c\/p\u003e\n\u003cp\u003eIt is also seen as a trophorestorative herb that can protect the integrity of bile canalicular membrane from chemically induced distortions. It does this by increasing glutathione peroxidase activity. This activity is also able to protect hepatocytes from oxidative stress,7 and its capacity to regenerate hepatocytes makes it the ideal partner to St Mary’s Thistle.\u003c\/p\u003e\n\u003ch3\u003eBeta Vulgaris\u003c\/h3\u003e\n\u003cp\u003eBeetroot is a valuable source of the constituent compounds betaine and betanin. These components also have supportive effects on both liver health and function. They do this by reducing fatty infiltration of hepatocytes, improving glutathione status, supporting phase one and two detox pathways, thinning the bile and supporting gall bladder function.\u003c\/p\u003e\n\u003ch3\u003eSchisandra chinensis\u003c\/h3\u003e\n\u003cp\u003eHistorically used in the Chinese medicinal paradigm, Schisandra is considered a warming herb that supports and protects many aspects of liver function. The main constituents that show activity are the lignan components. The lignans have been shown to support hepatic functions such as glycogen and protein synthesis, and enzymatic activity during both phase one and two detox pathways. They also support liver health by assisting the regeneration of hepatocytes and inhibiting lipid peroxidation in liver tissues.\u003c\/p\u003e\n\u003ch3\u003eRosmarinus Officinalis\u003c\/h3\u003e\n\u003cp\u003eAs mentioned above, it is necessary to maintain a balance between phase one and two detox pathways to maintain health. Phase two needs to “keep up” with phase one in order to prevent the build-up of the potentially toxic compounds produced during phase one.\u003c\/p\u003e\n\u003cp\u003eRosemary provides a valuable contribution to formulas aimed at supporting liver health and function as it has the ability to induce several enzymes involved in phase two pathways, helping to keep balance between the two detox systems.\u003c\/p\u003e\n\u003ch3\u003eTaurine\u003c\/h3\u003e\n\u003cp\u003eFound in food sources such as shellfish, meat, eggs and seaweed, taurine is necessary to produce bile through bile acid conjugation. Taurine is preferentially conjugated with bile acids to produce taurocholic acid.\u003c\/p\u003e\n\u003cp\u003eBile acid synthesis is a complicated process that involves several enzymes that convert cholesterol to a water-soluble bile acid. Bile acid molecules are then conjugated with either glycine or taurine to create a stronger acid before being excreted into the small intestine.8 It is also a co-factor in phase two conjugation systems. Further to this, as bile (a natural laxative) helps to support phase 3 detoxification, it may be said that taurine contributes to the functioning of phase three via this function as well).\u003c\/p\u003e\n\u003ch3\u003eInositol\u003c\/h3\u003e\n\u003cp\u003eThe ways in which Inositol supports the health of the liver is via its protective effects. Preclinical studies show that inositol may help support glutathione levels in hepatocytes. It also has a lipotropic action and is able to mobilise lipid compounds out of the liver and intestines.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach vegetarian hard capsule contains\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSilybum marianum extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e131.25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From min dry fruit\u003c\/td\u003e\n\u003ctd\u003e10.5g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Standardised to 105 mg silymarin\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Standardised to 26.25 mg silybin\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCynara scolymus (Globe Artichoke) extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e160mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From min. dry leaf\u003c\/td\u003e\n\u003ctd\u003e480mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Standardised to 8 mg caffeoylquinic acid calc. as cynarin\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSchisandra chinensis extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e30mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From dry fruit\u003c\/td\u003e\n\u003ctd\u003e750mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRosmarinus officinalis extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From dry leaf\u003c\/td\u003e\n\u003ctd\u003e500mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBeta vulgaris (Beetroot) extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e11.25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From dry root\u003c\/td\u003e\n\u003ctd\u003e112.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTaurine\u003c\/td\u003e\n\u003ctd\u003e225mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInositol\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eColloidal anhydrous silica, calcium saccharate, magnesium stearate, maltodextrin, microcrystalline cellulose, hypromellose, silica dioxide, purified water.\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eNo added gluten, dairy, soy, lactose, nuts.\u003c\/p\u003e\n\u003ch5\u003eQuality Guarantee\u003c\/h5\u003e\n\u003ch2\u003eQuality Guarantee: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eDesigns for Health medicines that are listed on the Australian Register of Therapeutic Goods will display an AUSTL number on the label.\u003c\/p\u003e\n\u003cp\u003eListed medicines in Australia need to be manufactured according to legislated standards set out in Therapeutic Goods Order 101.\u003c\/p\u003e\n\u003cp\u003eTGO101 legislation sets out minimum quality standards for medicines supplied in Australia that display an AUSTL number.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTGO101 mandates testing for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImpurities such as heavy metals (including lead, mercury, cadmium and arsenic), pesticides and residual solvents\u003c\/li\u003e\n\u003cli\u003eDissolution (to ensure the capsule will dissolve once taken)\u003c\/li\u003e\n\u003cli\u003eUniformity (to ensure that every capsule is the same)\u003c\/li\u003e\n\u003cli\u003eFinal assay testing is also performed to ensure that what we have on the label is in each capsule, and microbiological testing is performed to ensure that no microbial contamination has occurred during the encapsulation and packing process.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eGlobe Artichoke can cause contact dermatitis in those allergic to plants in the asteraceae\/compositae family.\u003c\/li\u003e\n\u003cli\u003eRosemary may cause uterine stimulation. Do not use when pregnant.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2024-10-08T17:44:49+11:00","created_at":"2024-10-08T16:31:10+11:00","vendor":"Designs For Health","type":"Designs For Health Naturopathic Medicines","tags":["Designs For Health","Naturopathic"],"price":4496,"price_min":4496,"price_max":4496,"available":true,"price_varies":false,"compare_at_price":4995,"compare_at_price_min":4995,"compare_at_price_max":4995,"compare_at_price_varies":false,"variants":[{"id":45406261575910,"title":"120 Capsules","option1":"120 Capsules","option2":null,"option3":null,"sku":"DFHLV-GBComplex120caps","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Designs For Health LV-GB Complex - 120 Capsules","public_title":"120 Capsules","options":["120 Capsules"],"price":4496,"weight":0,"compare_at_price":4995,"inventory_quantity":19999,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9353993000764","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLV-GBComplex120caps10_offRRPatHealthMastersDesignsForHealth_a3436881-cd9c-4424-97f1-462c1be1bb9d.png?v=1728368986","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLV-GBComplex10_offRRPatHealthMastersIngredientsPanel_98b9a91e-5605-4d2e-a2b2-a38c7b78f71d.png?v=1728368986","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLogo.jpg?v=1728369798"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLV-GBComplex120caps10_offRRPatHealthMastersDesignsForHealth_a3436881-cd9c-4424-97f1-462c1be1bb9d.png?v=1728368986","options":["Size"],"media":[{"alt":"Designs For Health LV-GB Complex 120 caps 10% off RRP at HealthMasters Designs For Health","id":34830019952870,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLV-GBComplex120caps10_offRRPatHealthMastersDesignsForHealth_a3436881-cd9c-4424-97f1-462c1be1bb9d.png?v=1728368986"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLV-GBComplex120caps10_offRRPatHealthMastersDesignsForHealth_a3436881-cd9c-4424-97f1-462c1be1bb9d.png?v=1728368986","width":1200},{"alt":"Designs For Health LV-GB Complex 10% off RRP at HealthMasters Designs For Health Ingredients","id":34830019920102,"position":2,"preview_image":{"aspect_ratio":1.998,"height":401,"width":801,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLV-GBComplex10_offRRPatHealthMastersIngredientsPanel_98b9a91e-5605-4d2e-a2b2-a38c7b78f71d.png?v=1728368986"},"aspect_ratio":1.998,"height":401,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLV-GBComplex10_offRRPatHealthMastersIngredientsPanel_98b9a91e-5605-4d2e-a2b2-a38c7b78f71d.png?v=1728368986","width":801},{"alt":"Designs For Health LV-GB Complex 10% off RRP at HealthMasters Designs For Health Logo","id":34830087815398,"position":3,"preview_image":{"aspect_ratio":2.5,"height":142,"width":355,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLogo.jpg?v=1728369798"},"aspect_ratio":2.5,"height":142,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLogo.jpg?v=1728369798","width":355}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eDesigns For Health LV-GB Complex\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eA Standardised Herbal and Nutritional Liver \u0026amp; Gall Bladder Support Formula\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 120 Capsules\u003c\/p\u003e\n\u003cp\u003eDesigns For Health LV-GB Complex Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA unique formula aimed at maintaining the health and function of the liver and gall bladder.\u003c\/li\u003e\n\u003cli\u003eSupports bile production and secretion.\u003c\/li\u003e\n\u003cli\u003eStandardised extracts of both St. Mary’s Thistle and Globe Artichoke at therapeutic dose.\u003c\/li\u003e\n\u003cli\u003eGlobe Artichoke, beetroot and taurine are involved in bile production and secretion. \u003c\/li\u003e\n\u003cli\u003eSchisandra chinensis, Rosmarinus officinalis, Beta vulgaris, Taurine and Inositol support the health and function of the liver.\u003c\/li\u003e\n\u003cli\u003eCalcium saccharate (calcium d-glucarate) as an excipient ingredient to support liver function via phase 2 glucuronidation pathways.\u003c\/li\u003e\n\u003cli\u003eThe unique blend of herbs and nutrients supports liver function by maintaining phase one, two and three detox pathways.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health LV-GB Complex has No added gluten, dairy, soy, lactose, nuts.\u003c\/p\u003e\n\u003cp\u003eDesigns For Health LV-GB Complex AUST L 422244\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 4 capsules daily with a large glass of water,  or as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eThe liver is a complex and vital organ that makes up around 2% of our body weight and receives nutrient-rich blood from the stomach, intestines, pancreas and spleen via the portal vein and oxygenated blood from the aorta via the hepatic artery. It holds around 13% of the body’s total blood volume at any given time. It functions in several critical physiological processes, including detoxification, digestion, metabolism \u0026amp; energy production, immunity, macro and micronutrient storage and metabolism, endocrine signalling, lipid and cholesterol maintenance, glycogen production and storage, blood coagulation homeostasis, heme breakdown and the synthesis of bile, hormones, amino acids and other compounds vital for cellular functioning and the sustenance of life.\u003c\/p\u003e\n\u003cp\u003eThe most well-known function of the liver is that of detoxification, which occurs in three phases – two of them biochemical and one mechanical.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase one (functionalisation):\u003c\/strong\u003e The addition of a reactive oxygen group, such as a hydroxyl, carboxyl, or amino group, to form a reactive site on the toxic compound in readiness for phase two. \u003cspan style=\"font-size: 0.875rem;\"\u003eThe addition of this group can render the compound highly reactive and contribute to tissue damage and subsequent disease or adverse drug events if phase two doesn’t begin immediately or is dysfunctional.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase two (conjugation):\u003c\/strong\u003e The addition of a water-soluble group to the reactive site created in phase one. The water-soluble group can include glucuronic acid, sulfate, glutathione, amino acids, or an acetyl or methyl group. This increases the hydrophilicity, enabling it to be safely excreted via the bile or urine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase three (elimination):\u003c\/strong\u003e Includes the excretion of the end product either via the bowel under the influence of peristalsis, healthy microbiota and adequate stool bulk or the kidneys (in urine)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eA fine balance between phases one and two needs to be maintained as the metabolites produced during phase one can be more toxic and reactive than the starting compound. If phase two isn’t initiated immediately or is initiated poorly or dysfunctionally, tissue damage and disease can ensue.\u003c\/p\u003e\n\u003ch3\u003eSilybum marianum\u003c\/h3\u003e\n\u003cp\u003eTraditionally used in Western Herbal Medicine as a hepatoprotective, St Mary’s Thistle now enjoys a reputation as one of the most well-used and loved herbs to support the health and function of the liver.\u003c\/p\u003e\n\u003cp\u003eThe therapeutic activity of St Mary’s Thistle can be attributed to the flavonolignan compound silymarin. Research has suggested that standardisation to between 70-80% of this component is best to achieve therapeutic effects.\u003c\/p\u003e\n\u003cp\u003eThe term “silymarin” actually refers to 7 flavonolignan compounds: silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, and silydianin. Some extracts may also contain the flavonoid taxifolin.\u003c\/p\u003e\n\u003cp\u003eSt Mary’s Thistle supports the healthy functioning of the liver via the induction of both phase one and two detoxification pathways, therefore keeping the two vital phases balanced. Research into this herb is extensive and has identified the following functions that contribute to its activity in supporting liver health.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePrevents uptake of toxins and pathogens by stabilisation of cell membranes. Silybinin and silymarin are incorporated into the outer cell membrane thereby altering its structure. In doing so, these compounds stabilise the membranes and regulate their permeability and subsequent intracellular contents. They prevent the penetration of toxins into the hepatocytes, providing a “toxin blockade”\u003c\/li\u003e\n\u003cli\u003eAids hepatic repair and regeneration by enhancing ribosomal RNA synthesis (via stimulating nucleolar polymerase A) and cellular proliferation.\u003c\/li\u003e\n\u003cli\u003eImproves intracellular glutathione concentration.\u003c\/li\u003e\n\u003cli\u003eIncreases the proliferation of Kupffer cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eCynara scolymus\u003c\/h3\u003e\n\u003cp\u003eThe chlorogenic acids (cynarin and caffeoylquinic acid) found in Globe Artichoke also support the healthy functioning of both phase one and two detoxification pathways in the liver. In addition to this, Globe Artichoke is seen as the herb of choice in protocols targeting bile production and the gall bladder, as Globe Artichoke is seen as one of the most paramount choleretic and cholagogue herbs available to practitioners. Effects on bile secretion occurs an hour after the administration of a single dose. The excretion of cholesterol and other solids, as well as increases in faecal bile salts, have been shown in both pre-clinical and clinical studies. As a result of this, conditions requiring either the maintenance or increase of choleresis may benefit from the administration of globe artichoke.\u003c\/p\u003e\n\u003cp\u003eIt is also seen as a trophorestorative herb that can protect the integrity of bile canalicular membrane from chemically induced distortions. It does this by increasing glutathione peroxidase activity. This activity is also able to protect hepatocytes from oxidative stress,7 and its capacity to regenerate hepatocytes makes it the ideal partner to St Mary’s Thistle.\u003c\/p\u003e\n\u003ch3\u003eBeta Vulgaris\u003c\/h3\u003e\n\u003cp\u003eBeetroot is a valuable source of the constituent compounds betaine and betanin. These components also have supportive effects on both liver health and function. They do this by reducing fatty infiltration of hepatocytes, improving glutathione status, supporting phase one and two detox pathways, thinning the bile and supporting gall bladder function.\u003c\/p\u003e\n\u003ch3\u003eSchisandra chinensis\u003c\/h3\u003e\n\u003cp\u003eHistorically used in the Chinese medicinal paradigm, Schisandra is considered a warming herb that supports and protects many aspects of liver function. The main constituents that show activity are the lignan components. The lignans have been shown to support hepatic functions such as glycogen and protein synthesis, and enzymatic activity during both phase one and two detox pathways. They also support liver health by assisting the regeneration of hepatocytes and inhibiting lipid peroxidation in liver tissues.\u003c\/p\u003e\n\u003ch3\u003eRosmarinus Officinalis\u003c\/h3\u003e\n\u003cp\u003eAs mentioned above, it is necessary to maintain a balance between phase one and two detox pathways to maintain health. Phase two needs to “keep up” with phase one in order to prevent the build-up of the potentially toxic compounds produced during phase one.\u003c\/p\u003e\n\u003cp\u003eRosemary provides a valuable contribution to formulas aimed at supporting liver health and function as it has the ability to induce several enzymes involved in phase two pathways, helping to keep balance between the two detox systems.\u003c\/p\u003e\n\u003ch3\u003eTaurine\u003c\/h3\u003e\n\u003cp\u003eFound in food sources such as shellfish, meat, eggs and seaweed, taurine is necessary to produce bile through bile acid conjugation. Taurine is preferentially conjugated with bile acids to produce taurocholic acid.\u003c\/p\u003e\n\u003cp\u003eBile acid synthesis is a complicated process that involves several enzymes that convert cholesterol to a water-soluble bile acid. Bile acid molecules are then conjugated with either glycine or taurine to create a stronger acid before being excreted into the small intestine.8 It is also a co-factor in phase two conjugation systems. Further to this, as bile (a natural laxative) helps to support phase 3 detoxification, it may be said that taurine contributes to the functioning of phase three via this function as well).\u003c\/p\u003e\n\u003ch3\u003eInositol\u003c\/h3\u003e\n\u003cp\u003eThe ways in which Inositol supports the health of the liver is via its protective effects. Preclinical studies show that inositol may help support glutathione levels in hepatocytes. It also has a lipotropic action and is able to mobilise lipid compounds out of the liver and intestines.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach vegetarian hard capsule contains\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSilybum marianum extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e131.25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From min dry fruit\u003c\/td\u003e\n\u003ctd\u003e10.5g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Standardised to 105 mg silymarin\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Standardised to 26.25 mg silybin\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCynara scolymus (Globe Artichoke) extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e160mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From min. dry leaf\u003c\/td\u003e\n\u003ctd\u003e480mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Standardised to 8 mg caffeoylquinic acid calc. as cynarin\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSchisandra chinensis extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e30mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From dry fruit\u003c\/td\u003e\n\u003ctd\u003e750mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRosmarinus officinalis extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From dry leaf\u003c\/td\u003e\n\u003ctd\u003e500mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBeta vulgaris (Beetroot) extract dry concentrate\u003c\/td\u003e\n\u003ctd\u003e11.25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- From dry root\u003c\/td\u003e\n\u003ctd\u003e112.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTaurine\u003c\/td\u003e\n\u003ctd\u003e225mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInositol\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eColloidal anhydrous silica, calcium saccharate, magnesium stearate, maltodextrin, microcrystalline cellulose, hypromellose, silica dioxide, purified water.\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eNo added gluten, dairy, soy, lactose, nuts.\u003c\/p\u003e\n\u003ch5\u003eQuality Guarantee\u003c\/h5\u003e\n\u003ch2\u003eQuality Guarantee: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cp\u003eDesigns for Health medicines that are listed on the Australian Register of Therapeutic Goods will display an AUSTL number on the label.\u003c\/p\u003e\n\u003cp\u003eListed medicines in Australia need to be manufactured according to legislated standards set out in Therapeutic Goods Order 101.\u003c\/p\u003e\n\u003cp\u003eTGO101 legislation sets out minimum quality standards for medicines supplied in Australia that display an AUSTL number.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTGO101 mandates testing for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImpurities such as heavy metals (including lead, mercury, cadmium and arsenic), pesticides and residual solvents\u003c\/li\u003e\n\u003cli\u003eDissolution (to ensure the capsule will dissolve once taken)\u003c\/li\u003e\n\u003cli\u003eUniformity (to ensure that every capsule is the same)\u003c\/li\u003e\n\u003cli\u003eFinal assay testing is also performed to ensure that what we have on the label is in each capsule, and microbiological testing is performed to ensure that no microbial contamination has occurred during the encapsulation and packing process.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health LV-GB Complex\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eGlobe Artichoke can cause contact dermatitis in those allergic to plants in the asteraceae\/compositae family.\u003c\/li\u003e\n\u003cli\u003eRosemary may cause uterine stimulation. Do not use when pregnant.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- \/TABS --\u003e"}