{"id":8375226892518,"title":"BioCeuticals Clinical UC Promega","handle":"bioceuticals-clinical-uc-promega","description":"\u003ch2\u003eBioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eRelieve Inflammation with Specialised Pro‑Resolving Mediators from Herring Roe\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSizes: 60 Capsules\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical UC Promega Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Clinical UC Promega features sustainably sourced Norwegian herring roe oil, a rich source of specialised pro-resolving mediators (SPMs) and their precursors.\u003c\/li\u003e\n\u003cli\u003eSPMs are lipid mediators induced during inflammation and encourage the resolution of inflammation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Clinical UC Promega has No Added Dairy, No Added Gluten, No Added Yeast\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical UC Promega AUST L 392695\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule one to four times a day, or as professionally prescribed.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eHerring roe is a natural source of specialised pro-resolving mediators, with minimal processing required.\u003c\/li\u003e\n\u003cli\u003eSpecialised pro-resolving mediators are used in the body's natural inflammation resolution process.\u003c\/li\u003e\n\u003cli\u003eRelieves inflammation.\u003c\/li\u003e\n\u003cli\u003eSupports cardiovascular system health.\u003c\/li\u003e\n\u003cli\u003eMaintains heart health.\u003c\/li\u003e\n\u003cli\u003eMaintains healthy vision.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWhat Are SPMs?\u003c\/h5\u003e\n\u003ch2\u003eWhat Are SPMs?: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003ch3\u003eWhat are SPMs?\u003c\/h3\u003e\n\u003cp\u003eSpecialised pro-resolving mediators (SPMs) are lipid mediators synthesised from omega-3 fatty acids EPA and DHA, that are imperative in the resolution phase of inflammation.\u003c\/p\u003e\n\u003ch3\u003eBioCeuticals Clinical UC Promega Difference\u003c\/h3\u003e\n\u003cp\u003eA low-excipient, bioefficient phospholipid form of broad spectrum omega-3 SPMs, including 18-HEPE, 14-HDHA, 17-HDHA and RvE2.\u003c\/p\u003e\n\u003ch3\u003eInflammation Resolution\u003c\/h3\u003e\n\u003cp\u003eSPMs actively promote the resolution of inflammation and restoration of homoeostasis. Endogenous SPM production may be impaired by inflammation and ageing. \u003cbr data-mce-fragment=\"1\"\u003eNATURAL SOURCE\u003cbr data-mce-fragment=\"1\"\u003e Sustainably supplied Norwegian herring roe is a natural source of SPMs, with minimal processing required.\u003c\/p\u003e\n\u003ch3\u003eSpecialised pro-resolving mediators (SPMs)\u003c\/h3\u003e\n\u003cp\u003eSpecialised pro-resolving mediators (SPMs) are lipid mediators that are induced in the resolution phase following acute inflammation. They are synthesised from the essential omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).\u003c\/p\u003e\n\u003cp\u003eThey are a class of cell-signalling molecules that are produced via tightly controlled enzymatic reactions that convert EPA and DHA to stereochemically defined molecules known as resolvins.1-2\u003c\/p\u003e\n\u003cp\u003eSPMs are endogenously produced however, production is impaired by inflammation and ageing.2\u003c\/p\u003e\n\u003cp\u003eHerring roe is a natural source of a broad spectrum of SPMs including 18-HEPE, 14-HDHA, 17-HDHA and RvE2.\u003c\/p\u003e\n\u003ch3\u003eResolution of inflammation\u003c\/h3\u003e\n\u003cp\u003ePreviously, it was thought the resolution of inflammation was mostly a passive process, and that chronic inflammation was due to an influx of pro-inflammatory mediators. Ongoing research on SPMs has shown inflammation resolution to be an active process involving a biosynthetic shift from pro-inflammatory to pro-resolution mediators.\u003c\/p\u003e\n\u003cp\u003eTherefore, chronic inflammation is a result of impaired signalling or reduced production of resolving mediators,2-3 and this impairment leads to a pro-inflammatory state.4\u003c\/p\u003e\n\u003cp\u003eSPMs have highly specific, immunoregulatory activities in the body at picomolar and nanomolar concentrations.5 They function by countering the regulatory production of proinflammatory mediators (cytokines, chemokines and inflammatory eicosanoids), restricting leukocytic infiltration and stimulating leukocyte phenotype switch. Therefore, they do not prevent inflammation but instead promote its termination. Additionally, SPMs have demonstrated active tissue repair and restoration.6\u003c\/p\u003e\n\u003ch3\u003eSPMs in the Inflammatory Response 7\u003c\/h3\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticalsClinicalUCPromega60Caps10_offRRPatHealthMastersBioCeuticalsCliSPMsintheinflammatoryresponse_bc1111d0-0d7c-4bf0-9a3e-c8eec5642eea_1024x1024.png?v=1701855275\" alt=\"BioCeuticals Clinical UC Promega 60 Caps 10% off RRP at HealthMasters BioCeuticals Cli SPMs in the inflammatory response\" data-mce-style=\"display: block; margin-left: auto; margin-right: auto;\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticalsClinicalUCPromega60Caps10_offRRPatHealthMastersBioCeuticalsCliSPMsintheinflammatoryresponse_bc1111d0-0d7c-4bf0-9a3e-c8eec5642eea_1024x1024.png?v=1701855275\"\u003e\u003c\/p\u003e\n\u003ch3\u003eSupplementing SPMs\u003c\/h3\u003e\n\u003cp\u003eSupplementation with EPA and DHA has been shown to increase serum SPMs in humans,1,8 however, conversion of pro-resolving mediators from EPA and DHA is a multi-step process and may be inhibited in conditions underpinned by inflammation.2\u003c\/p\u003e\n\u003cp\u003eThe enzymes required for the conversion of fish oil to SPMs have roles in other enzymatic pathways, which may redirect the catalysis away and reduce conversion. Ageing may also diminish the biosynthesis and bioavailability of SPMs from fish oil.9-10\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eResearch in healthy populations have demonstrated that fish oil supplements which feature SPMs exert benefits in a manner that is superior to fish oil containing negligible amounts.1\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains: \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eClupea harengus lipid extract (herring roe)\u003c\/td\u003e\n\u003ctd\u003e232mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to docosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e39.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to eicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e14.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eConcentrated fish omega-3 triglycerides\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003econtaining omega-3 marine triglycerides as:\u003c\/td\u003e\n\u003ctd\u003e180mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003edocosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e150mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eeicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e30mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTotal DHA\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e189.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTotal EPA\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e44.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eDietary influence\u003c\/h5\u003e\n\u003ch2\u003eDietary influence: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cp\u003eNo Added Dairy, No Added Gluten, No Added Yeast\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cp\u003eContains sulfites and fish products.\u003c\/p\u003e\n\u003cp\u003eFor pregnancy and breastfeeding, the appropriateness of product use is at the clinical discretion of the health professional.\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSouza P. Marques R. Gomez E. et al. Enriched marine oil supplements increase peripheral blood specialized pro-resolving mediators concentrations and reprogram host immune responses. Circulation Research. 2020;126:75–90.\u003c\/li\u003e\n\u003cli\u003eSerhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014 Jun 5;510(7503):92-101.\u003c\/li\u003e\n\u003cli\u003eFattori V, Zaninelli T.H,. Rasquel-Oliveira F.S, et al. Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs. Pharmacological Research, Volume 151, 2020, 104549.\u003c\/li\u003e\n\u003cli\u003eSansbury BE, Spite M. Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology. Circ Res. 2016 Jun 24;119(1):113-30.\u003c\/li\u003e\n\u003cli\u003eHansen TV, Vik A, Serhan CN. The protectin family of specialized pro-resolving mediators: potent immunoresolvents enabling innovative approaches to target obesity and diabetes. Front Pharmacol. 2019 Jan 17;9:1582.\u003c\/li\u003e\n\u003cli\u003eNorling LV, Ly L, Dalli J. Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care. 2017 Mar;20(2):145-152.\u003c\/li\u003e\n\u003cli\u003ePlacek K, Schultze J. et al. Epigenetic reprogramming of immune cells in injury, repair and resolution. J Clin Invest. 2019;129(8):2994-3005.\u003c\/li\u003e\n\u003cli\u003eBarden AE, Moghaddami M, Mas E, et al. Specialised pro-resolving mediators of inflammation in inflammatory arthritis. Prostaglandins Leukot Essent Fatty Acids. 2016 Apr;107:24-9.\u003c\/li\u003e\n\u003cli\u003eChiang N, Serhan CN. Specialized pro-resolving mediator network: an update on production and actions. Essays Biochem. 2020 Sep 23;64(3):443-462.\u003c\/li\u003e\n\u003cli\u003eRosenthal MD, Patel J, Staton K. et al. Can Specialized Pro-resolving Mediators Deliver Benefit Originally Expected from Fish Oil? Curr Gastroenterol Rep. 2018. 20, 40.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2023-12-06T20:42:13+11:00","created_at":"2023-12-06T18:27:46+11:00","vendor":"BioCeuticals","type":"BioCeuticals Clinical Naturopathic Medicines","tags":["BioCeuticals Clinical","Naturopathic","PB"],"price":6656,"price_min":6656,"price_max":6656,"available":true,"price_varies":false,"compare_at_price":7395,"compare_at_price_min":7395,"compare_at_price_max":7395,"compare_at_price_varies":false,"variants":[{"id":44106078552294,"title":"60 Capsules","option1":"60 Capsules","option2":null,"option3":null,"sku":"BiCClUCPromega60c","requires_shipping":true,"taxable":true,"featured_image":{"id":40144079716582,"product_id":8375226892518,"position":1,"created_at":"2023-12-06T18:28:33+11:00","updated_at":"2023-12-06T20:48:20+11:00","alt":"BioCeuticals Clinical UC Promega 60 Caps 10% off RRP at HealthMasters BioCeuticals Clinical","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioCeuticalsClinicalUCPromega10_offRRPatHealthMastersBioCeuticalsClinical.png?v=1701856100","variant_ids":[44106078552294]},"available":true,"name":"BioCeuticals Clinical UC Promega - 60 Capsules","public_title":"60 Capsules","options":["60 Capsules"],"price":6656,"weight":0,"compare_at_price":7395,"inventory_quantity":29999,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9337896017487","featured_media":{"alt":"BioCeuticals Clinical UC Promega 60 Caps 10% off RRP at HealthMasters BioCeuticals Clinical","id":32756831486182,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioCeuticalsClinicalUCPromega10_offRRPatHealthMastersBioCeuticalsClinical.png?v=1701856100"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioCeuticalsClinicalUCPromega10_offRRPatHealthMastersBioCeuticalsClinical.png?v=1701856100","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bioceuticals-logo_e1146e42-1e58-4802-9a9a-614b47dfb07d.jpg?v=1701847815"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioCeuticalsClinicalUCPromega10_offRRPatHealthMastersBioCeuticalsClinical.png?v=1701856100","options":["Size:"],"media":[{"alt":"BioCeuticals Clinical UC Promega 60 Caps 10% off RRP at HealthMasters BioCeuticals Clinical","id":32756831486182,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioCeuticalsClinicalUCPromega10_offRRPatHealthMastersBioCeuticalsClinical.png?v=1701856100"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/BioCeuticalsClinicalUCPromega10_offRRPatHealthMastersBioCeuticalsClinical.png?v=1701856100","width":1200},{"alt":"BioCeuticals Clinical UC Promega 10% off RRP at HealthMasters BioCeuticals Clinical Logo","id":32756828504294,"position":2,"preview_image":{"aspect_ratio":4.656,"height":302,"width":1406,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bioceuticals-logo_e1146e42-1e58-4802-9a9a-614b47dfb07d.jpg?v=1701847815"},"aspect_ratio":4.656,"height":302,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bioceuticals-logo_e1146e42-1e58-4802-9a9a-614b47dfb07d.jpg?v=1701847815","width":1406}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eBioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eRelieve Inflammation with Specialised Pro‑Resolving Mediators from Herring Roe\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSizes: 60 Capsules\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical UC Promega Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Clinical UC Promega features sustainably sourced Norwegian herring roe oil, a rich source of specialised pro-resolving mediators (SPMs) and their precursors.\u003c\/li\u003e\n\u003cli\u003eSPMs are lipid mediators induced during inflammation and encourage the resolution of inflammation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Clinical UC Promega has No Added Dairy, No Added Gluten, No Added Yeast\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical UC Promega AUST L 392695\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule one to four times a day, or as professionally prescribed.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eHerring roe is a natural source of specialised pro-resolving mediators, with minimal processing required.\u003c\/li\u003e\n\u003cli\u003eSpecialised pro-resolving mediators are used in the body's natural inflammation resolution process.\u003c\/li\u003e\n\u003cli\u003eRelieves inflammation.\u003c\/li\u003e\n\u003cli\u003eSupports cardiovascular system health.\u003c\/li\u003e\n\u003cli\u003eMaintains heart health.\u003c\/li\u003e\n\u003cli\u003eMaintains healthy vision.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWhat Are SPMs?\u003c\/h5\u003e\n\u003ch2\u003eWhat Are SPMs?: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003ch3\u003eWhat are SPMs?\u003c\/h3\u003e\n\u003cp\u003eSpecialised pro-resolving mediators (SPMs) are lipid mediators synthesised from omega-3 fatty acids EPA and DHA, that are imperative in the resolution phase of inflammation.\u003c\/p\u003e\n\u003ch3\u003eBioCeuticals Clinical UC Promega Difference\u003c\/h3\u003e\n\u003cp\u003eA low-excipient, bioefficient phospholipid form of broad spectrum omega-3 SPMs, including 18-HEPE, 14-HDHA, 17-HDHA and RvE2.\u003c\/p\u003e\n\u003ch3\u003eInflammation Resolution\u003c\/h3\u003e\n\u003cp\u003eSPMs actively promote the resolution of inflammation and restoration of homoeostasis. Endogenous SPM production may be impaired by inflammation and ageing. \u003cbr data-mce-fragment=\"1\"\u003eNATURAL SOURCE\u003cbr data-mce-fragment=\"1\"\u003e Sustainably supplied Norwegian herring roe is a natural source of SPMs, with minimal processing required.\u003c\/p\u003e\n\u003ch3\u003eSpecialised pro-resolving mediators (SPMs)\u003c\/h3\u003e\n\u003cp\u003eSpecialised pro-resolving mediators (SPMs) are lipid mediators that are induced in the resolution phase following acute inflammation. They are synthesised from the essential omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).\u003c\/p\u003e\n\u003cp\u003eThey are a class of cell-signalling molecules that are produced via tightly controlled enzymatic reactions that convert EPA and DHA to stereochemically defined molecules known as resolvins.1-2\u003c\/p\u003e\n\u003cp\u003eSPMs are endogenously produced however, production is impaired by inflammation and ageing.2\u003c\/p\u003e\n\u003cp\u003eHerring roe is a natural source of a broad spectrum of SPMs including 18-HEPE, 14-HDHA, 17-HDHA and RvE2.\u003c\/p\u003e\n\u003ch3\u003eResolution of inflammation\u003c\/h3\u003e\n\u003cp\u003ePreviously, it was thought the resolution of inflammation was mostly a passive process, and that chronic inflammation was due to an influx of pro-inflammatory mediators. Ongoing research on SPMs has shown inflammation resolution to be an active process involving a biosynthetic shift from pro-inflammatory to pro-resolution mediators.\u003c\/p\u003e\n\u003cp\u003eTherefore, chronic inflammation is a result of impaired signalling or reduced production of resolving mediators,2-3 and this impairment leads to a pro-inflammatory state.4\u003c\/p\u003e\n\u003cp\u003eSPMs have highly specific, immunoregulatory activities in the body at picomolar and nanomolar concentrations.5 They function by countering the regulatory production of proinflammatory mediators (cytokines, chemokines and inflammatory eicosanoids), restricting leukocytic infiltration and stimulating leukocyte phenotype switch. Therefore, they do not prevent inflammation but instead promote its termination. Additionally, SPMs have demonstrated active tissue repair and restoration.6\u003c\/p\u003e\n\u003ch3\u003eSPMs in the Inflammatory Response 7\u003c\/h3\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticalsClinicalUCPromega60Caps10_offRRPatHealthMastersBioCeuticalsCliSPMsintheinflammatoryresponse_bc1111d0-0d7c-4bf0-9a3e-c8eec5642eea_1024x1024.png?v=1701855275\" alt=\"BioCeuticals Clinical UC Promega 60 Caps 10% off RRP at HealthMasters BioCeuticals Cli SPMs in the inflammatory response\" data-mce-style=\"display: block; margin-left: auto; margin-right: auto;\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticalsClinicalUCPromega60Caps10_offRRPatHealthMastersBioCeuticalsCliSPMsintheinflammatoryresponse_bc1111d0-0d7c-4bf0-9a3e-c8eec5642eea_1024x1024.png?v=1701855275\"\u003e\u003c\/p\u003e\n\u003ch3\u003eSupplementing SPMs\u003c\/h3\u003e\n\u003cp\u003eSupplementation with EPA and DHA has been shown to increase serum SPMs in humans,1,8 however, conversion of pro-resolving mediators from EPA and DHA is a multi-step process and may be inhibited in conditions underpinned by inflammation.2\u003c\/p\u003e\n\u003cp\u003eThe enzymes required for the conversion of fish oil to SPMs have roles in other enzymatic pathways, which may redirect the catalysis away and reduce conversion. Ageing may also diminish the biosynthesis and bioavailability of SPMs from fish oil.9-10\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eResearch in healthy populations have demonstrated that fish oil supplements which feature SPMs exert benefits in a manner that is superior to fish oil containing negligible amounts.1\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains: \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eClupea harengus lipid extract (herring roe)\u003c\/td\u003e\n\u003ctd\u003e232mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to docosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e39.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. to eicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e14.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eConcentrated fish omega-3 triglycerides\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003econtaining omega-3 marine triglycerides as:\u003c\/td\u003e\n\u003ctd\u003e180mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003edocosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e150mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eeicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e30mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTotal DHA\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e189.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTotal EPA\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e44.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eDietary influence\u003c\/h5\u003e\n\u003ch2\u003eDietary influence: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cp\u003eNo Added Dairy, No Added Gluten, No Added Yeast\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003cp\u003eContains sulfites and fish products.\u003c\/p\u003e\n\u003cp\u003eFor pregnancy and breastfeeding, the appropriateness of product use is at the clinical discretion of the health professional.\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Clinical UC Promega\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSouza P. Marques R. Gomez E. et al. Enriched marine oil supplements increase peripheral blood specialized pro-resolving mediators concentrations and reprogram host immune responses. Circulation Research. 2020;126:75–90.\u003c\/li\u003e\n\u003cli\u003eSerhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014 Jun 5;510(7503):92-101.\u003c\/li\u003e\n\u003cli\u003eFattori V, Zaninelli T.H,. Rasquel-Oliveira F.S, et al. Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs. Pharmacological Research, Volume 151, 2020, 104549.\u003c\/li\u003e\n\u003cli\u003eSansbury BE, Spite M. Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology. Circ Res. 2016 Jun 24;119(1):113-30.\u003c\/li\u003e\n\u003cli\u003eHansen TV, Vik A, Serhan CN. The protectin family of specialized pro-resolving mediators: potent immunoresolvents enabling innovative approaches to target obesity and diabetes. Front Pharmacol. 2019 Jan 17;9:1582.\u003c\/li\u003e\n\u003cli\u003eNorling LV, Ly L, Dalli J. Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care. 2017 Mar;20(2):145-152.\u003c\/li\u003e\n\u003cli\u003ePlacek K, Schultze J. et al. Epigenetic reprogramming of immune cells in injury, repair and resolution. J Clin Invest. 2019;129(8):2994-3005.\u003c\/li\u003e\n\u003cli\u003eBarden AE, Moghaddami M, Mas E, et al. Specialised pro-resolving mediators of inflammation in inflammatory arthritis. Prostaglandins Leukot Essent Fatty Acids. 2016 Apr;107:24-9.\u003c\/li\u003e\n\u003cli\u003eChiang N, Serhan CN. Specialized pro-resolving mediator network: an update on production and actions. Essays Biochem. 2020 Sep 23;64(3):443-462.\u003c\/li\u003e\n\u003cli\u003eRosenthal MD, Patel J, Staton K. et al. Can Specialized Pro-resolving Mediators Deliver Benefit Originally Expected from Fish Oil? Curr Gastroenterol Rep. 2018. 20, 40.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e"}