{"id":8384776208614,"title":"Designs For Health Magnesium Threonate","handle":"designs-for-health-magnesium-threonate","description":"\u003ch2\u003eDesigns For Health Magnesium Threonate\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eExtemporaneous Compounding\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eMagtein is a clinically researched form of Magnesium Threonate\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60g powder (scoop enclosed, 1g per level scoop)\u003c\/p\u003e\n\u003cp\u003eDesigns For Health Magnesium Threonate Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigns for Health Magnesium Threonate utilises Magtein, a clinically researched form of Magnesium Threonate.\u003c\/li\u003e\n\u003cli\u003eMagnesium Threonate is a 100% pure, easy-to-dissolve, excipient-free, virtually tasteless powder. \u003c\/li\u003e\n\u003cli\u003eMagtein was developed at the Massachusetts Institute of Technology and the Tsinghua University in Beijing to produce a unique and highly bioavailable form of magnesium capable of crossing the blood-brain barrier.\u003c\/li\u003e\n\u003cli\u003eMagnesium Threonate is a unique and highly bioavailable form of magnesium.\u003c\/li\u003e\n\u003cli\u003eThe compound consists of magnesium and the L-isomer of threonic acid L- Threonate, a metabolite of ascorbic acid.\u003c\/li\u003e\n\u003cli\u003eMagnesium is the second most abundant cation of the intracellular fluids of the body. It involves over 300 biochemical activities, including enzymatic processes, macromolecule-organelle binding (mRNA binding to ribosomes) and organelle functioning (mitochondria and ATP production).\u003c\/li\u003e\n\u003cli\u003eDue to its critical involvement in the functioning of the sodium\/potassium ATPase pump and calcium pumps, magnesium is also vital for optimal neuromuscular communication and muscle contractility and relaxation.\u003c\/li\u003e\n\u003cli\u003eMagnesium is vital for the adequate functioning of almost every biological system.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health Magnesium Threonate has No Added: Gluten, Eggs, Soy, Sesame, Nuts or Dairy.\u003c\/p\u003e\n\u003cp\u003eFree From: Sulfites, Flavours and Colours (100% Pure)\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003cp\u003eDesigns For Health Magnesium Threonate \u003cbr\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eEach scoop provides 1g of pure magnesium threonate powder\u003c\/p\u003e\n\u003cp\u003eDoses used in research range from 1.5g - 2g daily (1.5 - 2 scoops)\u003c\/p\u003e\n\u003cp\u003ePlease use as directed by your health practitioner.\u003c\/p\u003e\n\u003cp\u003eFor extemporaneous compounding only.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEach scoop provides 1g of pure Magnesium threonate\u003c\/li\u003e\n\u003cli\u003eUtilises Magtein, a clinically researched form of Magnesium Threonate\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003cli\u003e100 % Pure\u003c\/li\u003e\n\u003cli\u003eUnflavoured and Excipient Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach 1g scoop contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium threonate\u003c\/td\u003e\n\u003ctd\u003e1g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Magnesium\u003c\/td\u003e\n\u003ctd\u003e76mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eExcipient Free\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNo Added: Gluten, Eggs, Soy, Sesame, Nuts, Dairy.\u003c\/li\u003e\n\u003cli\u003eFree From: Sulfites, Flavours and Colours (100% Pure)\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eQuality Guarantee\u003c\/h5\u003e\n\u003ch2\u003eQuality Guarantee: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eDesigns for Health medicines that are listed on the Australian Register of Therapeutic Goods will display an AUSTL number on the label.\u003c\/p\u003e\n\u003cp\u003eListed medicines in Australia need to be manufactured according to legislated standards set out in Therapeutic Goods Order 101.\u003c\/p\u003e\n\u003cp\u003eTGO101 legislation sets out minimum quality standards for medicines supplied in Australia that display an AUSTL number.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTGO101 mandates testing for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImpurities such as heavy metals (including lead, mercury, cadmium and arsenic), pesticides and residual solvents\u003c\/li\u003e\n\u003cli\u003eDissolution (to ensure the capsule will dissolve once taken)\u003c\/li\u003e\n\u003cli\u003eUniformity (to ensure that every capsule is the same)\u003c\/li\u003e\n\u003cli\u003eFinal assay testing is also performed to ensure that what we have on the label is in each capsule, and microbiological testing is performed to ensure that no microbial contamination has occurred during the encapsulation and packing process.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist, talk to your health professional.\u003c\/p\u003e\n\u003cp\u003eDietary supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003ch3\u003eContraindications:\u003c\/h3\u003e\n\u003cp\u003eRenal failure.1 \u003cbr\u003eHeart block.1\u003c\/p\u003e\n\u003ch3\u003eCautions:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCaution advised with use of magnesium in individuals with renal dysfunction.1\u003c\/li\u003e\n\u003cli\u003eExcessive intake of magnesium may cause diarrhoea and gastric irritation.1,5\u003c\/li\u003e\n\u003cli\u003eExcessive intake of magnesium may result in reduced calcium levels.1\u003c\/li\u003e\n\u003cli\u003eMagnesium may potentiate the therapeutic effect of calcium-channel blockers and neuroblocker medications.1\u003c\/li\u003e\n\u003cli\u003eLong term use of loop and thiazide diuretics increase urinary magnesium excretion.1,5\u003c\/li\u003e\n\u003cli\u003eMagnesium may decrease absorption of fluoroquinolones. Separate doses by at least 2 hours before and 4 hours after oral magnesium.1\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eThe human body contains around 24g of Magnesium, and it is present in the serum, muscles and soft tissues, bones and extracellular fluid. It is also found in the cerebrospinal fluid where it regulates various brain functions, mainly related to excitatory neuronal function.11\u003c\/p\u003e\n\u003cp\u003eMagnesium is a critical regulator of the activity rate of the Sodium-Potassium ATPase pump (Na+, K+- ATPase pump)2 which is required for the removal of sodium from inside the cell in exchange for potassium (i.e., brings potassium back into the cell despite the chemical gradient favouring potassium movement out of the cell).3 This makes Magnesium critical for maintaining the electrical potential of skeletal and cardiac muscles and nerves and for neurotransmission across neuromuscular and neuronal junctions.2,3\u003c\/p\u003e\n\u003cp\u003eFurther to regulating the activity of the pumps and therefore the electrical potential, Magnesium in the extracellular space facilitates optimal neurotransmitter binding at the neuronal receptor site.7\u003c\/p\u003e\n\u003cp\u003eMagnesium is a calcium antagonist and competes with calcium for binding sites on calcium channels.8 Magnesium can displace calcium at N-methyl-D-aspartate (NMDA) glutamate binding\/ receptor sites preventing their activation.\u003c\/p\u003e\n\u003cp\u003eNMDA receptor activation is associated with numerous biological outcomes such as synaptic plasticity, learning and memory, pain emergence and migraine, sleep6,9 and mood fluctuations.10\u003c\/p\u003e\n\u003cp\u003eNMDA receptors are ion-channels that arbitrate the movement of calcium across synapses. An increase in calcium influx causes glutamate release and consequent excitatory neurotransmission in the central nervous system.6,9,11\u003c\/p\u003e\n\u003cp\u003eExcessive calcium influx in the brain may also disrupt the blood brain barrier, inflammation and oxidative stress.11\u003c\/p\u003e\n\u003cp\u003eMagnesium can also agonise GABAA receptors inhibiting neuronal excitation.11\u003c\/p\u003e\n\u003cp\u003eMagtein has been trialled in both preclinical and clinical studies.12,13\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2023-12-18T16:12:15+11:00","created_at":"2023-12-14T13:26:17+11:00","vendor":"Designs For Health","type":"Designs For Health Naturopathic Medicines","tags":["Compounding","Designs For Health","Naturopathic","PB"],"price":6206,"price_min":6206,"price_max":6206,"available":true,"price_varies":false,"compare_at_price":6895,"compare_at_price_min":6895,"compare_at_price_max":6895,"compare_at_price_varies":false,"variants":[{"id":44129163378918,"title":"50g Powder","option1":"50g Powder","option2":null,"option3":null,"sku":"DFHMagnesiumThreonate60g","requires_shipping":true,"taxable":true,"featured_image":{"id":40185139626214,"product_id":8384776208614,"position":1,"created_at":"2023-12-14T13:31:20+11:00","updated_at":"2023-12-14T13:31:47+11:00","alt":"Designs For Health Magnesium Threonate 60g 10% off RRP at HealthMasters Designs For Health","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealth.png?v=1702521107","variant_ids":[44129163378918]},"available":true,"name":"Designs For Health Magnesium Threonate - 50g Powder","public_title":"50g Powder","options":["50g Powder"],"price":6206,"weight":0,"compare_at_price":6895,"inventory_quantity":19998,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9353993000689","featured_media":{"alt":"Designs For Health Magnesium Threonate 60g 10% off RRP at HealthMasters Designs For Health","id":32798584864998,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealth.png?v=1702521107"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealth.png?v=1702521107","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate10_offRRPatHealthMastersDesignsForHealthLabel.png?v=1702521107","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealthMagteinLogo.png?v=1702878151","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLogo_8f2a9322-99eb-4b52-bfdf-e3672925d1df.jpg?v=1702878151"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealth.png?v=1702521107","options":["Size"],"media":[{"alt":"Designs For Health Magnesium Threonate 60g 10% off RRP at HealthMasters Designs For Health","id":32798584864998,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealth.png?v=1702521107"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealth.png?v=1702521107","width":1200},{"alt":"Designs For Health Magnesium Threonate 10% off RRP at HealthMasters Designs For Health Label","id":32798584832230,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate10_offRRPatHealthMastersDesignsForHealthLabel.png?v=1702521107"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate10_offRRPatHealthMastersDesignsForHealthLabel.png?v=1702521107","width":1200},{"alt":"Designs For Health Magnesium Threonate 60g 10% off RRP at HealthMasters Designs For Health Magtein Logo","id":32811219779814,"position":3,"preview_image":{"aspect_ratio":1.75,"height":800,"width":1400,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealthMagteinLogo.png?v=1702878151"},"aspect_ratio":1.75,"height":800,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthMagnesiumThreonate60g10_offRRPatHealthMastersDesignsForHealthMagteinLogo.png?v=1702878151","width":1400},{"alt":"Designs For Health Magnesium Threonate 10% off RRP at HealthMasters Designs For Health Logo","id":32798530961638,"position":4,"preview_image":{"aspect_ratio":2.5,"height":142,"width":355,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLogo_8f2a9322-99eb-4b52-bfdf-e3672925d1df.jpg?v=1702878151"},"aspect_ratio":2.5,"height":142,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/DesignsForHealthLogo_8f2a9322-99eb-4b52-bfdf-e3672925d1df.jpg?v=1702878151","width":355}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eDesigns For Health Magnesium Threonate\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eExtemporaneous Compounding\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eMagtein is a clinically researched form of Magnesium Threonate\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60g powder (scoop enclosed, 1g per level scoop)\u003c\/p\u003e\n\u003cp\u003eDesigns For Health Magnesium Threonate Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigns for Health Magnesium Threonate utilises Magtein, a clinically researched form of Magnesium Threonate.\u003c\/li\u003e\n\u003cli\u003eMagnesium Threonate is a 100% pure, easy-to-dissolve, excipient-free, virtually tasteless powder. \u003c\/li\u003e\n\u003cli\u003eMagtein was developed at the Massachusetts Institute of Technology and the Tsinghua University in Beijing to produce a unique and highly bioavailable form of magnesium capable of crossing the blood-brain barrier.\u003c\/li\u003e\n\u003cli\u003eMagnesium Threonate is a unique and highly bioavailable form of magnesium.\u003c\/li\u003e\n\u003cli\u003eThe compound consists of magnesium and the L-isomer of threonic acid L- Threonate, a metabolite of ascorbic acid.\u003c\/li\u003e\n\u003cli\u003eMagnesium is the second most abundant cation of the intracellular fluids of the body. It involves over 300 biochemical activities, including enzymatic processes, macromolecule-organelle binding (mRNA binding to ribosomes) and organelle functioning (mitochondria and ATP production).\u003c\/li\u003e\n\u003cli\u003eDue to its critical involvement in the functioning of the sodium\/potassium ATPase pump and calcium pumps, magnesium is also vital for optimal neuromuscular communication and muscle contractility and relaxation.\u003c\/li\u003e\n\u003cli\u003eMagnesium is vital for the adequate functioning of almost every biological system.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health Magnesium Threonate has No Added: Gluten, Eggs, Soy, Sesame, Nuts or Dairy.\u003c\/p\u003e\n\u003cp\u003eFree From: Sulfites, Flavours and Colours (100% Pure)\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003cp\u003eDesigns For Health Magnesium Threonate \u003cbr\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eEach scoop provides 1g of pure magnesium threonate powder\u003c\/p\u003e\n\u003cp\u003eDoses used in research range from 1.5g - 2g daily (1.5 - 2 scoops)\u003c\/p\u003e\n\u003cp\u003ePlease use as directed by your health practitioner.\u003c\/p\u003e\n\u003cp\u003eFor extemporaneous compounding only.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEach scoop provides 1g of pure Magnesium threonate\u003c\/li\u003e\n\u003cli\u003eUtilises Magtein, a clinically researched form of Magnesium Threonate\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003cli\u003e100 % Pure\u003c\/li\u003e\n\u003cli\u003eUnflavoured and Excipient Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach 1g scoop contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium threonate\u003c\/td\u003e\n\u003ctd\u003e1g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Magnesium\u003c\/td\u003e\n\u003ctd\u003e76mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eExcipient Free\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNo Added: Gluten, Eggs, Soy, Sesame, Nuts, Dairy.\u003c\/li\u003e\n\u003cli\u003eFree From: Sulfites, Flavours and Colours (100% Pure)\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eQuality Guarantee\u003c\/h5\u003e\n\u003ch2\u003eQuality Guarantee: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eDesigns for Health medicines that are listed on the Australian Register of Therapeutic Goods will display an AUSTL number on the label.\u003c\/p\u003e\n\u003cp\u003eListed medicines in Australia need to be manufactured according to legislated standards set out in Therapeutic Goods Order 101.\u003c\/p\u003e\n\u003cp\u003eTGO101 legislation sets out minimum quality standards for medicines supplied in Australia that display an AUSTL number.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTGO101 mandates testing for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImpurities such as heavy metals (including lead, mercury, cadmium and arsenic), pesticides and residual solvents\u003c\/li\u003e\n\u003cli\u003eDissolution (to ensure the capsule will dissolve once taken)\u003c\/li\u003e\n\u003cli\u003eUniformity (to ensure that every capsule is the same)\u003c\/li\u003e\n\u003cli\u003eFinal assay testing is also performed to ensure that what we have on the label is in each capsule, and microbiological testing is performed to ensure that no microbial contamination has occurred during the encapsulation and packing process.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist, talk to your health professional.\u003c\/p\u003e\n\u003cp\u003eDietary supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003ch3\u003eContraindications:\u003c\/h3\u003e\n\u003cp\u003eRenal failure.1 \u003cbr\u003eHeart block.1\u003c\/p\u003e\n\u003ch3\u003eCautions:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCaution advised with use of magnesium in individuals with renal dysfunction.1\u003c\/li\u003e\n\u003cli\u003eExcessive intake of magnesium may cause diarrhoea and gastric irritation.1,5\u003c\/li\u003e\n\u003cli\u003eExcessive intake of magnesium may result in reduced calcium levels.1\u003c\/li\u003e\n\u003cli\u003eMagnesium may potentiate the therapeutic effect of calcium-channel blockers and neuroblocker medications.1\u003c\/li\u003e\n\u003cli\u003eLong term use of loop and thiazide diuretics increase urinary magnesium excretion.1,5\u003c\/li\u003e\n\u003cli\u003eMagnesium may decrease absorption of fluoroquinolones. Separate doses by at least 2 hours before and 4 hours after oral magnesium.1\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health Magnesium Threonate\u003c\/h2\u003e\n\u003cp\u003eThe human body contains around 24g of Magnesium, and it is present in the serum, muscles and soft tissues, bones and extracellular fluid. It is also found in the cerebrospinal fluid where it regulates various brain functions, mainly related to excitatory neuronal function.11\u003c\/p\u003e\n\u003cp\u003eMagnesium is a critical regulator of the activity rate of the Sodium-Potassium ATPase pump (Na+, K+- ATPase pump)2 which is required for the removal of sodium from inside the cell in exchange for potassium (i.e., brings potassium back into the cell despite the chemical gradient favouring potassium movement out of the cell).3 This makes Magnesium critical for maintaining the electrical potential of skeletal and cardiac muscles and nerves and for neurotransmission across neuromuscular and neuronal junctions.2,3\u003c\/p\u003e\n\u003cp\u003eFurther to regulating the activity of the pumps and therefore the electrical potential, Magnesium in the extracellular space facilitates optimal neurotransmitter binding at the neuronal receptor site.7\u003c\/p\u003e\n\u003cp\u003eMagnesium is a calcium antagonist and competes with calcium for binding sites on calcium channels.8 Magnesium can displace calcium at N-methyl-D-aspartate (NMDA) glutamate binding\/ receptor sites preventing their activation.\u003c\/p\u003e\n\u003cp\u003eNMDA receptor activation is associated with numerous biological outcomes such as synaptic plasticity, learning and memory, pain emergence and migraine, sleep6,9 and mood fluctuations.10\u003c\/p\u003e\n\u003cp\u003eNMDA receptors are ion-channels that arbitrate the movement of calcium across synapses. An increase in calcium influx causes glutamate release and consequent excitatory neurotransmission in the central nervous system.6,9,11\u003c\/p\u003e\n\u003cp\u003eExcessive calcium influx in the brain may also disrupt the blood brain barrier, inflammation and oxidative stress.11\u003c\/p\u003e\n\u003cp\u003eMagnesium can also agonise GABAA receptors inhibiting neuronal excitation.11\u003c\/p\u003e\n\u003cp\u003eMagtein has been trialled in both preclinical and clinical studies.12,13\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}