{"id":7693286670566,"title":"Bioclinic Naturals MyO-Sense","handle":"bioclinic-naturals-myo-sense","description":"\u003ch2\u003eBioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eRegulates a Healthy Menstrual Cycle\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSizes: 180g Powder\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense Feature Summary:\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense is formulated to support female reproductive health, maintain healthy reproductive hormones and have a healthy menstrual cycle. Bioclinic Naturals MyO-Sense provides therapeutic doses of nutrients that may help support healthy preconception in females and maintain healthy blood glucose levels. It also provides antioxidant and anti-inflammatory support.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSpecifically formulated to provide nutritional support for female reproductive health and a healthy menstrual cycle without herbal extracts.\u003c\/li\u003e\n\u003cli\u003eProvides 4 g\/day of Myo-inositol to promote healthy oocyte maturation and pregnancy rates.\u003c\/li\u003e\n\u003cli\u003eDelivers 200 micrograms of chromium per day to support healthy glucose metabolism.\u003c\/li\u003e\n\u003cli\u003eContains quercetin with LipiSperse Technology for enhanced bioavailability.\u003c\/li\u003e\n\u003cli\u003eFlavourless powder for convenient dosage and improved compliance\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense AUST L358732\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense has been specifically formulated without herbal extracts to provide nutritional support for a healthy menstrual cycle, with key ingredients including Myo-inositol, quercetin and chromium.\u003c\/p\u003e\n\u003cp\u003eTherapeutic doses of these nutrients support biological mechanisms of action that specifically target underlying hormonal and metabolic imbalances known to adversely influence healthy reproductive hormone levels and activity, oocyte maturation, conception and pregnancy outcomes in females.\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense contains quercetin LipiSperse Technology. LipiSperse is an advanced cold water dispersion technology that allows lipophilic active ingredients with otherwise relatively low bioavailability and poor solubility in water, to be easily dispersed in cold water, thereby increasing their bioavailability and uptake in the body.\u003c\/p\u003e\n\u003ch5\u003eRecommended Use\u003c\/h5\u003e\n\u003ch2\u003eRecommended Use: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003e2 scoops per day or as directed by a health care practitioner.\u003c\/p\u003e\n\u003ch5\u003eMedicinal Ingredients\u003c\/h5\u003e\n\u003ch2\u003eMedicinal Ingredients: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Scoop (3 g) Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInositol\u003c\/td\u003e\n\u003ctd\u003e2g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eQuercetin dihydrate (LipiSperse Quercetin CWD 90)\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLevomefolate calcium\u003c\/td\u003e\n\u003ctd\u003e216.54micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e-equiv. levomefolic acid\u003c\/td\u003e\n\u003ctd\u003e200micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMecobalamin (co-methylcobalamin) (vitamin B12)\u003c\/td\u003e\n\u003ctd\u003e1.5micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChromium (picolinate, chloride)\u003c\/td\u003e\n\u003ctd\u003e100micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (selenomethionine)\u003c\/td\u003e\n\u003ctd\u003e75micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (citrate dihydrate)\u003c\/td\u003e\n\u003ctd\u003e5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eColecalciferol (vitamin D3)\u003c\/td\u003e\n\u003ctd\u003e12.5micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eKey Features \u0026amp; Benefits\u003c\/h5\u003e\n\u003ch2\u003eKey Features \u0026amp; Benefits: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense has been specifically formulated without herbal extracts to provide nutritional support for a healthy menstrual cycle, with key ingredients including Myo-inositol, quercetin and chromium. Therapeutic doses of these nutrients support biological mechanisms of action that specifically target underlying hormonal and metabolic imbalances known to adversely influence healthy reproductive hormone levels and activity, oocyte maturation, conception and pregnancy outcomes in females. \u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense contains quercetin LipiSperse Technology. LipiSperse is an advanced cold water dispersion technology that allows lipophilic active ingredients with otherwise relatively low bioavailability and poor solubility in water, to be easily dispersed in cold water, thereby increasing their bioavailability and uptake in the body. \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eHormonal Imbalances - Aetiology, Pathophysiology and Comorbidities \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eCurrent knowledge indicates that imbalances in female menstrual cycles and associated conditions are a result of aetiology and pathophysiology, involving interactions between multiple genetic, metabolic, endocrine, environmental (prenatal, postnatal) and lifestyle factors across the female lifecycle.1-5 \u003c\/p\u003e\n\u003cp\u003eThese factors, via varying mechanisms, can lead to physiological imbalances in androgens (synthesis, transport and regulation); sex-hormone-binding globulin synthesis; reproductive hormones (follicle-stimulating (FSH), luteinising and antimullerian hormones); insulin (metabolism, receptor binding or signalling); cortisol; reactive oxygen species levels and activity; inflammation (C-reactive protein, tumour necrosis factor-α, interleukin-8) and growth factors (inhibin).1-3,6-17 \u003c\/p\u003e\n\u003cp\u003eLocally this disrupts the maturation of follicles and oocytes into dominant follicles, resulting in ovarian dysfunction and altered morphology, menstrual irregularities, sub- and infertility, impaired embryo quality and pregnancy complications.1,2,6,10 Systemic consequences include comorbidities such as obesity, dyslipidaemia, metabolic syndrome, insulin resistance, type 2 diabetes mellitus, high homocysteine levels and cardiovascular disease.2-4,10,16,17,33 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eNutritional Support \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eAlong with appropriate dietary, lifestyle and environmental support, key nutrients can beneficially target hormonal and metabolic imbalances and associated conditions that result from these. \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMyo-inositol \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe polyol (sugar) Myo-inositol (MI) is the most concentrated form of inositol in the body.1,18,19 Endogenous MI is synthesised following isomerisation of glucose-6-phosphate to form Myo-inositol 1-phosphate and then dephosphorylated into free MI.20,21 Intracellularly, MI is then converted to inositol triphosphate (via phosphatidyl-myoinositol), which acts as a second messenger for insulin and FSH.1,18,19 Such second messenger mechanisms underlie the biological effect of MI on ovarian FSH signalling, insulin signalling and sensitivity, cellular glucose metabolism (transport, uptake, utilisation), glycogen synthesis and adipose tissue-derived free fatty acid release.1,18 \u003c\/p\u003e\n\u003cp\u003eAlso relevant to the significant impact of MI on ovarian health is its conversion into D-chiro-inositol by the epimerase enzyme, with rates varying in different body tissues based on physiological requirements and hormonal influences (e.g. MI\/DCI ratio in thecal cells is 20:1 vs 100:1 in follicular fluid).1,18,22,23 Insulin has a significant influence on the conversion rate of MI to DCI, with elevated systemic insulin levels overstimulating ovarian epimerase activity, thereby upregulating and downregulating DCI and MI synthesis, respectively. This results in impaired FSH signalling and elevated androgen synthesis, which consequently exacerbates elevated insulin levels, increases free fatty acid concentrations and promotes inflammation.22,23 \u003c\/p\u003e\n\u003cp\u003eIt is via the improved ovarian MI\/ DCI ratios and insulin and FSH second messenger actions that optimal MI levels can significantly and positively influence oocyte maturation and quality and consequently, ovulation, menstrual cyclicity, fertility and pregnancy outcomes.1,19,22,24 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eFolic Acid \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eHealthy folic acid levels are important for B12 activation, maintaining healthy homocysteine levels and healthy pregnancy outcomes.25 Optimal endogenous levels of both MI and folic acid has been positively associated with lower AMH and glucose levels, healthy follicular maturation, oocyte quality, fertilisation and embryo quality.24,26,27 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eQuercetin \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eIn support of healthy glucose metabolism, quercetin has been shown to enhance insulin signalling, sensitivity and secretion, promote pancreatic betacell proliferation and increase glucose transporter (GLUT) activity.9 Quercetin also has significant antioxidant and anti-inflammatory activity, and further, promotes healthy hormonal balance (by positively modulating androgens, LH, oestradiol and progesterone levels), follicular cell morphology (increasing the concentration of normal follicles) and healthy folliculogenesis and luteinisation activity.9 \u003c\/p\u003e\n\u003cp\u003eBy acting on these key underlying metabolic imbalances, quercetin may help improve clinical characteristics including impaired insulin sensitivity, oxidative stress, inflammation, menstrual cyclicity and fertility.9 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eChromium \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eChromium plays a central role in supporting healthy glucose and insulin metabolism. Specifically, chromium is involved in carbohydrate metabolism, promoting insulin-mediated glucose transport into cells, increasing insulin receptor concentrations and activity and enhancing pancreatic beta-cell sensitivity.25 These processes underlie its beneficial influence on fasting plasma glucose, insulin metabolism levels and sensitivity, lipid profiles, antioxidant activity and free testosterone levels.28-30 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eSelenium \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe essential mineral selenium has significant antioxidant properties which underlie its important role in maintaining healthy reproductive function.5,31 Low selenium concentrations are commonly attributed to the inhibitory effect of elevated androgens on selenium binding protein 1 (SBP1) gene expression and systemic inflammation.5,31,32 Increasing selenium concentrations have been associated with upregulated gene expression of insulin and glucose metabolic genes (PPAR-y and GLUT-1) and pancreatic beta-cells, and downregulation of inflammation (NF-ҡβ, TNF-α and IL1\/18) and oxidative stress.5,31 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eVitamin D \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSerum vitamin D levels, vital for normal reproductive health are associated with impaired insulin sensitivity, systemic inflammation, elevated AMH levels (impairing folliculogenesis) and hyperandrogenemia.1,34-36 Conversely, normal vitamin D concentrations are required for healthy glucose metabolism, insulin secretion, ovulatory function, oestrogen and progesterone synthesis, folliculogenesis, menstrual regularity and AMH levels.1,35 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eZinc and B12 \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eKey physiological functions of zinc include acting as a cofactor for antioxidant enzymes (catalase and superoxide dismutase) and involvement in insulin synthesis, secretion, storage, signalling and function.32,36 Some medications may contribute to low B12 levels, adversely influencing homocysteine levels due to B12’s essential role in homocysteine metabolism.33,37,38 \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e*References available on request. \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eContraindications\u003cbr\u003e\n\u003c\/h5\u003e\n\u003ch2\u003eContraindications: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eWARNINGS: If symptoms persist, talk to your health care practitioner.\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T16:13:55+11:00","created_at":"2022-03-19T06:54:31+11:00","vendor":"Bioclinic Naturals","type":"Bioclinic Naturals Naturopathic Medicines","tags":["Bioclinic Naturals","Inositol","Naturopathic","PB","Quercetin"],"price":4766,"price_min":4766,"price_max":4766,"available":true,"price_varies":false,"compare_at_price":5295,"compare_at_price_min":5295,"compare_at_price_max":5295,"compare_at_price_varies":false,"variants":[{"id":42694461718758,"title":"180g Powder","option1":"180g Powder","option2":null,"option3":null,"sku":"BcNMyOSense180g","requires_shipping":true,"taxable":true,"featured_image":{"id":37179402158310,"product_id":7693286670566,"position":1,"created_at":"2022-03-19T11:23:31+11:00","updated_at":"2022-03-19T11:26:18+11:00","alt":"Bioclinic Naturals MyOSense 180g 10% off RRP at HealthMasters Bioclinic Naturals","width":911,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioclinicNaturalsMyOSense180g10_offRRPatHealthMastersBioclinicNaturals.png?v=1647649578","variant_ids":[42694461718758]},"available":true,"name":"Bioclinic Naturals MyO-Sense - 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Bioclinic Naturals MyO-Sense provides therapeutic doses of nutrients that may help support healthy preconception in females and maintain healthy blood glucose levels. It also provides antioxidant and anti-inflammatory support.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSpecifically formulated to provide nutritional support for female reproductive health and a healthy menstrual cycle without herbal extracts.\u003c\/li\u003e\n\u003cli\u003eProvides 4 g\/day of Myo-inositol to promote healthy oocyte maturation and pregnancy rates.\u003c\/li\u003e\n\u003cli\u003eDelivers 200 micrograms of chromium per day to support healthy glucose metabolism.\u003c\/li\u003e\n\u003cli\u003eContains quercetin with LipiSperse Technology for enhanced bioavailability.\u003c\/li\u003e\n\u003cli\u003eFlavourless powder for convenient dosage and improved compliance\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense AUST L358732\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense has been specifically formulated without herbal extracts to provide nutritional support for a healthy menstrual cycle, with key ingredients including Myo-inositol, quercetin and chromium.\u003c\/p\u003e\n\u003cp\u003eTherapeutic doses of these nutrients support biological mechanisms of action that specifically target underlying hormonal and metabolic imbalances known to adversely influence healthy reproductive hormone levels and activity, oocyte maturation, conception and pregnancy outcomes in females.\u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense contains quercetin LipiSperse Technology. LipiSperse is an advanced cold water dispersion technology that allows lipophilic active ingredients with otherwise relatively low bioavailability and poor solubility in water, to be easily dispersed in cold water, thereby increasing their bioavailability and uptake in the body.\u003c\/p\u003e\n\u003ch5\u003eRecommended Use\u003c\/h5\u003e\n\u003ch2\u003eRecommended Use: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003e2 scoops per day or as directed by a health care practitioner.\u003c\/p\u003e\n\u003ch5\u003eMedicinal Ingredients\u003c\/h5\u003e\n\u003ch2\u003eMedicinal Ingredients: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Scoop (3 g) Contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInositol\u003c\/td\u003e\n\u003ctd\u003e2g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eQuercetin dihydrate (LipiSperse Quercetin CWD 90)\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLevomefolate calcium\u003c\/td\u003e\n\u003ctd\u003e216.54micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e-equiv. levomefolic acid\u003c\/td\u003e\n\u003ctd\u003e200micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMecobalamin (co-methylcobalamin) (vitamin B12)\u003c\/td\u003e\n\u003ctd\u003e1.5micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChromium (picolinate, chloride)\u003c\/td\u003e\n\u003ctd\u003e100micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (selenomethionine)\u003c\/td\u003e\n\u003ctd\u003e75micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (citrate dihydrate)\u003c\/td\u003e\n\u003ctd\u003e5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eColecalciferol (vitamin D3)\u003c\/td\u003e\n\u003ctd\u003e12.5micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eKey Features \u0026amp; Benefits\u003c\/h5\u003e\n\u003ch2\u003eKey Features \u0026amp; Benefits: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense has been specifically formulated without herbal extracts to provide nutritional support for a healthy menstrual cycle, with key ingredients including Myo-inositol, quercetin and chromium. Therapeutic doses of these nutrients support biological mechanisms of action that specifically target underlying hormonal and metabolic imbalances known to adversely influence healthy reproductive hormone levels and activity, oocyte maturation, conception and pregnancy outcomes in females. \u003c\/p\u003e\n\u003cp\u003eBioclinic Naturals MyO-Sense contains quercetin LipiSperse Technology. LipiSperse is an advanced cold water dispersion technology that allows lipophilic active ingredients with otherwise relatively low bioavailability and poor solubility in water, to be easily dispersed in cold water, thereby increasing their bioavailability and uptake in the body. \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eHormonal Imbalances - Aetiology, Pathophysiology and Comorbidities \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eCurrent knowledge indicates that imbalances in female menstrual cycles and associated conditions are a result of aetiology and pathophysiology, involving interactions between multiple genetic, metabolic, endocrine, environmental (prenatal, postnatal) and lifestyle factors across the female lifecycle.1-5 \u003c\/p\u003e\n\u003cp\u003eThese factors, via varying mechanisms, can lead to physiological imbalances in androgens (synthesis, transport and regulation); sex-hormone-binding globulin synthesis; reproductive hormones (follicle-stimulating (FSH), luteinising and antimullerian hormones); insulin (metabolism, receptor binding or signalling); cortisol; reactive oxygen species levels and activity; inflammation (C-reactive protein, tumour necrosis factor-α, interleukin-8) and growth factors (inhibin).1-3,6-17 \u003c\/p\u003e\n\u003cp\u003eLocally this disrupts the maturation of follicles and oocytes into dominant follicles, resulting in ovarian dysfunction and altered morphology, menstrual irregularities, sub- and infertility, impaired embryo quality and pregnancy complications.1,2,6,10 Systemic consequences include comorbidities such as obesity, dyslipidaemia, metabolic syndrome, insulin resistance, type 2 diabetes mellitus, high homocysteine levels and cardiovascular disease.2-4,10,16,17,33 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eNutritional Support \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eAlong with appropriate dietary, lifestyle and environmental support, key nutrients can beneficially target hormonal and metabolic imbalances and associated conditions that result from these. \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMyo-inositol \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe polyol (sugar) Myo-inositol (MI) is the most concentrated form of inositol in the body.1,18,19 Endogenous MI is synthesised following isomerisation of glucose-6-phosphate to form Myo-inositol 1-phosphate and then dephosphorylated into free MI.20,21 Intracellularly, MI is then converted to inositol triphosphate (via phosphatidyl-myoinositol), which acts as a second messenger for insulin and FSH.1,18,19 Such second messenger mechanisms underlie the biological effect of MI on ovarian FSH signalling, insulin signalling and sensitivity, cellular glucose metabolism (transport, uptake, utilisation), glycogen synthesis and adipose tissue-derived free fatty acid release.1,18 \u003c\/p\u003e\n\u003cp\u003eAlso relevant to the significant impact of MI on ovarian health is its conversion into D-chiro-inositol by the epimerase enzyme, with rates varying in different body tissues based on physiological requirements and hormonal influences (e.g. MI\/DCI ratio in thecal cells is 20:1 vs 100:1 in follicular fluid).1,18,22,23 Insulin has a significant influence on the conversion rate of MI to DCI, with elevated systemic insulin levels overstimulating ovarian epimerase activity, thereby upregulating and downregulating DCI and MI synthesis, respectively. This results in impaired FSH signalling and elevated androgen synthesis, which consequently exacerbates elevated insulin levels, increases free fatty acid concentrations and promotes inflammation.22,23 \u003c\/p\u003e\n\u003cp\u003eIt is via the improved ovarian MI\/ DCI ratios and insulin and FSH second messenger actions that optimal MI levels can significantly and positively influence oocyte maturation and quality and consequently, ovulation, menstrual cyclicity, fertility and pregnancy outcomes.1,19,22,24 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eFolic Acid \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eHealthy folic acid levels are important for B12 activation, maintaining healthy homocysteine levels and healthy pregnancy outcomes.25 Optimal endogenous levels of both MI and folic acid has been positively associated with lower AMH and glucose levels, healthy follicular maturation, oocyte quality, fertilisation and embryo quality.24,26,27 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eQuercetin \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eIn support of healthy glucose metabolism, quercetin has been shown to enhance insulin signalling, sensitivity and secretion, promote pancreatic betacell proliferation and increase glucose transporter (GLUT) activity.9 Quercetin also has significant antioxidant and anti-inflammatory activity, and further, promotes healthy hormonal balance (by positively modulating androgens, LH, oestradiol and progesterone levels), follicular cell morphology (increasing the concentration of normal follicles) and healthy folliculogenesis and luteinisation activity.9 \u003c\/p\u003e\n\u003cp\u003eBy acting on these key underlying metabolic imbalances, quercetin may help improve clinical characteristics including impaired insulin sensitivity, oxidative stress, inflammation, menstrual cyclicity and fertility.9 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eChromium \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eChromium plays a central role in supporting healthy glucose and insulin metabolism. Specifically, chromium is involved in carbohydrate metabolism, promoting insulin-mediated glucose transport into cells, increasing insulin receptor concentrations and activity and enhancing pancreatic beta-cell sensitivity.25 These processes underlie its beneficial influence on fasting plasma glucose, insulin metabolism levels and sensitivity, lipid profiles, antioxidant activity and free testosterone levels.28-30 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eSelenium \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe essential mineral selenium has significant antioxidant properties which underlie its important role in maintaining healthy reproductive function.5,31 Low selenium concentrations are commonly attributed to the inhibitory effect of elevated androgens on selenium binding protein 1 (SBP1) gene expression and systemic inflammation.5,31,32 Increasing selenium concentrations have been associated with upregulated gene expression of insulin and glucose metabolic genes (PPAR-y and GLUT-1) and pancreatic beta-cells, and downregulation of inflammation (NF-ҡβ, TNF-α and IL1\/18) and oxidative stress.5,31 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eVitamin D \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSerum vitamin D levels, vital for normal reproductive health are associated with impaired insulin sensitivity, systemic inflammation, elevated AMH levels (impairing folliculogenesis) and hyperandrogenemia.1,34-36 Conversely, normal vitamin D concentrations are required for healthy glucose metabolism, insulin secretion, ovulatory function, oestrogen and progesterone synthesis, folliculogenesis, menstrual regularity and AMH levels.1,35 \u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eZinc and B12 \u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eKey physiological functions of zinc include acting as a cofactor for antioxidant enzymes (catalase and superoxide dismutase) and involvement in insulin synthesis, secretion, storage, signalling and function.32,36 Some medications may contribute to low B12 levels, adversely influencing homocysteine levels due to B12’s essential role in homocysteine metabolism.33,37,38 \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e*References available on request. \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eContraindications\u003cbr\u003e\n\u003c\/h5\u003e\n\u003ch2\u003eContraindications: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003eWARNINGS: If symptoms persist, talk to your health care practitioner.\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Bioclinic Naturals MyO-Sense\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}