{"id":4775005192251,"title":"BioCeuticals Clinical Calcium D-Glucarate (calcium saccharate) 60g","handle":"bioceuticals-calcium-d-glucarate-calcium-saccharate","description":"\u003ch2\u003eBioCeuticals Clinical Calcium D-Glucarate (calcium saccharate) 60g\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eAssists phase 2 detoxification of oestrogen\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eBioCeuticals D-Glucarate is part of the BioCeuticals Compounding Range\u003c\/p\u003e\n\u003cp\u003eAvailable in sizes: 60g net powder\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBioCeuticals Calcium D-Glucarate has No Added Dairy, No Added gluten, No added Shellfish, No Added Soy protein, Vgan Friendly, Vegetarian Friendly, No Added Yeast.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"BioCeuticals Clinical 10% off RRP | HealthMasters\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003eBioCeuticals Clinical 10% off RRP\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"BioCeuticals Clinical 10% off RRP | HealthMasters\"\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cbig\u003eClick Here To Access\u003c\/big\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003e1 metric teaspoon (1.7g) provides 1.5g calcium D-glucarate (calcium saccharate)\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eDispensed after consultation with patient.\u003c\/p\u003e\n\u003ch5\u003eFeatures \u0026amp; Benefits\u003c\/h5\u003e\n\u003ch2\u003eFeatures \u0026amp; Benefits: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eContent for features \u0026amp; benefits\u003c\/p\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003econtent for Ingredient Summary\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach 1g contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium D-Glucarate (calcium saccharide)\u003c\/td\u003e\n\u003ctd\u003e900mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIn a base of maltodextrin and silica-colloidal anhydrous\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eFree Froms\u003c\/h5\u003e\n\u003ch2\u003eFree Froms: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eNo Added Dairy, No Added gluten, No added Shellfish, No Added Soy protein, Vgan Friendly, Vegetarian Friendly, No Added Yeast.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eInsufficient reliable information available for pregnancy and lactation, avoid using.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eTheoretically, \u003cspan\u003eCalcium D-Glucarate might increase the clearance of drugs that undergo glucuronidation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTheoretically, concominant use with alcohol might decrease Calcium D-Glucarate activity. There is some evidence that urinary excretion of D-glucarate is increased in people consuming alcohol.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eCompanion Products:\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eContent for Companion Products\u003c\/p\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Calcium_D-glucarate_main_Image_-_HealthMasters_1024x1024.jpg?v=1584752961\" alt=\"Calcium D-glucarate main Image - HealthMasters\" width=\"1024x1024\" height=\"1024x1024\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003ch2\u003eBackground\u003c\/h2\u003e\n\u003cp\u003eD-glucaric acid is a natural, non-toxic compound produced by the body in small amounts. In addition to being found in fruits and vegetables: the richest sources include oranges, apples, grapefruits and cruciferous vegetables.1,2\u003c\/p\u003e\n\u003cp\u003eCalcium D-glucarate is the supplemental form of D-glucaric acid, where it is bound to calcium. When ingested, calcium d-glucarate is metabolised to D-glucaric acid, which may be further metabolised into D-glucaro-1,4-lactone or D-glucaro-6,3-lactone compounds which have important roles in the body, particularly regarding to detoxification.\u003c\/p\u003e\n\u003cp\u003eThe therapeutic benefits of calcium D-glucarate stem from its ability to indirectly inhibit beta-glucuronidase, an enzyme produced by colonic microflora which may disrupt phase 2 detoxification.\u003c\/p\u003e\n\u003cp\u003eElevated beta-glucuronidase activity has been linked to increased risk of various cancers, particularly hormone-dependent cancers such as breast and prostate cancer.2\u003c\/p\u003e\n\u003ch2\u003eKey benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAnti-carcinogenic\u003c\/li\u003e\n\u003cli\u003eAnti-infammatory\u003c\/li\u003e\n\u003cli\u003eEnhances glucuronidation (phase 2 liver detoxiication)\u003c\/li\u003e\n\u003cli\u003eInhibits beta-glucuronidase\u003c\/li\u003e\n\u003cli\u003eLipid lowering\u003c\/li\u003e\n\u003cli\u003eRegulates and supports healthy oestrogen metabolism\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eClinical applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eOestrogen dominance or excess:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- endometriosis\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- menorrhagia\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- uterine fibroids\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003eHyperlipidaemia\u003c\/li\u003e\n\u003cli\u003eBreast cancer\u003c\/li\u003e\n\u003cli\u003eColon cancer\u003c\/li\u003e\n\u003cli\u003eLiver cancer\u003c\/li\u003e\n\u003cli\u003eLung cancer\u003c\/li\u003e\n\u003cli\u003eSkin cancer\u003c\/li\u003e\n\u003cli\u003eEnhance detoxification\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003ch2\u003eMechanisms of action\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eDetoxification and inhibition of beta-glucuronidase\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eGlucuronidation is one of the primary pathways involved in phase 2 detoxification in the liver. Glucuronidation allows for the detoxification of endogenous compounds such as hormones and exogenous toxins such as drugs and carcinogens. During glucuronidation, glucuronic acid binds to potentially toxic compounds forming glucuronide conjugates. These newly formed glucuronide conjugates allow toxins, carcinogens and hormones to be safely eliminated from the body via the biliary tract.\u003c\/p\u003e\n\u003cp\u003eBeta-glucuronidase is an enzyme produced by the colonic microflora. It has a detrimental effect on detoxification by deconjugating glucuronide conjugates that are formed during phase 2 detoxification.3 This breaking of the toxin-glucuronic acid bond allows for toxins and hormones to be reabsorbed rather than excreted.\u003c\/p\u003e\n\u003cp\u003eIncreased beta-glucuronidase activity has been associated with an increased risk of certain cancers including breast, prostate and colon.2,4 By inhibiting beta-glucuronidase, calcium D-glucarate supports phase 2 detoxification by preventing the hydrolysis of glucuronide conjugates and increasing the detoxification and elimination of hormones, toxins and carcinogens.5\u003c\/p\u003e\n\u003cp\u003eThe acidic environment of the stomach allows for the metabolism of calcium D-glucarate into D-glucaric acid.3 Further metabolism of D-glucaric acid results in the formation of D-glucaro-1,4-lactone ord-glucaro-6,3-lactone. D-glucaro-1,4-lactone appears to be the most active and is a potent beta-glucuronidase inhibitor.\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Figure_I_Metabolism_of_calcium_D-glucarate3_480x480.jpg?v=1584740562\" alt=\"Figure I Metabolism of calcium D-glucarate3\" width=\"480x480\" height=\"480x480\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: Metabolism of calcium D-Glucarate3\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eCancer\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe majority of research surrounding calcium D-glucarate has focused on its effect on tumour growth and the prevention of cancer. In vitro and animal studies have shown that calcium d-glucarate inhibits the initiation and promotion of cancer cells by interacting with signal transduction pathways, inhibiting beta-glucuronidase activity, reducing pro-inflammatory cytokines, while also inducing apoptosis.6 A range of studies have been conducted on breast, colon, liver, lung, prostate and skin animal tumour models, with the majority of research focusing on breast cancer.3\u003c\/p\u003e\n\u003cp\u003eHigh beta-glucuronidase activity has been linked to low D-glucaric acid levels, which in turn is associated with an increased risk for various cancers.3 By inhibiting beta-glucuronidase, calcium D-glucarate increases the detoxification and elimination of carcinogens and hormones associated with cancer development.6\u003c\/p\u003e\n\u003cp\u003eCalcium D-glucarate reduces pro-inflammatory cytokines and increases the key anti-inflammatory and immune-regulating cytokine IL-10.\u003c\/p\u003e\n\u003cp\u003ePro-inflammatory cytokines are found in various tumours and may promote the transformation of precancerous cells to malignant cells, while also promoting tumour progression.7\u003c\/p\u003e\n\u003cp\u003eResearchers have suggested that the formation of 1,4-GL from calcium D-glucarate may be the prerequisite for the prevention of breast, prostate and colon cancer in humans.5\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eOestrogen metabolism\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eOestrogen is metabolised in the liver during phase 2 detoxification, specifically via the glucuronidation pathway. Oestrogen combines with glucuronic acid forming an oestrogen-glucuronic acid conjugate.8 This conjugate is then eliminated via the bile, allowing the body to maintain healthy oestrogen levels.\u003c\/p\u003e\n\u003cp\u003eIncreased beta-glucuronidase activity splits the oestrogen-glucuronic acid bond, causing the free oestrogen to be reabsorbed, which may increase oestrogen levels or lead to oestrogen dominance and a disturbed oestrogen:progesterone ratio.\u003c\/p\u003e\n\u003cp\u003eAnimal studies have shown that calcium D-glucarate lowers serum oestrogen levels and increases its urinary excretion.5 This appears to be due to the inhibition of beta-glucuronidase causing reduced oestrogen reabsorption and lower circulating oestrogen levels.8\u003c\/p\u003e\n\u003ch2\u003eClinical studies\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eD-glucarate reduces inflammatory biomarkers and enhances apoptosis in lung cancer\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e To investigate the effect of dietary calcium D-glucarate on inflammatory cytokines, inflammatory biomarkers and apoptosis in lung tumorigenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubjects\/Method:\u003c\/strong\u003e Animal study involving mice with induced lung tumorigenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntervention:\u003c\/strong\u003e Dietary calcium D-glucarate (2% and 4% w\/w) for 8 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c\/strong\u003e D-glucarate decreased pro-inflammatory cytokines, while increasing the anti-inflammatory cytokine IL-10 during early post-initiation stages of lung tumorigenesis in mice. D-glucarate also exhibited proapoptotic effects.\u003c\/p\u003e\n\u003cp\u003eThe researchers concluded that calcium D-glucarate may prevent lung cancer in tobacco smokers and ex-smokers by enhancing apoptosis and suppressing the acute inflammation and proliferation induced by tobacco related carcinogens.\u003c\/p\u003e\n\u003cp\u003eZoltaszek R, Kowalczyk P, Kowalczyk MC, et al. Dietary D-glucarate effects on the biomarkers of inlammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A\/J mice. Oncol Lett 2011;2(1):145-154.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eD-glucarate induces D-glucaro-1,4-lactone, a potent beta-glucuronidase inhibitor\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e To demonstrate the \u003cem\u003ein vivo\u003c\/em\u003e formation of the betaglucuronidase inhibitor D-glucaro-1,4-lactone (1,4-GL) from a D-glucarate salt and determine its metabolism, uptake by selected organs and excretion following oral administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubjects\/Method:\u003c\/strong\u003e Animal study.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntervention:\u003c\/strong\u003e Male and female Sprague-Dawley rats received oral D-glucarate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c\/strong\u003e D-glucarate administration resulted in the formation of 1,4-GL in the stomach of rats. The researchers concluded that the formation of 1,4-GL from d-glucaric acid derivatives may be a prerequisite for the inhibition ofchemical carcinogenesis in rodents, and the prevention of breast, prostate and colon cancer in humans.\u003c\/p\u003e\n\u003cp\u003eWalaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-190.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eCalcium D-glucarate inhibits breast carcinogenesis\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e To evaluate the effect of calcium D-glucarate on rat mammary carcinogenesis, compared to a known chemopreventive agent (N-(4-hydroxyphenyl) retinamide).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubjects\/Method:\u003c\/strong\u003e Animal study involving rats with induced mammary carcinogenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntervention:\u003c\/strong\u003e Dietary calcium glucarate (128 mmol\/kg) fed during either the initiation, promotion, or combined initiation and promotion phases of mammary carcinogenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c\/strong\u003e Compared to controls, mammary tumour incidence was reduced in the initiation phase by 18%, the promotion phase by 42% and both phases by 50% in rats fed a calcium D-glucarate-enriched diet.\u003c\/p\u003e\n\u003cp\u003eCalcium D-glucarate also significantly increased tumour latency, and significantly reduced tumour multiplicity compared to controls. These results were similar to the chemopreventive agent.\u003c\/p\u003e\n\u003cp\u003eAbou-Issa H, Moeschberger M, el-Masry W, et al. Relative eficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995;15(3):805-810.\u003c\/p\u003e\n\u003ch2\u003eDosage range according to clinical studies\u003c\/h2\u003e\n\u003cp\u003eAs human trials utilising calcium D-glucarate are still in the preliminary stages, the optimal recommended dosage is yet to be determined.\u003c\/p\u003e\n\u003cp\u003eThe current available literature suggests a daily dosage of 1500-3000mg.3\u003c\/p\u003e\n\u003ch2\u003eCautions and contraindications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAs hormonal detoxification is contraindicated in pregnancy, calcium D-glucarate use during pregnancy is not recommended.\u003c\/li\u003e\n\u003cli\u003eAlcohol consumption may increase calcium D-glucarate excretion and may theoretically decrease its activity.8\u003c\/li\u003e\n\u003cli\u003eTheoretically, calcium D-glucarate may increase the elimination of drugs metabolised via glucuronidation thereby reducing their effectiveness.3\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Figure_2_Calcium_D-glucarate_enhances_phase_2_glucuronidation_by_inhibiting_beta-glucuronidase3_600x600.jpg?v=1584740629\" alt=\"Figure 2 Calcium D-glucarate enhances phase 2 glucuronidation by inhibiting beta glucuronidase3\" width=\"600x600\" height=\"600x600\" style=\"float: none;\"\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: Calcium D-glucarate enhances phase 2 glucuronidation by inhibiting beta-glucuronidase3\u003c\/strong\u003e\u003c\/div\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eDwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol 1990;43(2):83-92.\u003c\/li\u003e\n\u003cli\u003eZółtaszek R, Hanausek M, Kilianska ZM, et al. The biological role of d-glucaric acid and its derivatives: potential use in medicine. Postepy Hig Med Dosw 2008;62:451-462.\u003c\/li\u003e\n\u003cli\u003eCalcium-D-glucarate monograph. Altern Med Rev 2002;7(4):336-339.\u003c\/li\u003e\n\u003cli\u003eKim DH, Jin YH. Intestinal bacterial beta-glucuronidase activity of patients with colon cancer. Arch Pharm Res 2001;24(6):564-567.\u003c\/li\u003e\n\u003cli\u003eWalaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-190.\u003c\/li\u003e\n\u003cli\u003eCalcium glucarate. Memorial Sloan Kettering Cancer Center 2012. Viewed 26 Feb 2015, http:\/\/www.mskcc.org\/cancer-care\/herb\/calcium-glucarate\u003c\/li\u003e\n\u003cli\u003eZoltaszek R, Kowalczyk P, Kowalczyk MC, et al. Dietary D-glucarate effects on the biomarkers of inlammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A\/J mice. Oncol Lett 2011;2(1):145-154.\u003c\/li\u003e\n\u003cli\u003eCalcium D-glucarate. Natural Medicine Comprehensive Database 2015. Viewed 17 Feb 2015, www.naturaldatabase.com\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eDwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol 1990;43(2):83-92.\u003c\/li\u003e\n\u003cli\u003eZółtaszek R, Hanausek M, Kilianska ZM, et al. The biological role of d-glucaric acid and its derivatives: potential use in medicine. Postepy Hig Med Dosw 2008;62:451-462.\u003c\/li\u003e\n\u003cli\u003eCalcium-D-glucarate monograph. Altern Med Rev 2002;7(4):336-339.\u003c\/li\u003e\n\u003cli\u003eKim DH, Jin YH. Intestinal bacterial beta-glucuronidase activity of patients with colon cancer. Arch Pharm Res 2001;24(6):564-567.\u003c\/li\u003e\n\u003cli\u003eWalaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-190.\u003c\/li\u003e\n\u003cli\u003eCalcium glucarate. Memorial Sloan Kettering Cancer Center 2012. Viewed 26 Feb 2015, http:\/\/www.mskcc.org\/cancer-care\/herb\/calcium-glucarate\u003c\/li\u003e\n\u003cli\u003eZoltaszek R, Kowalczyk P, Kowalczyk MC, et al. Dietary D-glucarate effects on the biomarkers of inlammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A\/J mice. Oncol Lett 2011;2(1):145-154.\u003c\/li\u003e\n\u003cli\u003eCalcium D-glucarate. Natural Medicine Comprehensive Database 2015. Viewed 17 Feb 2015, www.naturaldatabase.com\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2020-04-11T10:19:08+10:00","created_at":"2020-04-10T16:57:58+10:00","vendor":"BioCeuticals","type":"Buy Naturopathic Products 10% off RRP","tags":["BioCeuticals Clinical"],"price":2041,"price_min":2041,"price_max":2041,"available":true,"price_varies":false,"compare_at_price":2268,"compare_at_price_min":2268,"compare_at_price_max":2268,"compare_at_price_varies":false,"variants":[{"id":33266002362427,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"BioCeuticals Calcium D-Glucarate","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"BioCeuticals Clinical Calcium D-Glucarate (calcium saccharate) 60g","public_title":null,"options":["Default Title"],"price":2041,"weight":201,"compare_at_price":2268,"inventory_quantity":9998,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9337896002926"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsCalciumD-Glucarate10_offRRPatHealthMasters.jpg?v=1586564375"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsCalciumD-Glucarate10_offRRPatHealthMasters.jpg?v=1586564375","options":["Title"],"media":[{"alt":"BioCeuticals Calcium D-Glucarate 10% off RRP | HealthMasters","id":7740749774907,"position":1,"preview_image":{"aspect_ratio":0.538,"height":500,"width":269,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsCalciumD-Glucarate10_offRRPatHealthMasters.jpg?v=1586564359"},"aspect_ratio":0.538,"height":500,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsCalciumD-Glucarate10_offRRPatHealthMasters.jpg?v=1586564359","width":269}],"content":"\u003ch2\u003eBioCeuticals Clinical Calcium D-Glucarate (calcium saccharate) 60g\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eAssists phase 2 detoxification of oestrogen\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eBioCeuticals D-Glucarate is part of the BioCeuticals Compounding Range\u003c\/p\u003e\n\u003cp\u003eAvailable in sizes: 60g net powder\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBioCeuticals Calcium D-Glucarate has No Added Dairy, No Added gluten, No added Shellfish, No Added Soy protein, Vgan Friendly, Vegetarian Friendly, No Added Yeast.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"BioCeuticals Clinical 10% off RRP | HealthMasters\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003eBioCeuticals Clinical 10% off RRP\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"BioCeuticals Clinical 10% off RRP | HealthMasters\"\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cbig\u003eClick Here To Access\u003c\/big\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003e1 metric teaspoon (1.7g) provides 1.5g calcium D-glucarate (calcium saccharate)\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eDispensed after consultation with patient.\u003c\/p\u003e\n\u003ch5\u003eFeatures \u0026amp; Benefits\u003c\/h5\u003e\n\u003ch2\u003eFeatures \u0026amp; Benefits: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eContent for features \u0026amp; benefits\u003c\/p\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003econtent for Ingredient Summary\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach 1g contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium D-Glucarate (calcium saccharide)\u003c\/td\u003e\n\u003ctd\u003e900mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIn a base of maltodextrin and silica-colloidal anhydrous\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eFree Froms\u003c\/h5\u003e\n\u003ch2\u003eFree Froms: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eNo Added Dairy, No Added gluten, No added Shellfish, No Added Soy protein, Vgan Friendly, Vegetarian Friendly, No Added Yeast.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eInsufficient reliable information available for pregnancy and lactation, avoid using.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eTheoretically, \u003cspan\u003eCalcium D-Glucarate might increase the clearance of drugs that undergo glucuronidation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTheoretically, concominant use with alcohol might decrease Calcium D-Glucarate activity. There is some evidence that urinary excretion of D-glucarate is increased in people consuming alcohol.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eCompanion Products:\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cp\u003eContent for Companion Products\u003c\/p\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Calcium_D-glucarate_main_Image_-_HealthMasters_1024x1024.jpg?v=1584752961\" alt=\"Calcium D-glucarate main Image - HealthMasters\" width=\"1024x1024\" height=\"1024x1024\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003ch2\u003eBackground\u003c\/h2\u003e\n\u003cp\u003eD-glucaric acid is a natural, non-toxic compound produced by the body in small amounts. In addition to being found in fruits and vegetables: the richest sources include oranges, apples, grapefruits and cruciferous vegetables.1,2\u003c\/p\u003e\n\u003cp\u003eCalcium D-glucarate is the supplemental form of D-glucaric acid, where it is bound to calcium. When ingested, calcium d-glucarate is metabolised to D-glucaric acid, which may be further metabolised into D-glucaro-1,4-lactone or D-glucaro-6,3-lactone compounds which have important roles in the body, particularly regarding to detoxification.\u003c\/p\u003e\n\u003cp\u003eThe therapeutic benefits of calcium D-glucarate stem from its ability to indirectly inhibit beta-glucuronidase, an enzyme produced by colonic microflora which may disrupt phase 2 detoxification.\u003c\/p\u003e\n\u003cp\u003eElevated beta-glucuronidase activity has been linked to increased risk of various cancers, particularly hormone-dependent cancers such as breast and prostate cancer.2\u003c\/p\u003e\n\u003ch2\u003eKey benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAnti-carcinogenic\u003c\/li\u003e\n\u003cli\u003eAnti-infammatory\u003c\/li\u003e\n\u003cli\u003eEnhances glucuronidation (phase 2 liver detoxiication)\u003c\/li\u003e\n\u003cli\u003eInhibits beta-glucuronidase\u003c\/li\u003e\n\u003cli\u003eLipid lowering\u003c\/li\u003e\n\u003cli\u003eRegulates and supports healthy oestrogen metabolism\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eClinical applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eOestrogen dominance or excess:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- endometriosis\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- menorrhagia\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003e- uterine fibroids\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003eHyperlipidaemia\u003c\/li\u003e\n\u003cli\u003eBreast cancer\u003c\/li\u003e\n\u003cli\u003eColon cancer\u003c\/li\u003e\n\u003cli\u003eLiver cancer\u003c\/li\u003e\n\u003cli\u003eLung cancer\u003c\/li\u003e\n\u003cli\u003eSkin cancer\u003c\/li\u003e\n\u003cli\u003eEnhance detoxification\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003ch2\u003eMechanisms of action\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eDetoxification and inhibition of beta-glucuronidase\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eGlucuronidation is one of the primary pathways involved in phase 2 detoxification in the liver. Glucuronidation allows for the detoxification of endogenous compounds such as hormones and exogenous toxins such as drugs and carcinogens. During glucuronidation, glucuronic acid binds to potentially toxic compounds forming glucuronide conjugates. These newly formed glucuronide conjugates allow toxins, carcinogens and hormones to be safely eliminated from the body via the biliary tract.\u003c\/p\u003e\n\u003cp\u003eBeta-glucuronidase is an enzyme produced by the colonic microflora. It has a detrimental effect on detoxification by deconjugating glucuronide conjugates that are formed during phase 2 detoxification.3 This breaking of the toxin-glucuronic acid bond allows for toxins and hormones to be reabsorbed rather than excreted.\u003c\/p\u003e\n\u003cp\u003eIncreased beta-glucuronidase activity has been associated with an increased risk of certain cancers including breast, prostate and colon.2,4 By inhibiting beta-glucuronidase, calcium D-glucarate supports phase 2 detoxification by preventing the hydrolysis of glucuronide conjugates and increasing the detoxification and elimination of hormones, toxins and carcinogens.5\u003c\/p\u003e\n\u003cp\u003eThe acidic environment of the stomach allows for the metabolism of calcium D-glucarate into D-glucaric acid.3 Further metabolism of D-glucaric acid results in the formation of D-glucaro-1,4-lactone ord-glucaro-6,3-lactone. D-glucaro-1,4-lactone appears to be the most active and is a potent beta-glucuronidase inhibitor.\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Figure_I_Metabolism_of_calcium_D-glucarate3_480x480.jpg?v=1584740562\" alt=\"Figure I Metabolism of calcium D-glucarate3\" width=\"480x480\" height=\"480x480\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: Metabolism of calcium D-Glucarate3\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eCancer\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe majority of research surrounding calcium D-glucarate has focused on its effect on tumour growth and the prevention of cancer. In vitro and animal studies have shown that calcium d-glucarate inhibits the initiation and promotion of cancer cells by interacting with signal transduction pathways, inhibiting beta-glucuronidase activity, reducing pro-inflammatory cytokines, while also inducing apoptosis.6 A range of studies have been conducted on breast, colon, liver, lung, prostate and skin animal tumour models, with the majority of research focusing on breast cancer.3\u003c\/p\u003e\n\u003cp\u003eHigh beta-glucuronidase activity has been linked to low D-glucaric acid levels, which in turn is associated with an increased risk for various cancers.3 By inhibiting beta-glucuronidase, calcium D-glucarate increases the detoxification and elimination of carcinogens and hormones associated with cancer development.6\u003c\/p\u003e\n\u003cp\u003eCalcium D-glucarate reduces pro-inflammatory cytokines and increases the key anti-inflammatory and immune-regulating cytokine IL-10.\u003c\/p\u003e\n\u003cp\u003ePro-inflammatory cytokines are found in various tumours and may promote the transformation of precancerous cells to malignant cells, while also promoting tumour progression.7\u003c\/p\u003e\n\u003cp\u003eResearchers have suggested that the formation of 1,4-GL from calcium D-glucarate may be the prerequisite for the prevention of breast, prostate and colon cancer in humans.5\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eOestrogen metabolism\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eOestrogen is metabolised in the liver during phase 2 detoxification, specifically via the glucuronidation pathway. Oestrogen combines with glucuronic acid forming an oestrogen-glucuronic acid conjugate.8 This conjugate is then eliminated via the bile, allowing the body to maintain healthy oestrogen levels.\u003c\/p\u003e\n\u003cp\u003eIncreased beta-glucuronidase activity splits the oestrogen-glucuronic acid bond, causing the free oestrogen to be reabsorbed, which may increase oestrogen levels or lead to oestrogen dominance and a disturbed oestrogen:progesterone ratio.\u003c\/p\u003e\n\u003cp\u003eAnimal studies have shown that calcium D-glucarate lowers serum oestrogen levels and increases its urinary excretion.5 This appears to be due to the inhibition of beta-glucuronidase causing reduced oestrogen reabsorption and lower circulating oestrogen levels.8\u003c\/p\u003e\n\u003ch2\u003eClinical studies\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eD-glucarate reduces inflammatory biomarkers and enhances apoptosis in lung cancer\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e To investigate the effect of dietary calcium D-glucarate on inflammatory cytokines, inflammatory biomarkers and apoptosis in lung tumorigenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubjects\/Method:\u003c\/strong\u003e Animal study involving mice with induced lung tumorigenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntervention:\u003c\/strong\u003e Dietary calcium D-glucarate (2% and 4% w\/w) for 8 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c\/strong\u003e D-glucarate decreased pro-inflammatory cytokines, while increasing the anti-inflammatory cytokine IL-10 during early post-initiation stages of lung tumorigenesis in mice. D-glucarate also exhibited proapoptotic effects.\u003c\/p\u003e\n\u003cp\u003eThe researchers concluded that calcium D-glucarate may prevent lung cancer in tobacco smokers and ex-smokers by enhancing apoptosis and suppressing the acute inflammation and proliferation induced by tobacco related carcinogens.\u003c\/p\u003e\n\u003cp\u003eZoltaszek R, Kowalczyk P, Kowalczyk MC, et al. Dietary D-glucarate effects on the biomarkers of inlammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A\/J mice. Oncol Lett 2011;2(1):145-154.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eD-glucarate induces D-glucaro-1,4-lactone, a potent beta-glucuronidase inhibitor\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e To demonstrate the \u003cem\u003ein vivo\u003c\/em\u003e formation of the betaglucuronidase inhibitor D-glucaro-1,4-lactone (1,4-GL) from a D-glucarate salt and determine its metabolism, uptake by selected organs and excretion following oral administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubjects\/Method:\u003c\/strong\u003e Animal study.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntervention:\u003c\/strong\u003e Male and female Sprague-Dawley rats received oral D-glucarate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c\/strong\u003e D-glucarate administration resulted in the formation of 1,4-GL in the stomach of rats. The researchers concluded that the formation of 1,4-GL from d-glucaric acid derivatives may be a prerequisite for the inhibition ofchemical carcinogenesis in rodents, and the prevention of breast, prostate and colon cancer in humans.\u003c\/p\u003e\n\u003cp\u003eWalaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-190.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eCalcium D-glucarate inhibits breast carcinogenesis\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e To evaluate the effect of calcium D-glucarate on rat mammary carcinogenesis, compared to a known chemopreventive agent (N-(4-hydroxyphenyl) retinamide).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubjects\/Method:\u003c\/strong\u003e Animal study involving rats with induced mammary carcinogenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntervention:\u003c\/strong\u003e Dietary calcium glucarate (128 mmol\/kg) fed during either the initiation, promotion, or combined initiation and promotion phases of mammary carcinogenesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c\/strong\u003e Compared to controls, mammary tumour incidence was reduced in the initiation phase by 18%, the promotion phase by 42% and both phases by 50% in rats fed a calcium D-glucarate-enriched diet.\u003c\/p\u003e\n\u003cp\u003eCalcium D-glucarate also significantly increased tumour latency, and significantly reduced tumour multiplicity compared to controls. These results were similar to the chemopreventive agent.\u003c\/p\u003e\n\u003cp\u003eAbou-Issa H, Moeschberger M, el-Masry W, et al. Relative eficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995;15(3):805-810.\u003c\/p\u003e\n\u003ch2\u003eDosage range according to clinical studies\u003c\/h2\u003e\n\u003cp\u003eAs human trials utilising calcium D-glucarate are still in the preliminary stages, the optimal recommended dosage is yet to be determined.\u003c\/p\u003e\n\u003cp\u003eThe current available literature suggests a daily dosage of 1500-3000mg.3\u003c\/p\u003e\n\u003ch2\u003eCautions and contraindications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAs hormonal detoxification is contraindicated in pregnancy, calcium D-glucarate use during pregnancy is not recommended.\u003c\/li\u003e\n\u003cli\u003eAlcohol consumption may increase calcium D-glucarate excretion and may theoretically decrease its activity.8\u003c\/li\u003e\n\u003cli\u003eTheoretically, calcium D-glucarate may increase the elimination of drugs metabolised via glucuronidation thereby reducing their effectiveness.3\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Figure_2_Calcium_D-glucarate_enhances_phase_2_glucuronidation_by_inhibiting_beta-glucuronidase3_600x600.jpg?v=1584740629\" alt=\"Figure 2 Calcium D-glucarate enhances phase 2 glucuronidation by inhibiting beta glucuronidase3\" width=\"600x600\" height=\"600x600\" style=\"float: none;\"\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: Calcium D-glucarate enhances phase 2 glucuronidation by inhibiting beta-glucuronidase3\u003c\/strong\u003e\u003c\/div\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eDwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol 1990;43(2):83-92.\u003c\/li\u003e\n\u003cli\u003eZółtaszek R, Hanausek M, Kilianska ZM, et al. The biological role of d-glucaric acid and its derivatives: potential use in medicine. Postepy Hig Med Dosw 2008;62:451-462.\u003c\/li\u003e\n\u003cli\u003eCalcium-D-glucarate monograph. Altern Med Rev 2002;7(4):336-339.\u003c\/li\u003e\n\u003cli\u003eKim DH, Jin YH. Intestinal bacterial beta-glucuronidase activity of patients with colon cancer. Arch Pharm Res 2001;24(6):564-567.\u003c\/li\u003e\n\u003cli\u003eWalaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-190.\u003c\/li\u003e\n\u003cli\u003eCalcium glucarate. Memorial Sloan Kettering Cancer Center 2012. Viewed 26 Feb 2015, http:\/\/www.mskcc.org\/cancer-care\/herb\/calcium-glucarate\u003c\/li\u003e\n\u003cli\u003eZoltaszek R, Kowalczyk P, Kowalczyk MC, et al. Dietary D-glucarate effects on the biomarkers of inlammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A\/J mice. Oncol Lett 2011;2(1):145-154.\u003c\/li\u003e\n\u003cli\u003eCalcium D-glucarate. Natural Medicine Comprehensive Database 2015. Viewed 17 Feb 2015, www.naturaldatabase.com\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Calcium D-Glucarate\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eDwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol 1990;43(2):83-92.\u003c\/li\u003e\n\u003cli\u003eZółtaszek R, Hanausek M, Kilianska ZM, et al. The biological role of d-glucaric acid and its derivatives: potential use in medicine. Postepy Hig Med Dosw 2008;62:451-462.\u003c\/li\u003e\n\u003cli\u003eCalcium-D-glucarate monograph. Altern Med Rev 2002;7(4):336-339.\u003c\/li\u003e\n\u003cli\u003eKim DH, Jin YH. Intestinal bacterial beta-glucuronidase activity of patients with colon cancer. Arch Pharm Res 2001;24(6):564-567.\u003c\/li\u003e\n\u003cli\u003eWalaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-190.\u003c\/li\u003e\n\u003cli\u003eCalcium glucarate. Memorial Sloan Kettering Cancer Center 2012. Viewed 26 Feb 2015, http:\/\/www.mskcc.org\/cancer-care\/herb\/calcium-glucarate\u003c\/li\u003e\n\u003cli\u003eZoltaszek R, Kowalczyk P, Kowalczyk MC, et al. Dietary D-glucarate effects on the biomarkers of inlammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A\/J mice. Oncol Lett 2011;2(1):145-154.\u003c\/li\u003e\n\u003cli\u003eCalcium D-glucarate. Natural Medicine Comprehensive Database 2015. Viewed 17 Feb 2015, www.naturaldatabase.com\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e"}

BioCeuticals Clinical Calcium D-Glucarate (calcium saccharate) 60g

Product Description

BioCeuticals Clinical Calcium D-Glucarate (calcium saccharate) 60g

Assists phase 2 detoxification of oestrogen

BioCeuticals D-Glucarate is part of the BioCeuticals Compounding Range

Available in sizes: 60g net powder

BioCeuticals Calcium D-Glucarate has No Added Dairy, No Added gluten, No added Shellfish, No Added Soy protein, Vgan Friendly, Vegetarian Friendly, No Added Yeast.

BioCeuticals Clinical 10% off RRP

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