{"id":7923054543078,"title":"RN Labs L-5MTHF 120 Caps","handle":"rn-labs-l-5mthf","description":"\u003ch2\u003eRN Labs L-5MTHF 120 Caps\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eRN Labs L-5MTHF is a pure and highly bioavailable form of folate\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 120 Capsules\u003c\/p\u003e\n\u003cp\u003eRN Labs L-5MTHF AUST L 270098\u003c\/p\u003e\n\u003cp\u003eRN Labs L-5MTHF is part of the RN Labs Range of Practitioner Brand quality naturopathic medicines available for patients under the care of a practitioner.\u003c\/p\u003e\n\u003cp\u003eRN Labs was formerly named Research Nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eTo access RN Labs L-5MTHF select the \u003ca href=\"#how-to-access\" title=\"How To Access RN Labs Naturopathic Medicines 10% off RRP | HealthMasters RN Labs\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eHow To Access tab\u003c\/span\u003e\u003c\/a\u003e for more information.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicines you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-metagen-methyl-active-60caps\" title=\"Metagenics Metagen Methyl-Active 10% off RRP | HealthMasters Metagenics\" target=\"_blank\"\u003eMetagenics Metagen Methyl-Active \u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate naturopathic medicines, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca title=\"Contact HealthMasters For Assistance\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\n\u003ch2\u003eSummary: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003eDirectly facilitating methyl group donation in the body, RN Labs L-5MTHF supports numerous metabolic processes for optimum healing, development, detoxification, mental health and wellbeing.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eAbsorption\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eA study comparing the bioavailability of [6S]-5-MTHF (L-5MTHF) and folic acid (a form used in many dietary supplements) found significantly greater absorption of [6S]-5-MTHF over folic acid in healthy individuals.\u003c\/p\u003e\n\u003cp\u003eThis study was conducted on females profiled for genotypes with the homozygous 677C\u0026gt;T mutation, which was compared to individuals without this mutation.\u003c\/p\u003e\n\u003cp\u003eThey found an increase in plasma folate irrespective of the gene mutation, therefore, research suggests [6S]-5-MTHF is a highly absorbable form of supplementation for the general population.\u003c\/p\u003e\n\u003cp\u003ePrinz-Langenohl R, Brämswig S, Tobolski O, Smulders YM, Smith DE, Finglas PM, Pietrzik K, 2009, [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C–\u0026gt;T polymorphism of methylenetetrahydrofolate reductase, British Journal of Pharmacology, vol. 158, no. 8, pp. 2014-2021.\u003c\/p\u003e\n\u003cp\u003ePentieva, K, McNulty, H, Reichert, R, Ward, M, Strain, JJ, McKillop, DJ, McPartlin, JM, Connolly, E, Molloy, A, Krämer, K \u0026amp; Scott, JM 2004, ‘The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men’, Journal of Nutrition, vol. 134, pp. 580-5.\u003c\/p\u003e\n\u003cp\u003eHoughton, LA, Sherwood, KL, Pawlosky, R, Ito, S \u0026amp; O’Connor, DL 2006, ‘[6S]-5-methyltetrahydrofolate is at least as effectiveas folic acid in preventing a decline in blood folate concentrations during lactation’, American Journal of Clinical Nutrition, vol. 83, pp. 842-50.\u003c\/p\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eProvides a methylated and metabolically active form of folate\u003c\/li\u003e\n\u003cli\u003eBypasses the biochemical steps normally required by other folates\u003c\/li\u003e\n\u003cli\u003eDemonstrates greater metabolic activity than folic acid as a source of folate, with reduced potential for side effects\u003c\/li\u003e\n\u003cli\u003eContributes to the normal growth of the foetus during pregnancy\u003c\/li\u003e\n\u003cli\u003eMay support normal stress and cognitive function through healthy neurotransmitter production\u003c\/li\u003e\n\u003cli\u003eSupports healthy red blood cell formation\u003c\/li\u003e\n\u003cli\u003ePlays an important role in supporting healthy methylation\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine levels\u003c\/li\u003e\n\u003cli\u003eSupports healthy cardiovascular and vascular endothelial function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003eAdults take 1 capsule daily or as prescribed by your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003e(Ingredients from Oborne)\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach vegetarian capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium L-5-methyltetrahydrofolate\u003c\/td\u003e\n\u003ctd\u003e550mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Levomefolic acid (L-5-MTHF)\u003c\/td\u003e\n\u003ctd\u003e500mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003eLeucine, Tapioca Starch, Microcrystalline Cellulose, Colloidal Anhydrous Silica\u003c\/p\u003e\n\u003ch5\u003eFAQs\u003c\/h5\u003e\n\u003ch2\u003eFAQs: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHow would a practitioner know whether to use an active unmethylated vs a methylated folate?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGenerally speaking, it is best to start with folinic acid. Methyltetrahydrofolate (5-MTHF) is best utilised once a practitioner is aware of the patient’s current methylation status (i.e. via Plasma Methylation Profile and DNA Health tests).\u003c\/p\u003e\n\u003cp\u003eMethylated nutrients increase SAMe, the principal methyl donor. If the body detects an excess of methyl groups, the body can downregulate the enzyme process, creating a negative feedback loop. The use of folinic acid is generally better tolerated by a greater number of individuals. Folinic will still convert to 5-MTHFR whilst allowing the body to have better regulation and control of the methylation cycle.\u003c\/p\u003e\n\u003cp\u003eIf supplying pre-methylated nutrients, giving them in combination with vitamin B3 would be ideal to quench any excess methyl groups that may occur.\u003c\/p\u003e\n\u003cp\u003eFurthermore, taking vitamin B3 may be advantageous to support healthy overall regulation of the methylation cycle in many individuals.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003ch3\u003eFOR PRACTITIONER DISPENSING ONLY.\u003c\/h3\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eFolate is considered safe during pregnancy.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eKnown Side Effects\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eIn doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.\u003c\/p\u003e\n\u003cp\u003eWhilst some concern exists that supplementation with high doses of folic acid could mask a vitamin B12 deficiency, supplementation with 5-MTHF appears to sidestep this potential problem. Since 5-MTHF can only be converted to 5,10-methylenetetrahydrofolate (involved in DNA synthesis) after participating in homocysteine recycling with vitamin B12, 5-MTHF will not mask a B12 deficiency.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMedication Interactions\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe activity of 5-MTHF may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.\u003c\/p\u003e\n\u003ch5\u003eQuality \u0026amp; Purity\u003c\/h5\u003e\n\u003ch2\u003eQuality \u0026amp; Purity: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eResearch Nutrition uses only the highest grade ingredients and materials available. Research Nutrition purity standards for manufacturing and sourcing are extensively researched and verified.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRN Labs L-5MTHF is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePure \u0026amp; Free From\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.\u003c\/p\u003e\n\u003ch5\u003eThe RN Difference\u003c\/h5\u003e\n\u003ch2\u003eThe RN Difference: \u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/325810732\" allowfullscreen=\"\" mozallowfullscreen=\"\" webkitallowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T15:58:36+11:00","created_at":"2022-08-15T16:44:57+10:00","vendor":"RN Labs","type":"RN Labs Naturopathic Medicines","tags":["Adrenal \u0026 Stress","Antioxidant","Bone \u0026 Joint","Cardiovascular","Detoxification","Diarrhoea","Dysbiosis","Energy","Functional Foods","Gut and Digestion","Hair \u0026 Nails","Immunity","Indigestion","Inflammation","Methylation","Musculoskeletal","Naturopathic","Nerves \u0026 Brain","Pain Management","PB","RN Labs","Sex Hormones","Skin","Thyroid","Vegan","Weight and Metabolism"],"price":3794,"price_min":3794,"price_max":3794,"available":true,"price_varies":false,"compare_at_price":4215,"compare_at_price_min":4215,"compare_at_price_max":4215,"compare_at_price_varies":false,"variants":[{"id":43226619871462,"title":"120 Capsules","option1":"120 Capsules","option2":null,"option3":null,"sku":"RNLL-5MTHF120C","requires_shipping":true,"taxable":true,"featured_image":{"id":38156058034406,"product_id":7923054543078,"position":2,"created_at":"2022-08-15T17:05:33+10:00","updated_at":"2022-08-15T17:05:51+10:00","alt":"RN Labs L 5MTHF 120caps 10% off RRP at HealthMasters RN Labs","width":1200,"height":1199,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsL5MTHF120caps10_offRRPatHealthMastersRNLabs.png?v=1660547151","variant_ids":[43226619871462]},"available":true,"name":"RN Labs L-5MTHF 120 Caps - 120 Capsules","public_title":"120 Capsules","options":["120 Capsules"],"price":3794,"weight":0,"compare_at_price":4215,"inventory_quantity":29998,"inventory_management":"shopify","inventory_policy":"deny","barcode":"0737452887414","featured_media":{"alt":"RN Labs L 5MTHF 120caps 10% off RRP at HealthMasters RN Labs","id":30732063867110,"position":2,"preview_image":{"aspect_ratio":1.001,"height":1199,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsL5MTHF120caps10_offRRPatHealthMastersRNLabs.png?v=1660547151"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_8d84877f-952a-4830-9619-8480d81564b5.png?v=1660545900","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsL5MTHF120caps10_offRRPatHealthMastersRNLabs.png?v=1660547151","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_1a45e572-f70b-4d1f-8aaf-cdd24dc78c8d.jpg?v=1660547151"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_8d84877f-952a-4830-9619-8480d81564b5.png?v=1660545900","options":["Size:"],"media":[{"alt":"RN Labs Naturopathic Medicines 10% off RRP at HealthMasters RN Labs","id":30731962253542,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_8d84877f-952a-4830-9619-8480d81564b5.png?v=1660545900"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabs10_offRRPatHealthMastersRNLabsLogo1200px_8d84877f-952a-4830-9619-8480d81564b5.png?v=1660545900","width":1200},{"alt":"RN Labs L 5MTHF 120caps 10% off RRP at HealthMasters RN Labs","id":30732063867110,"position":2,"preview_image":{"aspect_ratio":1.001,"height":1199,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsL5MTHF120caps10_offRRPatHealthMastersRNLabs.png?v=1660547151"},"aspect_ratio":1.001,"height":1199,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsL5MTHF120caps10_offRRPatHealthMastersRNLabs.png?v=1660547151","width":1200},{"alt":"RN Labs L 5MTHF 10% off RRP at HealthMasters RN Labs Logo","id":30731962286310,"position":3,"preview_image":{"aspect_ratio":3.0,"height":100,"width":300,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_1a45e572-f70b-4d1f-8aaf-cdd24dc78c8d.jpg?v=1660547151"},"aspect_ratio":3.0,"height":100,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/RNLabsLogo_1a45e572-f70b-4d1f-8aaf-cdd24dc78c8d.jpg?v=1660547151","width":300}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eRN Labs L-5MTHF 120 Caps\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eRN Labs L-5MTHF is a pure and highly bioavailable form of folate\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 120 Capsules\u003c\/p\u003e\n\u003cp\u003eRN Labs L-5MTHF AUST L 270098\u003c\/p\u003e\n\u003cp\u003eRN Labs L-5MTHF is part of the RN Labs Range of Practitioner Brand quality naturopathic medicines available for patients under the care of a practitioner.\u003c\/p\u003e\n\u003cp\u003eRN Labs was formerly named Research Nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eTo access RN Labs L-5MTHF select the \u003ca href=\"#how-to-access\" title=\"How To Access RN Labs Naturopathic Medicines 10% off RRP | HealthMasters RN Labs\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eHow To Access tab\u003c\/span\u003e\u003c\/a\u003e for more information.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicines you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-metagen-methyl-active-60caps\" title=\"Metagenics Metagen Methyl-Active 10% off RRP | HealthMasters Metagenics\" target=\"_blank\"\u003eMetagenics Metagen Methyl-Active \u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate naturopathic medicines, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca title=\"Contact HealthMasters For Assistance\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\n\u003ch2\u003eSummary: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003eDirectly facilitating methyl group donation in the body, RN Labs L-5MTHF supports numerous metabolic processes for optimum healing, development, detoxification, mental health and wellbeing.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eAbsorption\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eA study comparing the bioavailability of [6S]-5-MTHF (L-5MTHF) and folic acid (a form used in many dietary supplements) found significantly greater absorption of [6S]-5-MTHF over folic acid in healthy individuals.\u003c\/p\u003e\n\u003cp\u003eThis study was conducted on females profiled for genotypes with the homozygous 677C\u0026gt;T mutation, which was compared to individuals without this mutation.\u003c\/p\u003e\n\u003cp\u003eThey found an increase in plasma folate irrespective of the gene mutation, therefore, research suggests [6S]-5-MTHF is a highly absorbable form of supplementation for the general population.\u003c\/p\u003e\n\u003cp\u003ePrinz-Langenohl R, Brämswig S, Tobolski O, Smulders YM, Smith DE, Finglas PM, Pietrzik K, 2009, [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C–\u0026gt;T polymorphism of methylenetetrahydrofolate reductase, British Journal of Pharmacology, vol. 158, no. 8, pp. 2014-2021.\u003c\/p\u003e\n\u003cp\u003ePentieva, K, McNulty, H, Reichert, R, Ward, M, Strain, JJ, McKillop, DJ, McPartlin, JM, Connolly, E, Molloy, A, Krämer, K \u0026amp; Scott, JM 2004, ‘The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men’, Journal of Nutrition, vol. 134, pp. 580-5.\u003c\/p\u003e\n\u003cp\u003eHoughton, LA, Sherwood, KL, Pawlosky, R, Ito, S \u0026amp; O’Connor, DL 2006, ‘[6S]-5-methyltetrahydrofolate is at least as effectiveas folic acid in preventing a decline in blood folate concentrations during lactation’, American Journal of Clinical Nutrition, vol. 83, pp. 842-50.\u003c\/p\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eProvides a methylated and metabolically active form of folate\u003c\/li\u003e\n\u003cli\u003eBypasses the biochemical steps normally required by other folates\u003c\/li\u003e\n\u003cli\u003eDemonstrates greater metabolic activity than folic acid as a source of folate, with reduced potential for side effects\u003c\/li\u003e\n\u003cli\u003eContributes to the normal growth of the foetus during pregnancy\u003c\/li\u003e\n\u003cli\u003eMay support normal stress and cognitive function through healthy neurotransmitter production\u003c\/li\u003e\n\u003cli\u003eSupports healthy red blood cell formation\u003c\/li\u003e\n\u003cli\u003ePlays an important role in supporting healthy methylation\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine levels\u003c\/li\u003e\n\u003cli\u003eSupports healthy cardiovascular and vascular endothelial function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003eAdults take 1 capsule daily or as prescribed by your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003e(Ingredients from Oborne)\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach vegetarian capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium L-5-methyltetrahydrofolate\u003c\/td\u003e\n\u003ctd\u003e550mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. Levomefolic acid (L-5-MTHF)\u003c\/td\u003e\n\u003ctd\u003e500mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003eLeucine, Tapioca Starch, Microcrystalline Cellulose, Colloidal Anhydrous Silica\u003c\/p\u003e\n\u003ch5\u003eFAQs\u003c\/h5\u003e\n\u003ch2\u003eFAQs: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHow would a practitioner know whether to use an active unmethylated vs a methylated folate?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGenerally speaking, it is best to start with folinic acid. Methyltetrahydrofolate (5-MTHF) is best utilised once a practitioner is aware of the patient’s current methylation status (i.e. via Plasma Methylation Profile and DNA Health tests).\u003c\/p\u003e\n\u003cp\u003eMethylated nutrients increase SAMe, the principal methyl donor. If the body detects an excess of methyl groups, the body can downregulate the enzyme process, creating a negative feedback loop. The use of folinic acid is generally better tolerated by a greater number of individuals. Folinic will still convert to 5-MTHFR whilst allowing the body to have better regulation and control of the methylation cycle.\u003c\/p\u003e\n\u003cp\u003eIf supplying pre-methylated nutrients, giving them in combination with vitamin B3 would be ideal to quench any excess methyl groups that may occur.\u003c\/p\u003e\n\u003cp\u003eFurthermore, taking vitamin B3 may be advantageous to support healthy overall regulation of the methylation cycle in many individuals.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003ch3\u003eFOR PRACTITIONER DISPENSING ONLY.\u003c\/h3\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eFolate is considered safe during pregnancy.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eKnown Side Effects\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eIn doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.\u003c\/p\u003e\n\u003cp\u003eWhilst some concern exists that supplementation with high doses of folic acid could mask a vitamin B12 deficiency, supplementation with 5-MTHF appears to sidestep this potential problem. Since 5-MTHF can only be converted to 5,10-methylenetetrahydrofolate (involved in DNA synthesis) after participating in homocysteine recycling with vitamin B12, 5-MTHF will not mask a B12 deficiency.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMedication Interactions\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eThe activity of 5-MTHF may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.\u003c\/p\u003e\n\u003ch5\u003eQuality \u0026amp; Purity\u003c\/h5\u003e\n\u003ch2\u003eQuality \u0026amp; Purity: RN Labs L-5MTHF\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eResearch Nutrition uses only the highest grade ingredients and materials available. Research Nutrition purity standards for manufacturing and sourcing are extensively researched and verified.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRN Labs L-5MTHF is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePure \u0026amp; Free From\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.\u003c\/p\u003e\n\u003ch5\u003eThe RN Difference\u003c\/h5\u003e\n\u003ch2\u003eThe RN Difference: \u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/325810732\" allowfullscreen=\"\" mozallowfullscreen=\"\" webkitallowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003c!-- \/TABS --\u003e"}