{"id":8115218612454,"title":"Designs For Health C Plus Supreme","handle":"designs-for-health-c-plus-supreme","description":"\u003ch2\u003eDesigns For Health C Plus Supreme\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eSupports a healthy immune and stress response\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 150g Powder    Servings: 30 Serves\u003c\/p\u003e\n\u003cp\u003eDesigns For Health C Plus Supreme Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eContains 5 different sources of Vitamin C\u003c\/li\u003e\n\u003cli\u003eDelivering 2g of ascorbic acid per serve\u003c\/li\u003e\n\u003cli\u003eFeatures PureWay-C, a clinically studied form of vitamin C with exceptional absorption and bioavailability\u003c\/li\u003e\n\u003cli\u003eIncludes a comprehensive range of supporting antioxidant ingredients\u003c\/li\u003e\n\u003cli\u003eIncludes hesperidin, rutoside, bioflavonoids, quercetin and annatto tocotrienols\u003c\/li\u003e\n\u003cli\u003eSupporting a healthy immune system function\u003c\/li\u003e\n\u003cli\u003eMaintains skin health\u003c\/li\u003e\n\u003cli\u003eSupports a healthy stress response\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health C Plus Supreme Has No added: gluten, dairy, lactose, soy or nuts.\u003c\/p\u003e\n\u003cp\u003eDesigns For Health C Plus Supreme AUST L 380294\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003eAdults: take 5 g (1 level teaspoon) mixed with 200 mL water daily or as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients per 5 gm dose\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (PureWay-C)\u003c\/td\u003e\n\u003ctd\u003e1.25g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium ascorbate dihydrate\u003c\/td\u003e\n\u003ctd\u003e680.85mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e562.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium ascorbate monohydrate\u003c\/td\u003e\n\u003ctd\u003e139.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbyl palmitate\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e42.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePhyllanthus emblica ext dry conc.\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFrom dry fruit\u003c\/td\u003e\n\u003ctd\u003e6.25g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e62.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal Ascorbic Acid\u003c\/td\u003e\n\u003ctd\u003e2.043g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBixa orellana ext dry conc.\u003c\/td\u003e\n\u003ctd\u003e166.65mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFrom dry seed\u003c\/td\u003e\n\u003ctd\u003e55.5g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent total tocotrienols\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHesperidin\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRutoside\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCitrus bioflavonoids extract\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eQuercetin dihydrate\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003eAmmonium glycyrrhizinate, Modified food starch, Citric acid, Maltodextrin, Colloidal anhydrous silica, Stevia rebaudiana, Hypromellose, Thaumatin, Silicon dioxide, Sodium bicarbonate, Tartaric acid, Natural orange flavour\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003eNo added: Gluten, Dairy, Soy, Yeast, Nuts, Eggs, Seeds.\u003c\/p\u003e\n\u003cp\u003eFree From: Benzoates, Sorabtes, Artificial colours or flavours\u003c\/p\u003e\n\u003cp\u003eContains: Sulfites\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist, talk to your health professional.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescribing Information:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCaution is advised regarding use of vitamin C in individuals with iron overload sensitivities including erythrocyte glucose-6-phosphate dehydrogenase deficiency, haemochromatosis, thalassaemia major or sideroblastic anaemia.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003ch3\u003eEndogenous roles of vitamin C\u003c\/h3\u003e\n\u003cp\u003eVitamin C, a nomenclature that encompasses both ascorbic acid and its oxidised form dehydroascorbic acid, is an essential water-soluble vitamin that the body requires from exogenous sources due to its low endogenous storage capacity and inability to enzymatically synthesise it (because of the absence of L-gulonolactone oxidase enzyme).\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthTri-magSupreme60Caps10_offRRPatHealthMastersDesignsForHealthFigure1_600x600.png?v=1674111047\" alt=\"Designs For Health Tri-mag Supreme 60 Caps 10% off RRP at HealthMasters Designs For Health Figure 1\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003eFigure 1:\u003c\/strong\u003e Linus Pauling Institute: Vitamin C and dehydroascorbic acid chemical structures.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003eWhile vitamin C is widely available in many fruits and vegetables, inadequate levels (ranging from serum levels \u0026lt;11.4μmol\/L [severe deficiency], \u0026lt;23 μmol\/L [marginal deficiency] to \u0026lt;40-50 μmol\/L [suboptimal]) are relatively prevalent across the average Western population, with vitamin C being the fourth most common nutrient deficiency in the United States.\u003c\/p\u003e\n\u003cp\u003eRisk factors associated with inadequate and deficient levels include suboptimal nutrient (macro- and\/or micronutrients) dietary intake patterns, gastrointestinal conditions, older age, smoking, alcohol, environmental pollution, significant physical or psychological stress, medication use (aspirin, indomethacin, oral contraceptive pill, tetracyclines, corticosteroids) and the presence of genetic polymorphisms\u003c\/p\u003e\n\u003cp\u003eSuch factors influence the complex endogenous pharmacokinetics of vitamin C, with absorption, transport, metabolism and elimination regulated by intestinal absorption, tissue concentrations and renal reabsorption.3,5 Depending on the presence of risk factors associated with inadequate endogenous vitamin C concentrations, following oral intake plasma levels increase until reaching repletion\/saturation levels (60-80 μmol\/L).\u003c\/p\u003e\n\u003cp\u003eIn addition to the broad range of common risk factors associated with suboptimal or deficient levels, the involvement of vitamin C in over 150 metabolic processes emphasises the importance of maintaining optimal levels to support normal antioxidant, immune, cardiovascular, connective tissue, adrenal and functional health in the body\u003c\/p\u003e\n\u003ch3\u003eAntioxidant\u003c\/h3\u003e\n\u003cp\u003eThe body is continually exposed to free radicals from those generated by endogenous metabolic processes and exogenous environmental sources, and optimal vitamin C levels are required to ameliorate the impact of oxidative damage on body cells and tissues (proteins, lipids, carbohydrates, and nucleic acids) via both direct and indirect mechanisms.\u003c\/p\u003e\n\u003cp\u003eDirect mechanisms include donating electrons and neutralising reactive oxygen and nitrogen species, while indirect mechanisms include mitigating the impact of hydrogen peroxide, regenerating endogenous vitamin E and supporting antioxidant enzyme system function. Vitamin C’s antioxidant mechanisms also underlie its effect on other body systems and tissues.\u003c\/p\u003e\n\u003ch3\u003eImmune\u003c\/h3\u003e\n\u003cp\u003eVitamin C helps the immune system to maintain homeostasis and generate appropriate responses when exposed to infectious pathogens via multiple mechanisms (see table 1).\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1:\u003c\/strong\u003e Vitamin C immune system mechanisms5\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIMMUNE COMPONENT\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eMECHANISM\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEpithelial barriers\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eSupports collagen synthesis and integrity.\u003c\/li\u003e\n\u003cli\u003eProtects against reactive oxygen species damage. \u003c\/li\u003e\n\u003cli\u003eInfluences keratinocyte and fibroblast activity.\u003c\/li\u003e\n\u003cli\u003eSupports wound healing.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePhagocytes (neutrophils, macrophages)\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAntioxidant.\u003c\/li\u003e\n\u003cli\u003eSupports chemotaxis and phagocytosis.\u003c\/li\u003e\n\u003cli\u003eSupports phagocytosis and chemotaxis.\u003c\/li\u003e\n\u003cli\u003eFacilitates apoptosis and clearance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eB and T-lymphocytes\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eSupports differentiation and proliferation.\u003c\/li\u003e\n\u003cli\u003eFacilitates production of antibodies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInflammatory mediators\u003c\/td\u003e\n\u003ctd\u003e• Modulates cytokine synthesis. • Influences histamine levels.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eCardiovascular\u003c\/h3\u003e\n\u003cp\u003eVitamin C’s antioxidant mechanisms support cardiovascular system health by inhibiting low-density lipoprotein oxidation, supporting healthy endothelial function and homocysteine and inducible nitric oxide synthase metabolism.\u003c\/p\u003e\n\u003ch3\u003eAdrenal and nervous system\u003c\/h3\u003e\n\u003cp\u003eStress, both physical and psychological, is a normal part of life and the body responds to stress with cascade of complex and coordinated sympathetic nervous and hypothalamic-pituitaryadrenal system processes.\u003c\/p\u003e\n\u003cp\u003eOptimal levels of vitamin C are required to support this stress response via its involvement in mitochondrial energy synthesis, adrenal glucocorticoid and catecholamine synthesis (promoting a healthy cortisol response) and antioxidant effects\/mechanisms ameliorating the central nervous system's particular sensitivity to oxidative stress.\u003c\/p\u003e\n\u003ch3\u003eConnective tissue\u003c\/h3\u003e\n\u003cp\u003eVitamin C is integral for the maintenance of normal connective tissue, bone and joint health as a consequence of its role in collagen synthesis and stabilisation (as a lysyl and prolyl hydroxylase cofactor), bone matrix formation and repair (promotes osteoblast differentiation, modulates chondrocyte gene expression) and antioxidant activity (reducing bone resorption).\u003c\/p\u003e\n\u003ch3\u003ePureWay-C\u003c\/h3\u003e\n\u003cp\u003ePureWay-C is a clinically studied form of vitamin C comprised of a lipid-vitamin C complex that has demonstrated excellent absorption and bioavailability. Clinical studies involving healthy human subjects have shown that the proprietary fatty acid formulation allows vitamin C to rapidly enter the cells by acting as a carrier to facilitate intestinal absorption, cellular uptake and tissue distribution without effects commonly associated with concentrated doses of vitamin C.   \u003c\/p\u003e\n\u003cp\u003e\u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Designs For Health C Plus Supreme 10% off RRP at HealthMasters Designs For Health Graph 1\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthCPlusSupreme10_offRRPatHealthMastersDesignsForHealthGraph1_600x600.png?v=1674111786\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthCPlusSupreme10_offRRPatHealthMastersDesignsForHealthGraph1_600x600.png?v=1674111786\"\u003e  \u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2023-01-19T18:09:14+11:00","created_at":"2023-01-19T17:25:33+11:00","vendor":"Designs For Health","type":"Designs For Health Naturopathic Medicines","tags":["Designs For Health","Naturopathic","PB","Vitamin C"],"price":3326,"price_min":3326,"price_max":3326,"available":true,"price_varies":false,"compare_at_price":3695,"compare_at_price_min":3695,"compare_at_price_max":3695,"compare_at_price_varies":false,"variants":[{"id":43621404868838,"title":"150g Powder","option1":"150g Powder","option2":null,"option3":null,"sku":"DFHCPlusSupreme150g","requires_shipping":true,"taxable":true,"featured_image":{"id":39100541829350,"product_id":8115218612454,"position":1,"created_at":"2023-01-19T18:05:02+11:00","updated_at":"2023-01-19T18:05:35+11:00","alt":"Designs For Health C Plus Supreme 150g 10% off RRP at HealthMasters Designs For 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serve\u003c\/li\u003e\n\u003cli\u003eFeatures PureWay-C, a clinically studied form of vitamin C with exceptional absorption and bioavailability\u003c\/li\u003e\n\u003cli\u003eIncludes a comprehensive range of supporting antioxidant ingredients\u003c\/li\u003e\n\u003cli\u003eIncludes hesperidin, rutoside, bioflavonoids, quercetin and annatto tocotrienols\u003c\/li\u003e\n\u003cli\u003eSupporting a healthy immune system function\u003c\/li\u003e\n\u003cli\u003eMaintains skin health\u003c\/li\u003e\n\u003cli\u003eSupports a healthy stress response\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health C Plus Supreme Has No added: gluten, dairy, lactose, soy or nuts.\u003c\/p\u003e\n\u003cp\u003eDesigns For Health C Plus Supreme AUST L 380294\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003eAdults: take 5 g (1 level teaspoon) mixed with 200 mL water daily or as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients per 5 gm dose\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (PureWay-C)\u003c\/td\u003e\n\u003ctd\u003e1.25g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium ascorbate dihydrate\u003c\/td\u003e\n\u003ctd\u003e680.85mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e562.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium ascorbate monohydrate\u003c\/td\u003e\n\u003ctd\u003e139.3mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbyl palmitate\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e42.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePhyllanthus emblica ext dry conc.\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFrom dry fruit\u003c\/td\u003e\n\u003ctd\u003e6.25g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent ascorbic acid\u003c\/td\u003e\n\u003ctd\u003e62.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal Ascorbic Acid\u003c\/td\u003e\n\u003ctd\u003e2.043g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBixa orellana ext dry conc.\u003c\/td\u003e\n\u003ctd\u003e166.65mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFrom dry seed\u003c\/td\u003e\n\u003ctd\u003e55.5g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent total tocotrienols\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHesperidin\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRutoside\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCitrus bioflavonoids extract\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eQuercetin dihydrate\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003eAmmonium glycyrrhizinate, Modified food starch, Citric acid, Maltodextrin, Colloidal anhydrous silica, Stevia rebaudiana, Hypromellose, Thaumatin, Silicon dioxide, Sodium bicarbonate, Tartaric acid, Natural orange flavour\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003eNo added: Gluten, Dairy, Soy, Yeast, Nuts, Eggs, Seeds.\u003c\/p\u003e\n\u003cp\u003eFree From: Benzoates, Sorabtes, Artificial colours or flavours\u003c\/p\u003e\n\u003cp\u003eContains: Sulfites\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist, talk to your health professional.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescribing Information:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCaution is advised regarding use of vitamin C in individuals with iron overload sensitivities including erythrocyte glucose-6-phosphate dehydrogenase deficiency, haemochromatosis, thalassaemia major or sideroblastic anaemia.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health C Plus Supreme\u003c\/h2\u003e\n\u003ch3\u003eEndogenous roles of vitamin C\u003c\/h3\u003e\n\u003cp\u003eVitamin C, a nomenclature that encompasses both ascorbic acid and its oxidised form dehydroascorbic acid, is an essential water-soluble vitamin that the body requires from exogenous sources due to its low endogenous storage capacity and inability to enzymatically synthesise it (because of the absence of L-gulonolactone oxidase enzyme).\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthTri-magSupreme60Caps10_offRRPatHealthMastersDesignsForHealthFigure1_600x600.png?v=1674111047\" alt=\"Designs For Health Tri-mag Supreme 60 Caps 10% off RRP at HealthMasters Designs For Health Figure 1\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003eFigure 1:\u003c\/strong\u003e Linus Pauling Institute: Vitamin C and dehydroascorbic acid chemical structures.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003eWhile vitamin C is widely available in many fruits and vegetables, inadequate levels (ranging from serum levels \u0026lt;11.4μmol\/L [severe deficiency], \u0026lt;23 μmol\/L [marginal deficiency] to \u0026lt;40-50 μmol\/L [suboptimal]) are relatively prevalent across the average Western population, with vitamin C being the fourth most common nutrient deficiency in the United States.\u003c\/p\u003e\n\u003cp\u003eRisk factors associated with inadequate and deficient levels include suboptimal nutrient (macro- and\/or micronutrients) dietary intake patterns, gastrointestinal conditions, older age, smoking, alcohol, environmental pollution, significant physical or psychological stress, medication use (aspirin, indomethacin, oral contraceptive pill, tetracyclines, corticosteroids) and the presence of genetic polymorphisms\u003c\/p\u003e\n\u003cp\u003eSuch factors influence the complex endogenous pharmacokinetics of vitamin C, with absorption, transport, metabolism and elimination regulated by intestinal absorption, tissue concentrations and renal reabsorption.3,5 Depending on the presence of risk factors associated with inadequate endogenous vitamin C concentrations, following oral intake plasma levels increase until reaching repletion\/saturation levels (60-80 μmol\/L).\u003c\/p\u003e\n\u003cp\u003eIn addition to the broad range of common risk factors associated with suboptimal or deficient levels, the involvement of vitamin C in over 150 metabolic processes emphasises the importance of maintaining optimal levels to support normal antioxidant, immune, cardiovascular, connective tissue, adrenal and functional health in the body\u003c\/p\u003e\n\u003ch3\u003eAntioxidant\u003c\/h3\u003e\n\u003cp\u003eThe body is continually exposed to free radicals from those generated by endogenous metabolic processes and exogenous environmental sources, and optimal vitamin C levels are required to ameliorate the impact of oxidative damage on body cells and tissues (proteins, lipids, carbohydrates, and nucleic acids) via both direct and indirect mechanisms.\u003c\/p\u003e\n\u003cp\u003eDirect mechanisms include donating electrons and neutralising reactive oxygen and nitrogen species, while indirect mechanisms include mitigating the impact of hydrogen peroxide, regenerating endogenous vitamin E and supporting antioxidant enzyme system function. Vitamin C’s antioxidant mechanisms also underlie its effect on other body systems and tissues.\u003c\/p\u003e\n\u003ch3\u003eImmune\u003c\/h3\u003e\n\u003cp\u003eVitamin C helps the immune system to maintain homeostasis and generate appropriate responses when exposed to infectious pathogens via multiple mechanisms (see table 1).\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1:\u003c\/strong\u003e Vitamin C immune system mechanisms5\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIMMUNE COMPONENT\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eMECHANISM\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEpithelial barriers\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eSupports collagen synthesis and integrity.\u003c\/li\u003e\n\u003cli\u003eProtects against reactive oxygen species damage. \u003c\/li\u003e\n\u003cli\u003eInfluences keratinocyte and fibroblast activity.\u003c\/li\u003e\n\u003cli\u003eSupports wound healing.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePhagocytes (neutrophils, macrophages)\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAntioxidant.\u003c\/li\u003e\n\u003cli\u003eSupports chemotaxis and phagocytosis.\u003c\/li\u003e\n\u003cli\u003eSupports phagocytosis and chemotaxis.\u003c\/li\u003e\n\u003cli\u003eFacilitates apoptosis and clearance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eB and T-lymphocytes\u003c\/td\u003e\n\u003ctd\u003e\n\u003cul\u003e\n\u003cli\u003eSupports differentiation and proliferation.\u003c\/li\u003e\n\u003cli\u003eFacilitates production of antibodies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInflammatory mediators\u003c\/td\u003e\n\u003ctd\u003e• Modulates cytokine synthesis. • Influences histamine levels.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eCardiovascular\u003c\/h3\u003e\n\u003cp\u003eVitamin C’s antioxidant mechanisms support cardiovascular system health by inhibiting low-density lipoprotein oxidation, supporting healthy endothelial function and homocysteine and inducible nitric oxide synthase metabolism.\u003c\/p\u003e\n\u003ch3\u003eAdrenal and nervous system\u003c\/h3\u003e\n\u003cp\u003eStress, both physical and psychological, is a normal part of life and the body responds to stress with cascade of complex and coordinated sympathetic nervous and hypothalamic-pituitaryadrenal system processes.\u003c\/p\u003e\n\u003cp\u003eOptimal levels of vitamin C are required to support this stress response via its involvement in mitochondrial energy synthesis, adrenal glucocorticoid and catecholamine synthesis (promoting a healthy cortisol response) and antioxidant effects\/mechanisms ameliorating the central nervous system's particular sensitivity to oxidative stress.\u003c\/p\u003e\n\u003ch3\u003eConnective tissue\u003c\/h3\u003e\n\u003cp\u003eVitamin C is integral for the maintenance of normal connective tissue, bone and joint health as a consequence of its role in collagen synthesis and stabilisation (as a lysyl and prolyl hydroxylase cofactor), bone matrix formation and repair (promotes osteoblast differentiation, modulates chondrocyte gene expression) and antioxidant activity (reducing bone resorption).\u003c\/p\u003e\n\u003ch3\u003ePureWay-C\u003c\/h3\u003e\n\u003cp\u003ePureWay-C is a clinically studied form of vitamin C comprised of a lipid-vitamin C complex that has demonstrated excellent absorption and bioavailability. Clinical studies involving healthy human subjects have shown that the proprietary fatty acid formulation allows vitamin C to rapidly enter the cells by acting as a carrier to facilitate intestinal absorption, cellular uptake and tissue distribution without effects commonly associated with concentrated doses of vitamin C.   \u003c\/p\u003e\n\u003cp\u003e\u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Designs For Health C Plus Supreme 10% off RRP at HealthMasters Designs For Health Graph 1\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthCPlusSupreme10_offRRPatHealthMastersDesignsForHealthGraph1_600x600.png?v=1674111786\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthCPlusSupreme10_offRRPatHealthMastersDesignsForHealthGraph1_600x600.png?v=1674111786\"\u003e  \u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}