{"id":2288394829883,"title":"BioCeuticals Iron Sustain 30 tabs","handle":"bioceuticals-iron-sustain-30-tabs","description":"\u003ch2\u003eBioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eBioavailable Iron with Cofactors for Increased Absorption and Utilisation\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eBioCeuticals Iron Sustain Serving Type: Tablet\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Iron Sustain Available In Sizes: 30 tablets\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Iron Sustain provides highly bioavailable iron in the form of ferrous bisglycinate. Activated B vitamins and vitamin C support the formulation.\u003c\/li\u003e\n\u003cli\u003eIron may be of assistance to people with an increased demand for iron or whose dietary intake of iron is inadequate.\u003c\/li\u003e\n\u003cli\u003eIron is necessary for the formation of haemoglobin in the blood, which transports oxygen to the tissues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Iron Sustain has No Added Dairy, No Added Gluten, Pregnancy Friendly, No Added Shellfish, No Added Soy Protein, Vegan Friendly, Vegetarian Friendly, No Added Yeast\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eConditions Associated: Women's Health, Pregnancy Health, Nutritional Support\u003ca title=\"BioCeuticals 10% off RRP | HealthMasters\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003e\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 tablet once daily or as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eUses easily absorbed ferrous bisglycinate chelate (Ferrochel®).\u003c\/li\u003e\n\u003cli\u003eProvides 24mg of elemental iron.\u003c\/li\u003e\n\u003cli\u003eIncludes activated B6, B9 and B12 vitamins.\u003c\/li\u003e\n\u003cli\u003eIron, folic acid and vitamin B12 help maintain healthy blood.\u003c\/li\u003e\n\u003cli\u003eAssists normal red blood cell formation.\u003c\/li\u003e\n\u003cli\u003eHelps support dietary iron intake.\u003c\/li\u003e\n\u003cli\u003eContains vitamin C to assist with non-haem iron absorption.\u003c\/li\u003e\n\u003cli\u003eBeneficial during pregnancy when iron need is greater.\u003c\/li\u003e\n\u003cli\u003eGentle on the stomach.\u003c\/li\u003e\n\u003cli\u003eVegetarian and vegan friendly.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach tablet contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIron (II) glycinate (bisglycinate) (Ferrochel) \u003c\/td\u003e\n\u003ctd\u003e88.8mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. iron\u003c\/td\u003e\n\u003ctd\u003e24mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (vitamin C)\u003c\/td\u003e\n\u003ctd\u003e200mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyridoxal-5-phosphate monohydrate (P5P) (active vitamin B6)\u003c\/td\u003e\n\u003ctd\u003e24.4mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. pyridoxine (vitamin B6)\u003c\/td\u003e\n\u003ctd\u003e15mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLevomefolate calcium\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. levomefolic acid (5-MTHF) (active folate)\u003c\/td\u003e\n\u003ctd\u003e115.44mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium folinate\u003c\/td\u003e\n\u003ctd\u003e135.05mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. folinic acid (activated vitamin B9)\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMecobalamin (co-methylcobalamin) (active vitamin B12)\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCyanocobalamin (vitamin B12)\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAbsorption and bioavailability\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Iron Sustain uses Ferrochel, an amino acid iron chelate, which is composed of two glycine molecules bound to a ferrous cation to form a double heterocyclic ring compound. This configuration is thought to be responsible for its high bioavailability as it protects the iron from dietary inhibitors such as phytates and polyphenols.[5]\u003c\/li\u003e\n\u003cli\u003eThis form of iron can survive the pH of the stomach. This pH resistance allows the chelate to maintain iron in a soluble form and further protects it from dietary inhibitors.[6]\u003c\/li\u003e\n\u003cli\u003eIron absorption from chelates is well regulated,[7] and absorption of iron from ferrous bisglycinate has been shown to correlate inversely with body iron stores.[7] This means\u003c\/li\u003e\n\u003cli\u003ethat individuals with lower iron status may absorb greater amounts of iron.\u003c\/li\u003e\n\u003cli\u003eStudies have shown that iron bisglycine chelate has better iron bioavailability and tolerability compared to inorganic iron salts such as ferrous sulphate.[6]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eActivated B vitamins\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivated forms of B vitamins bypass the metabolic pathways that are necessary in the conversion of standard B vitamins into their metabolically active forms for improved utilisation in the body.\u003c\/li\u003e\n\u003cli\u003eThe metabolically active form of vitamin B6, pyridoxal-5-phosphate (P5P) is involved in the formation of haem. Both pyridoxal and P5P are able to bind haemoglobin and affect its ability to pick up and release oxygen.[8]\u003c\/li\u003e\n\u003cli\u003eFolinic acid is the metabolically active form of folic acid. Folic acid is involved in the formation and healthy maturation of red blood cells. 5-MTHF is the active metabolite of folic acid and helps maintain normal red blood cell formation.[9]\u003c\/li\u003e\n\u003cli\u003eVitamin B12 is required for the production of red blood cells (erythropoiesis) as well as other haematological cells.[10]\u003c\/li\u003e\n\u003cli\u003eAdditionally, the bioavailability of iron from the bisglycine chelate is enhanced by ascorbic acid.[11] Vitamin C acts as a reducing agent and forms a chelate with non-haem ferric iron at an acid pH.[9]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIron Absorption Research\u003c\/h5\u003e\n\u003ch2\u003eIron Absorption Research:\u003c\/h2\u003e\n\u003ch3\u003eABSORPTION + MINIMAL SIDE EFFECTS\u003c\/h3\u003e\n\u003cp\u003eCompliance with iron supplementation, especially among pregnant women, is poor, due in part to the commonly associated side effects.\u003c\/p\u003e\n\u003cp\u003eIron deficiency anaemia during pregnancy affects 12% of pregnant women in Australia, and is associated with an increased risk of prematurity, low birth weight, and maternal morbidity.\u003c\/p\u003e\n\u003cp\u003eOut of 453 women using iron supplements, containing various forms of iron (ferrous fumarate, ferrous sulfate, ferric polymaltose, and ferric bisglycinate), during pregnancy, almost half (45%) reported at least one adverse effect (particularly constipation and nausea).\u003c\/p\u003e\n\u003cp\u003eFerric bisglycinate was associated with the fewest side effects (21.2%), compared to ferrous fumarate and ferrous sulfate, which caused the most (56.3% and 53.7%, respectively). 83 women discontinued their prescribed iron preparation, mainly due to side effects. Compliance rates were the highest for the ferric bisglycinate, due to its favourable absorption and tolerance characteristics.\u003cbr\u003e\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003ePasricha, SRS, Flecknoe-Brown, SC, Allen, KJ, Gibson, PR, McMahon, LP, Olynyk, JK, Roger, SD, Savoia, HF, Tampi, R, Thomson, AR, Wood, EM \u0026amp; Robinson, KL 2010, ‘Diagnosis and management of iron deficiency anaemia: a clinical update’, The Medical Journal of Australia, vol. 193, no. 9, pp. 525-32.\u003c\/p\u003e\n\u003cp\u003eMelamed, N, Ben-Haroush, A, Kaplan, B \u0026amp; Yogev, Y 2007, ‘Iron supplementation in pregnancy—does the preparation matter?’, Archives of Gynecology and Obstetrics, vol. 276, pp. 601-4.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIf symptoms persist talk to your health professional.\u003c\/li\u003e\n\u003cli\u003eNot for the treatment of iron deficiency conditions.\u003c\/li\u003e\n\u003cli\u003eVitamin supplements should not replace a balanced diet.\u003c\/li\u003e\n\u003cli\u003eAlways read the label. Use only as directed.\u003c\/li\u003e\n\u003cli\u003eIf you have any pre-existing conditions, are on any medications, always talk to your health professional before use.\u003c\/li\u003e\n\u003cli\u003eSome products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eCompanion Products\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003eBioCeuticals Women's Essentials\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals FemmePlex\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Vitex Capsules\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003e[1] Duque X, Martinez H, Vilchis-Gil J, et al. Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial. Nutr J 2014;13:71.\u003c\/p\u003e\n\u003cp\u003e[2] Ashmead HD. The absorption and metabolism of iron amino acid chelate. Arch Latinoam Nutr, 2001;5(1):13-21.\u003c\/p\u003e\n\u003cp\u003e[3] Anton R, Barlow S, Boskou D, et al. Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with (AFC) related to ferrous bisglycinate as a source of iron for use in the manufacturing of foods and in food supplements. EFSA 2006;4(1):299,1-17.\u003c\/p\u003e\n\u003cp\u003e[4] Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ, 2014;349.\u003c\/p\u003e\n\u003cp\u003e[5] Koyama K, Usami T, Takeuchi O, et al. Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation. Nephrol Dial Transplant, 2002;17(96):916-922.\u003c\/p\u003e\n\u003cp\u003e[6] Reynolds E. Vitamin B12, folic acid, and the nervous system. The Lancet Neurology, 2006;5(11): 949-960.\u003c\/p\u003e\n\u003cp\u003e[7] Gropper SS, Smith JL. Advanced nutrition and human metabolism, 6th ed. Boston: Cengage Learning.\u003c\/p\u003e\n\u003cp\u003e[8] Higdon J. An evidence-based approach to vitamins and minerals. New York: Thieme Medical Publishers, 2003.\u003c\/p\u003e\n\u003cp\u003e[9] Iron. Nutrient Reference Values for Australia and New Zealand, 2016. Available from https:\/\/www.nrv.gov.au\/nutrients\/iron.\u003c\/p\u003e\n\u003cp\u003e[10] Iron. Natural Medicines Comprehensive Database. Viewed 28 May 2014, www.naturaldatabase.com\u003c\/p\u003e\n\u003cp\u003e[11] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T14:07:24+11:00","created_at":"2019-07-09T17:20:59+10:00","vendor":"BioCeuticals","type":"BioCeuticals Naturopathic Medicines","tags":["BioCeuticals","Iron","Naturopathic","Nutritional Support","PB","Pregnany Health","Women's Health"],"price":1976,"price_min":1976,"price_max":1976,"available":true,"price_varies":false,"compare_at_price":2195,"compare_at_price_min":2195,"compare_at_price_max":2195,"compare_at_price_varies":false,"variants":[{"id":21199237414971,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"IronSustain30T","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"BioCeuticals Iron Sustain 30 tabs","public_title":null,"options":["Default Title"],"price":1976,"weight":53,"compare_at_price":2195,"inventory_quantity":19951,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9337896006504","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/bioceuticals-ironsustain-biron30_524x690_782cd122-752c-46f5-9bd9-7b7c4251be34.png?v=1562656859","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioCeuticalsIronSustain_pill10_offRRPatHealthMasters.jpg?v=1590386847"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/bioceuticals-ironsustain-biron30_524x690_782cd122-752c-46f5-9bd9-7b7c4251be34.png?v=1562656859","options":["Title"],"media":[{"alt":"BioCeuticals Iron Sustain 30 tabs 10% off RRP | HealthMasters","id":2798240825403,"position":1,"preview_image":{"aspect_ratio":0.754,"height":690,"width":520,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/bioceuticals-ironsustain-biron30_524x690_782cd122-752c-46f5-9bd9-7b7c4251be34.png?v=1562656859"},"aspect_ratio":0.754,"height":690,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/bioceuticals-ironsustain-biron30_524x690_782cd122-752c-46f5-9bd9-7b7c4251be34.png?v=1562656859","width":520},{"alt":"BioCeuticals Iron Sustain pill 10% off RRP at HealthMasters","id":8507042660411,"position":2,"preview_image":{"aspect_ratio":1.556,"height":90,"width":140,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioCeuticalsIronSustain_pill10_offRRPatHealthMasters.jpg?v=1590386847"},"aspect_ratio":1.556,"height":90,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioCeuticalsIronSustain_pill10_offRRPatHealthMasters.jpg?v=1590386847","width":140}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eBioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eBioavailable Iron with Cofactors for Increased Absorption and Utilisation\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eBioCeuticals Iron Sustain Serving Type: Tablet\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Iron Sustain Available In Sizes: 30 tablets\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Iron Sustain provides highly bioavailable iron in the form of ferrous bisglycinate. Activated B vitamins and vitamin C support the formulation.\u003c\/li\u003e\n\u003cli\u003eIron may be of assistance to people with an increased demand for iron or whose dietary intake of iron is inadequate.\u003c\/li\u003e\n\u003cli\u003eIron is necessary for the formation of haemoglobin in the blood, which transports oxygen to the tissues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Iron Sustain has No Added Dairy, No Added Gluten, Pregnancy Friendly, No Added Shellfish, No Added Soy Protein, Vegan Friendly, Vegetarian Friendly, No Added Yeast\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eConditions Associated: Women's Health, Pregnancy Health, Nutritional Support\u003ca title=\"BioCeuticals 10% off RRP | HealthMasters\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003e\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 tablet once daily or as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eUses easily absorbed ferrous bisglycinate chelate (Ferrochel®).\u003c\/li\u003e\n\u003cli\u003eProvides 24mg of elemental iron.\u003c\/li\u003e\n\u003cli\u003eIncludes activated B6, B9 and B12 vitamins.\u003c\/li\u003e\n\u003cli\u003eIron, folic acid and vitamin B12 help maintain healthy blood.\u003c\/li\u003e\n\u003cli\u003eAssists normal red blood cell formation.\u003c\/li\u003e\n\u003cli\u003eHelps support dietary iron intake.\u003c\/li\u003e\n\u003cli\u003eContains vitamin C to assist with non-haem iron absorption.\u003c\/li\u003e\n\u003cli\u003eBeneficial during pregnancy when iron need is greater.\u003c\/li\u003e\n\u003cli\u003eGentle on the stomach.\u003c\/li\u003e\n\u003cli\u003eVegetarian and vegan friendly.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach tablet contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIron (II) glycinate (bisglycinate) (Ferrochel) \u003c\/td\u003e\n\u003ctd\u003e88.8mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. iron\u003c\/td\u003e\n\u003ctd\u003e24mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (vitamin C)\u003c\/td\u003e\n\u003ctd\u003e200mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyridoxal-5-phosphate monohydrate (P5P) (active vitamin B6)\u003c\/td\u003e\n\u003ctd\u003e24.4mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. pyridoxine (vitamin B6)\u003c\/td\u003e\n\u003ctd\u003e15mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLevomefolate calcium\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. levomefolic acid (5-MTHF) (active folate)\u003c\/td\u003e\n\u003ctd\u003e115.44mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium folinate\u003c\/td\u003e\n\u003ctd\u003e135.05mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. folinic acid (activated vitamin B9)\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMecobalamin (co-methylcobalamin) (active vitamin B12)\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCyanocobalamin (vitamin B12)\u003c\/td\u003e\n\u003ctd\u003e125mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAbsorption and bioavailability\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Iron Sustain uses Ferrochel, an amino acid iron chelate, which is composed of two glycine molecules bound to a ferrous cation to form a double heterocyclic ring compound. This configuration is thought to be responsible for its high bioavailability as it protects the iron from dietary inhibitors such as phytates and polyphenols.[5]\u003c\/li\u003e\n\u003cli\u003eThis form of iron can survive the pH of the stomach. This pH resistance allows the chelate to maintain iron in a soluble form and further protects it from dietary inhibitors.[6]\u003c\/li\u003e\n\u003cli\u003eIron absorption from chelates is well regulated,[7] and absorption of iron from ferrous bisglycinate has been shown to correlate inversely with body iron stores.[7] This means\u003c\/li\u003e\n\u003cli\u003ethat individuals with lower iron status may absorb greater amounts of iron.\u003c\/li\u003e\n\u003cli\u003eStudies have shown that iron bisglycine chelate has better iron bioavailability and tolerability compared to inorganic iron salts such as ferrous sulphate.[6]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eActivated B vitamins\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivated forms of B vitamins bypass the metabolic pathways that are necessary in the conversion of standard B vitamins into their metabolically active forms for improved utilisation in the body.\u003c\/li\u003e\n\u003cli\u003eThe metabolically active form of vitamin B6, pyridoxal-5-phosphate (P5P) is involved in the formation of haem. Both pyridoxal and P5P are able to bind haemoglobin and affect its ability to pick up and release oxygen.[8]\u003c\/li\u003e\n\u003cli\u003eFolinic acid is the metabolically active form of folic acid. Folic acid is involved in the formation and healthy maturation of red blood cells. 5-MTHF is the active metabolite of folic acid and helps maintain normal red blood cell formation.[9]\u003c\/li\u003e\n\u003cli\u003eVitamin B12 is required for the production of red blood cells (erythropoiesis) as well as other haematological cells.[10]\u003c\/li\u003e\n\u003cli\u003eAdditionally, the bioavailability of iron from the bisglycine chelate is enhanced by ascorbic acid.[11] Vitamin C acts as a reducing agent and forms a chelate with non-haem ferric iron at an acid pH.[9]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIron Absorption Research\u003c\/h5\u003e\n\u003ch2\u003eIron Absorption Research:\u003c\/h2\u003e\n\u003ch3\u003eABSORPTION + MINIMAL SIDE EFFECTS\u003c\/h3\u003e\n\u003cp\u003eCompliance with iron supplementation, especially among pregnant women, is poor, due in part to the commonly associated side effects.\u003c\/p\u003e\n\u003cp\u003eIron deficiency anaemia during pregnancy affects 12% of pregnant women in Australia, and is associated with an increased risk of prematurity, low birth weight, and maternal morbidity.\u003c\/p\u003e\n\u003cp\u003eOut of 453 women using iron supplements, containing various forms of iron (ferrous fumarate, ferrous sulfate, ferric polymaltose, and ferric bisglycinate), during pregnancy, almost half (45%) reported at least one adverse effect (particularly constipation and nausea).\u003c\/p\u003e\n\u003cp\u003eFerric bisglycinate was associated with the fewest side effects (21.2%), compared to ferrous fumarate and ferrous sulfate, which caused the most (56.3% and 53.7%, respectively). 83 women discontinued their prescribed iron preparation, mainly due to side effects. Compliance rates were the highest for the ferric bisglycinate, due to its favourable absorption and tolerance characteristics.\u003cbr\u003e\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003ePasricha, SRS, Flecknoe-Brown, SC, Allen, KJ, Gibson, PR, McMahon, LP, Olynyk, JK, Roger, SD, Savoia, HF, Tampi, R, Thomson, AR, Wood, EM \u0026amp; Robinson, KL 2010, ‘Diagnosis and management of iron deficiency anaemia: a clinical update’, The Medical Journal of Australia, vol. 193, no. 9, pp. 525-32.\u003c\/p\u003e\n\u003cp\u003eMelamed, N, Ben-Haroush, A, Kaplan, B \u0026amp; Yogev, Y 2007, ‘Iron supplementation in pregnancy—does the preparation matter?’, Archives of Gynecology and Obstetrics, vol. 276, pp. 601-4.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIf symptoms persist talk to your health professional.\u003c\/li\u003e\n\u003cli\u003eNot for the treatment of iron deficiency conditions.\u003c\/li\u003e\n\u003cli\u003eVitamin supplements should not replace a balanced diet.\u003c\/li\u003e\n\u003cli\u003eAlways read the label. Use only as directed.\u003c\/li\u003e\n\u003cli\u003eIf you have any pre-existing conditions, are on any medications, always talk to your health professional before use.\u003c\/li\u003e\n\u003cli\u003eSome products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eCompanion Products\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003eBioCeuticals Women's Essentials\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals FemmePlex\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Vitex Capsules\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Iron Sustain\u003c\/h2\u003e\n\u003cp\u003e[1] Duque X, Martinez H, Vilchis-Gil J, et al. Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial. Nutr J 2014;13:71.\u003c\/p\u003e\n\u003cp\u003e[2] Ashmead HD. The absorption and metabolism of iron amino acid chelate. Arch Latinoam Nutr, 2001;5(1):13-21.\u003c\/p\u003e\n\u003cp\u003e[3] Anton R, Barlow S, Boskou D, et al. Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with (AFC) related to ferrous bisglycinate as a source of iron for use in the manufacturing of foods and in food supplements. EFSA 2006;4(1):299,1-17.\u003c\/p\u003e\n\u003cp\u003e[4] Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ, 2014;349.\u003c\/p\u003e\n\u003cp\u003e[5] Koyama K, Usami T, Takeuchi O, et al. Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation. Nephrol Dial Transplant, 2002;17(96):916-922.\u003c\/p\u003e\n\u003cp\u003e[6] Reynolds E. Vitamin B12, folic acid, and the nervous system. The Lancet Neurology, 2006;5(11): 949-960.\u003c\/p\u003e\n\u003cp\u003e[7] Gropper SS, Smith JL. Advanced nutrition and human metabolism, 6th ed. Boston: Cengage Learning.\u003c\/p\u003e\n\u003cp\u003e[8] Higdon J. An evidence-based approach to vitamins and minerals. New York: Thieme Medical Publishers, 2003.\u003c\/p\u003e\n\u003cp\u003e[9] Iron. Nutrient Reference Values for Australia and New Zealand, 2016. Available from https:\/\/www.nrv.gov.au\/nutrients\/iron.\u003c\/p\u003e\n\u003cp\u003e[10] Iron. Natural Medicines Comprehensive Database. Viewed 28 May 2014, www.naturaldatabase.com\u003c\/p\u003e\n\u003cp\u003e[11] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}