{"id":8922145095910,"title":"Bio-Practica NMN","handle":"bio-practica-nmn","description":"\u003ch2\u003eBio-Practica NMN\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eExtemporaneous Compounding\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eFor Practitioner Dispensing Only\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003ePack Size: 120g Powder\u003c\/p\u003e\n\u003cp\u003eBio-Practica NMN is Dairy Free, Gluten Free, Vegetarian and Vegan\u003c\/p\u003e\n\u003cp\u003eBio-Practica NMN is Naturally flavoured and sweetened\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: Bio-Practica NMN\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNMN, as the precursor to NAD+, plays a critical role in ATP production and cellular energy efficiency.\u003c\/li\u003e\n\u003cli\u003eIt is required for glycolysis, oxidative decarboxylation of pyruvate, oxidation of acetyl CoA, and β-oxidation of fatty acids.\u003c\/li\u003e\n\u003cli\u003eD-Ribose acts as a co-substrate during the salvage pathway for NAD+, facilitating the conversion of NMN to NAD+.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDose \u0026amp; Administration\u003c\/h5\u003e\n\u003ch2\u003eDose \u0026amp; Administration: \u003c\/h2\u003e\n\u003cp\u003eAs directed by your health practitioner. For extemporaneous compounding only.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePractitioner Prescribing Guide\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003emg\/day\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003escoops per day\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eNotes\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMetabolic Flexibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePoor exercise resilience [10]\u003c\/td\u003e\n\u003ctd\u003e300 – 600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e1 - 2 scoops\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFemale hormone imbalance [15]\u003c\/td\u003e\n\u003ctd\u003e250 - 300 mg\/day\u003c\/td\u003e\n\u003ctd\u003e3\/4 - 1 scoop\u003c\/td\u003e\n\u003ctd\u003ePlus Magnesium Citrate, DIM and CDG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHirsutism\u003c\/td\u003e\n\u003ctd\u003eD-Ribose 1280 [16]\u003c\/td\u003e\n\u003ctd\u003e3\/4 scoop\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFat weight loss\u003c\/td\u003e\n\u003ctd\u003e250 mg\/day\u003c\/td\u003e\n\u003ctd\u003e3\/4 scoop\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEnergy Efficiency\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInconsistent daily energy levels (spikes and troughs)\u003c\/td\u003e\n\u003ctd\u003e300 – 600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e1 - 2 scoop\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChronic Fatigue Syndrome [19]\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e250 – 600 mg\/day\u003c\/p\u003e\n\u003cp\u003e+ D-Ribose 5g\/day\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e3\/4 - 1 scoop\u003c\/td\u003e\n\u003ctd\u003ePlus Magnesium Citrate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDaytime fatigue or malaise\u003c\/td\u003e\n\u003ctd\u003e600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e2 scoops\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFibromyalgia\u003c\/td\u003e\n\u003ctd\u003e600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e2 scoops\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Bio-Practica NMN\u003c\/h2\u003e\n\u003ch1\u003eNMN + D-RIBOSE FOR METABOLIC FLEXIBILITY AND ENERGY\u003c\/h1\u003e\n\u003cp\u003eMetabolic flexibility is the ability to respond or adapt to metabolic or energy demand changes. 1 Specifically, it is the ability to switch between glucose and fatty acid utilisation depending on availability.2 Metabolic inflexibility, the failure to effectively switch between energy substrates, results in energy inefficiency, energy slumps, and fatigue; and hormonal and metabolic disorders such as polycystic ovarian syndrome (PCOS), insulin resistance, prediabetes, and type II diabetes mellitus (T2DM). 2,3,4\u003c\/p\u003e\n\u003cp\u003eImpaired metabolic flexibility is primarily driven by two main factors, firstly, a chronic hypercaloric state that overwhelms metabolic balance and, secondly, an insufficiency in tricarboxylic acid (TCA) cofactors, particularly nicotinamide adenine dinucleotide (NAD+). Over time, chronic energy excess leads to incomplete fatty acid oxidation, an elevated NADH\/NAD+ ratio, and the accumulation of acetyl CoA. This, in turn, induces protein modifications that compromise mitochondrial function and fuel switching. 5\u003c\/p\u003e\n\u003cp\u003eAny disruption to the complex interplay involved in cellular respiration, whether due to mitochondrial dysfunction or a lack of cofactors, leads to reduced adenosine triphosphate (ATP) production and increased accumulation of inflammatory mediators, reactive oxygen species (ROS), and metabolites (calcium ions and acyl groups) that disrupt cell signalling and further impair metabolic flexibility.\u003c\/p\u003e\n\u003cp\u003eMitochondrial dysfunction also leads to a cascade of effects on cellular functioning; disrupting calcium handling, anaplerosis (TCA cycle replenishment), proteostasis, apoptosis, and autophagy.6 Therefore, both metabolic inflexibility and mitochondrial function underpin a range of metabolic conditions spurred on by a decline in cellular energy efficiency.\u003c\/p\u003e\n\u003cp\u003eRecent research, however, indicates that strategies aimed at improving metabolic flexibility, may mitigate or even reverse these effects, leading to improved energy, metabolic preservation, and overall health.5  \u003c\/p\u003e\n\u003cp\u003eOne such strategy is the provision of cofactors for energy production. Nicotinamide mononucleotide (NMN) is particularly important as the orally bioavailable precursor to NAD+, the essential coenzyme required for energy transduction and cell signalling.7\u003c\/p\u003e\n\u003cp\u003eInterestingly, whole-body metabolic flexibility has been shown to be regulated by white adipose tissue (WAT) nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ biosynthesis in humans. Further, a loss of WAT NAMPT impairs metabolic pathways involved in insulin sensitivity, substrate catabolism, and mitochondrial function in WAT and impairs whole-body metabolic flexibility. Collectively, this suggests adipocyte-specific NAMPT depletion impairs adaptive fuel switching from glucose to lipids in response to reduced energy input.8\u003c\/p\u003e\n\u003ch2\u003eNMN + Cofactors for Whole Body Metabolic Flexibility\u003c\/h2\u003e\n\u003cp\u003eAn imbalance between a hypercaloric state of carbohydrates and fats combined with undernutrition, coupled with age related NAD+ and energy pathway inefficiencies gives rise to metabolic inflexibility.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"text-decoration: underline;\"\u003eFatigue, insulin resistance \u0026amp; age-related energy decline - Metabolic Inflexibility\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3\u003eClinical Signs of Metabolic Inflexibility\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eEnergy slumps \/ inconsistent energy throughout the day\u003c\/li\u003e\n\u003cli\u003eReliance on high G.I. energy sources\u003c\/li\u003e\n\u003cli\u003eDifficulty in fasting \u0026amp; maintaining fasts\u003c\/li\u003e\n\u003cli\u003ePost-prandial carbohydrate energy\u003c\/li\u003e\n\u003cli\u003ePoor exercise resiliences to low, moderate, and high-intensity exercise\u003c\/li\u003e\n\u003cli\u003eCentral adiposity Resistance to ketogenic diets Low lean body mass or muscle mass\u003c\/li\u003e\n\u003cli\u003eDifficult maintaining muscle \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eClinical Measures of Metabolic Inflexibility Include:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAbnormal fasting blood glucose or glycated haemoglobin (HbA1c)\u003c\/li\u003e\n\u003cli\u003eInconsistent continual measures of blood sugar throughout the day (continued monitoring)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eImpaired metabolic switching leads to fatty acid accumulation, ROS and; \u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eImpaired glucose oxidation \u0026amp; lipolysis;\u003c\/li\u003e\n\u003cli\u003eInsulin resistance; \u003c\/li\u003e\n\u003cli\u003eImpaired mitochondrial function; \u003c\/li\u003e\n\u003cli\u003eImpaired branched chain amino acid catabolism: \u003c\/li\u003e\n\u003cli\u003eInflammation \u0026amp; oxidative stress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cspan style=\"text-decoration: underline;\"\u003eEnergy efficiency, metabolic balance \u0026amp; healthy ageing - Metabolic Flexibility\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3\u003eClinical Signs of Metabolic Flexibility\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eSustained energy \u0026amp; more resilient stress responses\u003c\/li\u003e\n\u003cli\u003eImproved exercise resilience to low, moderate and high-Intensity exercise\u003c\/li\u003e\n\u003cli\u003eincreased lean body mass or muscle mass\u003c\/li\u003e\n\u003cli\u003eImproved response to ketogenic diets (energy, sustainability, efficacy)\u003c\/li\u003e\n\u003cli\u003eMuscle mass growth\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eClinIcal Measures of Metabolic Flexibility Include:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eConsistent normal testing of blood glucose or glycated haemoglobin (HbA1c)\u003c\/li\u003e\n\u003cli\u003eConsistent continual measures of blood sugar throughout the day (continued monitoring)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eEfficient metabolic switching between biological fuel sources glucose and fatty acids, leading to:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eImproved glucose regulation \u0026amp; insulin sensitivity\u003c\/li\u003e\n\u003cli\u003eEnhanced cellular stress resistance Increased muscie cell mitochondria capacity\u003c\/li\u003e\n\u003cli\u003eIncreased Autophagy\/senescence\u003c\/li\u003e\n\u003cli\u003eKetogenic pathway augmentation\u003c\/li\u003e\n\u003cli\u003eAntioxidative \u0026amp; anti-inflammatory pathway induction\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe fundamental goal of treating metabolic inflexibility is to relieve the reducing pressure and buildup of reactive oxygen species (ROS) from carbon overload across the mitochondria. This is achieved by enhancing the buffering capacity of the various systems that mitigate mitochondrial reductive stress like augmenting antioxidant defence, carnitine-mediated acycl group buffering and sirtuin-mediated protein deacylation.\u003c\/p\u003e\n\u003ch2\u003eMETABOLIC FLEXIBILITY\u003c\/h2\u003e\n\u003cp\u003eNMN supports metabolic flexibility via NAMPT and, as it’s a precursor, NAD+ production. For example, in T2DM, the physical manifestation of entrenched metabolic inflexibility; reduced sirtuin-1 (SIRT-1) and subsequent AMP-activated protein kinase (AMPK) expression leads to decreased NAMPT levels. This, in turn, increases ROS and activates poly-ADP ribose polymerase (PARP), elevating both NAD+ consumption and demand.21\u003c\/p\u003e\n\u003cp\u003eIn this scenario, NMN may be used to replenish NAD+ to correct metabolic inflexibility, however, it must be supplied with appropriate cofactors to reduce oxidative stress caused by increased nicotinamide metabolites. For diabetic individuals with entrenched metabolic inflexibility and excessive ROS, a co-prescription of Clinically Proven TRIMAGNESIUM Dicitrate provides additional blood sugar support.\u003c\/p\u003e\n\u003cp\u003eNMN has been shown to improve insulin sensitivity in several studies. In one placebo-controlled trial, 250 mg\/day of NMN for 10 weeks was shown to improve skeletal muscle insulin signalling and insulin sensitivity in postmenopausal women with prediabetes who were overweight or obese.11 Another trial demonstrated 250 mg\/day for 12 weeks improved post-prandial insulin signalling in healthy individuals.12\u003c\/p\u003e\n\u003cp\u003eD-ribose acts as a co-substrate during the salvage pathway for NAD+, facilitating the conversion of NMN to NAD+. Studies supporting the combination of 240 mg\/day NMN and 1280 mg\/day D-ribose demonstrate improvements in high energy phosphates, blood glucose levels, insulin sensitivity, ATP\/AMP ratios, and salivary cortisol reduction.16 These results suggest the combination of NMN and D-ribose synergistically enhances cellular energy metabolism and regulates key metabolic processes for improved metabolic flexibility.\u003c\/p\u003e\n\u003ch2\u003eENERGY EFFICIENCY\u003c\/h2\u003e\n\u003cp\u003eEfficient energy production is integral to maintaining cellular function, mitigating oxidative stress, preventing metabolic imbalances, and supporting the overall resilience of cells. These factors contribute to better management and prevention of metabolic disorders and fatigue.\u003c\/p\u003e\n\u003cp\u003eNMN, as the precursor to NAD+, plays a critical role in ATP production and cellular energy efficiency. It is required for glycolysis, oxidative decarboxylation of pyruvate, oxidation of acetyl CoA, and β-oxidation of fatty acids. Other active ingredients also act as important intermediates and cofactors in the TCA, and subsequent energy production (Figure 2). These include Benfotiamine, acetylL-carnitine, D-ribose, α-ketoglucarate, and malic acid.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eFigure 2. NAD+ and cofactors in cellular respiration\u003c\/p\u003e\n\u003cp\u003eNMN, given for 12 weeks at a dose of 250 mg\/day was shown to prevent physical performance loss and improve fatigue in older adults.20 A combination of 240 mg\/day NMN and 1280 mg\/day D-ribose also demonstrated improvements in fatigue, mental concentration, and motivation over the baseline, addressing both physical and cognitive aspects of energy efficiency.16\u003c\/p\u003e\n\u003cp\u003eFor more severe conditions, such as chronic fatigue and fibromyalgia, 600 mg\/day NMN is recommended based on the anti-fatigue effect in healthy individuals23 and clinical efficacy of 600 mg\/day.13\u003c\/p\u003e\n\u003cp\u003eIn these more severe conditions, the combination of NMN and D-ribose bolsters these effects as D-ribose has shown benefits in CFS and fibromyalgia where oxidative stress and ischemia disrupt ATP production and impair cellular energy metabolism.\u003c\/p\u003e\n\u003cp\u003eIn a pilot study, 41 patients received 5 g of D-ribose three times daily. Results showed significant improvements in energy, sleep, mental clarity, pain intensity, and overall well-being, as well as patients’ global assessment. Approximately 66% of patients experienced significant improvement with D-ribose supplementation.9\u003c\/p\u003e\n\u003cp\u003eNMN + D-Ribose for Metabolic Flexibility and Energy is an important treatment consideration for conditions associated with metabolic inflexibility to help restore metabolic control and manage fatigue, particularly in conditions where cellular energy production is impaired. \u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Bio-Practica NMN\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAvg. qty. per one gram\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eβ-Nicotinamide Mononucleotide (NMN)\u003c\/td\u003e\n\u003ctd\u003e75mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eD-Ribose (398 mg \/ g), glycine, citric acid, orange flavour, vanilla flavour, colloidal anhydrous silica, Stevia rebaudiana (stevia) ext. dry conc. derived from dry leaf.\u003c\/p\u003e\n\u003cp\u003eNaturally flavoured and sweetened\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eDairy Free, Gluten Free, Vegetarian and Vegan\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eAlways read the label and follow the directions for use\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C away from direct sunlight and keep airtight\u003cbr\u003e\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2025-01-16T12:04:04+11:00","created_at":"2025-01-16T11:56:03+11:00","vendor":"Bio-Practica","type":"Bio-Practica 10% off RRP","tags":["Bio-Practica","Naturopathic"],"price":4496,"price_min":4496,"price_max":4496,"available":true,"price_varies":false,"compare_at_price":4995,"compare_at_price_min":4995,"compare_at_price_max":4995,"compare_at_price_varies":false,"variants":[{"id":45629162258662,"title":"120g Powder","option1":"120g Powder","option2":null,"option3":null,"sku":"BiPNMN120g","requires_shipping":true,"taxable":true,"featured_image":{"id":43146302128358,"product_id":8922145095910,"position":1,"created_at":"2025-01-16T17:03:01+11:00","updated_at":"2025-01-16T17:03:24+11:00","alt":"Bio-Practica NMN 120g 10% off RRP at HealthMasters Bio-Practica ","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bio-PracticaNMN120g10_offRRPatHealthMastersBio-Practica.png?v=1737007404","variant_ids":[45629162258662]},"available":true,"name":"Bio-Practica NMN - 120g Powder","public_title":"120g Powder","options":["120g Powder"],"price":4496,"weight":0,"compare_at_price":4995,"inventory_quantity":20000,"inventory_management":"shopify","inventory_policy":"deny","barcode":"09346054001329","featured_media":{"alt":"Bio-Practica NMN 120g 10% off RRP at HealthMasters Bio-Practica ","id":35321994051814,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bio-PracticaNMN120g10_offRRPatHealthMastersBio-Practica.png?v=1737007404"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bio-PracticaNMN120g10_offRRPatHealthMastersBio-Practica.png?v=1737007404","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Bio-PracticaLOGO_5ab4af45-33df-46fa-bdf6-b588d3d4f526.png?v=1737007404"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bio-PracticaNMN120g10_offRRPatHealthMastersBio-Practica.png?v=1737007404","options":["Size:"],"media":[{"alt":"Bio-Practica NMN 120g 10% off RRP at HealthMasters Bio-Practica ","id":35321994051814,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bio-PracticaNMN120g10_offRRPatHealthMastersBio-Practica.png?v=1737007404"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/Bio-PracticaNMN120g10_offRRPatHealthMastersBio-Practica.png?v=1737007404","width":1200},{"alt":"Bio-Practica 10% off RRP | HealthMasters Bio-Practica Logo","id":29874373886182,"position":2,"preview_image":{"aspect_ratio":3.154,"height":591,"width":1864,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Bio-PracticaLOGO_5ab4af45-33df-46fa-bdf6-b588d3d4f526.png?v=1737007404"},"aspect_ratio":3.154,"height":591,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Bio-PracticaLOGO_5ab4af45-33df-46fa-bdf6-b588d3d4f526.png?v=1737007404","width":1864}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eBio-Practica NMN\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eExtemporaneous Compounding\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eFor Practitioner Dispensing Only\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003ePack Size: 120g Powder\u003c\/p\u003e\n\u003cp\u003eBio-Practica NMN is Dairy Free, Gluten Free, Vegetarian and Vegan\u003c\/p\u003e\n\u003cp\u003eBio-Practica NMN is Naturally flavoured and sweetened\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eIndications\u003c\/h5\u003e\n\u003ch2\u003eIndications: Bio-Practica NMN\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNMN, as the precursor to NAD+, plays a critical role in ATP production and cellular energy efficiency.\u003c\/li\u003e\n\u003cli\u003eIt is required for glycolysis, oxidative decarboxylation of pyruvate, oxidation of acetyl CoA, and β-oxidation of fatty acids.\u003c\/li\u003e\n\u003cli\u003eD-Ribose acts as a co-substrate during the salvage pathway for NAD+, facilitating the conversion of NMN to NAD+.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDose \u0026amp; Administration\u003c\/h5\u003e\n\u003ch2\u003eDose \u0026amp; Administration: \u003c\/h2\u003e\n\u003cp\u003eAs directed by your health practitioner. For extemporaneous compounding only.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePractitioner Prescribing Guide\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003emg\/day\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003escoops per day\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eNotes\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMetabolic Flexibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePoor exercise resilience [10]\u003c\/td\u003e\n\u003ctd\u003e300 – 600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e1 - 2 scoops\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFemale hormone imbalance [15]\u003c\/td\u003e\n\u003ctd\u003e250 - 300 mg\/day\u003c\/td\u003e\n\u003ctd\u003e3\/4 - 1 scoop\u003c\/td\u003e\n\u003ctd\u003ePlus Magnesium Citrate, DIM and CDG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHirsutism\u003c\/td\u003e\n\u003ctd\u003eD-Ribose 1280 [16]\u003c\/td\u003e\n\u003ctd\u003e3\/4 scoop\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFat weight loss\u003c\/td\u003e\n\u003ctd\u003e250 mg\/day\u003c\/td\u003e\n\u003ctd\u003e3\/4 scoop\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEnergy Efficiency\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInconsistent daily energy levels (spikes and troughs)\u003c\/td\u003e\n\u003ctd\u003e300 – 600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e1 - 2 scoop\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChronic Fatigue Syndrome [19]\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e250 – 600 mg\/day\u003c\/p\u003e\n\u003cp\u003e+ D-Ribose 5g\/day\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e3\/4 - 1 scoop\u003c\/td\u003e\n\u003ctd\u003ePlus Magnesium Citrate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDaytime fatigue or malaise\u003c\/td\u003e\n\u003ctd\u003e600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e2 scoops\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFibromyalgia\u003c\/td\u003e\n\u003ctd\u003e600 mg\/day\u003c\/td\u003e\n\u003ctd\u003e2 scoops\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Bio-Practica NMN\u003c\/h2\u003e\n\u003ch1\u003eNMN + D-RIBOSE FOR METABOLIC FLEXIBILITY AND ENERGY\u003c\/h1\u003e\n\u003cp\u003eMetabolic flexibility is the ability to respond or adapt to metabolic or energy demand changes. 1 Specifically, it is the ability to switch between glucose and fatty acid utilisation depending on availability.2 Metabolic inflexibility, the failure to effectively switch between energy substrates, results in energy inefficiency, energy slumps, and fatigue; and hormonal and metabolic disorders such as polycystic ovarian syndrome (PCOS), insulin resistance, prediabetes, and type II diabetes mellitus (T2DM). 2,3,4\u003c\/p\u003e\n\u003cp\u003eImpaired metabolic flexibility is primarily driven by two main factors, firstly, a chronic hypercaloric state that overwhelms metabolic balance and, secondly, an insufficiency in tricarboxylic acid (TCA) cofactors, particularly nicotinamide adenine dinucleotide (NAD+). Over time, chronic energy excess leads to incomplete fatty acid oxidation, an elevated NADH\/NAD+ ratio, and the accumulation of acetyl CoA. This, in turn, induces protein modifications that compromise mitochondrial function and fuel switching. 5\u003c\/p\u003e\n\u003cp\u003eAny disruption to the complex interplay involved in cellular respiration, whether due to mitochondrial dysfunction or a lack of cofactors, leads to reduced adenosine triphosphate (ATP) production and increased accumulation of inflammatory mediators, reactive oxygen species (ROS), and metabolites (calcium ions and acyl groups) that disrupt cell signalling and further impair metabolic flexibility.\u003c\/p\u003e\n\u003cp\u003eMitochondrial dysfunction also leads to a cascade of effects on cellular functioning; disrupting calcium handling, anaplerosis (TCA cycle replenishment), proteostasis, apoptosis, and autophagy.6 Therefore, both metabolic inflexibility and mitochondrial function underpin a range of metabolic conditions spurred on by a decline in cellular energy efficiency.\u003c\/p\u003e\n\u003cp\u003eRecent research, however, indicates that strategies aimed at improving metabolic flexibility, may mitigate or even reverse these effects, leading to improved energy, metabolic preservation, and overall health.5  \u003c\/p\u003e\n\u003cp\u003eOne such strategy is the provision of cofactors for energy production. Nicotinamide mononucleotide (NMN) is particularly important as the orally bioavailable precursor to NAD+, the essential coenzyme required for energy transduction and cell signalling.7\u003c\/p\u003e\n\u003cp\u003eInterestingly, whole-body metabolic flexibility has been shown to be regulated by white adipose tissue (WAT) nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ biosynthesis in humans. Further, a loss of WAT NAMPT impairs metabolic pathways involved in insulin sensitivity, substrate catabolism, and mitochondrial function in WAT and impairs whole-body metabolic flexibility. Collectively, this suggests adipocyte-specific NAMPT depletion impairs adaptive fuel switching from glucose to lipids in response to reduced energy input.8\u003c\/p\u003e\n\u003ch2\u003eNMN + Cofactors for Whole Body Metabolic Flexibility\u003c\/h2\u003e\n\u003cp\u003eAn imbalance between a hypercaloric state of carbohydrates and fats combined with undernutrition, coupled with age related NAD+ and energy pathway inefficiencies gives rise to metabolic inflexibility.\u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"text-decoration: underline;\"\u003eFatigue, insulin resistance \u0026amp; age-related energy decline - Metabolic Inflexibility\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3\u003eClinical Signs of Metabolic Inflexibility\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eEnergy slumps \/ inconsistent energy throughout the day\u003c\/li\u003e\n\u003cli\u003eReliance on high G.I. energy sources\u003c\/li\u003e\n\u003cli\u003eDifficulty in fasting \u0026amp; maintaining fasts\u003c\/li\u003e\n\u003cli\u003ePost-prandial carbohydrate energy\u003c\/li\u003e\n\u003cli\u003ePoor exercise resiliences to low, moderate, and high-intensity exercise\u003c\/li\u003e\n\u003cli\u003eCentral adiposity Resistance to ketogenic diets Low lean body mass or muscle mass\u003c\/li\u003e\n\u003cli\u003eDifficult maintaining muscle \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eClinical Measures of Metabolic Inflexibility Include:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAbnormal fasting blood glucose or glycated haemoglobin (HbA1c)\u003c\/li\u003e\n\u003cli\u003eInconsistent continual measures of blood sugar throughout the day (continued monitoring)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eImpaired metabolic switching leads to fatty acid accumulation, ROS and; \u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eImpaired glucose oxidation \u0026amp; lipolysis;\u003c\/li\u003e\n\u003cli\u003eInsulin resistance; \u003c\/li\u003e\n\u003cli\u003eImpaired mitochondrial function; \u003c\/li\u003e\n\u003cli\u003eImpaired branched chain amino acid catabolism: \u003c\/li\u003e\n\u003cli\u003eInflammation \u0026amp; oxidative stress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cspan style=\"text-decoration: underline;\"\u003eEnergy efficiency, metabolic balance \u0026amp; healthy ageing - Metabolic Flexibility\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3\u003eClinical Signs of Metabolic Flexibility\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eSustained energy \u0026amp; more resilient stress responses\u003c\/li\u003e\n\u003cli\u003eImproved exercise resilience to low, moderate and high-Intensity exercise\u003c\/li\u003e\n\u003cli\u003eincreased lean body mass or muscle mass\u003c\/li\u003e\n\u003cli\u003eImproved response to ketogenic diets (energy, sustainability, efficacy)\u003c\/li\u003e\n\u003cli\u003eMuscle mass growth\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eClinIcal Measures of Metabolic Flexibility Include:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eConsistent normal testing of blood glucose or glycated haemoglobin (HbA1c)\u003c\/li\u003e\n\u003cli\u003eConsistent continual measures of blood sugar throughout the day (continued monitoring)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eEfficient metabolic switching between biological fuel sources glucose and fatty acids, leading to:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eImproved glucose regulation \u0026amp; insulin sensitivity\u003c\/li\u003e\n\u003cli\u003eEnhanced cellular stress resistance Increased muscie cell mitochondria capacity\u003c\/li\u003e\n\u003cli\u003eIncreased Autophagy\/senescence\u003c\/li\u003e\n\u003cli\u003eKetogenic pathway augmentation\u003c\/li\u003e\n\u003cli\u003eAntioxidative \u0026amp; anti-inflammatory pathway induction\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe fundamental goal of treating metabolic inflexibility is to relieve the reducing pressure and buildup of reactive oxygen species (ROS) from carbon overload across the mitochondria. This is achieved by enhancing the buffering capacity of the various systems that mitigate mitochondrial reductive stress like augmenting antioxidant defence, carnitine-mediated acycl group buffering and sirtuin-mediated protein deacylation.\u003c\/p\u003e\n\u003ch2\u003eMETABOLIC FLEXIBILITY\u003c\/h2\u003e\n\u003cp\u003eNMN supports metabolic flexibility via NAMPT and, as it’s a precursor, NAD+ production. For example, in T2DM, the physical manifestation of entrenched metabolic inflexibility; reduced sirtuin-1 (SIRT-1) and subsequent AMP-activated protein kinase (AMPK) expression leads to decreased NAMPT levels. This, in turn, increases ROS and activates poly-ADP ribose polymerase (PARP), elevating both NAD+ consumption and demand.21\u003c\/p\u003e\n\u003cp\u003eIn this scenario, NMN may be used to replenish NAD+ to correct metabolic inflexibility, however, it must be supplied with appropriate cofactors to reduce oxidative stress caused by increased nicotinamide metabolites. For diabetic individuals with entrenched metabolic inflexibility and excessive ROS, a co-prescription of Clinically Proven TRIMAGNESIUM Dicitrate provides additional blood sugar support.\u003c\/p\u003e\n\u003cp\u003eNMN has been shown to improve insulin sensitivity in several studies. In one placebo-controlled trial, 250 mg\/day of NMN for 10 weeks was shown to improve skeletal muscle insulin signalling and insulin sensitivity in postmenopausal women with prediabetes who were overweight or obese.11 Another trial demonstrated 250 mg\/day for 12 weeks improved post-prandial insulin signalling in healthy individuals.12\u003c\/p\u003e\n\u003cp\u003eD-ribose acts as a co-substrate during the salvage pathway for NAD+, facilitating the conversion of NMN to NAD+. Studies supporting the combination of 240 mg\/day NMN and 1280 mg\/day D-ribose demonstrate improvements in high energy phosphates, blood glucose levels, insulin sensitivity, ATP\/AMP ratios, and salivary cortisol reduction.16 These results suggest the combination of NMN and D-ribose synergistically enhances cellular energy metabolism and regulates key metabolic processes for improved metabolic flexibility.\u003c\/p\u003e\n\u003ch2\u003eENERGY EFFICIENCY\u003c\/h2\u003e\n\u003cp\u003eEfficient energy production is integral to maintaining cellular function, mitigating oxidative stress, preventing metabolic imbalances, and supporting the overall resilience of cells. These factors contribute to better management and prevention of metabolic disorders and fatigue.\u003c\/p\u003e\n\u003cp\u003eNMN, as the precursor to NAD+, plays a critical role in ATP production and cellular energy efficiency. It is required for glycolysis, oxidative decarboxylation of pyruvate, oxidation of acetyl CoA, and β-oxidation of fatty acids. Other active ingredients also act as important intermediates and cofactors in the TCA, and subsequent energy production (Figure 2). These include Benfotiamine, acetylL-carnitine, D-ribose, α-ketoglucarate, and malic acid.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eFigure 2. NAD+ and cofactors in cellular respiration\u003c\/p\u003e\n\u003cp\u003eNMN, given for 12 weeks at a dose of 250 mg\/day was shown to prevent physical performance loss and improve fatigue in older adults.20 A combination of 240 mg\/day NMN and 1280 mg\/day D-ribose also demonstrated improvements in fatigue, mental concentration, and motivation over the baseline, addressing both physical and cognitive aspects of energy efficiency.16\u003c\/p\u003e\n\u003cp\u003eFor more severe conditions, such as chronic fatigue and fibromyalgia, 600 mg\/day NMN is recommended based on the anti-fatigue effect in healthy individuals23 and clinical efficacy of 600 mg\/day.13\u003c\/p\u003e\n\u003cp\u003eIn these more severe conditions, the combination of NMN and D-ribose bolsters these effects as D-ribose has shown benefits in CFS and fibromyalgia where oxidative stress and ischemia disrupt ATP production and impair cellular energy metabolism.\u003c\/p\u003e\n\u003cp\u003eIn a pilot study, 41 patients received 5 g of D-ribose three times daily. Results showed significant improvements in energy, sleep, mental clarity, pain intensity, and overall well-being, as well as patients’ global assessment. Approximately 66% of patients experienced significant improvement with D-ribose supplementation.9\u003c\/p\u003e\n\u003cp\u003eNMN + D-Ribose for Metabolic Flexibility and Energy is an important treatment consideration for conditions associated with metabolic inflexibility to help restore metabolic control and manage fatigue, particularly in conditions where cellular energy production is impaired. \u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Bio-Practica NMN\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAvg. qty. per one gram\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eβ-Nicotinamide Mononucleotide (NMN)\u003c\/td\u003e\n\u003ctd\u003e75mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eD-Ribose (398 mg \/ g), glycine, citric acid, orange flavour, vanilla flavour, colloidal anhydrous silica, Stevia rebaudiana (stevia) ext. dry conc. derived from dry leaf.\u003c\/p\u003e\n\u003cp\u003eNaturally flavoured and sweetened\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eDairy Free, Gluten Free, Vegetarian and Vegan\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eAlways read the label and follow the directions for use\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Bio-Practica NMN\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C away from direct sunlight and keep airtight\u003cbr\u003e\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}