{"id":7854687518950,"title":"Activated Probiotics Biome Her Probiotic","handle":"activated-probiotics-biome-her-probiotic","description":"\u003ch2\u003eActivated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eTo help maintain a healthy vaginal microbiome\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003ePack Size: 30 VegeCaps\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Her Probiotic Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMaintains a healthy vaginal microbiome with strains native to this environment\u003c\/li\u003e\n\u003cli\u003eClinically trialled probiotic strains\u003c\/li\u003e\n\u003cli\u003eGuaranteed potency\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eActivated Probiotics formulate premium probiotic products backed by cutting-edge scientific research on the human gut microbiome. Using targeted bacterial strains at doses supported by clinical trials.\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics seek to provide tangible improvements in health and wellbeing with a new generation of evidence-based probiotics.\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Her Probiotic AUST L 364311\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eAilments\u003c\/h5\u003e\n\u003ch2\u003eAilments: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eVaginal dysbiosis\u003c\/li\u003e\n\u003cli\u003eBacterial vaginosis\u003c\/li\u003e\n\u003cli\u003eVulvovaginal\u003c\/li\u003e\n\u003cli\u003eCandidiasis (thrush)\u003c\/li\u003e\n\u003cli\u003eUrinary tract infections\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eVideo\u003c\/h5\u003e\n\u003ch2\u003eVideo: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe title=\"Biome Her Probiotics\" src=\"https:\/\/www.youtube.com\/embed\/lzrVpQIpb7k\" height=\"720\" width=\"1264\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003ch5\u003eInstructions For Use\u003c\/h5\u003e\n\u003ch2\u003eInstructions For Use: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eCan be taken Orally or as a Pessary, see the video TAB and Clinical Study TAB\u003c\/p\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003eOrally: take 1 capsule daily (with or without food), or as directed by your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eAs a Pessary:\u003c\/p\u003e\n\u003cp\u003ePhase 1 = One capsule inserted into the vagina on alternate days for 10 consecutive nights\u003c\/p\u003e\n\u003cp\u003ePhase 2 =  One capsule inserted into the vagina every week for the next 10 weeks\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003edip capsule in warm water before inserting (best before bed), OR\u003c\/li\u003e\n\u003cli\u003eopen capsule \u0026amp; mix with personal care cream before application, OR\u003c\/li\u003e\n\u003cli\u003eopen capsule \u0026amp; pour powder on the inside layer of underwear before bed\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus crispatus LCR01 (DSM 24619)\u003c\/td\u003e\n\u003ctd\u003e1 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus fermentum LF10 (DSM 19187) (Limosilactobacillus fermentum)\u003c\/td\u003e\n\u003ctd\u003e1 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus acidophilus LA02 (DSM 21717)\u003c\/td\u003e\n\u003ctd\u003e1 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal live bacteria\u003c\/td\u003e\n\u003ctd\u003e3 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*BLB = Billion Live Bacteria\"No Refrigeration Required\u003c\/p\u003e\n\u003ch5\u003eNo Added\u003c\/h5\u003e\n\u003ch2\u003eNo Added: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eNO ADDED GMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanut, soy, egg, fish, shellfish, or animal derivatives.\u003c\/p\u003e\n\u003cp\u003eNo artificial colours, flavours, sweeteners, or preservatives.\u003c\/p\u003e\n\u003cp\u003eSuitable for vegetarians and vegans.\u003c\/p\u003e\n\u003ch5\u003eWarnings and Cautions\u003c\/h5\u003e\n\u003ch2\u003eWarnings and Cautions: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist, talk to your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eStorage Conditions\u003c\/h5\u003e\n\u003ch2\u003eStorage Conditions: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eFridge Free\u003c\/p\u003e\n\u003ch5\u003eClinical Study\u003c\/h5\u003e\n\u003ch2\u003eClinical Study: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eActivated Probiotics Biome Her Pessary research for Thrush (LA02 \u0026amp; LF10 probiotic strains):\u003c\/p\u003e\n\u003cp\u003eSee Pubmed for study \u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25291115\/\" title=\"Clinical Study: Prevention of Recurrent Vulvovaginal Candidiasis | HealthMasters Pubmed\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e58 women diagnosed with recurrent vulvovaginal candidiasis (≥4 culture-confirmed episodes in a 12-mo period)\u003c\/li\u003e\n\u003cli\u003eAll patients were given 200mg of fluconazole orally for 3 alternate days during the first treatment week\u003c\/li\u003e\n\u003cli\u003eProbiotic pessary: 2 phases\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003ePhase 1 = one vaginal tablet was inserted into the vagina on alternate days for 10 consecutive nights\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003ePhase 2 =  one vaginal tablet every week for the next 10 weeks\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003eDuring the second 10-week prophylactic phase, 49 of 57 (86.0%) patients remained free of clinical recurrence\u003c\/li\u003e\n\u003cli\u003e42 of 58 women enrolled in the study (72.4%) experienced no clinical recurrence throughout the 7-month observation phase\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eA HEALTHY VAGINAL MICROBIOTA\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUnlike the gut microbiota, a healthy vaginal microbiome (VMB) is characterised by low diversity of microorganisms and Lactobacilli dominance.\u003c\/li\u003e\n\u003cli\u003eLactobacilli are necessary for the production of lactic acid to help maintain optimal vaginal pH (3.5-4.5) and deter the growth of pathogenic microorganisms.\u003c\/li\u003e\n\u003cli\u003eParticular species of Lactobacilli protect against vaginal infections by producing lactic acid and antimicrobial metabolites such as hydrogen peroxide, competing for nutrients and adhesion sites, and promoting a healthy vaginal mucosal barrier.\u003c\/li\u003e\n\u003cli\u003eAcross different women, there are five recognised vaginal microbial community state types (CSTs) characterised by the abundance of specific Lactobacilli species, including Lactobacillus crispatus (CST-I), L. gasseri (CST-II), L. iners (CST-III) and L. jensenii (CST-V).\u003c\/li\u003e\n\u003cli\u003eThe fourth subtype (CST-IV) is characterised by a greater diversity of non-Lactobacilli microorganisms, which may be healthy in some ethnic groups or represent a dysbiotic vaginal microbiome.\u003c\/li\u003e\n\u003cli\u003eAlthough individual variations occur, L. crispatus is widely regarded as the best marker for vaginal microbiome health largely due to its proficiency in producing lactic acid and hydrogen peroxide1.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eVULVOVAGINAL INFECTIONS AND DYSBIOSIS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe two most common causes of vaginitis, bacterial vaginosis (40-50%) and vulvovaginal candidiasis (20-25%) are vulvovaginal infections (VVIs) associated with disruptions to the vaginal microbiome and can be regarded as various types of vaginal dysbiosis.\u003c\/li\u003e\n\u003cli\u003eBacterial vaginosis (BV) is caused by a relative deficiency of Lactobacilli microorganisms and lactic acid (with a vaginal pH \u0026gt;4.5), and an overgrowth of a diverse community of anaerobic bacteria, such as Gardnerella vaginalis.\u003c\/li\u003e\n\u003cli\u003eWhile treatment with antibiotics is effective for short-term relief, 25% of women will experience a recurrence within 4 weeks and up to 50% within 3 months1.\u003c\/li\u003e\n\u003cli\u003eIt’s also estimated that 70% of women will experience long-term recurrence.\u003c\/li\u003e\n\u003cli\u003eVulvovaginal candidiasis (VVC) is caused by an overgrowth of opportunistic Candida species, 90% of which are C. albicans4.\u003c\/li\u003e\n\u003cli\u003eDisturbances to the Lactobacilli balance of the VMB, such as from antibiotic use, reduces competition for space, acidity levels and production of antifungal substances and allows for Candida overgrowth.\u003c\/li\u003e\n\u003cli\u003eUnfortunately, of all women treated with standard oral antifungals such as fluconazole, recurrence occurs in up to 57% within 6 months and an estimated 9% of women experience recurrent VVC, with at least 4 episodes occurring within a 12 month period4,5,6.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg style=\"float: none;\" alt=\"Activated Probiotics Biome Her Probiotic Figure 1 10% off RRP at HealthMasters Activated Probiotics\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Activated_Probiotics_Biome_Her_Probiotic_Figure_1_10_off_RRP_at_HealthMasters_Activated_Probiotics_600x600.png?v=1656569435\"\u003e\u003c\/div\u003e\n\u003cp\u003eTHE VAGINAL MICROBIOTA AND URINARY TRACT INFECTIONS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUrinary tract infections (UTIs) are also associated with vaginal colonisation of non-native pathogens such as E. coli, with the vagina acting as a reservoir for the translocation of pathogens to the urethra, bladder and kidneys.\u003c\/li\u003e\n\u003cli\u003eNot surprisingly, a vaginal microbiome with increased colonisation of E. coli, depleted hydrogen peroxide producing Lactobacilli and a composition resembling BV are all associated with increased rates of recurrent UTIs7.\u003c\/li\u003e\n\u003cli\u003eDespite treatment, approximately 20% of women experience recurrent UTIs, defined as two or more UTIs in six months or three or more UTIs in one year8.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePSYCHOSOCIAL AND PHYSIOLOGICAL IMPACTS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRecurrent genitourinary infections are a growing public health issue with large social, psychological and physiological consequences for affected women.\u003c\/li\u003e\n\u003cli\u003eLeft untreated or inadequately controlled, vaginal microbiome dysbiosis can severely impact the systemic health of a woman and the outcomes of any future pregnancy.\u003c\/li\u003e\n\u003cli\u003eFor example, BV has been associated with increased risks of sexually-transmitted infections, such as HIV, HSV-2, gonorrhoeae, chlamydia and trichomoniasis, preterm birth, early pregnancy loss, low infant birth weight, increased neonatal morbidity, higher rates of postpartum endometritis and pelvic inflammatory disease1,2.\u003c\/li\u003e\n\u003cli\u003eParticularly in those with recurrent symptoms, many women experience anxiety, shame, and concerns about hygiene.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTHE ROLE OF PROBIOTICS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe need for new therapeutic strategies to address genitourinary tract infections is growing due to significant rates of recurrence following treatment and an increase in antimicrobial-resistant pathogens, largely as a result of indiscriminate use of antibiotics and antifungals9.\u003c\/li\u003e\n\u003cli\u003eDue to the underlying disruptions in Lactobacilli balance in many genitourinary tract infections, probiotic supplements containing Lactobacilli strains native to the vaginal environment can help to restore Lactobacilli dominance and promote resolution of these infections.\u003c\/li\u003e\n\u003cli\u003eFor example, women with recurrent VVC who were administered a combination of Lactobacillus fermentum LF10 (DSM 19187) and Lactobacillus acidophilus LA02 (DSM 21717) for 10 weeks following a single dose of fluconazole demonstrated a 14.3% recurrence rate 7 months after cessation of treatment (Figure 1).\u003c\/li\u003e\n\u003cli\u003eThis is significantly lower than the recurrence rate of up to 57% observed in other studies using long-term prophylactic oral fluconazole over a 6 month period5.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKalia N, Singh J, Kaur M. Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review. Ann Clin Microbiol Antimicrob [Internet]. 2020 Dec 28;19(1):5.\u003c\/li\u003e\n\u003cli\u003ePaladine HL, Desai UA. Vaginitis: Diagnosis and Treatment. Am Fam Physician. 2018;97(5):321–9.\u003c\/li\u003e\n\u003cli\u003eVicariotto F, Mogna L, Del Piano M. Effectiveness of the two microorganisms Lactobacillus fermentum LF15 and Lactobacillus plantarum LP01, formulated in slow-release vaginal tablets, in women affected by bacterial vaginosis: A pilot study. J Clin Gastroenterol. 2014;48(December):S106–12.\u003c\/li\u003e\n\u003cli\u003eRosati D, Bruno M, Jaeger M, ten Oever J, Netea MG. Recurrent Vulvovaginal Candidiasis: An Immunological Perspective. Microorganisms [Internet]. 2020 Jan 21;8(2):144.\u003c\/li\u003e\n\u003cli\u003eMurina F, Graziottin A, Vicariotto F, De Seta F. Can Lactobacillus fermentum LF10 and Lactobacillus acidophilus LA02 in a slow-release vaginal product be useful for prevention of recurrent vulvovaginal candidiasis?: A clinical study. J Clin Gastroenterol. 2014;48(December):S102–5.\u003c\/li\u003e\n\u003cli\u003eCenter for Disease Control and Prevention. 2015 Sexually Transmitted Diseases Treatment Guidelines. https:\/\/www.cdc.gov\/ std\/tg2015\/candidiasis.htm\u003c\/li\u003e\n\u003cli\u003eStapleton AE. The Vaginal Microbiota and Urinary Tract Infection. Microbiol Spectr. 2016;4(6).\u003c\/li\u003e\n\u003cli\u003eNikpoor P, Dwyer PL. Recurrent urinary tract infections: Management in women. Med Today. 2020;21(9):14–9.\u003c\/li\u003e\n\u003cli\u003eSuperti F, De Seta F. Warding Off Recurrent Yeast and Bacterial Vaginal Infections: Lactoferrin and Lactobacilli. Microorganisms [Internet]. 2020 Jan 17;8(1):130.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T13:58:47+11:00","created_at":"2022-06-30T15:34:46+10:00","vendor":"Activated Probiotics","type":"Activated Probiotics Naturopathic Medicine","tags":["Activated Probiotics","Naturopathic","PB","Refrigeration Not Required"],"price":4495,"price_min":4495,"price_max":4495,"available":true,"price_varies":false,"compare_at_price":4995,"compare_at_price_min":4995,"compare_at_price_max":4995,"compare_at_price_varies":false,"variants":[{"id":43073813151974,"title":"30 VegeCaps","option1":"30 VegeCaps","option2":null,"option3":null,"sku":"AcPBiomeHerProbiotic30VC","requires_shipping":true,"taxable":true,"featured_image":{"id":39856522658022,"product_id":7854687518950,"position":1,"created_at":"2023-09-25T12:57:43+10:00","updated_at":"2023-09-25T12:57:46+10:00","alt":"Activated Probiotics Biome Her Probiotic 30vcaps 10% off RRP at HealthMasters Activated Probiotics","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeHerProbiotic30vcaps10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666","variant_ids":[43073813151974]},"available":true,"name":"Activated Probiotics Biome Her Probiotic - 30 VegeCaps","public_title":"30 VegeCaps","options":["30 VegeCaps"],"price":4495,"weight":0,"compare_at_price":4995,"inventory_quantity":19452,"inventory_management":"shopify","inventory_policy":"continue","barcode":"9349308001816","featured_media":{"alt":"Activated Probiotics Biome Her Probiotic 30vcaps 10% off RRP at HealthMasters Activated Probiotics","id":32463261827302,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeHerProbiotic30vcaps10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeHerProbiotic30vcaps10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/ActivatedProbiotics10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeHerProbiotic30vcaps10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666","options":["Size"],"media":[{"alt":"Activated Probiotics Biome Her Probiotic 30vcaps 10% off RRP at HealthMasters Activated Probiotics","id":32463261827302,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeHerProbiotic30vcaps10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeHerProbiotic30vcaps10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666","width":1200},{"alt":"Activated Probiotics Biome IBS Probiotic 10% off RRP at HealthMasters Activated Probiotics Logo","id":30442653876454,"position":2,"preview_image":{"aspect_ratio":0.747,"height":300,"width":224,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/ActivatedProbiotics10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666"},"aspect_ratio":0.747,"height":300,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/ActivatedProbiotics10_offRRPatHealthMastersActivatedProbiotics.png?v=1695610666","width":224}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eActivated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eTo help maintain a healthy vaginal microbiome\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003ePack Size: 30 VegeCaps\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Her Probiotic Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMaintains a healthy vaginal microbiome with strains native to this environment\u003c\/li\u003e\n\u003cli\u003eClinically trialled probiotic strains\u003c\/li\u003e\n\u003cli\u003eGuaranteed potency\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eActivated Probiotics formulate premium probiotic products backed by cutting-edge scientific research on the human gut microbiome. Using targeted bacterial strains at doses supported by clinical trials.\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics seek to provide tangible improvements in health and wellbeing with a new generation of evidence-based probiotics.\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Her Probiotic AUST L 364311\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eAilments\u003c\/h5\u003e\n\u003ch2\u003eAilments: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eVaginal dysbiosis\u003c\/li\u003e\n\u003cli\u003eBacterial vaginosis\u003c\/li\u003e\n\u003cli\u003eVulvovaginal\u003c\/li\u003e\n\u003cli\u003eCandidiasis (thrush)\u003c\/li\u003e\n\u003cli\u003eUrinary tract infections\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eVideo\u003c\/h5\u003e\n\u003ch2\u003eVideo: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe title=\"Biome Her Probiotics\" src=\"https:\/\/www.youtube.com\/embed\/lzrVpQIpb7k\" height=\"720\" width=\"1264\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003ch5\u003eInstructions For Use\u003c\/h5\u003e\n\u003ch2\u003eInstructions For Use: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eCan be taken Orally or as a Pessary, see the video TAB and Clinical Study TAB\u003c\/p\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003eOrally: take 1 capsule daily (with or without food), or as directed by your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eAs a Pessary:\u003c\/p\u003e\n\u003cp\u003ePhase 1 = One capsule inserted into the vagina on alternate days for 10 consecutive nights\u003c\/p\u003e\n\u003cp\u003ePhase 2 =  One capsule inserted into the vagina every week for the next 10 weeks\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003edip capsule in warm water before inserting (best before bed), OR\u003c\/li\u003e\n\u003cli\u003eopen capsule \u0026amp; mix with personal care cream before application, OR\u003c\/li\u003e\n\u003cli\u003eopen capsule \u0026amp; pour powder on the inside layer of underwear before bed\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus crispatus LCR01 (DSM 24619)\u003c\/td\u003e\n\u003ctd\u003e1 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus fermentum LF10 (DSM 19187) (Limosilactobacillus fermentum)\u003c\/td\u003e\n\u003ctd\u003e1 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus acidophilus LA02 (DSM 21717)\u003c\/td\u003e\n\u003ctd\u003e1 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal live bacteria\u003c\/td\u003e\n\u003ctd\u003e3 BLB*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*BLB = Billion Live Bacteria\"No Refrigeration Required\u003c\/p\u003e\n\u003ch5\u003eNo Added\u003c\/h5\u003e\n\u003ch2\u003eNo Added: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eNO ADDED GMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanut, soy, egg, fish, shellfish, or animal derivatives.\u003c\/p\u003e\n\u003cp\u003eNo artificial colours, flavours, sweeteners, or preservatives.\u003c\/p\u003e\n\u003cp\u003eSuitable for vegetarians and vegans.\u003c\/p\u003e\n\u003ch5\u003eWarnings and Cautions\u003c\/h5\u003e\n\u003ch2\u003eWarnings and Cautions: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist, talk to your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eStorage Conditions\u003c\/h5\u003e\n\u003ch2\u003eStorage Conditions: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eFridge Free\u003c\/p\u003e\n\u003ch5\u003eClinical Study\u003c\/h5\u003e\n\u003ch2\u003eClinical Study: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eActivated Probiotics Biome Her Pessary research for Thrush (LA02 \u0026amp; LF10 probiotic strains):\u003c\/p\u003e\n\u003cp\u003eSee Pubmed for study \u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25291115\/\" title=\"Clinical Study: Prevention of Recurrent Vulvovaginal Candidiasis | HealthMasters Pubmed\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e58 women diagnosed with recurrent vulvovaginal candidiasis (≥4 culture-confirmed episodes in a 12-mo period)\u003c\/li\u003e\n\u003cli\u003eAll patients were given 200mg of fluconazole orally for 3 alternate days during the first treatment week\u003c\/li\u003e\n\u003cli\u003eProbiotic pessary: 2 phases\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003ePhase 1 = one vaginal tablet was inserted into the vagina on alternate days for 10 consecutive nights\u003c\/div\u003e\n\u003cdiv style=\"padding-left: 30px;\"\u003ePhase 2 =  one vaginal tablet every week for the next 10 weeks\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003eDuring the second 10-week prophylactic phase, 49 of 57 (86.0%) patients remained free of clinical recurrence\u003c\/li\u003e\n\u003cli\u003e42 of 58 women enrolled in the study (72.4%) experienced no clinical recurrence throughout the 7-month observation phase\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003cp\u003eA HEALTHY VAGINAL MICROBIOTA\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUnlike the gut microbiota, a healthy vaginal microbiome (VMB) is characterised by low diversity of microorganisms and Lactobacilli dominance.\u003c\/li\u003e\n\u003cli\u003eLactobacilli are necessary for the production of lactic acid to help maintain optimal vaginal pH (3.5-4.5) and deter the growth of pathogenic microorganisms.\u003c\/li\u003e\n\u003cli\u003eParticular species of Lactobacilli protect against vaginal infections by producing lactic acid and antimicrobial metabolites such as hydrogen peroxide, competing for nutrients and adhesion sites, and promoting a healthy vaginal mucosal barrier.\u003c\/li\u003e\n\u003cli\u003eAcross different women, there are five recognised vaginal microbial community state types (CSTs) characterised by the abundance of specific Lactobacilli species, including Lactobacillus crispatus (CST-I), L. gasseri (CST-II), L. iners (CST-III) and L. jensenii (CST-V).\u003c\/li\u003e\n\u003cli\u003eThe fourth subtype (CST-IV) is characterised by a greater diversity of non-Lactobacilli microorganisms, which may be healthy in some ethnic groups or represent a dysbiotic vaginal microbiome.\u003c\/li\u003e\n\u003cli\u003eAlthough individual variations occur, L. crispatus is widely regarded as the best marker for vaginal microbiome health largely due to its proficiency in producing lactic acid and hydrogen peroxide1.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eVULVOVAGINAL INFECTIONS AND DYSBIOSIS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe two most common causes of vaginitis, bacterial vaginosis (40-50%) and vulvovaginal candidiasis (20-25%) are vulvovaginal infections (VVIs) associated with disruptions to the vaginal microbiome and can be regarded as various types of vaginal dysbiosis.\u003c\/li\u003e\n\u003cli\u003eBacterial vaginosis (BV) is caused by a relative deficiency of Lactobacilli microorganisms and lactic acid (with a vaginal pH \u0026gt;4.5), and an overgrowth of a diverse community of anaerobic bacteria, such as Gardnerella vaginalis.\u003c\/li\u003e\n\u003cli\u003eWhile treatment with antibiotics is effective for short-term relief, 25% of women will experience a recurrence within 4 weeks and up to 50% within 3 months1.\u003c\/li\u003e\n\u003cli\u003eIt’s also estimated that 70% of women will experience long-term recurrence.\u003c\/li\u003e\n\u003cli\u003eVulvovaginal candidiasis (VVC) is caused by an overgrowth of opportunistic Candida species, 90% of which are C. albicans4.\u003c\/li\u003e\n\u003cli\u003eDisturbances to the Lactobacilli balance of the VMB, such as from antibiotic use, reduces competition for space, acidity levels and production of antifungal substances and allows for Candida overgrowth.\u003c\/li\u003e\n\u003cli\u003eUnfortunately, of all women treated with standard oral antifungals such as fluconazole, recurrence occurs in up to 57% within 6 months and an estimated 9% of women experience recurrent VVC, with at least 4 episodes occurring within a 12 month period4,5,6.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg style=\"float: none;\" alt=\"Activated Probiotics Biome Her Probiotic Figure 1 10% off RRP at HealthMasters Activated Probiotics\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Activated_Probiotics_Biome_Her_Probiotic_Figure_1_10_off_RRP_at_HealthMasters_Activated_Probiotics_600x600.png?v=1656569435\"\u003e\u003c\/div\u003e\n\u003cp\u003eTHE VAGINAL MICROBIOTA AND URINARY TRACT INFECTIONS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUrinary tract infections (UTIs) are also associated with vaginal colonisation of non-native pathogens such as E. coli, with the vagina acting as a reservoir for the translocation of pathogens to the urethra, bladder and kidneys.\u003c\/li\u003e\n\u003cli\u003eNot surprisingly, a vaginal microbiome with increased colonisation of E. coli, depleted hydrogen peroxide producing Lactobacilli and a composition resembling BV are all associated with increased rates of recurrent UTIs7.\u003c\/li\u003e\n\u003cli\u003eDespite treatment, approximately 20% of women experience recurrent UTIs, defined as two or more UTIs in six months or three or more UTIs in one year8.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePSYCHOSOCIAL AND PHYSIOLOGICAL IMPACTS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRecurrent genitourinary infections are a growing public health issue with large social, psychological and physiological consequences for affected women.\u003c\/li\u003e\n\u003cli\u003eLeft untreated or inadequately controlled, vaginal microbiome dysbiosis can severely impact the systemic health of a woman and the outcomes of any future pregnancy.\u003c\/li\u003e\n\u003cli\u003eFor example, BV has been associated with increased risks of sexually-transmitted infections, such as HIV, HSV-2, gonorrhoeae, chlamydia and trichomoniasis, preterm birth, early pregnancy loss, low infant birth weight, increased neonatal morbidity, higher rates of postpartum endometritis and pelvic inflammatory disease1,2.\u003c\/li\u003e\n\u003cli\u003eParticularly in those with recurrent symptoms, many women experience anxiety, shame, and concerns about hygiene.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTHE ROLE OF PROBIOTICS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe need for new therapeutic strategies to address genitourinary tract infections is growing due to significant rates of recurrence following treatment and an increase in antimicrobial-resistant pathogens, largely as a result of indiscriminate use of antibiotics and antifungals9.\u003c\/li\u003e\n\u003cli\u003eDue to the underlying disruptions in Lactobacilli balance in many genitourinary tract infections, probiotic supplements containing Lactobacilli strains native to the vaginal environment can help to restore Lactobacilli dominance and promote resolution of these infections.\u003c\/li\u003e\n\u003cli\u003eFor example, women with recurrent VVC who were administered a combination of Lactobacillus fermentum LF10 (DSM 19187) and Lactobacillus acidophilus LA02 (DSM 21717) for 10 weeks following a single dose of fluconazole demonstrated a 14.3% recurrence rate 7 months after cessation of treatment (Figure 1).\u003c\/li\u003e\n\u003cli\u003eThis is significantly lower than the recurrence rate of up to 57% observed in other studies using long-term prophylactic oral fluconazole over a 6 month period5.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Activated Probiotics Biome Her Probiotic\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKalia N, Singh J, Kaur M. Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review. Ann Clin Microbiol Antimicrob [Internet]. 2020 Dec 28;19(1):5.\u003c\/li\u003e\n\u003cli\u003ePaladine HL, Desai UA. Vaginitis: Diagnosis and Treatment. Am Fam Physician. 2018;97(5):321–9.\u003c\/li\u003e\n\u003cli\u003eVicariotto F, Mogna L, Del Piano M. Effectiveness of the two microorganisms Lactobacillus fermentum LF15 and Lactobacillus plantarum LP01, formulated in slow-release vaginal tablets, in women affected by bacterial vaginosis: A pilot study. J Clin Gastroenterol. 2014;48(December):S106–12.\u003c\/li\u003e\n\u003cli\u003eRosati D, Bruno M, Jaeger M, ten Oever J, Netea MG. Recurrent Vulvovaginal Candidiasis: An Immunological Perspective. Microorganisms [Internet]. 2020 Jan 21;8(2):144.\u003c\/li\u003e\n\u003cli\u003eMurina F, Graziottin A, Vicariotto F, De Seta F. Can Lactobacillus fermentum LF10 and Lactobacillus acidophilus LA02 in a slow-release vaginal product be useful for prevention of recurrent vulvovaginal candidiasis?: A clinical study. J Clin Gastroenterol. 2014;48(December):S102–5.\u003c\/li\u003e\n\u003cli\u003eCenter for Disease Control and Prevention. 2015 Sexually Transmitted Diseases Treatment Guidelines. https:\/\/www.cdc.gov\/ std\/tg2015\/candidiasis.htm\u003c\/li\u003e\n\u003cli\u003eStapleton AE. The Vaginal Microbiota and Urinary Tract Infection. Microbiol Spectr. 2016;4(6).\u003c\/li\u003e\n\u003cli\u003eNikpoor P, Dwyer PL. Recurrent urinary tract infections: Management in women. Med Today. 2020;21(9):14–9.\u003c\/li\u003e\n\u003cli\u003eSuperti F, De Seta F. Warding Off Recurrent Yeast and Bacterial Vaginal Infections: Lactoferrin and Lactobacilli. Microorganisms [Internet]. 2020 Jan 17;8(1):130.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e"}