{"id":8430962508006,"title":"Activated Probiotics Biome Acne Probiotic","handle":"activated-probiotics-biome-acne-probiotic","description":"\u003ch2\u003eActivated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eRelieves symptoms of acne via the gut-skin axis\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003ePack Size: 30 VegeCaps\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Acne Probiotic Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRelieves the symptoms of acne\u003c\/li\u003e\n\u003cli\u003eReduces skin redness\u003c\/li\u003e\n\u003cli\u003eImproves healthy skin flora\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eClinically trialled probiotic strains\u003c\/p\u003e\n\u003cp\u003eGuaranteed potency\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivated Probiotics formulate premium probiotic products backed by cutting-edge scientific research on the human gut microbiome. Using targeted bacterial strains at doses supported by clinical trials.\u003c\/li\u003e\n\u003cli\u003eActivated Probiotics seeks to provide tangible improvements in health and wellbeing with a new generation of evidence-based probiotics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eActivated Probiotics Biome Acne Probiotic has No Added: GMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanuts, soy, egg, fish, shellfish, or animal derivatives.\u003cbr data-mce-fragment=\"1\"\u003eNo artificial colours, flavours, sweeteners, or preservatives.\u003c\/p\u003e\n\u003cp\u003eSuitable for vegetarians and vegans.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Acne Probiotic AUST L 377514\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eAilments\u003c\/h5\u003e\n\u003ch2\u003eAilments: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcne\u003c\/li\u003e\n\u003cli\u003eSkin Redness\u003c\/li\u003e\n\u003cli\u003eTest\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eInstructions For Use\u003c\/h5\u003e\n\u003ch2\u003eInstructions For Use: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eAdults and children over 2 years:\u003c\/p\u003e\n\u003cp\u003eTake 1 capsule daily (with or without food), or as directed by your healthcare practitioner.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus salivarius (LS03-DSM 22776)\u003c\/td\u003e\n\u003ctd\u003e1 billion CFU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBifidobacterium breve (BR03-DSM 16604)\u003c\/td\u003e\n\u003ctd\u003e.5 billion CFU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus casei (LC03-DSM 27537)\u003c\/td\u003e\n\u003ctd\u003e.5 billion CFU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eNo Added\u003c\/h5\u003e\n\u003ch2\u003eNo Added: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eGMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanuts, soy, egg, fish, shellfish, or animal derivatives.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eNo artificial colours, flavours, sweeteners, or preservatives.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eSuitable for vegetarians and vegans.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eWarnings and Cautions\u003c\/h5\u003e\n\u003ch2\u003eWarnings and Cautions: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist, talk to your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eStorage Conditions\u003c\/h5\u003e\n\u003ch2\u003eStorage Conditions: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eRefrigeration Not Required\u003c\/p\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003ch3\u003eACNE VULGARIS\u003c\/h3\u003e\n\u003cp\u003eAcne is a highly prevalent inflammatory skin disorder, affecting approximately 80% of adolescents and young adults aged 11 to 30 years1, 2. Due to the appearance of lesions and scarring, acne is associated with significant mental health impacts, such as anxiety, depression, social inhibition and impaired self-esteem, all of which improve with effective treatment1, 3.\u003c\/p\u003e\n\u003ch3\u003eINFLAMMATION AND SKIN DYSBIOSIS IN ACNE\u003c\/h3\u003e\n\u003cp\u003eAcne is an inflammatory disease of the pilosebaceous unit (PSU), the hair follicle and associated oil glands, which involves various immunochemical pathways and secondary overgrowth of Cutibacterium acnes4. In acne, various underlying metabolic and inflammatory mediators drive excessive sebum (oil) production and induce hyperproliferation of skin cells, creating blocked PSUs and the formation of early acne lesions (comedones)4. These structural changes within the PSU facilitate opportunistic overgrowth of C. acnes and create a dysbiotic skin environment that triggers immune-mediated inflammatory responses and the highly inflammatory lesions (papules, pustules, etc.) characteristic of acne5.\u003c\/p\u003e\n\u003ch3\u003eC. ACNES AND PROGRESSION OF ACNE LESIONS\u003c\/h3\u003e\n\u003cp\u003eC. acnes (previously known as Propionibacterium acnes) is an opportunistic resident of the skin microbiome that exacerbates acne severity when conditions allow for its overgrowth1, 5. Proliferation of C. acnes stimulates a pro-inflammatory immune response and promotes the progression of comedones into more inflammatory acne lesions1. Increasing concentrations of metabolites produced by C. acnes in the skin, such as lipases and chemotactic factors, elicit the generation of free radicals and skin cell damage1.\u003c\/p\u003e\n\u003cp\u003eThese effects promote further keratinocyte proliferation and the production of more inflammatory sebum via oxidation of its lipid contents, increasing the comedogenic potential of the skin and worsening the severity of acne1, 6. Controlling overgrowth of C. acnes, and addressing underlying metabolic and inflammatory mediators of blocked PSUs, can assist in the reduction of acne symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/ActivatedProbioticsBiomeAcneProbiotic10_offRRPatHealthMastersActivatedProbioticsFigure1_600x600.png?v=1707108356\" alt=\"Activated Probiotics Biome Acne Probiotic 10% off RRP at HealthMasters Activated Probiotics Figure 1\"\u003e\u003c\/p\u003e\n\u003ch3\u003eTHE ROLE OF THE GUT MICROBIOTA AND SPECIFIC PROBIOTICS\u003c\/h3\u003e\n\u003cp\u003eThe health of the gut microbiota is thought to influence skin health and the development of acne through its effects on the immune system and systemic inflammation, as well as its interactions with the skin microbiome through the production of antimicrobial metabolites which enter circulation and accumulate in the skin5.\u003c\/p\u003e\n\u003cp\u003eStudies on individuals with acne have demonstrated unfavourable gut microbiota compositions, with lower microbial diversity and a higher ratio of Bacteroidetes to Firmicutes, which may predispose these individuals to immune dysregulation, greater inflammatory responses and thus acne5.\u003c\/p\u003e\n\u003cp\u003eSpecific probiotic strains are being investigated for their ability to harness the links that exist between the gut microbiome, systemic inflammatory processes, and the skin microbiome. For example, in-vitro studies have demonstrated that Lactobacillus salivarius LS03 can inhibit the growth of C. acnes and reduce the production of key inflammatory cytokines in response to its opportunistic growth (1).\u003c\/p\u003e\n\u003cp\u003eFollowing on from this promising mechanistic research, LS03 formed the basis of a probiotic combination that has been clinically trialled for the treatment of acne; a combination of Lactobacillus salivarius LS03 (1 BLB*), Lactobacillus casei LC03 (0.5 BLB*) and Bifidobacterium breve BR03 (0.5 BLB*).\u003c\/p\u003e\n\u003ch3\u003eHUMAN CLINICAL TRIAL\u003c\/h3\u003e\n\u003cp\u003eIn one arm of this recently published double-blind, randomised, placebo-controlled trial, subjects with mild to moderate acne received this probiotic formulation once a day for 8 weeks7. At week 4, there was a statistically significant (p \u0026lt; 0.05) decrease in the number of acne lesions in the subjects taking the probiotic (-31.11%) compared to placebo (-10%), measured using the global acne grading system (GAGS) score (see Figure 1).\u003c\/p\u003e\n\u003cp\u003eThis continued to improve after 8 weeks (-38.89% vs 18.89%, p \u0026lt; 0.05). Significant reductions in skin redness (T0 1.82 ± 0.06 vs T2 0.73 ± 0.74, p \u0026lt; 0.05) (see Figure 2) and  relative abundance of C. acnes (26.8 vs 21.7 log RA, p \u0026lt; 0.01) on the skin were observed following the use of this probiotic supplement for 8 weeks, as were significant reductions in sebum production.\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/ActivatedProbioticsBiomeAcneProbiotic10_offRRPatHealthMastersActivatedProbioticsFigure2_600x600.png?v=1707108348\" alt=\"Activated Probiotics Biome Acne Probiotic 10% off RRP at HealthMasters Activated Probiotics Figure 2\"\u003e\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003e1. Deidda F, Amoruso A, Nicola S, Graziano T, Pane M, Mogna L. New Approach in Acne Therapy A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03. J Clin Gastroenterol. 2018 Nov 1;52:S78–81.\u003c\/p\u003e\n\u003cp\u003e2. Dréno, B., Dagnelie, M. A., Khammari, A., \u0026amp; Corvec, S. (2020). The Skin Microbiome: A New Actor in Inflammatory Acne. American journal of clinical dermatology, 21(Suppl 1), 18–24.\u003c\/p\u003e\n\u003cp\u003e3. Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012;379:361–72.\u003c\/p\u003e\n\u003cp\u003e4. Tanghetti, Emil. A. (2013). The role of inflammation in the pathology of acne. Journal of Clinical and Aesthetic Dermatology, 6(9), 16–24.\u003c\/p\u003e\n\u003cp\u003e5. Lee, Byun, \u0026amp; Kim. (2019). Potential Role of the Microbiome in Acne: A Comprehensive Review. Journal of Clinical Medicine, 8(7)\u003c\/p\u003e\n\u003cp\u003e6. Jourdan, E., Trompezinski, S., Weber, S., Cadars, B., Larue, F., Ardiet, N., Chavagnac-Bonneville, M., \u0026amp; Sayag, M. (2016). Assessment of a new biological complex efficacy on dysseborrhea, inflammation, and Propionibacterium acnes proliferation. Clinical, Cosmetic and Investigational Dermatology, Volume 9, 233–239.\u003c\/p\u003e\n\u003cp\u003e7. Rinaldi, F., Marotta, L., Mascolo, A., Amoruso, A., Pane, M., Giuliani, G., \u0026amp; Pinto, D. (2022). Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement. Dermatology and Therapy.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2024-02-05T15:51:26+11:00","created_at":"2024-02-05T15:22:04+11:00","vendor":"Activated Probiotics","type":"Activated Probiotics Naturopathic Medicine","tags":["Activated Probiotics","Naturopathic","PB","Refrigeration Not Required"],"price":3596,"price_min":3596,"price_max":3596,"available":true,"price_varies":false,"compare_at_price":3995,"compare_at_price_min":3995,"compare_at_price_max":3995,"compare_at_price_varies":false,"variants":[{"id":44275505725670,"title":"30 VegeCaps","option1":"30 VegeCaps","option2":null,"option3":null,"sku":"AcPBiomeAcneProbiotic30vc","requires_shipping":true,"taxable":true,"featured_image":{"id":40395573493990,"product_id":8430962508006,"position":1,"created_at":"2024-02-05T15:24:55+11:00","updated_at":"2024-02-05T15:35:44+11:00","alt":"Activated Probiotics Biome Acne Probiotic 30vc 10% off RRP at HealthMasters Activated Probiotics","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeAcneProbiotic30vc10_offRRPatHealthMastersActivatedProbiotics.png?v=1707107744","variant_ids":[44275505725670]},"available":true,"name":"Activated Probiotics Biome Acne Probiotic - 30 VegeCaps","public_title":"30 VegeCaps","options":["30 VegeCaps"],"price":3596,"weight":0,"compare_at_price":3995,"inventory_quantity":19987,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9349308001953","featured_media":{"alt":"Activated Probiotics Biome Acne Probiotic 30vc 10% off RRP at HealthMasters Activated Probiotics","id":33014249095398,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeAcneProbiotic30vc10_offRRPatHealthMastersActivatedProbiotics.png?v=1707107744"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeAcneProbiotic30vc10_offRRPatHealthMastersActivatedProbiotics.png?v=1707107744","\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbiotics10_offRRPatHealthMastersActivatedProbiotics_18304b30-928b-4fe0-855a-6a3762835487.png?v=1707107744"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeAcneProbiotic30vc10_offRRPatHealthMastersActivatedProbiotics.png?v=1707107744","options":["Size:"],"media":[{"alt":"Activated Probiotics Biome Acne Probiotic 30vc 10% off RRP at HealthMasters Activated Probiotics","id":33014249095398,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeAcneProbiotic30vc10_offRRPatHealthMastersActivatedProbiotics.png?v=1707107744"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbioticsBiomeAcneProbiotic30vc10_offRRPatHealthMastersActivatedProbiotics.png?v=1707107744","width":1200},{"alt":"Activated Probiotics 10% off RRP at HealthMasters Activated Probiotics Logo","id":33014240674022,"position":2,"preview_image":{"aspect_ratio":0.747,"height":300,"width":224,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbiotics10_offRRPatHealthMastersActivatedProbiotics_18304b30-928b-4fe0-855a-6a3762835487.png?v=1707107744"},"aspect_ratio":0.747,"height":300,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/files\/ActivatedProbiotics10_offRRPatHealthMastersActivatedProbiotics_18304b30-928b-4fe0-855a-6a3762835487.png?v=1707107744","width":224}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eActivated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eRelieves symptoms of acne via the gut-skin axis\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003ePack Size: 30 VegeCaps\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Acne Probiotic Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRelieves the symptoms of acne\u003c\/li\u003e\n\u003cli\u003eReduces skin redness\u003c\/li\u003e\n\u003cli\u003eImproves healthy skin flora\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eClinically trialled probiotic strains\u003c\/p\u003e\n\u003cp\u003eGuaranteed potency\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivated Probiotics formulate premium probiotic products backed by cutting-edge scientific research on the human gut microbiome. Using targeted bacterial strains at doses supported by clinical trials.\u003c\/li\u003e\n\u003cli\u003eActivated Probiotics seeks to provide tangible improvements in health and wellbeing with a new generation of evidence-based probiotics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eActivated Probiotics Biome Acne Probiotic has No Added: GMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanuts, soy, egg, fish, shellfish, or animal derivatives.\u003cbr data-mce-fragment=\"1\"\u003eNo artificial colours, flavours, sweeteners, or preservatives.\u003c\/p\u003e\n\u003cp\u003eSuitable for vegetarians and vegans.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eActivated Probiotics Biome Acne Probiotic AUST L 377514\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eAilments\u003c\/h5\u003e\n\u003ch2\u003eAilments: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcne\u003c\/li\u003e\n\u003cli\u003eSkin Redness\u003c\/li\u003e\n\u003cli\u003eTest\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eInstructions For Use\u003c\/h5\u003e\n\u003ch2\u003eInstructions For Use: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eAdults and children over 2 years:\u003c\/p\u003e\n\u003cp\u003eTake 1 capsule daily (with or without food), or as directed by your healthcare practitioner.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus salivarius (LS03-DSM 22776)\u003c\/td\u003e\n\u003ctd\u003e1 billion CFU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBifidobacterium breve (BR03-DSM 16604)\u003c\/td\u003e\n\u003ctd\u003e.5 billion CFU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLactobacillus casei (LC03-DSM 27537)\u003c\/td\u003e\n\u003ctd\u003e.5 billion CFU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eNo Added\u003c\/h5\u003e\n\u003ch2\u003eNo Added: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eGMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanuts, soy, egg, fish, shellfish, or animal derivatives.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eNo artificial colours, flavours, sweeteners, or preservatives.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eSuitable for vegetarians and vegans.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eWarnings and Cautions\u003c\/h5\u003e\n\u003ch2\u003eWarnings and Cautions: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist, talk to your healthcare practitioner.\u003c\/p\u003e\n\u003ch5\u003eStorage Conditions\u003c\/h5\u003e\n\u003ch2\u003eStorage Conditions: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003eRefrigeration Not Required\u003c\/p\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003ch3\u003eACNE VULGARIS\u003c\/h3\u003e\n\u003cp\u003eAcne is a highly prevalent inflammatory skin disorder, affecting approximately 80% of adolescents and young adults aged 11 to 30 years1, 2. Due to the appearance of lesions and scarring, acne is associated with significant mental health impacts, such as anxiety, depression, social inhibition and impaired self-esteem, all of which improve with effective treatment1, 3.\u003c\/p\u003e\n\u003ch3\u003eINFLAMMATION AND SKIN DYSBIOSIS IN ACNE\u003c\/h3\u003e\n\u003cp\u003eAcne is an inflammatory disease of the pilosebaceous unit (PSU), the hair follicle and associated oil glands, which involves various immunochemical pathways and secondary overgrowth of Cutibacterium acnes4. In acne, various underlying metabolic and inflammatory mediators drive excessive sebum (oil) production and induce hyperproliferation of skin cells, creating blocked PSUs and the formation of early acne lesions (comedones)4. These structural changes within the PSU facilitate opportunistic overgrowth of C. acnes and create a dysbiotic skin environment that triggers immune-mediated inflammatory responses and the highly inflammatory lesions (papules, pustules, etc.) characteristic of acne5.\u003c\/p\u003e\n\u003ch3\u003eC. ACNES AND PROGRESSION OF ACNE LESIONS\u003c\/h3\u003e\n\u003cp\u003eC. acnes (previously known as Propionibacterium acnes) is an opportunistic resident of the skin microbiome that exacerbates acne severity when conditions allow for its overgrowth1, 5. Proliferation of C. acnes stimulates a pro-inflammatory immune response and promotes the progression of comedones into more inflammatory acne lesions1. Increasing concentrations of metabolites produced by C. acnes in the skin, such as lipases and chemotactic factors, elicit the generation of free radicals and skin cell damage1.\u003c\/p\u003e\n\u003cp\u003eThese effects promote further keratinocyte proliferation and the production of more inflammatory sebum via oxidation of its lipid contents, increasing the comedogenic potential of the skin and worsening the severity of acne1, 6. Controlling overgrowth of C. acnes, and addressing underlying metabolic and inflammatory mediators of blocked PSUs, can assist in the reduction of acne symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/ActivatedProbioticsBiomeAcneProbiotic10_offRRPatHealthMastersActivatedProbioticsFigure1_600x600.png?v=1707108356\" alt=\"Activated Probiotics Biome Acne Probiotic 10% off RRP at HealthMasters Activated Probiotics Figure 1\"\u003e\u003c\/p\u003e\n\u003ch3\u003eTHE ROLE OF THE GUT MICROBIOTA AND SPECIFIC PROBIOTICS\u003c\/h3\u003e\n\u003cp\u003eThe health of the gut microbiota is thought to influence skin health and the development of acne through its effects on the immune system and systemic inflammation, as well as its interactions with the skin microbiome through the production of antimicrobial metabolites which enter circulation and accumulate in the skin5.\u003c\/p\u003e\n\u003cp\u003eStudies on individuals with acne have demonstrated unfavourable gut microbiota compositions, with lower microbial diversity and a higher ratio of Bacteroidetes to Firmicutes, which may predispose these individuals to immune dysregulation, greater inflammatory responses and thus acne5.\u003c\/p\u003e\n\u003cp\u003eSpecific probiotic strains are being investigated for their ability to harness the links that exist between the gut microbiome, systemic inflammatory processes, and the skin microbiome. For example, in-vitro studies have demonstrated that Lactobacillus salivarius LS03 can inhibit the growth of C. acnes and reduce the production of key inflammatory cytokines in response to its opportunistic growth (1).\u003c\/p\u003e\n\u003cp\u003eFollowing on from this promising mechanistic research, LS03 formed the basis of a probiotic combination that has been clinically trialled for the treatment of acne; a combination of Lactobacillus salivarius LS03 (1 BLB*), Lactobacillus casei LC03 (0.5 BLB*) and Bifidobacterium breve BR03 (0.5 BLB*).\u003c\/p\u003e\n\u003ch3\u003eHUMAN CLINICAL TRIAL\u003c\/h3\u003e\n\u003cp\u003eIn one arm of this recently published double-blind, randomised, placebo-controlled trial, subjects with mild to moderate acne received this probiotic formulation once a day for 8 weeks7. At week 4, there was a statistically significant (p \u0026lt; 0.05) decrease in the number of acne lesions in the subjects taking the probiotic (-31.11%) compared to placebo (-10%), measured using the global acne grading system (GAGS) score (see Figure 1).\u003c\/p\u003e\n\u003cp\u003eThis continued to improve after 8 weeks (-38.89% vs 18.89%, p \u0026lt; 0.05). Significant reductions in skin redness (T0 1.82 ± 0.06 vs T2 0.73 ± 0.74, p \u0026lt; 0.05) (see Figure 2) and  relative abundance of C. acnes (26.8 vs 21.7 log RA, p \u0026lt; 0.01) on the skin were observed following the use of this probiotic supplement for 8 weeks, as were significant reductions in sebum production.\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/ActivatedProbioticsBiomeAcneProbiotic10_offRRPatHealthMastersActivatedProbioticsFigure2_600x600.png?v=1707108348\" alt=\"Activated Probiotics Biome Acne Probiotic 10% off RRP at HealthMasters Activated Probiotics Figure 2\"\u003e\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Activated Probiotics Biome Acne Probiotic\u003c\/h2\u003e\n\u003cp\u003e1. Deidda F, Amoruso A, Nicola S, Graziano T, Pane M, Mogna L. New Approach in Acne Therapy A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03. J Clin Gastroenterol. 2018 Nov 1;52:S78–81.\u003c\/p\u003e\n\u003cp\u003e2. Dréno, B., Dagnelie, M. A., Khammari, A., \u0026amp; Corvec, S. (2020). The Skin Microbiome: A New Actor in Inflammatory Acne. American journal of clinical dermatology, 21(Suppl 1), 18–24.\u003c\/p\u003e\n\u003cp\u003e3. Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012;379:361–72.\u003c\/p\u003e\n\u003cp\u003e4. Tanghetti, Emil. A. (2013). The role of inflammation in the pathology of acne. Journal of Clinical and Aesthetic Dermatology, 6(9), 16–24.\u003c\/p\u003e\n\u003cp\u003e5. Lee, Byun, \u0026amp; Kim. (2019). Potential Role of the Microbiome in Acne: A Comprehensive Review. Journal of Clinical Medicine, 8(7)\u003c\/p\u003e\n\u003cp\u003e6. Jourdan, E., Trompezinski, S., Weber, S., Cadars, B., Larue, F., Ardiet, N., Chavagnac-Bonneville, M., \u0026amp; Sayag, M. (2016). Assessment of a new biological complex efficacy on dysseborrhea, inflammation, and Propionibacterium acnes proliferation. Clinical, Cosmetic and Investigational Dermatology, Volume 9, 233–239.\u003c\/p\u003e\n\u003cp\u003e7. Rinaldi, F., Marotta, L., Mascolo, A., Amoruso, A., Pane, M., Giuliani, G., \u0026amp; Pinto, D. (2022). Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement. Dermatology and Therapy.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}