Metagenics Gut InflamX

Directions

Adults:

Take 2 capsules, twice daily, or as directed by your healthcare professional.

If symptoms persist consult your healthcare professional.

Benefits

The CAP activation involves the vagus nerve and has anti-inflammatory effects.1 Association with a reduction in gastrointestinal and systemic inflammation, make the CAP a potential treatment target for intestinal permeability, gastrointestinal resilience, and systemic inflammation2 (Figure 1). Studies conducted in animals and in vitro found that Andrographis paniculata3 and Coptis chinensis4 both activate the CAP. Zingiber officinale (Ginger) inhibits Acetylcholinesterase in vitro, which reduces the breakdown of acetylcholine (Figure 1).

Immune activation, partly driven by pro-inflammatory macrophages, can be a driver of gut and systemic inflammatory conditions and diseases (Figure 1). Activating the CAP enhances T-regulatory (T-reg) cells and reduces inflammatory cytokines (in animal and in vitro studies).6 Mast cells within the gastrointestinal tract release inflammatory mediators when triggered.7 In vitro and animal studies show that vitamin D and constituents from Andrographis and Coptis chinensis (dehydroandrographolide and berberine), Boswellia and Zingiber officinalis (shogaols and gingerols), reduce the activation of mast cells, and thus help to minimise inflammation.

Vagal nerve stimulation promotes healthy neuronal communication, which can downregulate the inflammatory response in a range of conditions.9 Zinc stimulates vagal nerve fibres and nervous system function.10 Herbal extracts with bitter characteristics, such as Andrographis and Coptis chinensis11,12 stimulate taste receptors throughout the gastrointestinal (GI) tract.13,14 Such effects have been shown to trigger the release of gut hormones, such as cholecystokinin (CCK), which activate afferent vagal receptors.15,16

Gut InflamX's unique herbal and nutrient combination provides anti-inflammatory support for systemic conditions where GI dysfunction is present. Studies in vitro demonstrate that zinc, vitamin D, Boswellia serrata and berberine all support intestinal mucosal barrier function via several mechanisms including antioxidant action, cell membrane repair and tight junction support.17 Boswellia serrata is traditionally used in Ayruvedic medicine to relieve gastrointestinal pain, digestive discomfort, and GI inflammation.18 Zinc carnosine's anti-inflammatory and antioxidant actions are thought to be responsible for its beneficial effects in the maintenance, prevention, and treatment of the mucosal lining and other epithelial tissues.19 In addition, a review found that berberine has a protective effect and reduces cell permeability, and protects the intestinal mucosal epithelial barrier from TNF - a damage.20

Ingredients

Excipients

Content

Allergen Advice

Free from dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein. Free from artificial colours, sweeteners, flavours and preservatives.

Warnings

Andrographis may cause allergic reactions or taste disturbance (including loss of taste) in some people. If you have a severe reaction (i.e. anaphylaxis) or develop any adverse symptoms, stop use and seek immediate medical attention. Vitamin and mineral supplements should not replace a balanced diet.

Not all cautions and contraindications are listed. For full details, references or more information contact HealthMasters in Australia by email: reception@healthmasters.com.au HERE.

Always read the label. Use only as directed. If symptoms persist consult your healthcare professional.

Storage

Store below 30° C

TruQuality

Metagenics has stringent testing policies and practices means that Practitioners can prescribe products with complete confidence to deliver an exceptional patient product experience that provides health outcomes. When we say "check us", we mean it. It's easy to say we care about quality - let us show you. TruQuality grants full visibility to product ingredients and testing information for every single product we make.

For more information about product testing, click here.

To learn about excipients used in this product, see our full excipient list here.

The products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.

Can't see an appropriate product, or have any other questions? You can contact HealthMasters for assistance HERE