Metagenics Resist-X Advanced

Directions

Adults:

Take 1 tablet twice daily with food.

or as directed by your healthcare professional.

If symptoms persist consult your healthcare professional.

Description

• Metgenics Resist-X Advanced contains chromium, which supports healthy blood sugar balance and glucose homeostasis.
• Indian barberry (in traditional Ayurvedic medicine), and milk thistle have been shown to support liver function and together, exert a synergistic effect.
• Indian barberry (in traditional Ayurvedic medicine) assists in the breakdown of dietary fats.
• Chromium in Resist-X Advanced supports carbohydrate metabolism and milk thistle protects healthy cells from oxidative damage via antioxidant activity.

Benefits

Berberine from Indian barberry and milk thistle exert a synergistic effect.1 Milk thistle supports healthy liver function and reduces free radicals formed in the body.2 Berberine typically has low oral bioavailability, and its cellular uptake is limited by the P-glycoprotein efflux pump located on cell membranes. Milk thistle flavonolignans act as inhibitors of this pump,3 supporting berberine?s cellular uptake (Figure 1).4 In a single-blind, randomised placebo-controlled trial, patients with elevated blood sugar given the combination of 210 mg per day of milk thistle flavonolignans with Indian barberry, equating to 1 g per day of berberine, was shown to synergistically increase berberine's therapeutic effects on glycosylated haemoglobin (HbA1c) compared to the same dose of Indian barberry given alone (p<0.05).5 The two ingredients in a randomised double-blind placebo-controlled trial led to signification reductions in biomarkers: body mass index (BMI), waist circumference and visceral fat compared to placebo after 12 months of supplementation (p<0.01).6

Poor blood sugar control is associated with low-grade systemic inflammation (meta inflammation) caused by nutrient excess.8 The twin-cycle hypothesis presents the interconnecting pathways following overnutrition and inflammation, leading to fat accumulation in the liver and insulin resistance. The result of higher very low-density lipoprotein (VLDL) in the circulation leads to fat accumulation in the pancreas and subsequently, beta cells (?-cells) dysfunction.9 To improve insulin resistance, both pancreatic ? islet cell dysfunction and liver lipid metabolism must be addressed (Figure 2).10,11

Chromium assists carbohydrate metabolism, supports healthy blood sugar, and is an essential element in glucose homeostasis.13 It achieves this by promoting insulin signalling.14 A meta-analysis of human clinical trials showed combining milk thistle and Indian barberry presented a significant reduction in fasting blood glucose, total cholesterol, triglycerides, low density lipoproteins, and a significant increase in high-density lipoproteins.15

Metabolic stress, such as lipodysfunction and meta inflammation may predispose to pancreatic impairment.16 Metabolic imbalances (e.g. fatty liver, insulin resistance, weight gain and hormonal imbalances) all involve liver function alterations, fatty acid abnormalities and changes in blood sugar control.17 Berberine aids the breakdown of dietary fat and protects the liver. In an animal study, berberine improves pancreatic ? islet cell function under metabolic stress.18 In another animal study, berberine has been shown to reduce hypercaloric induced liver lipid infiltration,19 and was also shown to inhibit pancreatic inflammation and pancreatic ? islet cell damage associated with insulin resistance.20

Figure 1: Milk thistle's Flavanolignans Support Berberine?s Cellular Uptake.7

Figure 2: The Twin Cycle Hypothesis ? Addressing the Pancreas and the Liver.12

Ingredients

Excipients

For more information about excipients used in this product, see a full excipient list HERE.

Allergen Advice

Free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and salt. Free from artificial colours, flavours and preservatives.

Warnings

Not recommended for use by pregnant or lactating women.

Mineral supplements should not replace a balanced diet.

Do not use if cap and/or bottle seals are missing or broken.

Not all cautions and contraindications are listed.

For full details, references or more information contact HealthMasters in Australia by email: reception@healthmasters.com.au HERE.

Storage

Store below 30°C.

TruQuality

Metagenics has stringent testing policies and practices means that Practitioners can prescribe products with complete confidence to deliver an exceptional patient product experience that provides health outcomes. When Metagenics say "check us", they mean it. It's easy to say we care about quality - let us show you. TruQuality grants full visibility to product ingredients and testing information for every single product we make.

For more information about product testing, click HERE.

To learn about excipients used in this product, see our full excipient list HERE.

The products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.

• Metagenics Resist-X

Can't see an appropriate product, or have any other questions? You can contact HealthMasters for assistance HERE