Metagenics UltraFlora Sensitive Skin Postbiotic

Description

• Nourishing Skin Health and Repair, Metagenics UltraFlora Sensitive Skin Postbiotic contains a blend of L-92™ Postbiotic to relieve symptoms of mild eczema and dermatitis, and NutroxSun™ to help enhance skin elasticity.
• By reducing sensitivity, alleviating redness, and soothing irritation and inflammation, Metagenics UltraFlora Sensitive Skin Postbiotic offers support for your skin’s wellbeing.

Clinical Benefits

Relieves the symptoms of mild eczema/dermatitis: Heat-treated Lactobacillus acidophilus L-92™ (L-92™) is a postbiotic backed by over 20 years of research. L-92™ positively influences the immune system through the gut, increasing T-regulatory cells and addressing immune imbalances between Th1 and Th2 cells, which is linked to atopic dermatitis.[1- 3] Research shows that a daily dose of 20.7 mg of L-92™ can regulate this imbalance and reduce inflammatory cytokines involved in mild eczema and dermatitis.[1,4] (Inoue and Yamamoto)

Two separate placebo-controlled, double-blind studies demonstrated significant reductions in skin itching and redness (p<0.02) after eight weeks of taking 20.7 mg of L-92™ daily.[1] One of the studies, which lasted six months, showed the improvements in itching and eczema severity experienced at eight weeks continued to improve for the duration of the trial. [4]

Reduces skin redness and promotes skin elasticity: Increased reactive oxygen species (ROS) may contribute to skin barrier dysfunction and exacerbate skin inflammation. NutroxSun™ is a clinically proven combination of Citrus X paradisi (grapefruit) and Mediterranean rosemary that is rich in polyphenols and has an antioxidant-like effect in the skin.[5] In as little as two weeks, taking 100 mg/day of NutroxSun™ improved skin elasticity in skin exposed to a UV radiation model of inflammation.[6] These results suggest NutroxSun™ has a reparative effect on the skin, enhancing elasticity and reducing inflammation and redness.

Promotes skin health from the inside out: Adequate nutrition is important to maintain overall skin health. The combination of exclusive L-92™ postbiotic, NutroxSun™ and Vitamins C, D, E, B3 and zinc helps to nourish the skin and support repair.[1-8]

1. Inoue, Y. et al. Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial. Int Arch Allergy Imm 165, 247–254 (2015).

2. Shah, M. M. et al. Lactobacillus acidophilus Strain L-92 Induces CD4+CD25+Foxp3+ Regulatory T Cells and Suppresses Allergic Contact Dermatitis. Biological Pharm Bulletin 35, 612–616 (2012).

3. Sasai M, Kano C, Sakano K, Ishikawa S, Sawada D, Hirota T. Effect of oral intake of Lactobacillus acidophilus L-92 on systemic and intestinal immune parameters. Jap Phar Ther. 2022;50(9):1699-1707.

4. Yamamoto, K. et al. Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis. J Dairy Sci 99, 5039–5046 (2016).

5. Pérez-Sánchez, A. et al. Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. J. Photochem. Photobiol. B: Biol. 136, 12–18 (2014).

6. Nobile V, Michelotti A, Cestone E, Caturla N, Castillo J, Benavente-García O, et al. Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols. Food Nutr Res. 2016;60(0):31871. doi:10.3402/fnr.v60.31871.

7. Doseděl, M. et al. Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients 13, 615 (2021)

8. Podgórska, A., Kicman, A., Naliwajko, S., Wacewicz-Muczyńska, M. & Niczyporuk, M. Zinc, Copper, and Iron in Selected Skin Diseases. Int. J. Mol. Sci. 25, 3823 (2024).

Directions

Warnings

Vitamin and mineral supplements should not replace a balanced diet.

If symptoms persist consult your healthcare professional.

Storage

Store below 30°C.

Key Ingredients

Active Ingredients

Free From

Free from: Dairy, Lactose, Eggs, Yeast, Nuts, Soy protein.

Free from: Artificial colours, Artificial sweeteners, Artificial flavours.

Excipients

Acacia, citric acid, disodium edetate, dl-alpha-tocopherol, gellan gum, glycine, hypromellose, magnesium stearate, maize starch, medium chain triglycerides, microcrystalline cellulose, potable water, potassium acetate, silicon dioxide, sucrose.

Frequently asked questions

What is a postbiotic?

Postbiotics are therapeutic ingredients derived from non-living microorganisms, including cell wall fragments, metabolites, and other compounds that remain after the microorganism has been inactivated. The therapeutic value of a postbiotic lies in substances produced by the microorganism during their life cycle, which provide benefits after the microorganisms themselves are no longer alive.3 For example, heat-treated postbiotic, Lactobacillus acidophilus (L-92™) can have positive effects on the immune system by interacting with gut microbiota, shown to reduce skin sensitivity in individuals prone to skin allergies.4

How long before I will see results with eczema?

Research shows clear benefits of Lactobacillus acidophilus (LP-92™) from 8 weeks, however people may notice potential benefits sooner. Expect to notice 20%- 25% less eczema symptoms, with less skin redness and swelling after 8 weeks.1,2

What is NutroxSun & how does it work?

NutroxSun™ is a potent mix of antioxidant ingredients from grapefruit and rosemary, which help to protect skin from environmental damage.5,6 Taking 100 mg of NutroxSun™ each day has been shown to improve your skin’s elasticity and reduce skin redness and inflammation within 2 weeks.7

Can I use this product if I am using topical creams for mild dermatitis or eczema?

Yes, you can. Metagenics UltraFlora Sensitive Skin Postbiotic supports the immune system and reduces skin inflammation from within, while your topical creams and lotions can be applied externally.

How long will it take to effect?

Studies have found that the ingredients in Metagenics UltraFlora Sensitive Skin Postbiotic can start to work in supporting skin health in as little as two weeks, however the full benefits may take up to eight weeks to be seen.

Is this product suitable for children?

This product is not recommended for children. Instead, children can use Metagenics UltraFlora Kids Care Probiotic which may assist in reducing the symptoms of mild eczema and dermatitis.

References

1. Yamamoto K,Yokoyama K, Matsukawa T, et al. Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis. J Dairy Sci. 2016;99(7):5039-5046. doi:10.3168/jds.2015-10605
2. Inoue Y, Kambara T, Murata N, et al. Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum cytokines of atopic dermatitis in Japanese adults: a double-blind, randomized, clinical trial. Int Arch Allergy Immunol. 2014;165(4):247-254. doi:10.1159/000369806
3. Salminen, S. et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterology Hepatology 18, 1–19 (2021).
4. Sasai, M. et al. Effect of oral intake of Lactobacillus acidophilus L-92 on systemic and intestinal parameters. Jpn Pharmacol Ther. Vol. 50:9 (2022)
5. Pérez-Sánchez, A. et al. Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. J. Photochem. Photobiol. B: Biol. 136, 12–18 (2014).
6. Simoni, E. D. et al. Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review. Front. Nutr. 11, 1393673 (2024).
7. Nobile, V. et al. Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols. Food Nutr Res 60, 31871 (2016).

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Metagenics UltraFlora Sensitive Skin Postbiotic AUST L 463873

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