(Discontinued) MD Nutritionals Indolplex

Benefits

• Features 3, 3?-diindolylmethane (DIM), is a natural plant indole that is abundant in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage.
• In supplemental form, DIM can be difficult to absorb. MD Nutritionals Indolplex contains a proprietary DIM complex to enhance absorption. This microencapsulated formulation provides higher bioavailability.
• MD Nutritionals Indolplex features absorption-enhanced DIM to support female healthy hormone balance.
• Supports oestrogen hormone levels in both women and men. Oestrogens are a group of three biochemically distinct hormones, oestradiol (E2), oestrone (E1), and oestriol (E3). Furthermore, oestrogen is enzymatically converted to specific oestrogen metabolites such as 16-alpha hydroxyoestrones, 2-methoxyoestrogens, 16-alpha hydroxyoestrone, 4-hydroxyoestrogens and 4-methoxyoestrogens.
• May help support healthy prostate function.
• Helps reduce free radicals formed in the body.
• When comparing dietary indoles studies show MD Nutritionals Indolplex is more stable than indole-3-carbinol (I3C), the precursor to DIM.

Ingredients

Excipient Ingredients

Cellulose microcrystalline, calcium hydrogen phosphate, silicon dioxide, and magnesium stearate (vegetable source).

Contains no gluten, soy, dairy, yeast, wheat, artificial flavours, colours or preservatives. Suitable for vegetarians.

Directions

Women: Take 2 capsules once or twice daily, or as directed by your healthcare professional.

Men: Take 2 capsules twice daily, or as directed by your healthcare professional.

Warnings

Do not use MD Nutritionals Indolplex if you are pregnant, may become pregnant or are lactating.

Precautions & Considerations

Harmless changes in urine colour may occur with MD Nutritionals Indolplex. Increased water consumption can reduce this side effect.

Symptoms of nausea and/or headaches may occur with MD Nutritionals Indolplex. MD Nutritionals Indolplex assists activity of hepatic cytochrome P450 enzymes (CYP1A1) pathways. Nutrients required to support phase 2 liver detoxification pathways can assist in reducing these symptoms.

MD Nutritionals Indolplex does not contain goitrogenic compounds which could affect thyroid function.

A short term increase in symptoms with MD Nutritionals Indolplex may be due to increased metabolism of available oestrogen.

MD Nutritionals Indolplex can be used in used in conjunction with phytoestrogenic herbs.

MD Nutritionals Indolplex may assist hormone health when taken with Hormone Replacement Therapy (HRT)

MD Nutritionals Indolplex may assist hormone health when taken with the oral contraceptive pill (OCP). MD Nutritionals Indolplex has no inducing action on CYP3A4, the enzyme that metabolises the OCP. Therefore, MD Nutritionals Indolplex does not affect efficacy of the OCP.

MD Nutritionals Indolplex may assist effective metabolism of increased available oestrogen when taken with bioidentical hormone replacement therapy (BHRT).

Safety studies support concomitant use of MD Nutritionals Indolplex with Tamoxifen.

Combined use of MD Nutritionals Indolplex and Zoladex is supported.

Concomitant use of MD Nutritionals Indolplex with aromatase inhibitors is not recommended. This includes drugs such as Arimidex and Femara.

MD Nutritionals Indolplex may increase the clearance of the following; caffeine, theophylline, paracetamol, tamoxifen, phenacetin, tacrine and verapamil at prolonged doses >300mg daily.

Storage

Store below 30°C out of direct sunlight.

Technical Information

Indoles are natural phytonutrients found in cruciferous vegetables such as cabbage, Brussels sprouts, cauliflower and broccoli. These biologically active compounds are associated with a lower risk of major health issues. DIM is the most abundant and active dietary indole derived from cruciferous vegetables. Indolplex contains bioavailable DIM, a unique and highly absorbable diindolylmethane with demonstrated clinical activity.

Indolplex is not phytoestrogenic and has no inherent oestrogenic activity. Indolplex assists the favourable metabolism of oestrogen down the 2-hydroxylation pathway. A beneficial shift in metabolism can help maintain healthy oestrogen ratios and reduce the symptoms of oestrogen dominance. The active 2-hydroxyoestrone metabolites are considered the ?good? oestrogens. Whereas the 4-hydroxyoestrone and 16-alpha-hydroxyoestrone metabolites are often termed the ?bad? oestrogens. The common symptoms of oestrogen dominance are often due to underactive oestrogen metabolism and the overproduction of unfavourable oestrogen metabolites.

Indolplex may be beneficial in symptoms associated with pre-menstrual syndrome (PMS) and medically diagnosed conditions such as fibrocystic breast disease, polycystic ovarian syndrome (PCOS), uterine fibroids, cyclical mastalgia and cervical dysplasia.

Indolplex may assist health of the reproductive tract and breast in women.

Indolplex may assist symptoms of medically diagnosed prostate disorders.

Indolplex may assist the metabolic changes observed in obesity in both men and women. Obesity, often considered an oestrogen excess condition is associated with an increased incidence of reproductive dysfunction and oestrogen linked disorders. Obesity is also associated with a significant reduction in 2-hydroxylation of oestrogen. This metabolic alteration could further aggravate a relative hyperoestrogenic state. Unlike other oestrogen metabolites, the 2-hydroxyoestrogen compounds display relatively little peripheral oestrogenic activity. When used in conjunction with a nutritious diet and regular exercise Indolplex can support improvements in body composition.

The Indolplex Range

There are three unique Indolplex products to assist hormone health issues affecting both men and women. The Indolplex products feature the enhanced DIM delivery system.

MD Nutritionals Indolplex

50 & 100 VCaps

Features bioavailable diindolylmethane for optimal hormone balance.

MD Nutritionals Indolplex contains 65mg of bioavailable diindolylmethane (DIM). DIM is beneficial in promoting beneficial oestrogen metabolism in both men and women. It is indicated in conditions associated with oestrogen dominance.

MD Nutritionals FemBalance

60 VCaps

Indolplex with high strength co-factors for balanced hormone health.

This unique formula provides 45mg of bioavailable diindolylmethane (DIM) along with Vitex agnus castus (Chaste Tree), Fucus vesiculosus (Bladderwrack), selenium & vitamin D3. This blend will help support healthy menstrual function and symptoms of premenstrual syndrome (PMS).

MD Nutritionals Estro-Sense

60 VCaps

Features 120mg of Indolplex with important co-factors to help restore hormone balance.

Contains high strength bioavailable diindolylmethane (DIM), along with Fucus vesiculosus (Bladderwrack), selenium and vitamin D3 to support metabolism of oestrogen to the protective metabolites. This is particularly important to assist breast health.

The naturopathic medicines listed below are suggestions that may be used as a substitute if the naturopathic medicine you are looking for is unavailable.

• Metagenics Indole-3-Carbinol (I3C) (best form because DIM is converted to I3C)
• RN Labs DIM Powder

Can't see an appropriate naturopathic medicine, or have any other questions?

You can contact HealthMasters for assistance HERE