Give Back Health Clinic Collection NMN

Directions

Dosage range: 250mg - 1,000mg.

1 to 4 scoops as directed by a health care professional.

Each 0.25g scoop contains 250mg

For extemporaneous compounding.

Ingredients

Excipients

Excipients: None

Incidental Minor Excipients: None

Ingredient Information

Nicotinamide mononucleotide (NMN)

How increasing NAD+  promotes healthy ageing

Nicotinamide adenine dinucleotide (NAD+) is an essential molecule that plays a critical role in almost every metabolic process in the body.

Through its roles as a cofactor, electron donor and signalling molecule, NAD+ is essential for many biological processes. These include ATP synthesis, DNA repair, secondary messenger signalling, epigenetic regulation of gene expression and cell survival.

NAD+ naturally declines with age. The gradual decline of NAD+ concentrations takes place across multiple human organs and tissues, including skin, blood, liver, muscles and brain. Reduced concentration of NAD+ results in suboptimal functioning of the NAD+ dependent pathways. This in turn results in an increase in issues relating to metabolic function, inflammation, senescence and degeneration of the nervous system. When NAD+ dependent mechanism are compromised, diseases of ageing are then more likely to occur. 

By increasing NAD+ and therefore increasing the activity of the NAD-dependent processes, we can help prevent, delay or improve the NAD+ mechanisms of ageing.  In doing so, we can prevent, delay or improve the seven diseases of ageing.

Free From

Gluten, corn, lactose, egg, sulfites, tree nuts, soy, maltodextrin and magnesium stearate.

Storage

Store below 25ºC in a cool, dry place away from direct sunlight.

Warnings

Always read the label. Follow the directions for use. If symptoms persist, talk to your healthcare practitioner.

Vitamin and mineral supplements should not replace a balanced diet.  

Do not use if tamper evidence seal is broken. Bottle sealed under cap for your protection. 

CONTRAINDICATIONS

None known. Well tolerated in human clinical trials.

Companion Products

• N-acetyl cysteine (NAC)
• Magnesium
• L-glycine
•  L-theanine
• Saffron
• Phyto-melatonin

FAQ's

What is nicotinamide mononucleotide (NMN)?

NMN is a naturally occurring molecule that helps produce energy in the body.

NMN is a molecule called a nucleotide. Nucleotides have many roles in the body including the production of DNA.

NMN is converted into another molecule within the cells known as nicotinamide adenine dinucleotide (NAD). Your body needs NAD for a variety of functions involved in metabolism and energy production.

The amount of NAD your body can make depends on the amount of NMN available in your body.

What is the difference between NR, NMN and NAD?

In the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to NAD (Nicotinamide Adenine Dinucleotide).  

The best form to take is NMN (Nicotinamide Mono Nucleotide).

Is it better to take a supplement containing NMN or NAD?

Research has found that taking a supplement containing NMN is better than taking a NAD supplement. This is because NAD is unable to enter the cell because the cells have receptors for NMN but do not have receptors for NAD. So, it is best to take NMN because NMN can enter the cells where it is converted to NAD.

Researchers who study NMN and NAD believe that the goal is to get NAD levels in the cells to levels closer to those levels in our youth.

Why is NMN so important?

All the cells in your body use NAD and NMN is required to make NAD. 

What are the benefits of NAD?

NAD helps cells regulate a number of essential functions in cells, including:

• energy metabolism
• DNA repair
• gene expression
• cellular stress responses
• oxidative stress

Sufficient NMN is essential to produce enough NAD to support cell functions.

How is NMN and NAD related to ageing?

The levels of NMN decline naturally as we age, and, as a result, your NAD levels also decline. This contributes to some of the health effects experienced during ageing.

Low levels of NMN and NAD can be involved in conditions including:

• diabetes
• liver disease
• brain health
• heart health
• longevity
• jet lag
• muscle function and strength
• endurance

Can NMN increase longevity?

In the cells are proteins called Sirtuins that help repair DNA. Sirtuins are linked to longevity.

Is NMN safe, and does it have side effects?

NMN is an ideal supplement to increase cellular levels of NAD. It is well-tolerated, and both human and animal studies have observed it had minimal side effects.

Research in humans has shown that doses of up to 1,200 mg daily are safe to consume.

Is NMN in food?

NMN is found in a variety of foods. Some NMN-rich dietary sources:

avocados - 0.36 to 1.60mg per 100grams

broccoli - 0.25 to 1.12mg per 100grams

cabbage - up to 0.9mg per 100grams

cucumber -  small amounts

cow’s milk -  small amounts

edamame  -  small amounts

tomatoes - 0.26 to 0.30mg per 100grams

raw beef - 0.06 to 0.42mg per 100grams

Studies in mice have found that the gut absorbs NMN readily. More studies are needed to investigate how eating foods containing NMN may increase NAD levels in cells.

Can NMN  help with ageing?

NMN and NAD levels naturally decline with age. Researchers have suggested that taking NMN supplements may help with age-related health concerns.

A study in 10 Japanese men found that taking NMN at 100, 250, or 500mg increased levels of NAD. 

Insulin resistance can develop as we age and is one of the reasons diabetes is more common in older adults. Although studies haven’t specifically looked at the effects of taking NMN supplements, the research available suggests that it may help you maintain or regain insulin sensitivity with age.

More studies on these effects in humans are needed to investigate this potential benefit

Taking NMN supplements has also been shown to reduce drowsiness and improve muscle responsiveness in older adults, which may improve both physical and mental health with age.