{"id":8061484728550,"title":"Designs For Health NR Supreme","handle":"designs-for-health-nr-supreme","description":"\u003ch2\u003eDesigns For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003e100% \u003cspan data-mce-fragment=\"1\"\u003eNicotinamide riboside\u003c\/span\u003e\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eAssists with NAD+ production and enhances NAD+ levels in the body\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 30 Vegetarian Capsules   Servings Per Pack: 30 serves\u003c\/p\u003e\n\u003cp\u003eDesigns For Health NR Supreme Summary:\u003c\/p\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e100% Nicotinamide Riboside Chloride\u003c\/li\u003e\n\u003cli\u003eContains 300 mg Nicotinamide Riboside Chloride per capsule\u003c\/li\u003e\n\u003cli\u003eAssists with NAD+ Production\u003c\/li\u003e\n\u003cli\u003eEnhances NAD+ levels in the body\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health NR Supreme AUST L 394330\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e \u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioactiv-healthcare-10-off-rrp\/products\/bioactiv-healthcare-nmn\" title=\"BioActiv HealthCare NMN 10% off RRP | HealthMasters BioActiv HealthCare\" target=\"_blank\"\u003eBioActiv HealthCare NMN\u003c\/a\u003e\u003c\/span\u003e - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"Designs For Health NR Supreme 10% off RRP | HealthMasters Designs For Health\" target=\"_blank\"\u003eDesigns For Health NR Supreme\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"RN Labs Nicotinamide Riboside NR 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs Nicotinamide Riboside NR\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNote:\u003c\/p\u003e\n\u003cp\u003eIn the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eAdults: Take one capsule daily\u003c\/p\u003e\n\u003cp\u003eor as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases NAD+ status and replenishes the body’s NAD+ pool\u003c\/li\u003e\n\u003cli\u003eProvides nutritional support for NAD+ replenishment which can:\u003c\/li\u003e\n\u003cul\u003e\n\u003cli\u003eSupport energy production\u003c\/li\u003e\n\u003cli\u003eSupport healthy aging\u003c\/li\u003e\n\u003cli\u003eProvide antioxidant support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients (per vegetarian hard capsule) \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide Riboside Chloride\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. ribose\u003c\/td\u003e\n\u003ctd\u003e154.8mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eHydrated silica, Hypromellose, Purified water\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNo Added: Soy, Dairy, Nuts, Eggs, Yeast, Sesame.\u003c\/p\u003e\n\u003cp\u003eFree From: Colours, Flavours, Benzoates, Sulfites, Sorbates.\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNot to be taken by children under 12 years old.\u003c\/p\u003e\n\u003cp\u003eNot recommended for use during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eContains ribose which is a sugar.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eNicotinamide (NAM) is required for the synthesis of NAD+, an essential coenzyme involved in several metabolic pathways. In fact, an estimated 200 enzymes – including dehydrogenases – require NAD and NADP as coenzymes. As an electron carrier, NAD+ is necessary for oxidative reactions that occur in the cytosol and mitochondria. Due to its capacity to extract energy from substrates, NAD+ is fundamental to cellular health. NAD+ is also required for carbohydrate oxidation during adenosine triphosphate (ATP) production.\u003c\/p\u003e\n\u003ch3\u003ePharmacokinetics\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAbsorption:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNicotinamide is absorbed predominantly in the small intestine via facilitated diffusion. Once in the bloodstream, nicotinamide moves across cell membranes via passive diffusion.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMetabolism to NAD+:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNR acts as a precursor in producing NAD+ via two pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe NRK1\/2 Pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR is phosphorylated to nicotinamide mononucleotide (NMN) by the enzyme NR kinase Nrk1. The resulting MNM is then converted to NAD+ by NMN adenylyltransferase.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe salvage pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR, Nicotinic acid (NA) or NAM is converted to NMN under the influence of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NMN is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT aka NMN transferase).\u003c\/p\u003e\n\u003cp\u003eNR has the ability to maintain intracellular levels of NAD+ in the body.4 In the first human clinical trial conducted with NR, results found that blood NAD+ levels can increase up to 2.7 fold with a single oral dose of NR.\u003c\/p\u003e\n\u003cp\u003eA randomised, double-blind, placebo-controlled trial consisting of 113 people receiving NR in combination with pterostilbene (NRPT) found that the group receiving NRPT at 250mg per day had significantly increased NAD+ levels to 40% over baseline.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eElimination:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe enzyme glycohydrolase transforms NAD into adenosine diphosphate-ribose and nicotinamide. The resulting nicotinamide is then released from cells for processing by the liver. Nicotinamide undergoes methylation and oxidation in the liver – its metabolites are then excreted in the urine. Much of the free nicotinamide is reabsorbed into the body via glomerular filtrate \u003c\/p\u003e\n\u003cp\u003e\u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 1 The Salvage Pathway\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: The salvage pathway\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eIn the salvage pathway, the precursors are converted into an intermediate called nicotinamide mononucleotide (NMN) through nicotinamide phosphoribosyltransferase (NAMPT). Then NMN is converted into NAD+ via nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD+ generated by this pathway is consumed by multiple enzymes including sirtuins, PARPs, and cADPR synthases.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure2TheNRK1-2Pathway_600x600.png?v=1674101380\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 2 The NRK1-2 Pathway\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: The NRK1\/2 Pathway.4\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eNRK 1\/2 mediated NAD+ biosynthesis pathway. Nicotinamide riboside (NR) is metabolised by nicotinamide riboside kinase (NRK 1\/2) to nicotinamide mononucleotide (NMN) and subsequently converted to NAD+ by NMN-adenylyltransferase (NMNAT) activity).\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2023-01-18T18:26:46+11:00","created_at":"2022-11-19T14:51:54+11:00","vendor":"Designs For Health","type":"Designs For Health Naturopathic Medicines","tags":["Designs For Health","Naturopathic","Nicotinamide riboside"],"price":3776,"price_min":3776,"price_max":3776,"available":true,"price_varies":false,"compare_at_price":4195,"compare_at_price_min":4195,"compare_at_price_max":4195,"compare_at_price_varies":false,"variants":[{"id":43539694026982,"title":"30 capsules","option1":"30 capsules","option2":null,"option3":null,"sku":"DFHNRSupreme30C","requires_shipping":true,"taxable":true,"featured_image":{"id":39097033064678,"product_id":8061484728550,"position":1,"created_at":"2023-01-18T18:14:53+11:00","updated_at":"2023-01-18T18:15:34+11:00","alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health","width":1200,"height":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","variant_ids":[43539694026982]},"available":true,"name":"Designs For Health NR Supreme - 30 capsules","public_title":"30 capsules","options":["30 capsules"],"price":3776,"weight":0,"compare_at_price":4195,"inventory_quantity":19981,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9353993000580","featured_media":{"alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health","id":31690153722086,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthLogo_81184dda-d8aa-4287-b79d-4506562caafe.jpg?v=1674026099"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","options":["Size"],"media":[{"alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health","id":31690153722086,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealth.png?v=1674026134","width":1200},{"alt":"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Logo","id":31344425337062,"position":2,"preview_image":{"aspect_ratio":2.5,"height":142,"width":355,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthLogo_81184dda-d8aa-4287-b79d-4506562caafe.jpg?v=1674026099"},"aspect_ratio":2.5,"height":142,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/DesignsForHealthLogo_81184dda-d8aa-4287-b79d-4506562caafe.jpg?v=1674026099","width":355}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eDesigns For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003e100% \u003cspan data-mce-fragment=\"1\"\u003eNicotinamide riboside\u003c\/span\u003e\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cem\u003eAssists with NAD+ production and enhances NAD+ levels in the body\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 30 Vegetarian Capsules   Servings Per Pack: 30 serves\u003c\/p\u003e\n\u003cp\u003eDesigns For Health NR Supreme Summary:\u003c\/p\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e100% Nicotinamide Riboside Chloride\u003c\/li\u003e\n\u003cli\u003eContains 300 mg Nicotinamide Riboside Chloride per capsule\u003c\/li\u003e\n\u003cli\u003eAssists with NAD+ Production\u003c\/li\u003e\n\u003cli\u003eEnhances NAD+ levels in the body\u003c\/li\u003e\n\u003cli\u003eVegan Friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health NR Supreme AUST L 394330\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e \u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioactiv-healthcare-10-off-rrp\/products\/bioactiv-healthcare-nmn\" title=\"BioActiv HealthCare NMN 10% off RRP | HealthMasters BioActiv HealthCare\" target=\"_blank\"\u003eBioActiv HealthCare NMN\u003c\/a\u003e\u003c\/span\u003e - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"Designs For Health NR Supreme 10% off RRP | HealthMasters Designs For Health\" target=\"_blank\"\u003eDesigns For Health NR Supreme\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/rn-labs-nicotinamide-riboside-nr\" title=\"RN Labs Nicotinamide Riboside NR 10% off RRP | HealthMasters RN Labs\" target=\"_blank\"\u003eRN Labs Nicotinamide Riboside NR\u003c\/a\u003e\u003c\/span\u003e - NR (Nicotinamide Riboside Chloride) 300mg per capsule\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNote:\u003c\/p\u003e\n\u003cp\u003eIn the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).\u003c\/p\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eAdults: Take one capsule daily\u003c\/p\u003e\n\u003cp\u003eor as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eBenefits: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases NAD+ status and replenishes the body’s NAD+ pool\u003c\/li\u003e\n\u003cli\u003eProvides nutritional support for NAD+ replenishment which can:\u003c\/li\u003e\n\u003cul\u003e\n\u003cli\u003eSupport energy production\u003c\/li\u003e\n\u003cli\u003eSupport healthy aging\u003c\/li\u003e\n\u003cli\u003eProvide antioxidant support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eActive Ingredients\u003c\/h5\u003e\n\u003ch2\u003eActive Ingredients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients (per vegetarian hard capsule) \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide Riboside Chloride\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. ribose\u003c\/td\u003e\n\u003ctd\u003e154.8mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eHydrated silica, Hypromellose, Purified water\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNo Added: Soy, Dairy, Nuts, Eggs, Yeast, Sesame.\u003c\/p\u003e\n\u003cp\u003eFree From: Colours, Flavours, Benzoates, Sulfites, Sorbates.\u003c\/p\u003e\n\u003cp\u003eVegan Friendly\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003cp\u003eNot to be taken by children under 12 years old.\u003c\/p\u003e\n\u003cp\u003eNot recommended for use during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003eContains ribose which is a sugar.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health NR Supreme\u003c\/h2\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eNicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eNicotinamide (NAM) is required for the synthesis of NAD+, an essential coenzyme involved in several metabolic pathways. In fact, an estimated 200 enzymes – including dehydrogenases – require NAD and NADP as coenzymes. As an electron carrier, NAD+ is necessary for oxidative reactions that occur in the cytosol and mitochondria. Due to its capacity to extract energy from substrates, NAD+ is fundamental to cellular health. NAD+ is also required for carbohydrate oxidation during adenosine triphosphate (ATP) production.\u003c\/p\u003e\n\u003ch3\u003ePharmacokinetics\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAbsorption:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNicotinamide is absorbed predominantly in the small intestine via facilitated diffusion. Once in the bloodstream, nicotinamide moves across cell membranes via passive diffusion.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMetabolism to NAD+:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNR acts as a precursor in producing NAD+ via two pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe NRK1\/2 Pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR is phosphorylated to nicotinamide mononucleotide (NMN) by the enzyme NR kinase Nrk1. The resulting MNM is then converted to NAD+ by NMN adenylyltransferase.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eThe salvage pathway\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 30px;\"\u003eNR, Nicotinic acid (NA) or NAM is converted to NMN under the influence of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NMN is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT aka NMN transferase).\u003c\/p\u003e\n\u003cp\u003eNR has the ability to maintain intracellular levels of NAD+ in the body.4 In the first human clinical trial conducted with NR, results found that blood NAD+ levels can increase up to 2.7 fold with a single oral dose of NR.\u003c\/p\u003e\n\u003cp\u003eA randomised, double-blind, placebo-controlled trial consisting of 113 people receiving NR in combination with pterostilbene (NRPT) found that the group receiving NRPT at 250mg per day had significantly increased NAD+ levels to 40% over baseline.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eElimination:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe enzyme glycohydrolase transforms NAD into adenosine diphosphate-ribose and nicotinamide. The resulting nicotinamide is then released from cells for processing by the liver. Nicotinamide undergoes methylation and oxidation in the liver – its metabolites are then excreted in the urine. Much of the free nicotinamide is reabsorbed into the body via glomerular filtrate \u003c\/p\u003e\n\u003cp\u003e\u003cimg data-mce-fragment=\"1\" style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 1 The Salvage Pathway\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure1TheSalvagePathway_600x600.png?v=1674101312\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1: The salvage pathway\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eIn the salvage pathway, the precursors are converted into an intermediate called nicotinamide mononucleotide (NMN) through nicotinamide phosphoribosyltransferase (NAMPT). Then NMN is converted into NAD+ via nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD+ generated by this pathway is consumed by multiple enzymes including sirtuins, PARPs, and cADPR synthases.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/DesignsForHealthNRSupreme10_offRRPatHealthMastersDesignsForHealthFigure2TheNRK1-2Pathway_600x600.png?v=1674101380\" alt=\"Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 2 The NRK1-2 Pathway\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2: The NRK1\/2 Pathway.4\u003c\/strong\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eNRK 1\/2 mediated NAD+ biosynthesis pathway. Nicotinamide riboside (NR) is metabolised by nicotinamide riboside kinase (NRK 1\/2) to nicotinamide mononucleotide (NMN) and subsequently converted to NAD+ by NMN-adenylyltransferase (NMNAT) activity).\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c!-- \/TABS --\u003e"}

Designs For Health NR Supreme

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Product Details

Designs For Health NR Supreme

100% Nicotinamide riboside

Assists with NAD+ production and enhances NAD+ levels in the body

Size: 30 Vegetarian Capsules   Servings Per Pack: 30 serves

Designs For Health NR Supreme Summary:

Nicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body

  • 100% Nicotinamide Riboside Chloride
  • Contains 300 mg Nicotinamide Riboside Chloride per capsule
  • Assists with NAD+ Production
  • Enhances NAD+ levels in the body
  • Vegan Friendly

Designs For Health NR Supreme AUST L 394330

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The products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.

Note:

In the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).

Can't see an appropriate product, or have any other questions?

You can contact HealthMasters for assistance HERE

Directions: Designs For Health NR Supreme

Adults: Take one capsule daily

or as directed by your health professional.

Benefits: Designs For Health NR Supreme

  • Increases NAD+ status and replenishes the body’s NAD+ pool
  • Provides nutritional support for NAD+ replenishment which can:
    • Support energy production
    • Support healthy aging
    • Provide antioxidant support

Active Ingredients: Designs For Health NR Supreme

Active Ingredients (per vegetarian hard capsule)
Nicotinamide Riboside Chloride 300mg
equiv. ribose 154.8mg

Excipients: Designs For Health NR Supreme

Hydrated silica, Hypromellose, Purified water

Allergen Information: Designs For Health NR Supreme

No Added: Soy, Dairy, Nuts, Eggs, Yeast, Sesame.

Free From: Colours, Flavours, Benzoates, Sulfites, Sorbates.

Vegan Friendly

Warnings: Designs For Health NR Supreme

Not to be taken by children under 12 years old.

Not recommended for use during pregnancy or lactation.

Vitamin supplements should not replace a balanced diet.

Contains ribose which is a sugar.

Education: Designs For Health NR Supreme

Background

Nicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body

Mechanism of Action

Nicotinamide (NAM) is required for the synthesis of NAD+, an essential coenzyme involved in several metabolic pathways. In fact, an estimated 200 enzymes – including dehydrogenases – require NAD and NADP as coenzymes. As an electron carrier, NAD+ is necessary for oxidative reactions that occur in the cytosol and mitochondria. Due to its capacity to extract energy from substrates, NAD+ is fundamental to cellular health. NAD+ is also required for carbohydrate oxidation during adenosine triphosphate (ATP) production.

Pharmacokinetics

Absorption:

Nicotinamide is absorbed predominantly in the small intestine via facilitated diffusion. Once in the bloodstream, nicotinamide moves across cell membranes via passive diffusion.

Metabolism to NAD+:

NR acts as a precursor in producing NAD+ via two pathways:

  • The NRK1/2 Pathway

NR is phosphorylated to nicotinamide mononucleotide (NMN) by the enzyme NR kinase Nrk1. The resulting MNM is then converted to NAD+ by NMN adenylyltransferase.

  • The salvage pathway

NR, Nicotinic acid (NA) or NAM is converted to NMN under the influence of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NMN is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT aka NMN transferase).

NR has the ability to maintain intracellular levels of NAD+ in the body.4 In the first human clinical trial conducted with NR, results found that blood NAD+ levels can increase up to 2.7 fold with a single oral dose of NR.

A randomised, double-blind, placebo-controlled trial consisting of 113 people receiving NR in combination with pterostilbene (NRPT) found that the group receiving NRPT at 250mg per day had significantly increased NAD+ levels to 40% over baseline.

Elimination:

The enzyme glycohydrolase transforms NAD into adenosine diphosphate-ribose and nicotinamide. The resulting nicotinamide is then released from cells for processing by the liver. Nicotinamide undergoes methylation and oxidation in the liver – its metabolites are then excreted in the urine. Much of the free nicotinamide is reabsorbed into the body via glomerular filtrate 

Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 1 The Salvage Pathway

Figure 1: The salvage pathway

In the salvage pathway, the precursors are converted into an intermediate called nicotinamide mononucleotide (NMN) through nicotinamide phosphoribosyltransferase (NAMPT). Then NMN is converted into NAD+ via nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD+ generated by this pathway is consumed by multiple enzymes including sirtuins, PARPs, and cADPR synthases.

Designs For Health NR Supreme 10% off RRP at HealthMasters Designs For Health Figure 2 The NRK1-2 Pathway

Figure 2: The NRK1/2 Pathway.4

NRK 1/2 mediated NAD+ biosynthesis pathway. Nicotinamide riboside (NR) is metabolised by nicotinamide riboside kinase (NRK 1/2) to nicotinamide mononucleotide (NMN) and subsequently converted to NAD+ by NMN-adenylyltransferase (NMNAT) activity).

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