{"id":7650534523110,"title":"Designs For Health GastroMend HP 60 caps","handle":"designs-for-health-gastromend-hp-60-caps","description":"\u003ch2\u003eDesigns For Health GastroMend HP 60 caps\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eIncludes liquorice, traditionally used in Western herbal medicine to help relieve mild gastrointestinal tract inflammation\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60 capsules\u003c\/p\u003e\n\u003cp\u003eOverview of Designs For Health GastroMend HP:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAssisting in the reduction of mild gastrointestinal tract inflammation\u003c\/li\u003e\n\u003cli\u003eSupports gastrointestinal system health\u003c\/li\u003e\n\u003cli\u003eSupports connective tissue\u003c\/li\u003e\n\u003cli\u003eAntioxidant support\u003c\/li\u003e\n\u003cli\u003eVegan friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health GastroMend HP does not contain Gluten, dairy, lactose, seeds or nuts.\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 4 capsules per day, or as directed by your healthcare professional\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Follow the directions for use. If symptoms persist, worsen, or change unexpectedly, talk to your health professional. This medicine may not be right for you. Read the warnings before purchase.\u003c\/p\u003e\n\u003ch5\u003eDetails\u003c\/h5\u003e\n\u003ch2\u003eDescription: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eInflammation, acute or chronic, is an important part of the immune system’s functional response. However, chronic gastrointestinal inflammation, where there is an imbalance between pro-and anti-inflammatory factors, underlies\/causes a broad range of local and extra-intestinal clinical symptoms and pathologies.\u003c\/p\u003e\n\u003cp\u003eLocally, gastrointestinal inflammation can induce abdominal pain, distention, cramping, altered motility, impaired intestinal barrier integrity, microbial dysbiosis and nerve dysfunction.4,5 Currently known extra-intestinal consequences of gastrointestinal inflammation includes neuropsychological (mood, anxiety, cognition); dermatological (atopic dermatitis, psoriasis); metabolic; disturbed sleep; poor oral health; and suboptimal nutritional status (vitamins A, D, K, carotenoids, folate, iron, zinc and selenium).\u003c\/p\u003e\n\u003cp\u003eJust as the endogenous maintenance of intestinal homeostasis involves a complex combination of factors (epithelial barrier function, innate and adaptive immunity, cell migration and autophagy), the aetiology of gastrointestinal inflammation is also complex and involves multiple antecedents. Such antecedents include genetic predisposition, immune dysregulation and responsivity, diet (excessive intake of animal protein, sugar, additives; inadequate intake of fruits, vegetables, fibre), smoking, stress and medications.12-15\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eLiquorice\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eLiquorice (Glycyrrhiza glabra) has a long history of use in Traditional Western Herbal Medicine for supporting gastrointestinal health and reducing mild gastrointestinal inflammation. Deglycyrrhizinated liquorice (DGL) has had the glycyrrhizin compound removed, and this form is used clinically to minimise glycyrrhizin-associated adverse side effects while maintaining the therapeutic properties of liquorice.1,17 The primary active constituents of DGL are flavonoids, with other compounds including isoflavonoids, chalcones, coumarins, triterpenoids, sterols, lignins, amino acids and volatile oils.18 DGL ameliorates gastrointestinal inflammation by stimulating mucosal blood supply and increasing mucous-producing cell concentrations and activity.1,18 This subsequently promotes intestinal tissue repair, proliferation and healing to occur when chronic gastrointestinal inflammation is present.1,18\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMastic\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eMastic gum (Pistacia lentiscus) has been used traditionally for over 2500 years, with records of its’ therapeutic use for stomach and intestinal disorders dating back to ancient Greek times.2,19,20 The primary active part of mastic gum is the unique natural polymer, comprising of constituents including volatile and active compounds, terpenic acids, phytosterols and polyphenols.2,20 Mastic gum has demonstrated significant anti-inflammatory effects (downregulating pro-inflammatory factors such as nitric oxide, prostaglandins E2, nuclear- factor Kappa B, tumour necrosis-factor-α, C-reactive protein, ICAM-1, IL-6, IL-8) and inhibiting macrophage migration and chemotaxis). Mastic gum also supports wound healing by ameliorating histological damage.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eZinc carnosine\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eOptimal endogenous zinc levels in the body are important for supporting gastrointestinal structure, function and repair, with deficiency associated with adverse effects on villi height and size, crypt cell number and depth, mucosal cell apoptosis, intestinal barrier integrity and function and local immune activity.\u003c\/p\u003e\n\u003cp\u003eZinc carnosine, also known as polaprezinc, is a chelated combination of zinc and L-carnosine that directly supports gastrointestinal health by protecting the gastric mucosa, restoring the gastric lining affected by intestinal damage.\u003c\/p\u003e\n\u003cp\u003eThese effects are attributed to several mechanisms including anti-inflammatory (inhibiting nuclear factor kappa-B); antioxidant (increasing superoxide dismutase-1, superoxide dismutase-2, hemeoxygenase-1, peroxiredoxin-1, and peroxiredoxin-V); and wound healing (increasing vascular endothelial growth factor, nerve growth factor, and platelet- derived growth factor, stimulating epithelial cell migration and proliferation, inhibiting mucosal injury).\u003c\/p\u003e\n\u003cp\u003eGastroMend HP includes botanical extracts traditionally used in Western herbal medicine to help soothe and relieve mild inflammation of the gastrointestinal tract. A combination of Chios Mastic gum, Zinc carnosine (polaprezinc), liquorice and vitamin C.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients (per vegetarian hard capsule)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlycyrrhiza glabra (DGL Liquorice) root extract std\u003c\/td\u003e\n\u003ctd\u003e46.88mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003emin. equiv. dry\u003c\/td\u003e\n\u003ctd\u003e375mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. glycyrrhizin NMT\u003c\/td\u003e\n\u003ctd\u003e700micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMastic\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePolaprezinc (zinc carnosine)\u003c\/td\u003e\n\u003ctd\u003e18.78mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. zinc\u003c\/td\u003e\n\u003ctd\u003e4mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (vitamin C)\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eHypromellose Purified water\u003c\/p\u003e\n\u003cp\u003eMagnesium stearate Microcrystalline cellulose\u003c\/p\u003e\n\u003cp\u003eMaltodextrin Silicon dioxide\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eNo added: Gluten, dairy, lactose, seeds or nuts\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003e\u0026lt;Content for Warnings from Info sheet Warnings\u0026gt;\u003c\/p\u003e\n\u003ch5\u003ePrescribing Information\u003c\/h5\u003e\n\u003ch2\u003ePrescribing Information: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eThe DGL form of liquorice is considered a safer form that is less likely to result in drug interactions.1\u003c\/li\u003e\n\u003cli\u003eCaution is advised with use of liquorice in individuals with hypertension, fluid retention, male impotence, infertility or reduced libido.1\u003c\/li\u003e\n\u003cli\u003eUse of liquorice for more than 2 weeks at therapeutic doses should be monitored due to potential side effects.1\u003c\/li\u003e\n\u003cli\u003eLiquorice is contraindicated in individuals with hypotonia, severe renal insufficiency, hypokalaemia, liver cirrhosis and cholestatic liver disease.1\u003c\/li\u003e\n\u003cli\u003eCaution is advised regarding use of vitamin C in individuals with iron overload sensitivities including erythrocyte glucose-6-phosphate dehydrogenase deficiency, haemochromatosis, thalassaemia major or sideroblastic anaemia.1\u003c\/li\u003e\n\u003cli\u003eCaution is advised with concomitant use of zinc with amiloride, as it reduces zinc excretion and may lead to zinc overload.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-03-02T11:14:12+11:00","created_at":"2022-03-01T19:00:51+11:00","vendor":"Designs For Health","type":"Designs For Health Naturopathic Medicines","tags":["Designs For Health","Naturopathic"],"price":3951,"price_min":3951,"price_max":3951,"available":true,"price_varies":false,"compare_at_price":4395,"compare_at_price_min":4395,"compare_at_price_max":4395,"compare_at_price_varies":false,"variants":[{"id":42520808030438,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"DesignsForHealthGastroMendHP60caps","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Designs For Health GastroMend HP 60 caps","public_title":null,"options":["Default Title"],"price":3951,"weight":0,"compare_at_price":4395,"inventory_quantity":10000,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9353993000061"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/DesignsForHealthGastroMendHP60caps10_offRRPatHealthMastersDesignsForHealth.jpg?v=1646179863","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/DesignsForHealthLogo.jpg?v=1646181415"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/DesignsForHealthGastroMendHP60caps10_offRRPatHealthMastersDesignsForHealth.jpg?v=1646179863","options":["Title"],"media":[{"alt":"Designs For Health GastroMend HP 60 caps 10% off RRP at HealthMasters Designs For 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Logo","id":29451400413414,"position":2,"preview_image":{"aspect_ratio":2.5,"height":142,"width":355,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/DesignsForHealthLogo.jpg?v=1646181415"},"aspect_ratio":2.5,"height":142,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/DesignsForHealthLogo.jpg?v=1646181415","width":355}],"content":"\u003ch2\u003eDesigns For Health GastroMend HP 60 caps\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eIncludes liquorice, traditionally used in Western herbal medicine to help relieve mild gastrointestinal tract inflammation\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60 capsules\u003c\/p\u003e\n\u003cp\u003eOverview of Designs For Health GastroMend HP:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAssisting in the reduction of mild gastrointestinal tract inflammation\u003c\/li\u003e\n\u003cli\u003eSupports gastrointestinal system health\u003c\/li\u003e\n\u003cli\u003eSupports connective tissue\u003c\/li\u003e\n\u003cli\u003eAntioxidant support\u003c\/li\u003e\n\u003cli\u003eVegan friendly\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health GastroMend HP does not contain Gluten, dairy, lactose, seeds or nuts.\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 4 capsules per day, or as directed by your healthcare professional\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Follow the directions for use. If symptoms persist, worsen, or change unexpectedly, talk to your health professional. This medicine may not be right for you. Read the warnings before purchase.\u003c\/p\u003e\n\u003ch5\u003eDetails\u003c\/h5\u003e\n\u003ch2\u003eDescription: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eInflammation, acute or chronic, is an important part of the immune system’s functional response. However, chronic gastrointestinal inflammation, where there is an imbalance between pro-and anti-inflammatory factors, underlies\/causes a broad range of local and extra-intestinal clinical symptoms and pathologies.\u003c\/p\u003e\n\u003cp\u003eLocally, gastrointestinal inflammation can induce abdominal pain, distention, cramping, altered motility, impaired intestinal barrier integrity, microbial dysbiosis and nerve dysfunction.4,5 Currently known extra-intestinal consequences of gastrointestinal inflammation includes neuropsychological (mood, anxiety, cognition); dermatological (atopic dermatitis, psoriasis); metabolic; disturbed sleep; poor oral health; and suboptimal nutritional status (vitamins A, D, K, carotenoids, folate, iron, zinc and selenium).\u003c\/p\u003e\n\u003cp\u003eJust as the endogenous maintenance of intestinal homeostasis involves a complex combination of factors (epithelial barrier function, innate and adaptive immunity, cell migration and autophagy), the aetiology of gastrointestinal inflammation is also complex and involves multiple antecedents. Such antecedents include genetic predisposition, immune dysregulation and responsivity, diet (excessive intake of animal protein, sugar, additives; inadequate intake of fruits, vegetables, fibre), smoking, stress and medications.12-15\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eLiquorice\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eLiquorice (Glycyrrhiza glabra) has a long history of use in Traditional Western Herbal Medicine for supporting gastrointestinal health and reducing mild gastrointestinal inflammation. Deglycyrrhizinated liquorice (DGL) has had the glycyrrhizin compound removed, and this form is used clinically to minimise glycyrrhizin-associated adverse side effects while maintaining the therapeutic properties of liquorice.1,17 The primary active constituents of DGL are flavonoids, with other compounds including isoflavonoids, chalcones, coumarins, triterpenoids, sterols, lignins, amino acids and volatile oils.18 DGL ameliorates gastrointestinal inflammation by stimulating mucosal blood supply and increasing mucous-producing cell concentrations and activity.1,18 This subsequently promotes intestinal tissue repair, proliferation and healing to occur when chronic gastrointestinal inflammation is present.1,18\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMastic\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eMastic gum (Pistacia lentiscus) has been used traditionally for over 2500 years, with records of its’ therapeutic use for stomach and intestinal disorders dating back to ancient Greek times.2,19,20 The primary active part of mastic gum is the unique natural polymer, comprising of constituents including volatile and active compounds, terpenic acids, phytosterols and polyphenols.2,20 Mastic gum has demonstrated significant anti-inflammatory effects (downregulating pro-inflammatory factors such as nitric oxide, prostaglandins E2, nuclear- factor Kappa B, tumour necrosis-factor-α, C-reactive protein, ICAM-1, IL-6, IL-8) and inhibiting macrophage migration and chemotaxis). Mastic gum also supports wound healing by ameliorating histological damage.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eZinc carnosine\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eOptimal endogenous zinc levels in the body are important for supporting gastrointestinal structure, function and repair, with deficiency associated with adverse effects on villi height and size, crypt cell number and depth, mucosal cell apoptosis, intestinal barrier integrity and function and local immune activity.\u003c\/p\u003e\n\u003cp\u003eZinc carnosine, also known as polaprezinc, is a chelated combination of zinc and L-carnosine that directly supports gastrointestinal health by protecting the gastric mucosa, restoring the gastric lining affected by intestinal damage.\u003c\/p\u003e\n\u003cp\u003eThese effects are attributed to several mechanisms including anti-inflammatory (inhibiting nuclear factor kappa-B); antioxidant (increasing superoxide dismutase-1, superoxide dismutase-2, hemeoxygenase-1, peroxiredoxin-1, and peroxiredoxin-V); and wound healing (increasing vascular endothelial growth factor, nerve growth factor, and platelet- derived growth factor, stimulating epithelial cell migration and proliferation, inhibiting mucosal injury).\u003c\/p\u003e\n\u003cp\u003eGastroMend HP includes botanical extracts traditionally used in Western herbal medicine to help soothe and relieve mild inflammation of the gastrointestinal tract. A combination of Chios Mastic gum, Zinc carnosine (polaprezinc), liquorice and vitamin C.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Ingredients (per vegetarian hard capsule)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlycyrrhiza glabra (DGL Liquorice) root extract std\u003c\/td\u003e\n\u003ctd\u003e46.88mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003emin. equiv. dry\u003c\/td\u003e\n\u003ctd\u003e375mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. glycyrrhizin NMT\u003c\/td\u003e\n\u003ctd\u003e700micrograms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMastic\u003c\/td\u003e\n\u003ctd\u003e250mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePolaprezinc (zinc carnosine)\u003c\/td\u003e\n\u003ctd\u003e18.78mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. zinc\u003c\/td\u003e\n\u003ctd\u003e4mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAscorbic acid (vitamin C)\u003c\/td\u003e\n\u003ctd\u003e125mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eHypromellose Purified water\u003c\/p\u003e\n\u003cp\u003eMagnesium stearate Microcrystalline cellulose\u003c\/p\u003e\n\u003cp\u003eMaltodextrin Silicon dioxide\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003eNo added: Gluten, dairy, lactose, seeds or nuts\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cp\u003e\u0026lt;Content for Warnings from Info sheet Warnings\u0026gt;\u003c\/p\u003e\n\u003ch5\u003ePrescribing Information\u003c\/h5\u003e\n\u003ch2\u003ePrescribing Information: Designs For Health GastroMend HP\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eThe DGL form of liquorice is considered a safer form that is less likely to result in drug interactions.1\u003c\/li\u003e\n\u003cli\u003eCaution is advised with use of liquorice in individuals with hypertension, fluid retention, male impotence, infertility or reduced libido.1\u003c\/li\u003e\n\u003cli\u003eUse of liquorice for more than 2 weeks at therapeutic doses should be monitored due to potential side effects.1\u003c\/li\u003e\n\u003cli\u003eLiquorice is contraindicated in individuals with hypotonia, severe renal insufficiency, hypokalaemia, liver cirrhosis and cholestatic liver disease.1\u003c\/li\u003e\n\u003cli\u003eCaution is advised regarding use of vitamin C in individuals with iron overload sensitivities including erythrocyte glucose-6-phosphate dehydrogenase deficiency, haemochromatosis, thalassaemia major or sideroblastic anaemia.1\u003c\/li\u003e\n\u003cli\u003eCaution is advised with concomitant use of zinc with amiloride, as it reduces zinc excretion and may lead to zinc overload.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- \/TABS --\u003e"}

Designs For Health GastroMend HP 60 caps

Product Details

Designs For Health GastroMend HP 60 caps

Includes liquorice, traditionally used in Western herbal medicine to help relieve mild gastrointestinal tract inflammation

Size: 60 capsules

Overview of Designs For Health GastroMend HP:

  • Assisting in the reduction of mild gastrointestinal tract inflammation
  • Supports gastrointestinal system health
  • Supports connective tissue
  • Antioxidant support
  • Vegan friendly

    Designs For Health GastroMend HP does not contain Gluten, dairy, lactose, seeds or nuts.

    Directions: Designs For Health GastroMend HP

    Adults: Take 4 capsules per day, or as directed by your healthcare professional

    Always read the label. Follow the directions for use. If symptoms persist, worsen, or change unexpectedly, talk to your health professional. This medicine may not be right for you. Read the warnings before purchase.

    Description: Designs For Health GastroMend HP

    Inflammation, acute or chronic, is an important part of the immune system’s functional response. However, chronic gastrointestinal inflammation, where there is an imbalance between pro-and anti-inflammatory factors, underlies/causes a broad range of local and extra-intestinal clinical symptoms and pathologies.

    Locally, gastrointestinal inflammation can induce abdominal pain, distention, cramping, altered motility, impaired intestinal barrier integrity, microbial dysbiosis and nerve dysfunction.4,5 Currently known extra-intestinal consequences of gastrointestinal inflammation includes neuropsychological (mood, anxiety, cognition); dermatological (atopic dermatitis, psoriasis); metabolic; disturbed sleep; poor oral health; and suboptimal nutritional status (vitamins A, D, K, carotenoids, folate, iron, zinc and selenium).

    Just as the endogenous maintenance of intestinal homeostasis involves a complex combination of factors (epithelial barrier function, innate and adaptive immunity, cell migration and autophagy), the aetiology of gastrointestinal inflammation is also complex and involves multiple antecedents. Such antecedents include genetic predisposition, immune dysregulation and responsivity, diet (excessive intake of animal protein, sugar, additives; inadequate intake of fruits, vegetables, fibre), smoking, stress and medications.12-15

    Liquorice

    Liquorice (Glycyrrhiza glabra) has a long history of use in Traditional Western Herbal Medicine for supporting gastrointestinal health and reducing mild gastrointestinal inflammation. Deglycyrrhizinated liquorice (DGL) has had the glycyrrhizin compound removed, and this form is used clinically to minimise glycyrrhizin-associated adverse side effects while maintaining the therapeutic properties of liquorice.1,17 The primary active constituents of DGL are flavonoids, with other compounds including isoflavonoids, chalcones, coumarins, triterpenoids, sterols, lignins, amino acids and volatile oils.18 DGL ameliorates gastrointestinal inflammation by stimulating mucosal blood supply and increasing mucous-producing cell concentrations and activity.1,18 This subsequently promotes intestinal tissue repair, proliferation and healing to occur when chronic gastrointestinal inflammation is present.1,18

    Mastic

    Mastic gum (Pistacia lentiscus) has been used traditionally for over 2500 years, with records of its’ therapeutic use for stomach and intestinal disorders dating back to ancient Greek times.2,19,20 The primary active part of mastic gum is the unique natural polymer, comprising of constituents including volatile and active compounds, terpenic acids, phytosterols and polyphenols.2,20 Mastic gum has demonstrated significant anti-inflammatory effects (downregulating pro-inflammatory factors such as nitric oxide, prostaglandins E2, nuclear- factor Kappa B, tumour necrosis-factor-α, C-reactive protein, ICAM-1, IL-6, IL-8) and inhibiting macrophage migration and chemotaxis). Mastic gum also supports wound healing by ameliorating histological damage.

    Zinc carnosine

    Optimal endogenous zinc levels in the body are important for supporting gastrointestinal structure, function and repair, with deficiency associated with adverse effects on villi height and size, crypt cell number and depth, mucosal cell apoptosis, intestinal barrier integrity and function and local immune activity.

    Zinc carnosine, also known as polaprezinc, is a chelated combination of zinc and L-carnosine that directly supports gastrointestinal health by protecting the gastric mucosa, restoring the gastric lining affected by intestinal damage.

    These effects are attributed to several mechanisms including anti-inflammatory (inhibiting nuclear factor kappa-B); antioxidant (increasing superoxide dismutase-1, superoxide dismutase-2, hemeoxygenase-1, peroxiredoxin-1, and peroxiredoxin-V); and wound healing (increasing vascular endothelial growth factor, nerve growth factor, and platelet- derived growth factor, stimulating epithelial cell migration and proliferation, inhibiting mucosal injury).

    GastroMend HP includes botanical extracts traditionally used in Western herbal medicine to help soothe and relieve mild inflammation of the gastrointestinal tract. A combination of Chios Mastic gum, Zinc carnosine (polaprezinc), liquorice and vitamin C.

    Ingredients: Designs For Health GastroMend HP

    Active Ingredients (per vegetarian hard capsule)
    Glycyrrhiza glabra (DGL Liquorice) root extract std 46.88mg
    min. equiv. dry 375mg
    equiv. glycyrrhizin NMT 700micrograms
    Mastic 250mg
    Polaprezinc (zinc carnosine) 18.78mg
    equiv. zinc 4mg
    Ascorbic acid (vitamin C) 125mg

    Excipients: Designs For Health GastroMend HP

    Hypromellose Purified water

    Magnesium stearate Microcrystalline cellulose

    Maltodextrin Silicon dioxide

    Allergen Information: Designs For Health GastroMend HP

    No added: Gluten, dairy, lactose, seeds or nuts

    Warnings: Designs For Health GastroMend HP

    <Content for Warnings from Info sheet Warnings>

    Prescribing Information: Designs For Health GastroMend HP

    • The DGL form of liquorice is considered a safer form that is less likely to result in drug interactions.1
    • Caution is advised with use of liquorice in individuals with hypertension, fluid retention, male impotence, infertility or reduced libido.1
    • Use of liquorice for more than 2 weeks at therapeutic doses should be monitored due to potential side effects.1
    • Liquorice is contraindicated in individuals with hypotonia, severe renal insufficiency, hypokalaemia, liver cirrhosis and cholestatic liver disease.1
    • Caution is advised regarding use of vitamin C in individuals with iron overload sensitivities including erythrocyte glucose-6-phosphate dehydrogenase deficiency, haemochromatosis, thalassaemia major or sideroblastic anaemia.1
    • Caution is advised with concomitant use of zinc with amiloride, as it reduces zinc excretion and may lead to zinc overload.

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