{"id":8115256066278,"title":"Designs For Health Curcum-Evail","handle":"designs-for-health-curcum-evail","description":"\u003ch2\u003eDesigns For Health Curcum-Evail\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eHighly concentrated and bioavailable  form of curcumin\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSize: 60 Soft Capsules    Servings: 30-60 serves\u003c\/p\u003e\n\u003cp\u003eDesigns For Health Curcum-Evail Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvides the equivalent of 26 g of curcumin rhizome per capsule\u003c\/li\u003e\n\u003cli\u003eStandardised to 380 mg of curcuminoids per capsule\u003c\/li\u003e\n\u003cli\u003eEvail Technology delivery system for optimal absorption\u003c\/li\u003e\n\u003cli\u003eAntioxidant support\u003c\/li\u003e\n\u003cli\u003eRelieves inflammation\u003c\/li\u003e\n\u003cli\u003eHelps maintain joint health\u003c\/li\u003e\n\u003cli\u003eSupports healthy digestion\u003c\/li\u003e\n\u003cli\u003eMaintains healthy blood lipids\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health Curcum-Evail has No added: Gluten, Soy, Dairy, Seeds, Nuts, Egg, Yeast, Sesame\u003c\/p\u003e\n\u003cp\u003eFree From: Artificial Colours, Artificial Flavours, Sorbates\u003c\/p\u003e\n\u003cp\u003eDesigns For Health Curcum-Evail AUST L 369992\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eAdults: take 1-2 capsules per day or as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive ingredients per soft capsule:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCurcuma Longa extract (C3 extract)\u003c\/td\u003e\n\u003ctd\u003e400mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv to minimum dry rhizome\u003c\/td\u003e\n\u003ctd\u003e26g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandardised to curcuminoids\u003c\/td\u003e\n\u003ctd\u003e380mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCurcuma longa essential oil\u003c\/td\u003e\n\u003ctd\u003e320mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv to dry rhizome\u003c\/td\u003e\n\u003ctd\u003e6.4g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eMedium chain triglycerides Bixa orellana (Annatto) seed Quillaja powder Gelatin Glycerol Purified water\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eNo added: Gluten, Soy, Dairy, Seeds, Nuts, Egg, Yeast, Sesame\u003c\/p\u003e\n\u003cp\u003eFree From: Artificial Colours, Artificial Flavours, Sorbates\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePrescribing Considerations\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1. Cautions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOral ingestion of concentrated curcumin extracts may theoretically increase the risk of bleeding. It is recommended to cease use at least 1 week prior to surgery and caution is advised regarding concomitant use with antiplatelet or anticoagulant medications.\u003cbr\u003eShould only be used in individuals with gallstones following advice from a health professional.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e2. Contraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe concomitant use of curcumin with cyclophosphamide in breast cancer patients is contraindicated.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist, seek the advice of a healthcare professional\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eStore below 25°C away from direct sunlight.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eCurcuma longa (turmeric) is a perennial, rhizomatous leafy plant (Curcuma longa) of the ginger (zingiberaceae) family that grows predominantly in tropical and subtropical Asian countries including India and China. Curcumin is the main biologically active curcuminoid constituent naturally occurring in turmeric roots and rhizomes that together with two curcuminoids (demethoxycurcumin and bis-demethoxycurcumin) and essential oils are responsible for the herb’s therapeutic effects. Other therapeutically relevant constituents in curcumin are turmerones and tetrahydrocurcumin (THC). Turmerones are essential oil constituents with properties that may also enhance the intestinal absorption of curcumin, while THC is a metabolite with significant antioxidant activity synthesized following the metabolism of curcumin by gastrointestinal bacteria. Every batch of Curcum-Evail tests for THC. Both turmeric and curcumin have been used extensively in traditional Chinese, Ayurvedic and Western herbal medicinal paradigms for many medicinal purposes including inflammatory conditions, pain, swelling, digestive and hepatic disturbances, wound healing, immune support and as an antioxidant.\u003c\/p\u003e\n\u003ch3\u003eEvail Technology\u003c\/h3\u003e\n\u003cp\u003eIn its raw state, curcumin is a lipophilic constituent and consequently has very low bioavailability, solubility, absorption and tissue distribution and is rapidly eliminated. Enabling curcumin’s full therapeutic potential requires appropriate modification to enhance such bioavailability and absorption while retaining its natural medicinal properties. Curcum-Evail™ is manufactured using the Designs for Health’s Evail™ technology, which is an all-natural formulation that improves the absorption and delivery of curcumin. This process uses a proprietary blend of sustainable MCT oils, Quillaja and Annatto Tocotrienols without the use of potentially harmful surfactants.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eJoint health \u0026amp; Anti-inflammatory support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOsteoarthritis is a common degenerative joint condition defined by the breakdown of cartilage and bone with inflammation, pain and loss of mobility occurring within joints throughout the body. Consequently, clinical management of osteoarthritis mainly requires targeting inflammation to help alleviate associated mild pain and joint mobility symptoms. Curcumin has been shown to be effective for improving mild pain and mobility parameters in osteoarthritis subjects. This is attributed to curcumin’s significant modulation of several inflammatory mediators (inhibiting activation, translocation, gene expression and activity) including NF-kB and toll-like receptor-4 pathways, subsequently reducing the synthesis and activity of a broad range of inflammatory cytokines, protein kinases and adhesion molecules (e.g. tumour-necrosis factor-alpha, interleukins, phospholipase A2, cyclo-oxygenase-2, 5-lipooxygenase activity, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase and monocyte chemoattractant protein-1, hs-C-reactive protein). Curcumin’s antioxidant mechanisms are also involved in supporting the management of osteoarthritic symptoms and support joint health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntioxidant support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCurcumin is known as a lipid-soluble antioxidant, reducing free radical damage to cells. Lipid soluble antioxidants work via several mechanisms; via directly scavenging and neutralising several forms of reactive oxygen, nitrogen and peroxyl radical species and via inducing endogenous antioxidant enzyme activity and levels (glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and catalase) and activates Nrf2 signalling pathways.\u003c\/p\u003e\n\u003cp\u003eCombined with Designs for Health Evail Technology for improved absorption and delivery. Helps to relieve inflammation and may assist in relieving symptoms of mild arthritis and maintaining joint health. Provides antioxidant support and assists in maintaining general health and wellbeing.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2023-01-19T18:38:24+11:00","created_at":"2023-01-19T18:14:13+11:00","vendor":"Designs For Health","type":"Designs For Health Naturopathic Medicines","tags":["Designs For Health","Naturopathic"],"price":4586,"price_min":4586,"price_max":4586,"available":true,"price_varies":false,"compare_at_price":5095,"compare_at_price_min":5095,"compare_at_price_max":5095,"compare_at_price_varies":false,"variants":[{"id":43621467881702,"title":"60 Capsules","option1":"60 Capsules","option2":null,"option3":null,"sku":"DFHCurcum-Evail60C","requires_shipping":true,"taxable":true,"featured_image":{"id":39100616114406,"product_id":8115256066278,"position":1,"created_at":"2023-01-19T18:32:38+11:00","updated_at":"2023-01-19T18:33:14+11:00","alt":"Designs For Health Curcum-Evail 60 Capsules 10% off RRP at HealthMasters Designs For 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capsule\u003c\/li\u003e\n\u003cli\u003eEvail Technology delivery system for optimal absorption\u003c\/li\u003e\n\u003cli\u003eAntioxidant support\u003c\/li\u003e\n\u003cli\u003eRelieves inflammation\u003c\/li\u003e\n\u003cli\u003eHelps maintain joint health\u003c\/li\u003e\n\u003cli\u003eSupports healthy digestion\u003c\/li\u003e\n\u003cli\u003eMaintains healthy blood lipids\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp\u003eDesigns For Health Curcum-Evail has No added: Gluten, Soy, Dairy, Seeds, Nuts, Egg, Yeast, Sesame\u003c\/p\u003e\n\u003cp\u003eFree From: Artificial Colours, Artificial Flavours, Sorbates\u003c\/p\u003e\n\u003cp\u003eDesigns For Health Curcum-Evail AUST L 369992\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eAdults: take 1-2 capsules per day or as directed by your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive ingredients per soft capsule:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCurcuma Longa extract (C3 extract)\u003c\/td\u003e\n\u003ctd\u003e400mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv to minimum dry rhizome\u003c\/td\u003e\n\u003ctd\u003e26g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandardised to curcuminoids\u003c\/td\u003e\n\u003ctd\u003e380mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCurcuma longa essential oil\u003c\/td\u003e\n\u003ctd\u003e320mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquiv to dry rhizome\u003c\/td\u003e\n\u003ctd\u003e6.4g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eMedium chain triglycerides Bixa orellana (Annatto) seed Quillaja powder Gelatin Glycerol Purified water\u003c\/p\u003e\n\u003ch5\u003eAllergen Information\u003c\/h5\u003e\n\u003ch2\u003eAllergen Information: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eNo added: Gluten, Soy, Dairy, Seeds, Nuts, Egg, Yeast, Sesame\u003c\/p\u003e\n\u003cp\u003eFree From: Artificial Colours, Artificial Flavours, Sorbates\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePrescribing Considerations\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1. Cautions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOral ingestion of concentrated curcumin extracts may theoretically increase the risk of bleeding. It is recommended to cease use at least 1 week prior to surgery and caution is advised regarding concomitant use with antiplatelet or anticoagulant medications.\u003cbr\u003eShould only be used in individuals with gallstones following advice from a health professional.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e2. Contraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe concomitant use of curcumin with cyclophosphamide in breast cancer patients is contraindicated.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIf symptoms persist, seek the advice of a healthcare professional\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eStore below 25°C away from direct sunlight.\u003c\/p\u003e\n\u003ch5\u003eEducation\u003c\/h5\u003e\n\u003ch2\u003eEducation: Designs For Health Curcum-Evail\u003c\/h2\u003e\n\u003cp\u003eCurcuma longa (turmeric) is a perennial, rhizomatous leafy plant (Curcuma longa) of the ginger (zingiberaceae) family that grows predominantly in tropical and subtropical Asian countries including India and China. Curcumin is the main biologically active curcuminoid constituent naturally occurring in turmeric roots and rhizomes that together with two curcuminoids (demethoxycurcumin and bis-demethoxycurcumin) and essential oils are responsible for the herb’s therapeutic effects. Other therapeutically relevant constituents in curcumin are turmerones and tetrahydrocurcumin (THC). Turmerones are essential oil constituents with properties that may also enhance the intestinal absorption of curcumin, while THC is a metabolite with significant antioxidant activity synthesized following the metabolism of curcumin by gastrointestinal bacteria. Every batch of Curcum-Evail tests for THC. Both turmeric and curcumin have been used extensively in traditional Chinese, Ayurvedic and Western herbal medicinal paradigms for many medicinal purposes including inflammatory conditions, pain, swelling, digestive and hepatic disturbances, wound healing, immune support and as an antioxidant.\u003c\/p\u003e\n\u003ch3\u003eEvail Technology\u003c\/h3\u003e\n\u003cp\u003eIn its raw state, curcumin is a lipophilic constituent and consequently has very low bioavailability, solubility, absorption and tissue distribution and is rapidly eliminated. Enabling curcumin’s full therapeutic potential requires appropriate modification to enhance such bioavailability and absorption while retaining its natural medicinal properties. Curcum-Evail™ is manufactured using the Designs for Health’s Evail™ technology, which is an all-natural formulation that improves the absorption and delivery of curcumin. This process uses a proprietary blend of sustainable MCT oils, Quillaja and Annatto Tocotrienols without the use of potentially harmful surfactants.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eJoint health \u0026amp; Anti-inflammatory support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOsteoarthritis is a common degenerative joint condition defined by the breakdown of cartilage and bone with inflammation, pain and loss of mobility occurring within joints throughout the body. Consequently, clinical management of osteoarthritis mainly requires targeting inflammation to help alleviate associated mild pain and joint mobility symptoms. Curcumin has been shown to be effective for improving mild pain and mobility parameters in osteoarthritis subjects. This is attributed to curcumin’s significant modulation of several inflammatory mediators (inhibiting activation, translocation, gene expression and activity) including NF-kB and toll-like receptor-4 pathways, subsequently reducing the synthesis and activity of a broad range of inflammatory cytokines, protein kinases and adhesion molecules (e.g. tumour-necrosis factor-alpha, interleukins, phospholipase A2, cyclo-oxygenase-2, 5-lipooxygenase activity, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase and monocyte chemoattractant protein-1, hs-C-reactive protein). Curcumin’s antioxidant mechanisms are also involved in supporting the management of osteoarthritic symptoms and support joint health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntioxidant support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCurcumin is known as a lipid-soluble antioxidant, reducing free radical damage to cells. Lipid soluble antioxidants work via several mechanisms; via directly scavenging and neutralising several forms of reactive oxygen, nitrogen and peroxyl radical species and via inducing endogenous antioxidant enzyme activity and levels (glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and catalase) and activates Nrf2 signalling pathways.\u003c\/p\u003e\n\u003cp\u003eCombined with Designs for Health Evail Technology for improved absorption and delivery. Helps to relieve inflammation and may assist in relieving symptoms of mild arthritis and maintaining joint health. Provides antioxidant support and assists in maintaining general health and wellbeing.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}

Designs For Health Curcum-Evail

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Product Details

Designs For Health Curcum-Evail

Highly concentrated and bioavailable  form of curcumin

Size: 60 Soft Capsules    Servings: 30-60 serves

Designs For Health Curcum-Evail Summary:

  • Provides the equivalent of 26 g of curcumin rhizome per capsule
  • Standardised to 380 mg of curcuminoids per capsule
  • Evail Technology delivery system for optimal absorption
  • Antioxidant support
  • Relieves inflammation
  • Helps maintain joint health
  • Supports healthy digestion
  • Maintains healthy blood lipids

    Designs For Health Curcum-Evail has No added: Gluten, Soy, Dairy, Seeds, Nuts, Egg, Yeast, Sesame

    Free From: Artificial Colours, Artificial Flavours, Sorbates

    Designs For Health Curcum-Evail AUST L 369992

    Directions: Designs For Health Curcum-Evail

    Adults: take 1-2 capsules per day or as directed by your healthcare professional.

    Ingredients: Designs For Health Curcum-Evail

    Active ingredients per soft capsule:
    Curcuma Longa extract (C3 extract) 400mg
    Equiv to minimum dry rhizome 26g
    Standardised to curcuminoids 380mg
    Curcuma longa essential oil 320mg
    Equiv to dry rhizome 6.4g

    Excipients: Designs For Health Curcum-Evail

    Medium chain triglycerides Bixa orellana (Annatto) seed Quillaja powder Gelatin Glycerol Purified water

    Allergen Information: Designs For Health Curcum-Evail

    No added: Gluten, Soy, Dairy, Seeds, Nuts, Egg, Yeast, Sesame

    Free From: Artificial Colours, Artificial Flavours, Sorbates

    Warnings: Designs For Health Curcum-Evail

    Prescribing Considerations

    1. Cautions:

    Oral ingestion of concentrated curcumin extracts may theoretically increase the risk of bleeding. It is recommended to cease use at least 1 week prior to surgery and caution is advised regarding concomitant use with antiplatelet or anticoagulant medications.
    Should only be used in individuals with gallstones following advice from a health professional.

    2. Contraindications:

    The concomitant use of curcumin with cyclophosphamide in breast cancer patients is contraindicated.

    Warnings:

    If symptoms persist, seek the advice of a healthcare professional

    Storage: Designs For Health Curcum-Evail

    Store below 25°C away from direct sunlight.

    Education: Designs For Health Curcum-Evail

    Curcuma longa (turmeric) is a perennial, rhizomatous leafy plant (Curcuma longa) of the ginger (zingiberaceae) family that grows predominantly in tropical and subtropical Asian countries including India and China. Curcumin is the main biologically active curcuminoid constituent naturally occurring in turmeric roots and rhizomes that together with two curcuminoids (demethoxycurcumin and bis-demethoxycurcumin) and essential oils are responsible for the herb’s therapeutic effects. Other therapeutically relevant constituents in curcumin are turmerones and tetrahydrocurcumin (THC). Turmerones are essential oil constituents with properties that may also enhance the intestinal absorption of curcumin, while THC is a metabolite with significant antioxidant activity synthesized following the metabolism of curcumin by gastrointestinal bacteria. Every batch of Curcum-Evail tests for THC. Both turmeric and curcumin have been used extensively in traditional Chinese, Ayurvedic and Western herbal medicinal paradigms for many medicinal purposes including inflammatory conditions, pain, swelling, digestive and hepatic disturbances, wound healing, immune support and as an antioxidant.

    Evail Technology

    In its raw state, curcumin is a lipophilic constituent and consequently has very low bioavailability, solubility, absorption and tissue distribution and is rapidly eliminated. Enabling curcumin’s full therapeutic potential requires appropriate modification to enhance such bioavailability and absorption while retaining its natural medicinal properties. Curcum-Evail™ is manufactured using the Designs for Health’s Evail™ technology, which is an all-natural formulation that improves the absorption and delivery of curcumin. This process uses a proprietary blend of sustainable MCT oils, Quillaja and Annatto Tocotrienols without the use of potentially harmful surfactants.

    Joint health & Anti-inflammatory support

    Osteoarthritis is a common degenerative joint condition defined by the breakdown of cartilage and bone with inflammation, pain and loss of mobility occurring within joints throughout the body. Consequently, clinical management of osteoarthritis mainly requires targeting inflammation to help alleviate associated mild pain and joint mobility symptoms. Curcumin has been shown to be effective for improving mild pain and mobility parameters in osteoarthritis subjects. This is attributed to curcumin’s significant modulation of several inflammatory mediators (inhibiting activation, translocation, gene expression and activity) including NF-kB and toll-like receptor-4 pathways, subsequently reducing the synthesis and activity of a broad range of inflammatory cytokines, protein kinases and adhesion molecules (e.g. tumour-necrosis factor-alpha, interleukins, phospholipase A2, cyclo-oxygenase-2, 5-lipooxygenase activity, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase and monocyte chemoattractant protein-1, hs-C-reactive protein). Curcumin’s antioxidant mechanisms are also involved in supporting the management of osteoarthritic symptoms and support joint health.

    Antioxidant support

    Curcumin is known as a lipid-soluble antioxidant, reducing free radical damage to cells. Lipid soluble antioxidants work via several mechanisms; via directly scavenging and neutralising several forms of reactive oxygen, nitrogen and peroxyl radical species and via inducing endogenous antioxidant enzyme activity and levels (glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and catalase) and activates Nrf2 signalling pathways.

    Combined with Designs for Health Evail Technology for improved absorption and delivery. Helps to relieve inflammation and may assist in relieving symptoms of mild arthritis and maintaining joint health. Provides antioxidant support and assists in maintaining general health and wellbeing.

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