Bioclinic Naturals Zinc Citrate 90tabs

Benefits

• Bioclinic Naturals Zinc Citrate provides a high dose of a well-absorbed form of zinc to support optimal levels of zinc in the body.

• It has been specifically formulated as a single active dose tablet that provides a highly bioavailable and efficacious form of zinc.

• This simple and focused formulation can be added to therapeutic treatment plans to promote optimal levels of zinc in the body for healthy immune, reproductive, antioxidant, cognitive, nervous system and skin health as well as the healthy metabolism of carbohydrates and protein.

Recommended Dosage

Adults:

1 tablet per day or as directed by a health care practitioner.

Medicinal Ingredients

Excipients

Contains sulfites

Product Summary

Bioclinic Naturals Zinc Citrate provides a high dose of a well-absorbed form of zinc to support optimal levels of zinc in the body. It has been specifically formulated as a singleactive dose tablet that provides a highly bioavailable and efficacious form of zinc. This simple and focused formulation can be added to therapeutic treatment plans to promote optimal levels of zinc in the body for healthy immune, reproductive, antioxidant, cognitive, nervous system and skin health as well as the healthy metabolism of carbohydrates and protein.

CLINICAL EVIDENCE

Zinc is a vital trace mineral required for many structural, catalytic and regulatory roles and processes, as evidenced by its presence in many body tissues, organs and secretions.1,2 Zinc is the second most abundant trace mineral used by the body, and both the transitional nature of its many biological roles and the absence of an endogenous storage system highlights the importance of an adequate daily intake to maintain optimal levels.1-3 Achieving a maximum level of efficacy following zinc intake requires efficient gastrointestinal absorption, cellular uptake and tissue distribution, and zinc citrate has been observed to be absorbed intracellularly at a higher rate than other salts due to superior solubility and utilisation rates.4

Over the last few decades, suboptimal or deficient zinc levels have become more prevalent, with current estimates that approximately 17% of the world’s population are zinc deficient.1,6,7 In Western countries particularly, marginal deficiency and suboptimal intakes of zinc are more prevalent, which can cause a significant range of clinically relevant health effects.1,7

Several subpopulations are at an increased risk of deficiency, partly due to many potential causal factors including inadequate intake (e.g. vegetarian, vegan or high phytate diets), suboptimal absorption, cellular uptake (e.g. gastrointestinal pathologies as well as high copper intake), poor tissue distribution (e.g. chronic inflammation, obesity), increased endogenous zinc utilisation (e.g. periods of growth or infection, increased loss) or a poorly bioavailable form of zinc used.1,3,7

Antioxidant Support

Zinc has significant antioxidant effects via both direct and indirect mechanisms. It inhibits free radical synthesis, supports cell membrane stability, is a cofactor in antioxidant enzymes including superoxide dismutase and glutathione peroxidase, is involved in metallothionine synthesis and also the upregulation of nuclear factor erythroid 2-related factor 2 (NRF2).1,2,7 This potent antioxidant activity of zinc underlies its role in immune, reproductive and skin health.

Immune Support

Optimal zinc levels are necessary for normal immune system health as a consequence of its significant involvement in several key aspects of immune (humoral and cell-mediated) functionality.7 Specifically, zinc is required for healthy immune cell development, growth and activity (neutrophils, natural killer cells, macrophages, lymphocytes, T and B-cells), immune cell membrane stabilisation, antibody responses and antiinflammatory activity (reducing nuclearfactor kappa-B, tumour-necrosis factor alpha and interleukin-beta).7,8

As a result, zinc deficiency has been observed to significantly impact the capacity of the immune system to function effectively and increase infection susceptibility. Such effects include delayed immune cell growth and development, impaired proliferative response and decreased activity, reduced cytokine secretion and complement activity and increased cell apoptosis.1,8 Clinically, zinc supplementation has shown a beneficial effect in the management of both bacterial and viral infections.6,8

Reproductive Health

Zinc is involved in many aspects of both male and female reproductive health and suboptimal or deficient levels can significantly impair fertility.1,7 In males, optimal levels of zinc are needed for normal sperm synthesis, maturation and function, to protect sperm from oxidative stress and also for prostate health. In females, zinc is involved in hormone synthesis, oocyte maturation, ovulation, foetal growth and breast lactational structural formation.1,7,9 Two separate systematic reviews/meta-analyses found that in infertile males, seminal plasma zinc were significantly lower than those from fertile males, and that zinc increased total sperm concentrations, motility and quality.10,11 In females, low zinc levels can lead to ovulation failure,9 women who had lower zinc levels had a delayed time to pregnancy.12

Skin Health

Zinc is highly concentrated in the epidermis layer of the skin, and is involved in several important roles in maintaining skin health.5 Such roles include cell membrane repair, keratinocyte proliferation and growth and wound healing (coagulation, inhibiting inflammation, immune support, scar formation).1,5,8 Low or deficient levels of zinc have been associated with the onset of skin lesions, impaired wound healing and inflammatory skin conditions.1,13

Warnings

Contains zinc, which may be dangerous if taken in large amounts or for a long period.

If symptoms persist, talk to your health care practitioner.

Advise your doctor of any medicine you take during pregnancy, particularly in your first trimester.

Vitamin and/or mineral supplements should not replace a balanced diet.

References

References available on request.