Bioclinic Naturals Opti B12 5mg

Benefits

Co-methylcobalamin bypasses active absorption routes enabling the restoration of normal B12 levels even in individuals with impaired absorptive capacity1-3

Provides B12 at a dose of 5 mg per day in sublingual tablet format, allowing for a fast-acting delivery system, directly into the bloodstream

Co-methylcobalamin supports sustained B12 levels in the body compared to cyanocobalamin due to decreased urinary excretion4

Suitable for vegetarians

Recommended Use

Adults:

1 tablet (B12 5000ug) per day or as directed by a health care practitioner.

Sublingual is oral delivery dissolved under the tongue, without chewing or swallowing. Absorption is very quick, and higher levels are achieved in the bloodstream by sublingual routes than when swallowed because the sublingual route avoids first-pass metabolism by the liver.

Medicinal Ingredients

Key Features and Benefits

• Helps prevent the dietary B12 deficiency.
• Helps promote body utilisation of vitamin B12.
• Vitamin B12 is a cofactor in enzymatic reactions with diverse physiological functions. It is required for the conversion of methylmalonyl CoA to succinyl CoA, as well as the conversion of homocysteine to methionine by methionine synthase, which is then converted into S-adenosylmethionine. In vitamin B12 deficiency, folate may accumulate in serum as a result of the slowing of the vitamin B12-dependent methyltransferase.5,7
• B12 is required for the synthesis of fatty acids in myelin and for DNA synthesis in conjunction with folate.
• Vitamin B12 lowers homocysteine levels for protective cardiovascular benefits.

Contraindications

Contraindications: Bioclinic Naturals Opti B12

WARNINGS: Vitamins can only be of assistance if the dietary vitamin intake is inadequate.

References

1. Parry TE. Megaloblastic anaemia in the elderly. Baillieres Clin Haematol. 1987 Jun;1(2):315-53.
2. Kim HI, Hyung WJ, Song KJ, Choi SH, Kim CB, Noh SH. Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients. Ann Surg Oncol. 2011 Dec;18(13):371-7.
3. Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther. 2003 Dec;25(12):3124-34.
4. Okuda K, Yashima K, Kitazaki T, et al. Intestinal absorption and concurrent chemical changes of methylcobalamin. J Lab Clin Med 1973;81:557-567.
5. Carmel R, Cobalamin (Vitamin B12) in Shils ME, et. al., eds., Modern Nutrition in Health and Disease, Lippincott Williams and Wilkens, Philadelphia, 2006, 482-497.
6. Wong CW1.Vitamin B12 deficiency in the elderly: is it worth screening? Hong Kong Med J. 2015 Apr;21(2):155-5.
7. Pawlak R, Parrot JS, Raj S et al. Understanding Vitamin B12. Am J Lifestyle Med. 2012 January; 7(1):60-65.