BioActiv HealthCare NMN

Dose

Directions for use as per label

1 scoop contains 600mg-800mg

From the data available on taking NMN supplements. Studies have found health benefits with doses from 250mg of NMN per day, up to a maximum of 1,200mg per day. The medium dose is 600mg to 800mg.

Three studies looked at the effects of taking NMN supplements over multiple doses and safety does not appear to differ across different doses used in the ranges above.

Amateur runners were studied for the aerobic benefits of NMN supplementation. Doses of NMN at 600mg were compared with doses of MNM at 300mg and there was no difference observed in the benefits observed at a high dose of MNM 1200mg compared with a medium dose of 600 mg.

Early studies suggest taking NMN at doses of up to 1,200mg per day may provide health benefits related to insulin sensitivity, aerobic function and fatigue, with minimal risk of undesirable side effects.

While animal studies have found that MNM supplements reversed many age-related health effects, the evidence in humans is still limited.

Ingredients

NMN (Nicotinamide Mono Nucleotide)

Excipients

No artificial colours, flavours, sweeteners or preservatives. No fillers.

Free From

No artificial colours, flavours, sweeteners or preservatives. No fillers.

Storage

Store in a cool dry place below 25°C.

Cautions

• Keep out of reach of children.
• Do not use if tamper evident seal is broken or missing.
• Ensure lid tightly closed after use
• Contains a silica gel sachet. Do not swallow.

Product Information

The following is an excerpt from The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule (Shade C., 2020).

In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.1 The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.4

Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.5 In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8

By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate the synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6

Taken orally, NMN is rapidly absorbed and converted to NAD+.14 In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.16

Shade C. The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integr Med (Encinitas). 2020 Feb;19(1):12-14. PMID: 32549859; PMCID: PMC7238909. Full article and references available on National Library of Medicine

FAQ's

What is nicotinamide mononucleotide (NMN)?

NMN is a naturally occurring molecule that helps produce energy in the body.

NMN is a molecule called a nucleotide. Nucleotides have many roles in the body including the production of DNA.

NMN is converted into another molecule within the cells known as nicotinamide adenine dinucleotide (NAD). Your body needs NAD for a variety of functions involved in metabolism and energy production.

The amount of NAD your body can make depends on the amount of NMN available in your body.

What is the difference between NR, NMN and NAD?

In the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to NAD (Nicotinamide Adenine Dinucleotide).  

The best form to take is NMN (Nicotinamide Mono Nucleotide).

Is it better to take a supplement containing NMN or NAD?

Research has found that taking a supplement containing NMN is better than taking a NAD supplement. This is because NAD is unable to enter the cell because the cells have receptors for NMN but do not have receptors for NAD. So, it is best to take NMN because NMN can enter the cells where it is converted to NAD.

Researchers who study NMN and NAD believe that the goal is to get NAD levels in the cells to levels closer to those levels in our youth.

Why is NMN so important?

All the cells in your body use NAD and NMN is required to make NAD. 

What are the benefits of NAD?

NAD helps cells regulate a number of essential functions in cells, including:

• energy metabolism
• DNA repair
• gene expression
• cellular stress responses
• oxidative stress

Sufficient NMN is essential to produce enough NAD to support cell functions.

How is NMN and NAD related to ageing?

The levels of NMN decline naturally as we age, and, as a result, your NAD levels also decline. This contributes to some of the health effects experienced during ageing.

Low levels of NMN and NAD can be involved in conditions including:

• diabetes
• liver disease
• brain health
• heart health
• longevity
• jet lag
• muscle function and strength
• endurance

Can NMN increase longevity?

In the cells are proteins called Sirtuins that help repair DNA. Sirtuins are linked to longevity.

Is NMN safe, and does it have side effects?

NMN is an ideal supplement to increase cellular levels of NAD. It is well-tolerated, and both human and animal studies have observed it had minimal side effects.

Research in humans has shown that doses of up to 1,200 mg daily are safe to consume.

Is NMN in food?

NMN is found in a variety of foods. Some NMN-rich dietary sources:

avocados - 0.36 to 1.60mg per 100grams

broccoli - 0.25 to 1.12mg per 100grams

cabbage - up to 0.9mg per 100grams

cucumber -  small amounts

cow’s milk -  small amounts

edamame  -  small amounts

tomatoes - 0.26 to 0.30mg per 100grams

raw beef - 0.06 to 0.42mg per 100grams

Studies in mice have found that the gut absorbs NMN readily. More studies are needed to investigate how eating foods containing NMN may increase NAD levels in cells.

Can NMN  help with ageing?

NMN and NAD levels naturally decline with age. Researchers have suggested that taking NMN supplements may help with age-related health concerns.

A study in 10 Japanese men found that taking NMN at 100, 250, or 500mg increased levels of NAD. 

Insulin resistance can develop as we age and is one of the reasons diabetes is more common in older adults. Although studies haven’t specifically looked at the effects of taking NMN supplements, the research available suggests that it may help you maintain or regain insulin sensitivity with age.

More studies on these effects in humans are needed to investigate this potential benefit

Taking NMN supplements has also been shown to reduce drowsiness and improve muscle responsiveness in older adults, which may improve both physical and mental health with age.

The products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.

• BioActiv HealthCare NMN - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop
• Designs For Health NR Supreme - NR (Nicotinamide Riboside Chloride) 300mg per capsule
• RN Labs Nicotinamide Riboside NR - NR (Nicotinamide Riboside Chloride) 300mg per capsule

Note:

In the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).

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