{"id":2270707417147,"title":"Metagenics SulforaClear 60 Capsules","handle":"metagenics-sulforaclear-60-capsules","description":"\u003ch3\u003e\u003cem\u003eBroccoli Seeds And Sprouts With Vitamin C For Detoxification And Antioxidant Support with Nrf2 Activation\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics SulforaClear 60 Capsules\u003c\/h2\u003e\n\u003cp\u003eAvailable in: 60 Capsules (60 days)\u003c\/p\u003e\n\u003cp\u003eMetagenics SulforaClear:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOptimise sulforaphane yield through the combination of glucoraphanin-rich broccoli seeds, and broccoli sprouts with high myrosinase activity.\u003c\/li\u003e\n\u003cli\u003eAssist detoxification processes.\u003c\/li\u003e\n\u003cli\u003eProvide antioxidant support protection against free radical damage.\u003c\/li\u003e\n\u003cli\u003eActivates the nuclear transcription factor Nrf2 and subsequently increasing the expression of cytoprotective genes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics SulforaClear is free from corn Dairy Protein Lactose free Gluten free Soy Protein Free from Nuts and Seeds\u003c\/p\u003e\n\u003cp\u003eMetagenics SulforaClear AUST L 314807\u003c\/p\u003e\n\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003eTake 1 capsule daily with food.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulforaphane has demonstrated far reaching and significant benefits with regard to detoxification, antioxidant support and anti-inflammatory effects in vitro, animal and human models.\u003c\/strong\u003e\u003csup\u003e1,2\u003c\/sup\u003e Through activating the nuclear transcription factor Nrf2 and subsequently increasing the expression of cytoprotective genes, sulforaphane is the most potent, known, naturally occurring inducer of phase II enzymes.\u003csup\u003e3\u003c\/sup\u003e These enzymes are known to play a key role in cellular defence mechanisms, protecting cells against inflammation, oxidative stress and free radical damage,\u003csup\u003e4,5,6\u003c\/sup\u003e in addition to supporting detoxification processes.\u003csup\u003e7,8,9,10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupplementing with one capsule of Metagenics SulforaClear is equivalent to consuming approximately 1¾ cups of fresh broccoli in regards to glucoraphanin intake.\u003c\/strong\u003e This is an important aspect when it comes to ensuring patients experience consistent therapeutic benefits of sulforaphane. Although dietary broccoli is an excellent source of nutrition and yields the highest amount of sulforaphane compared to other cruciferous vegetables, the cooking process reduces myrosinase levels, affecting conversion into sulforaphane (Figure 1).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics SulforaClear uses broccoli material that is grown without the use of herbicides, pesticides or other potentially harmful chemicals.\u003c\/strong\u003e In addition, the seed is tested and cleared for over 400 pesticides (Figure 2).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cimg alt=\"Metagenics SulforaClear Quality Control Process | HealthMasters\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_SulforaClear_Quality_Process_-_HealthMasters_1024x1024.jpg?v=1560718136\" style=\"float: none;\"\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics SulforaClear\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eEach capsule contains:\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eExtracts equivalent to:\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBrassica oleracea var. italica, seed dry (Broccoli)\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e2.0g\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Equivalent Glucoraphanin\u003c\/td\u003e\n\u003ctd\u003e26mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBrassica oleracea var. italica, sprout powder (Broccoli)\u003c\/td\u003e\n\u003ctd\u003e200mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium ascorbate dihydrate\u003c\/td\u003e\n\u003ctd\u003e97mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Equivalent Ascorbic acid (Vitamin C)\u003c\/td\u003e\n\u003ctd\u003e80mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFree from animal products, corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, and soy protein. Free from artificial colours and flavours.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003ch5\u003ePregnancy and Breastfeeding\u003c\/h5\u003e\n\u003ch2\u003ePregnancy and Breastfeeding: Metagenics SulforaClear\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003ePregnancy:\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eA review did not identify any concerns for use during pregnancy, however safety has not been conclusively established in humans. No risks found in humans, although research is limited or unavailable for broccoli.[98]\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003ch3\u003e\n\u003cem\u003eLactation:\u003c\/em\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003cp\u003eSafe to use in breastfeeding.[99]et.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003e[1] Linus Pauling Institute. [Internet]. Oregon (USA). Oregon State University; c2018. Isothiocyanates; 2005 [updated 2017 April; cited 2018 June 29].  Available from: https:\/\/lpi.oregonstate.edu\/mic\/dietary-factors\/phytochemicals\/isothiocyanates#metabolism-bioavailability.\u003c\/p\u003e\n\u003cp\u003e[2] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[3] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[4] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[5] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[6] Ferguson LR. Nutrigenetics, nutrogenomics and inflammatory bowel diseases. Expert Rev. Clin. Immunol. 2013;9(8):717-26.\u003c\/p\u003e\n\u003cp\u003e[7] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[8] Sulforaphane Glucosinolate Monograph. Alt Med Rev. 2010:15(4):352-60.\u003c\/p\u003e\n\u003cp\u003e[9] Tian S, Lei P, Liu X, Zhang X, Shan Y. Microbiota: a mediator to transform glucosinolate precursors in cruciferous vegetables to the active isothiocyanates. J Sci Food Agric. 2017 Sep 4.\u003c\/p\u003e\n\u003cp\u003e[10] Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson K, Talalay P. Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLoS One. 2015 Nov 2;10(11):e0140963.\u003c\/p\u003e\n\u003cp\u003e[11] Botti MG, Taylor MG, Botting NP. Studies on the mechaism of myrosinase. The Journal of Biological Chemistry. 1995;270(35):20530-35.\u003c\/p\u003e\n\u003cp\u003e[12] Hanschen FS, Klopsch R, Oliviero T, Schreiner M, Verkerk R, Dekker M. Optimizing isothiocyanate formation during enzymatic glucosinolate breakdown by adjusting pH value, temperature and dilution in Brassica vegetables and Arabidopsis thaliana. Scientific Reports. 2017:DOI: 10.1038\/srep40807.\u003c\/p\u003e\n\u003cp\u003e[13] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[14] Kansanen E, Kuosmanen SM, Leinonen H, Lenonen AL. The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biology. 2013:1(1):45-9.\u003c\/p\u003e\n\u003cp\u003e[15] Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson K, Talalay P. Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLoS One. 2015 Nov 2;10(11):e0140963.\u003c\/p\u003e\n\u003cp\u003e[16] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[17] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[18] Conzatti A, Telles da Silva Froes, FC, Perry IDS, Guerini de Souza C. Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans. Nutr Hosp. 2015;31(2):559-69.\u003c\/p\u003e\n\u003cp\u003e[19] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[20] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[21] Liska A, Lyon M, Jone DS. Detoxification and biotransformational imbalance. Explore. 2006; 2(2):122-140.\u003c\/p\u003e\n\u003cp\u003e[22] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[23] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.\u003c\/p\u003e\n\u003cp\u003e[24] Schwab M, Reynders V, Loitsch S, Steinhilber D, Schroder O, Stein J. The dietary histone deacetylase inhibitor sulforaphane induces human β-defensin-2 in intestinal epithelial cells. Innumology. 2008;125:241-51.\u003c\/p\u003e\n\u003cp\u003e[25] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.\u003c\/p\u003e\n\u003cp\u003e[26] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.\u003c\/p\u003e\n\u003cp\u003e[27] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.\u003c\/p\u003e\n\u003cp\u003e[28] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.\u003c\/p\u003e\n\u003cp\u003e[29] Dinkova-Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res. 2008;52:S128-38.\u003c\/p\u003e\n\u003cp\u003e[30] Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, et al. Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short term, cross-over clinical trial in Qidong, China. Cancer Prev Res. 2011;4(3):384-95.\u003c\/p\u003e\n\u003cp\u003e[31] Huarte M, Rinn JL. Large non-coding RNAs: missing links in cancer? Human Molecular Genetics. 2010;19(2):R152-61.\u003c\/p\u003e\n\u003cp\u003e[32] Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, Wong CP, et al. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. Journal of Nutritional Biochemistry. 2016;42:72-83.\u003c\/p\u003e\n\u003cp\u003e[33] Dinkova-Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res. 2008;52:S128-38.\u003c\/p\u003e\n\u003cp\u003e[34] Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Gent. 2009 Jan;10(1):32-42.\u003c\/p\u003e\n\u003cp\u003e[35] Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, et al. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3\/SMRT corepressor complex dissociation\/reassembly. Molecular Cancer.2011;10:68.\u003c\/p\u003e\n\u003cp\u003e[36] Singh K, Commors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, et al. Sulforaphane treatment of autism spectrum disorder (ASD). PNAS. 2014 Oct 28;111(43):15550-5.\u003c\/p\u003e\n\u003cp\u003e[37] Bahadoran Z, Mirmiran P, Hosseinpanah F, Rajab A, Asghari G, Azizi F. Broccoli sprouts powder could improve serum triglyceride and oxidised LDL\/HDL-cholesterol ratio in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Diabetes Research and Clinical Practice. 2012;96:348-54.\u003c\/p\u003e\n\u003cp\u003e[38] Mirmiran, P.; Bahadoran, Z.; Hosseinpanah, F.; Keyzad, A.; Azizi, F. Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. J Funct Foods. 2012;4:837-41.\u003c\/p\u003e\n\u003cp\u003e[39] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.\u003c\/p\u003e\n\u003cp\u003e[40] Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prevention Research. 2009;2(4):353-60.\u003c\/p\u003e\n\u003cp\u003e[41] Mirmiran P, Bahadoran Z, Golzarand M, Zojaji H, Azizi F. A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H. pylori eradication: a randomized clinical trial in patients with type 2 diabetes. Journal of Diabetes \u0026amp; Metabolic Disorders. 2014;13:64-71.\u003c\/p\u003e\n\u003cp\u003e[42] Heber D, Li Z, Garcia-Lloret M, Wong AM, Lee TY, Thames G, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food \u0026amp; Function. 2014;5:35-41.\u003c\/p\u003e\n\u003cp\u003e[43] Cipolla BG, Mandron E, Lefort JM, Coadou Y, Negra ED, Corbel L, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prevention Research.2015;8(8):712-9.\u003c\/p\u003e\n\u003cp\u003e[44] Medina S, Dominguez-Perles, Moreno DA, Garcia-Viguera C, Ferreres F, Gil JI, et al. The intake of broccoli sprouts modulates the inflammatory and vascular prostanoids but not the oxidative stress-related isoprostanes in healthy humans. Food Chemistry. 2015;173:1187-94.\u003c\/p\u003e\n\u003cp\u003e[45] Lopez-Chillon MT, Carazo-Diaz C, Prieto-Merino D, Zafrilla P, Moreno DA, Villano D. Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects. Clinical Nutrition. 2019;38:745-52.\u003c\/p\u003e\n\u003cp\u003e[46] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[47] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 1101-25.\u003c\/p\u003e\n\u003cp\u003e[48] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[49] Stargrove MB, Treasure J, McKee DL. Herb, nutrient, and drug interactions. St Louis (MO): Mosby Elsevier; 2010. p. 389-390.\u003c\/p\u003e\n\u003cp\u003e[50] Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altern Ther Health Med. 2007 Jan-Feb;13(1):22-28.\u003c\/p\u003e\n\u003cp\u003e[51] Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 2. Altern Ther Health Med. 2007 Jan-Feb;13(1):28-39.\u003c\/p\u003e\n\u003cp\u003e[52] Gaby AR, Batz F, Chester R, Constantine G. A-Z guide to drug-herb-vitamin interactions. 2nd ed. New York (NY): Three Rivers Press; 2006. p. 55-56.\u003c\/p\u003e\n\u003cp\u003e[53] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[54] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 drug interactions. [2017 Oct 1; cited 2017 Oct 20]. Available from: http:\/\/www.emims.com.au\/Australia\/pub\/latestIssue\/Clinical%20Resources\/CYP450%20Drug%20Interactions. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[55] Prescribers’ Digital Reference. Amiodarone hydrochloride – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Cordarone-amiodarone-hydrochloride-997.\u003c\/p\u003e\n\u003cp\u003e[56] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85.\u003c\/p\u003e\n\u003cp\u003e[57] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[58] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[59] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[60] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 1101-25.\u003c\/p\u003e\n\u003cp\u003e[61] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. Olanzapine – Full PI. [2017 Sep 1; cited 2017 Oct 24]. Available from: http:\/\/www.emims.com.au\/Australia\/drug\/info\/APO-Olanzapine\/APO-Olanzapine?type=full. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[62] Prescribers’ Digital Reference. Olanzapine – drug summary [Internet]. 2017 [cited 2017 Oct 24]. Available from: http:\/\/www.pdr.net\/drug-summary\/Zyprexa-olanzapine-2269.\u003c\/p\u003e\n\u003cp\u003e[63] Pope ND. Generic substitution of narrow therapeutic index drugs. US Pharm. 2009;34(6)(Generic Drug Review suppl):12-19.\u003c\/p\u003e\n\u003cp\u003e[64] Davis MP, Dickerson ED. Olanzapine: another psychotropic? Am J Hosp Palliat Care. 2001 Mar-Apr;18(2):129-32.\u003c\/p\u003e\n\u003cp\u003e[65] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[66] Prescribers’ Digital Reference. Phenobarbital – drug summary [Internet]. 2017 [cited 2017 Oct 24]. Available from: http:\/\/www.pdr.net\/drug-summary\/Phenobarbital-Tablets--15-mg--30-mg--60-mg--100-mg--phenobarbital-861.\u003c\/p\u003e\n\u003cp\u003e[67] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 Drug Interactions [cited 2017 Oct 24]. Available from:  http:\/\/www.emims.com.au\/Australia\/pub\/latestIssue\/Clinical%20Resources\/CYP450%20Drug%20Interactions. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[68] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/abbreviatednewdrugapplicationandagenerics\/ucm292676.pdf.\u003c\/p\u003e\n\u003cp\u003e[69] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[70] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[71] Prescribers’ Digital Reference. Phenytoin – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Dilantin-Capsules-phenytoin-sodium-1813.\u003c\/p\u003e\n\u003cp\u003e[72] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 Drug Interactions [cited 2017 Oct 24]. Available from:  http:\/\/www.emims.com.au\/Australia\/pub\/latestIssue\/Clinical%20Resources\/CYP450%20Drug%20Interactions. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[73] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/abbreviatednewdrugapplicationandagenerics\/ucm292676.pdf.\u003c\/p\u003e\n\u003cp\u003e[74] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85.\u003c\/p\u003e\n\u003cp\u003e[75] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[76] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[77] Drugbank. Propafenone [Internet]. 2017 [cited Oct 20]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB01182.\u003c\/p\u003e\n\u003cp\u003e[78] Prescribers’ Digital Reference. Propafenone hydrochloride – drug summary. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/rythmol?druglabelid=223.\u003c\/p\u003e\n\u003cp\u003e[79] Tamargo J, Le Heuzey JY, Mabo P. Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide. Eur J Clin Pharmacol. 2015 May;71(5):549-67.\u003c\/p\u003e\n\u003cp\u003e[80] Prescribers’ Digital Reference. Propafenone hydrochloride – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/rythmol?druglabelid=223.\u003c\/p\u003e\n\u003cp\u003e[81] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[82] Drugbank. Rifampicin [Internet]. 2017 [cited 2017 Oct 20]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB01045.\u003c\/p\u003e\n\u003cp\u003e[83] Prescribers’ Digital Reference. Rifampin – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Rifadin-rifampin-1036.\u003c\/p\u003e\n\u003cp\u003e[84] Lucas C, Donovan P. Medications: 'Just a repeat': When drug monitoring is indicated. Australian Family Physician. 2013 Jan;42(1\/2):18.\u003c\/p\u003e\n\u003cp\u003e[85] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[86] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[87] Prescribers’ Digital Reference. Theophylline – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Theophylline-Extended-Release-Tablets--100-mg--200-mg--300-mg--450-mg--theophylline-3337.\u003c\/p\u003e\n\u003cp\u003e[88] Drugbank. Theophylline [Internet]. 2017 [cited 2017 Oct 20]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB00277.\u003c\/p\u003e\n\u003cp\u003e[89] Lucas C, Donovan P. Medications:'Just a repeat': When drug monitoring is indicated. Australian Family Physician. 2013 Jan;42(1\/2):18.\u003c\/p\u003e\n\u003cp\u003e[90] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[91] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[92] Prescribers’ Digital Reference. Warfarin – drug summary [Internet]. 2017 [cited 2017 Oct 26]. Available from: http:\/\/www.pdr.net\/drug-summary\/Warfarin-warfarin-sodium-3720.\u003c\/p\u003e\n\u003cp\u003e[93] Drugbank. Warfarin [Internet]. 2017 [cited 2017 Oct 26]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB00682.\u003c\/p\u003e\n\u003cp\u003e[94] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/abbreviatednewdrugapplicationandagenerics\/ucm292676.pdf.\u003c\/p\u003e\n\u003cp\u003e[95] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85-.\u003c\/p\u003e\n\u003cp\u003e[96] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[97] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[98] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[99] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2019-06-17T06:37:35+10:00","created_at":"2019-06-17T06:42:12+10:00","vendor":"Metagenics","type":"Metagenics Naturopathic Medicines","tags":["1200px","Detoxification","Hormonal","Metagenics","Pain and Inflammation","Women's Hormonal"],"price":5216,"price_min":5216,"price_max":5216,"available":true,"price_varies":false,"compare_at_price":5795,"compare_at_price_min":5795,"compare_at_price_max":5795,"compare_at_price_varies":false,"variants":[{"id":21126012928059,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"SulforaClear60caps","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Metagenics SulforaClear 60 Capsules","public_title":null,"options":["Default Title"],"price":5216,"weight":179,"compare_at_price":5795,"inventory_quantity":9970,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9315771011270"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-1.jpg?v=1624951477","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-2.jpg?v=1624951507","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-3.jpg?v=1624951530","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_SulforaClear_60_caps_10_off_RRP_-_HealthMasters.jpg?v=1614919763","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear10_offRRPDiagram-HealthMastersMetagenics.jpg?v=1624951780","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear10_offRRPFig1_2-HealthMastersMetagenics.jpg?v=1614919809"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-1.jpg?v=1624951477","options":["Title"],"media":[{"alt":"Metagenics SulforaClear 60 caps 10% off RRP | HealthMasters Metagenics","id":9763605119134,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-1.jpg?v=1624951477"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-1.jpg?v=1624951477","width":1200},{"alt":"Metagenics SulforaClear 60 caps 10% off RRP | HealthMasters Metagenics Ingredients","id":9763605151902,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-2.jpg?v=1624951507"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-2.jpg?v=1624951507","width":1200},{"alt":"Metagenics SulforaClear 60 caps 10% off RRP | HealthMasters Metagenics Information","id":9763605184670,"position":3,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-3.jpg?v=1624951530"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear60Capsules-3.jpg?v=1624951530","width":1200},{"alt":"Metagenics SulforaClear 60 Caps 10% off RRP | HealthMasters","id":2777274712123,"position":4,"preview_image":{"aspect_ratio":1.0,"height":500,"width":500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_SulforaClear_60_caps_10_off_RRP_-_HealthMasters.jpg?v=1590128978"},"aspect_ratio":1.0,"height":500,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_SulforaClear_60_caps_10_off_RRP_-_HealthMasters.jpg?v=1590128978","width":500},{"alt":"Metagenics SulforaClear 60 caps 10% off RRP | HealthMasters Metagenics Summary","id":20401982832798,"position":5,"preview_image":{"aspect_ratio":2.51,"height":200,"width":502,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear10_offRRPDiagram-HealthMastersMetagenics.jpg?v=1614919798"},"aspect_ratio":2.51,"height":200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear10_offRRPDiagram-HealthMastersMetagenics.jpg?v=1614919798","width":502},{"alt":"Metagenics SulforaClear 10% off RRP Fig 1 \u0026 2 - HealthMasters Metagenics","id":20401982865566,"position":6,"preview_image":{"aspect_ratio":2.0,"height":400,"width":800,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear10_offRRPFig1_2-HealthMastersMetagenics.jpg?v=1614919774"},"aspect_ratio":2.0,"height":400,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSulforaClear10_offRRPFig1_2-HealthMastersMetagenics.jpg?v=1614919774","width":800}],"content":"\u003ch3\u003e\u003cem\u003eBroccoli Seeds And Sprouts With Vitamin C For Detoxification And Antioxidant Support with Nrf2 Activation\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics SulforaClear 60 Capsules\u003c\/h2\u003e\n\u003cp\u003eAvailable in: 60 Capsules (60 days)\u003c\/p\u003e\n\u003cp\u003eMetagenics SulforaClear:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOptimise sulforaphane yield through the combination of glucoraphanin-rich broccoli seeds, and broccoli sprouts with high myrosinase activity.\u003c\/li\u003e\n\u003cli\u003eAssist detoxification processes.\u003c\/li\u003e\n\u003cli\u003eProvide antioxidant support protection against free radical damage.\u003c\/li\u003e\n\u003cli\u003eActivates the nuclear transcription factor Nrf2 and subsequently increasing the expression of cytoprotective genes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics SulforaClear is free from corn Dairy Protein Lactose free Gluten free Soy Protein Free from Nuts and Seeds\u003c\/p\u003e\n\u003cp\u003eMetagenics SulforaClear AUST L 314807\u003c\/p\u003e\n\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003eTake 1 capsule daily with food.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulforaphane has demonstrated far reaching and significant benefits with regard to detoxification, antioxidant support and anti-inflammatory effects in vitro, animal and human models.\u003c\/strong\u003e\u003csup\u003e1,2\u003c\/sup\u003e Through activating the nuclear transcription factor Nrf2 and subsequently increasing the expression of cytoprotective genes, sulforaphane is the most potent, known, naturally occurring inducer of phase II enzymes.\u003csup\u003e3\u003c\/sup\u003e These enzymes are known to play a key role in cellular defence mechanisms, protecting cells against inflammation, oxidative stress and free radical damage,\u003csup\u003e4,5,6\u003c\/sup\u003e in addition to supporting detoxification processes.\u003csup\u003e7,8,9,10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupplementing with one capsule of Metagenics SulforaClear is equivalent to consuming approximately 1¾ cups of fresh broccoli in regards to glucoraphanin intake.\u003c\/strong\u003e This is an important aspect when it comes to ensuring patients experience consistent therapeutic benefits of sulforaphane. Although dietary broccoli is an excellent source of nutrition and yields the highest amount of sulforaphane compared to other cruciferous vegetables, the cooking process reduces myrosinase levels, affecting conversion into sulforaphane (Figure 1).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics SulforaClear uses broccoli material that is grown without the use of herbicides, pesticides or other potentially harmful chemicals.\u003c\/strong\u003e In addition, the seed is tested and cleared for over 400 pesticides (Figure 2).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cimg alt=\"Metagenics SulforaClear Quality Control Process | HealthMasters\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_SulforaClear_Quality_Process_-_HealthMasters_1024x1024.jpg?v=1560718136\" style=\"float: none;\"\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics SulforaClear\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eEach capsule contains:\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eExtracts equivalent to:\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBrassica oleracea var. italica, seed dry (Broccoli)\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e2.0g\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Equivalent Glucoraphanin\u003c\/td\u003e\n\u003ctd\u003e26mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBrassica oleracea var. italica, sprout powder (Broccoli)\u003c\/td\u003e\n\u003ctd\u003e200mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium ascorbate dihydrate\u003c\/td\u003e\n\u003ctd\u003e97mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- Equivalent Ascorbic acid (Vitamin C)\u003c\/td\u003e\n\u003ctd\u003e80mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFree from animal products, corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, and soy protein. Free from artificial colours and flavours.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003eVitamin supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003ch5\u003ePregnancy and Breastfeeding\u003c\/h5\u003e\n\u003ch2\u003ePregnancy and Breastfeeding: Metagenics SulforaClear\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003ePregnancy:\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eA review did not identify any concerns for use during pregnancy, however safety has not been conclusively established in humans. No risks found in humans, although research is limited or unavailable for broccoli.[98]\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003ch3\u003e\n\u003cem\u003eLactation:\u003c\/em\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003cp\u003eSafe to use in breastfeeding.[99]et.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics SulforaClear\u003c\/h2\u003e\n\u003cp\u003e[1] Linus Pauling Institute. [Internet]. Oregon (USA). Oregon State University; c2018. Isothiocyanates; 2005 [updated 2017 April; cited 2018 June 29].  Available from: https:\/\/lpi.oregonstate.edu\/mic\/dietary-factors\/phytochemicals\/isothiocyanates#metabolism-bioavailability.\u003c\/p\u003e\n\u003cp\u003e[2] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[3] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[4] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[5] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[6] Ferguson LR. Nutrigenetics, nutrogenomics and inflammatory bowel diseases. Expert Rev. Clin. Immunol. 2013;9(8):717-26.\u003c\/p\u003e\n\u003cp\u003e[7] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[8] Sulforaphane Glucosinolate Monograph. Alt Med Rev. 2010:15(4):352-60.\u003c\/p\u003e\n\u003cp\u003e[9] Tian S, Lei P, Liu X, Zhang X, Shan Y. Microbiota: a mediator to transform glucosinolate precursors in cruciferous vegetables to the active isothiocyanates. J Sci Food Agric. 2017 Sep 4.\u003c\/p\u003e\n\u003cp\u003e[10] Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson K, Talalay P. Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLoS One. 2015 Nov 2;10(11):e0140963.\u003c\/p\u003e\n\u003cp\u003e[11] Botti MG, Taylor MG, Botting NP. Studies on the mechaism of myrosinase. The Journal of Biological Chemistry. 1995;270(35):20530-35.\u003c\/p\u003e\n\u003cp\u003e[12] Hanschen FS, Klopsch R, Oliviero T, Schreiner M, Verkerk R, Dekker M. Optimizing isothiocyanate formation during enzymatic glucosinolate breakdown by adjusting pH value, temperature and dilution in Brassica vegetables and Arabidopsis thaliana. Scientific Reports. 2017:DOI: 10.1038\/srep40807.\u003c\/p\u003e\n\u003cp\u003e[13] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[14] Kansanen E, Kuosmanen SM, Leinonen H, Lenonen AL. The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biology. 2013:1(1):45-9.\u003c\/p\u003e\n\u003cp\u003e[15] Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson K, Talalay P. Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLoS One. 2015 Nov 2;10(11):e0140963.\u003c\/p\u003e\n\u003cp\u003e[16] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[17] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[18] Conzatti A, Telles da Silva Froes, FC, Perry IDS, Guerini de Souza C. Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans. Nutr Hosp. 2015;31(2):559-69.\u003c\/p\u003e\n\u003cp\u003e[19] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.\u003c\/p\u003e\n\u003cp\u003e[20] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[21] Liska A, Lyon M, Jone DS. Detoxification and biotransformational imbalance. Explore. 2006; 2(2):122-140.\u003c\/p\u003e\n\u003cp\u003e[22] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.\u003c\/p\u003e\n\u003cp\u003e[23] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.\u003c\/p\u003e\n\u003cp\u003e[24] Schwab M, Reynders V, Loitsch S, Steinhilber D, Schroder O, Stein J. The dietary histone deacetylase inhibitor sulforaphane induces human β-defensin-2 in intestinal epithelial cells. Innumology. 2008;125:241-51.\u003c\/p\u003e\n\u003cp\u003e[25] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.\u003c\/p\u003e\n\u003cp\u003e[26] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.\u003c\/p\u003e\n\u003cp\u003e[27] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.\u003c\/p\u003e\n\u003cp\u003e[28] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.\u003c\/p\u003e\n\u003cp\u003e[29] Dinkova-Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res. 2008;52:S128-38.\u003c\/p\u003e\n\u003cp\u003e[30] Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, et al. Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short term, cross-over clinical trial in Qidong, China. Cancer Prev Res. 2011;4(3):384-95.\u003c\/p\u003e\n\u003cp\u003e[31] Huarte M, Rinn JL. Large non-coding RNAs: missing links in cancer? Human Molecular Genetics. 2010;19(2):R152-61.\u003c\/p\u003e\n\u003cp\u003e[32] Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, Wong CP, et al. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. Journal of Nutritional Biochemistry. 2016;42:72-83.\u003c\/p\u003e\n\u003cp\u003e[33] Dinkova-Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res. 2008;52:S128-38.\u003c\/p\u003e\n\u003cp\u003e[34] Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Gent. 2009 Jan;10(1):32-42.\u003c\/p\u003e\n\u003cp\u003e[35] Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, et al. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3\/SMRT corepressor complex dissociation\/reassembly. Molecular Cancer.2011;10:68.\u003c\/p\u003e\n\u003cp\u003e[36] Singh K, Commors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, et al. Sulforaphane treatment of autism spectrum disorder (ASD). PNAS. 2014 Oct 28;111(43):15550-5.\u003c\/p\u003e\n\u003cp\u003e[37] Bahadoran Z, Mirmiran P, Hosseinpanah F, Rajab A, Asghari G, Azizi F. Broccoli sprouts powder could improve serum triglyceride and oxidised LDL\/HDL-cholesterol ratio in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Diabetes Research and Clinical Practice. 2012;96:348-54.\u003c\/p\u003e\n\u003cp\u003e[38] Mirmiran, P.; Bahadoran, Z.; Hosseinpanah, F.; Keyzad, A.; Azizi, F. Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. J Funct Foods. 2012;4:837-41.\u003c\/p\u003e\n\u003cp\u003e[39] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.\u003c\/p\u003e\n\u003cp\u003e[40] Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prevention Research. 2009;2(4):353-60.\u003c\/p\u003e\n\u003cp\u003e[41] Mirmiran P, Bahadoran Z, Golzarand M, Zojaji H, Azizi F. A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H. pylori eradication: a randomized clinical trial in patients with type 2 diabetes. Journal of Diabetes \u0026amp; Metabolic Disorders. 2014;13:64-71.\u003c\/p\u003e\n\u003cp\u003e[42] Heber D, Li Z, Garcia-Lloret M, Wong AM, Lee TY, Thames G, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food \u0026amp; Function. 2014;5:35-41.\u003c\/p\u003e\n\u003cp\u003e[43] Cipolla BG, Mandron E, Lefort JM, Coadou Y, Negra ED, Corbel L, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prevention Research.2015;8(8):712-9.\u003c\/p\u003e\n\u003cp\u003e[44] Medina S, Dominguez-Perles, Moreno DA, Garcia-Viguera C, Ferreres F, Gil JI, et al. The intake of broccoli sprouts modulates the inflammatory and vascular prostanoids but not the oxidative stress-related isoprostanes in healthy humans. Food Chemistry. 2015;173:1187-94.\u003c\/p\u003e\n\u003cp\u003e[45] Lopez-Chillon MT, Carazo-Diaz C, Prieto-Merino D, Zafrilla P, Moreno DA, Villano D. Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects. Clinical Nutrition. 2019;38:745-52.\u003c\/p\u003e\n\u003cp\u003e[46] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[47] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 1101-25.\u003c\/p\u003e\n\u003cp\u003e[48] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[49] Stargrove MB, Treasure J, McKee DL. Herb, nutrient, and drug interactions. St Louis (MO): Mosby Elsevier; 2010. p. 389-390.\u003c\/p\u003e\n\u003cp\u003e[50] Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altern Ther Health Med. 2007 Jan-Feb;13(1):22-28.\u003c\/p\u003e\n\u003cp\u003e[51] Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 2. Altern Ther Health Med. 2007 Jan-Feb;13(1):28-39.\u003c\/p\u003e\n\u003cp\u003e[52] Gaby AR, Batz F, Chester R, Constantine G. A-Z guide to drug-herb-vitamin interactions. 2nd ed. New York (NY): Three Rivers Press; 2006. p. 55-56.\u003c\/p\u003e\n\u003cp\u003e[53] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[54] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 drug interactions. [2017 Oct 1; cited 2017 Oct 20]. Available from: http:\/\/www.emims.com.au\/Australia\/pub\/latestIssue\/Clinical%20Resources\/CYP450%20Drug%20Interactions. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[55] Prescribers’ Digital Reference. Amiodarone hydrochloride – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Cordarone-amiodarone-hydrochloride-997.\u003c\/p\u003e\n\u003cp\u003e[56] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85.\u003c\/p\u003e\n\u003cp\u003e[57] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[58] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[59] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[60] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 1101-25.\u003c\/p\u003e\n\u003cp\u003e[61] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. Olanzapine – Full PI. [2017 Sep 1; cited 2017 Oct 24]. Available from: http:\/\/www.emims.com.au\/Australia\/drug\/info\/APO-Olanzapine\/APO-Olanzapine?type=full. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[62] Prescribers’ Digital Reference. Olanzapine – drug summary [Internet]. 2017 [cited 2017 Oct 24]. Available from: http:\/\/www.pdr.net\/drug-summary\/Zyprexa-olanzapine-2269.\u003c\/p\u003e\n\u003cp\u003e[63] Pope ND. Generic substitution of narrow therapeutic index drugs. US Pharm. 2009;34(6)(Generic Drug Review suppl):12-19.\u003c\/p\u003e\n\u003cp\u003e[64] Davis MP, Dickerson ED. Olanzapine: another psychotropic? Am J Hosp Palliat Care. 2001 Mar-Apr;18(2):129-32.\u003c\/p\u003e\n\u003cp\u003e[65] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[66] Prescribers’ Digital Reference. Phenobarbital – drug summary [Internet]. 2017 [cited 2017 Oct 24]. Available from: http:\/\/www.pdr.net\/drug-summary\/Phenobarbital-Tablets--15-mg--30-mg--60-mg--100-mg--phenobarbital-861.\u003c\/p\u003e\n\u003cp\u003e[67] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 Drug Interactions [cited 2017 Oct 24]. Available from:  http:\/\/www.emims.com.au\/Australia\/pub\/latestIssue\/Clinical%20Resources\/CYP450%20Drug%20Interactions. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[68] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/abbreviatednewdrugapplicationandagenerics\/ucm292676.pdf.\u003c\/p\u003e\n\u003cp\u003e[69] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[70] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[71] Prescribers’ Digital Reference. Phenytoin – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Dilantin-Capsules-phenytoin-sodium-1813.\u003c\/p\u003e\n\u003cp\u003e[72] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 Drug Interactions [cited 2017 Oct 24]. Available from:  http:\/\/www.emims.com.au\/Australia\/pub\/latestIssue\/Clinical%20Resources\/CYP450%20Drug%20Interactions. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[73] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/abbreviatednewdrugapplicationandagenerics\/ucm292676.pdf.\u003c\/p\u003e\n\u003cp\u003e[74] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85.\u003c\/p\u003e\n\u003cp\u003e[75] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[76] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[77] Drugbank. Propafenone [Internet]. 2017 [cited Oct 20]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB01182.\u003c\/p\u003e\n\u003cp\u003e[78] Prescribers’ Digital Reference. Propafenone hydrochloride – drug summary. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/rythmol?druglabelid=223.\u003c\/p\u003e\n\u003cp\u003e[79] Tamargo J, Le Heuzey JY, Mabo P. Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide. Eur J Clin Pharmacol. 2015 May;71(5):549-67.\u003c\/p\u003e\n\u003cp\u003e[80] Prescribers’ Digital Reference. Propafenone hydrochloride – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/rythmol?druglabelid=223.\u003c\/p\u003e\n\u003cp\u003e[81] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[82] Drugbank. Rifampicin [Internet]. 2017 [cited 2017 Oct 20]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB01045.\u003c\/p\u003e\n\u003cp\u003e[83] Prescribers’ Digital Reference. Rifampin – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Rifadin-rifampin-1036.\u003c\/p\u003e\n\u003cp\u003e[84] Lucas C, Donovan P. Medications: 'Just a repeat': When drug monitoring is indicated. Australian Family Physician. 2013 Jan;42(1\/2):18.\u003c\/p\u003e\n\u003cp\u003e[85] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[86] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[87] Prescribers’ Digital Reference. Theophylline – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http:\/\/www.pdr.net\/drug-summary\/Theophylline-Extended-Release-Tablets--100-mg--200-mg--300-mg--450-mg--theophylline-3337.\u003c\/p\u003e\n\u003cp\u003e[88] Drugbank. Theophylline [Internet]. 2017 [cited 2017 Oct 20]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB00277.\u003c\/p\u003e\n\u003cp\u003e[89] Lucas C, Donovan P. Medications:'Just a repeat': When drug monitoring is indicated. Australian Family Physician. 2013 Jan;42(1\/2):18.\u003c\/p\u003e\n\u003cp\u003e[90] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[91] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[92] Prescribers’ Digital Reference. Warfarin – drug summary [Internet]. 2017 [cited 2017 Oct 26]. Available from: http:\/\/www.pdr.net\/drug-summary\/Warfarin-warfarin-sodium-3720.\u003c\/p\u003e\n\u003cp\u003e[93] Drugbank. Warfarin [Internet]. 2017 [cited 2017 Oct 26]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB00682.\u003c\/p\u003e\n\u003cp\u003e[94] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/abbreviatednewdrugapplicationandagenerics\/ucm292676.pdf.\u003c\/p\u003e\n\u003cp\u003e[95] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85-.\u003c\/p\u003e\n\u003cp\u003e[96] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.\u003c\/p\u003e\n\u003cp\u003e[97] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[98] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1151. Subscription required to view.\u003c\/p\u003e\n\u003cp\u003e[99] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=1001. Subscription required to view.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}

Metagenics SulforaClear 60 Capsules

Product Description

Broccoli Seeds And Sprouts With Vitamin C For Detoxification And Antioxidant Support with Nrf2 Activation

Metagenics SulforaClear 60 Capsules

Available in: 60 Capsules (60 days)

Metagenics SulforaClear:

  • Optimise sulforaphane yield through the combination of glucoraphanin-rich broccoli seeds, and broccoli sprouts with high myrosinase activity.
  • Assist detoxification processes.
  • Provide antioxidant support protection against free radical damage.
  • Activates the nuclear transcription factor Nrf2 and subsequently increasing the expression of cytoprotective genes.

Metagenics SulforaClear is free from corn Dairy Protein Lactose free Gluten free Soy Protein Free from Nuts and Seeds

Metagenics SulforaClear AUST L 314807

Directions: Metagenics SulforaClear

Take 1 capsule daily with food.

Clinical Benefits: Metagenics SulforaClear

  • Sulforaphane has demonstrated far reaching and significant benefits with regard to detoxification, antioxidant support and anti-inflammatory effects in vitro, animal and human models.1,2 Through activating the nuclear transcription factor Nrf2 and subsequently increasing the expression of cytoprotective genes, sulforaphane is the most potent, known, naturally occurring inducer of phase II enzymes.3 These enzymes are known to play a key role in cellular defence mechanisms, protecting cells against inflammation, oxidative stress and free radical damage,4,5,6 in addition to supporting detoxification processes.7,8,9,10
  • Supplementing with one capsule of Metagenics SulforaClear is equivalent to consuming approximately 1¾ cups of fresh broccoli in regards to glucoraphanin intake. This is an important aspect when it comes to ensuring patients experience consistent therapeutic benefits of sulforaphane. Although dietary broccoli is an excellent source of nutrition and yields the highest amount of sulforaphane compared to other cruciferous vegetables, the cooking process reduces myrosinase levels, affecting conversion into sulforaphane (Figure 1).
  • Metagenics SulforaClear uses broccoli material that is grown without the use of herbicides, pesticides or other potentially harmful chemicals. In addition, the seed is tested and cleared for over 400 pesticides (Figure 2).

Metagenics SulforaClear Quality Control Process | HealthMasters

Ingredients: Metagenics SulforaClear

Each capsule contains:

Extracts equivalent to:

Brassica oleracea var. italica, seed dry (Broccoli)

2.0g

- Equivalent Glucoraphanin 26mg
Brassica oleracea var. italica, sprout powder (Broccoli) 200mg
Calcium ascorbate dihydrate 97mg
- Equivalent Ascorbic acid (Vitamin C) 80mg

Free from animal products, corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, and soy protein. Free from artificial colours and flavours.

Warnings: Metagenics SulforaClear

Vitamin supplements should not replace a balanced diet.

Pregnancy and Breastfeeding: Metagenics SulforaClear

Pregnancy:

A review did not identify any concerns for use during pregnancy, however safety has not been conclusively established in humans. No risks found in humans, although research is limited or unavailable for broccoli.[98]

Lactation:

Safe to use in breastfeeding.[99]et.

Storage: Metagenics SulforaClear

Store below 30°C

References: Metagenics SulforaClear

[1] Linus Pauling Institute. [Internet]. Oregon (USA). Oregon State University; c2018. Isothiocyanates; 2005 [updated 2017 April; cited 2018 June 29].  Available from: https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/isothiocyanates#metabolism-bioavailability.

[2] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.

[3] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.

[4] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.

[5] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.

[6] Ferguson LR. Nutrigenetics, nutrogenomics and inflammatory bowel diseases. Expert Rev. Clin. Immunol. 2013;9(8):717-26.

[7] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.

[8] Sulforaphane Glucosinolate Monograph. Alt Med Rev. 2010:15(4):352-60.

[9] Tian S, Lei P, Liu X, Zhang X, Shan Y. Microbiota: a mediator to transform glucosinolate precursors in cruciferous vegetables to the active isothiocyanates. J Sci Food Agric. 2017 Sep 4.

[10] Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson K, Talalay P. Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLoS One. 2015 Nov 2;10(11):e0140963.

[11] Botti MG, Taylor MG, Botting NP. Studies on the mechaism of myrosinase. The Journal of Biological Chemistry. 1995;270(35):20530-35.

[12] Hanschen FS, Klopsch R, Oliviero T, Schreiner M, Verkerk R, Dekker M. Optimizing isothiocyanate formation during enzymatic glucosinolate breakdown by adjusting pH value, temperature and dilution in Brassica vegetables and Arabidopsis thaliana. Scientific Reports. 2017:DOI: 10.1038/srep40807.

[13] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.

[14] Kansanen E, Kuosmanen SM, Leinonen H, Lenonen AL. The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biology. 2013:1(1):45-9.

[15] Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson K, Talalay P. Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLoS One. 2015 Nov 2;10(11):e0140963.

[16] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.

[17] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.

[18] Conzatti A, Telles da Silva Froes, FC, Perry IDS, Guerini de Souza C. Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans. Nutr Hosp. 2015;31(2):559-69.

[19] Houghton CA, Fasset RG, Coombes JS. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality? Oxidative Medicine and Cellular Longevity. 2016.

[20] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.

[21] Liska A, Lyon M, Jone DS. Detoxification and biotransformational imbalance. Explore. 2006; 2(2):122-140.

[22] Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS. 2001 Dec 18;98(26):15221-6.

[23] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.

[24] Schwab M, Reynders V, Loitsch S, Steinhilber D, Schroder O, Stein J. The dietary histone deacetylase inhibitor sulforaphane induces human β-defensin-2 in intestinal epithelial cells. Innumology. 2008;125:241-51.

[25] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.

[26] Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta. 2006;371:1-12.

[27] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.

[28] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.

[29] Dinkova-Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res. 2008;52:S128-38.

[30] Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, et al. Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short term, cross-over clinical trial in Qidong, China. Cancer Prev Res. 2011;4(3):384-95.

[31] Huarte M, Rinn JL. Large non-coding RNAs: missing links in cancer? Human Molecular Genetics. 2010;19(2):R152-61.

[32] Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, Wong CP, et al. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. Journal of Nutritional Biochemistry. 2016;42:72-83.

[33] Dinkova-Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res. 2008;52:S128-38.

[34] Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Gent. 2009 Jan;10(1):32-42.

[35] Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, et al. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Molecular Cancer.2011;10:68.

[36] Singh K, Commors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, et al. Sulforaphane treatment of autism spectrum disorder (ASD). PNAS. 2014 Oct 28;111(43):15550-5.

[37] Bahadoran Z, Mirmiran P, Hosseinpanah F, Rajab A, Asghari G, Azizi F. Broccoli sprouts powder could improve serum triglyceride and oxidised LDL/HDL-cholesterol ratio in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Diabetes Research and Clinical Practice. 2012;96:348-54.

[38] Mirmiran, P.; Bahadoran, Z.; Hosseinpanah, F.; Keyzad, A.; Azizi, F. Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. J Funct Foods. 2012;4:837-41.

[39] Reidl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane induces antioxidant phase II enzymes in the human airway. J Allergy Clin Immunol. 2009;119(1):S297.

[40] Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prevention Research. 2009;2(4):353-60.

[41] Mirmiran P, Bahadoran Z, Golzarand M, Zojaji H, Azizi F. A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H. pylori eradication: a randomized clinical trial in patients with type 2 diabetes. Journal of Diabetes & Metabolic Disorders. 2014;13:64-71.

[42] Heber D, Li Z, Garcia-Lloret M, Wong AM, Lee TY, Thames G, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food & Function. 2014;5:35-41.

[43] Cipolla BG, Mandron E, Lefort JM, Coadou Y, Negra ED, Corbel L, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prevention Research.2015;8(8):712-9.

[44] Medina S, Dominguez-Perles, Moreno DA, Garcia-Viguera C, Ferreres F, Gil JI, et al. The intake of broccoli sprouts modulates the inflammatory and vascular prostanoids but not the oxidative stress-related isoprostanes in healthy humans. Food Chemistry. 2015;173:1187-94.

[45] Lopez-Chillon MT, Carazo-Diaz C, Prieto-Merino D, Zafrilla P, Moreno DA, Villano D. Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects. Clinical Nutrition. 2019;38:745-52.

[46] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[47] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier/Churchill Livingstone; 2015. p. 1101-25.

[48] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1001. Subscription required to view.

[49] Stargrove MB, Treasure J, McKee DL. Herb, nutrient, and drug interactions. St Louis (MO): Mosby Elsevier; 2010. p. 389-390.

[50] Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altern Ther Health Med. 2007 Jan-Feb;13(1):22-28.

[51] Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 2. Altern Ther Health Med. 2007 Jan-Feb;13(1):28-39.

[52] Gaby AR, Batz F, Chester R, Constantine G. A-Z guide to drug-herb-vitamin interactions. 2nd ed. New York (NY): Three Rivers Press; 2006. p. 55-56.

[53] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1001. Subscription required to view.

[54] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 drug interactions. [2017 Oct 1; cited 2017 Oct 20]. Available from: http://www.emims.com.au/Australia/pub/latestIssue/Clinical%20Resources/CYP450%20Drug%20Interactions. Subscription required to view.

[55] Prescribers’ Digital Reference. Amiodarone hydrochloride – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http://www.pdr.net/drug-summary/Cordarone-amiodarone-hydrochloride-997.

[56] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85.

[57] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.

[58] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[59] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1001. Subscription required to view.

[60] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier/Churchill Livingstone; 2015. p. 1101-25.

[61] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. Olanzapine – Full PI. [2017 Sep 1; cited 2017 Oct 24]. Available from: http://www.emims.com.au/Australia/drug/info/APO-Olanzapine/APO-Olanzapine?type=full. Subscription required to view.

[62] Prescribers’ Digital Reference. Olanzapine – drug summary [Internet]. 2017 [cited 2017 Oct 24]. Available from: http://www.pdr.net/drug-summary/Zyprexa-olanzapine-2269.

[63] Pope ND. Generic substitution of narrow therapeutic index drugs. US Pharm. 2009;34(6)(Generic Drug Review suppl):12-19.

[64] Davis MP, Dickerson ED. Olanzapine: another psychotropic? Am J Hosp Palliat Care. 2001 Mar-Apr;18(2):129-32.

[65] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[66] Prescribers’ Digital Reference. Phenobarbital – drug summary [Internet]. 2017 [cited 2017 Oct 24]. Available from: http://www.pdr.net/drug-summary/Phenobarbital-Tablets--15-mg--30-mg--60-mg--100-mg--phenobarbital-861.

[67] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 Drug Interactions [cited 2017 Oct 24]. Available from:  http://www.emims.com.au/Australia/pub/latestIssue/Clinical%20Resources/CYP450%20Drug%20Interactions. Subscription required to view.

[68] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https://www.fda.gov/downloads/drugs/developmentapprovalprocess/howdrugsaredevelopedandapproved/approvalapplications/abbreviatednewdrugapplicationandagenerics/ucm292676.pdf.

[69] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.

[70] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[71] Prescribers’ Digital Reference. Phenytoin – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http://www.pdr.net/drug-summary/Dilantin-Capsules-phenytoin-sodium-1813.

[72] MIMs Online [Internet]. St Leonards (NSW): MIMs Australia Pty Ltd.; 2017. CYP450 Drug Interactions [cited 2017 Oct 24]. Available from:  http://www.emims.com.au/Australia/pub/latestIssue/Clinical%20Resources/CYP450%20Drug%20Interactions. Subscription required to view.

[73] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https://www.fda.gov/downloads/drugs/developmentapprovalprocess/howdrugsaredevelopedandapproved/approvalapplications/abbreviatednewdrugapplicationandagenerics/ucm292676.pdf.

[74] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85.

[75] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.

[76] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[77] Drugbank. Propafenone [Internet]. 2017 [cited Oct 20]. Available from: https://www.drugbank.ca/drugs/DB01182.

[78] Prescribers’ Digital Reference. Propafenone hydrochloride – drug summary. 2017 [cited 2017 Oct 20]. Available from: http://www.pdr.net/drug-summary/rythmol?druglabelid=223.

[79] Tamargo J, Le Heuzey JY, Mabo P. Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide. Eur J Clin Pharmacol. 2015 May;71(5):549-67.

[80] Prescribers’ Digital Reference. Propafenone hydrochloride – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http://www.pdr.net/drug-summary/rythmol?druglabelid=223.

[81] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[82] Drugbank. Rifampicin [Internet]. 2017 [cited 2017 Oct 20]. Available from: https://www.drugbank.ca/drugs/DB01045.

[83] Prescribers’ Digital Reference. Rifampin – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http://www.pdr.net/drug-summary/Rifadin-rifampin-1036.

[84] Lucas C, Donovan P. Medications: 'Just a repeat': When drug monitoring is indicated. Australian Family Physician. 2013 Jan;42(1/2):18.

[85] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.

[86] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[87] Prescribers’ Digital Reference. Theophylline – drug summary [Internet]. 2017 [cited 2017 Oct 20]. Available from: http://www.pdr.net/drug-summary/Theophylline-Extended-Release-Tablets--100-mg--200-mg--300-mg--450-mg--theophylline-3337.

[88] Drugbank. Theophylline [Internet]. 2017 [cited 2017 Oct 20]. Available from: https://www.drugbank.ca/drugs/DB00277.

[89] Lucas C, Donovan P. Medications:'Just a repeat': When drug monitoring is indicated. Australian Family Physician. 2013 Jan;42(1/2):18.

[90] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.

[91] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[92] Prescribers’ Digital Reference. Warfarin – drug summary [Internet]. 2017 [cited 2017 Oct 26]. Available from: http://www.pdr.net/drug-summary/Warfarin-warfarin-sodium-3720.

[93] Drugbank. Warfarin [Internet]. 2017 [cited 2017 Oct 26]. Available from: https://www.drugbank.ca/drugs/DB00682.

[94] Yu L. Quality and bioequivalence standards for narrow therapeutic index drugs. 2011 [cited 2017 May 18]. Available from: https://www.fda.gov/downloads/drugs/developmentapprovalprocess/howdrugsaredevelopedandapproved/approvalapplications/abbreviatednewdrugapplicationandagenerics/ucm292676.pdf.

[95] Snyder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012 Jun 1;35(3):85-.

[96] Liang BA, Mackey TK, Lovett KM. Illegal “no prescription” internet access to narrow therapeutic index drugs. Clinical Therapeutics. 2013 May 31;35(5):694-700.

[97] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[98] Broccoli. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2017 Oct 13; cited 2018 Jul 16]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1151. Subscription required to view.

[99] Vitamin C. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [cited 2018 Jan 5]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1001. Subscription required to view.

Related products  

x