{"id":2266519306299,"title":"Metagenics SPM Active 60 Capsules","handle":"metagenics-spm-active-60-capsules","description":"\u003ch3\u003e\u003cem\u003eSpecialised Pro-Resolving Mediators\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics SPM Active 60 Capsules\u003c\/h2\u003e\n\u003cp\u003eMetagenics SPM Active has been shown to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStimulate resolution of inflammation.\u003c\/li\u003e\n\u003cli\u003eAssist unresolved and chronic inflammatory processes by actively helping the body naturally restore homeostasis.\u003c\/li\u003e\n\u003cli\u003eSPM Active contains standardised and concentrated specialised proresolving mediators (SPMs) exclusive to Metagenics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics SPM Active is free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and starches.\u003c\/p\u003e\n\u003cp\u003eMetagenics SPM Active is free from artificial colours and flavours.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff0000;\"\u003e\u003cimg alt=\"Metagenics SPM Active 10% off RRP | HealthMasters\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_SPM_Active_Image_2_large.jpg?v=1560318694\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics SPM Active AUST L 313959\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule twice daily.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSpecialised Pro-Resolving Mediators (SPMs)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPM Active is a specific and targeted approach to facilitate the resolution phase in patients experiencing inflammation which may be failing to resolve in a timely manner.\u003c\/strong\u003e Unresolved inflammation can lead into low-grade, chronic inflammation that may worsen existing disease states, impair recovery and negatively affect healthy ageing.\u003csup\u003e3\u003c\/sup\u003e Chronic disease is an increasing health burden and it is now estimated that 1 in 3 Australians live with at least one chronic inflammatory condition including arthritis and other musculoskeletal disorders, cardiovascular disease and diabetes mellitus.\u003csup\u003e4\u003c\/sup\u003e These health issues are characterised by inflammatory processes disrupting healing and driving chronic states indicating the need for SPMs to help support healthy resolution outcomes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPMs found in SPM Active are lipid mediators that occur naturally in the body and have been found in various human tissue (such as the brain, lymph nodes and synovial fluid).\u003c\/strong\u003e\u003csup\u003e5\u003c\/sup\u003e SPMs orchestrate resolution at the site of inflammation to assist tissue repair, healing, recovery and the return to homeostasis.\u003csup\u003e6\u003c\/sup\u003e These mediators help to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivate the resolution phase.\u003c\/li\u003e\n\u003cli\u003eSignal to, and recruit certain immune cells and inflammatory mediators.\u003c\/li\u003e\n\u003cli\u003eRepair damage and clearance of pathogens.\u003c\/li\u003e\n\u003cli\u003ePrevent further pathological inflammation without immunosuppression.\u003csup\u003e7,8\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDespite omega-3 EPA and DHA being precursors of SPMs, they do not possess significant pro-resolving properties.\u003c\/strong\u003e\u003csup\u003e9\u003c\/sup\u003e Metagenics, in collaboration with SPMs experts and world-renowned leaders in the field of resolution physiology, are the first to set the standard for defining SPMs within a therapeutic supplement. Using a refined, patent pending fractionation process, specific SPM fractions are standardised for consistent dosing and therapeutic patient outcomes. The special fraction and ratio is isolated, concentrated and measured for bioactivity to verify the active SPMs 17-HDHA and 18-HEPE. This process is exclusive to Metagenics, providing an inflammation-specific solution.\u003c\/p\u003e\n\u003cp\u003eLiponva SPM's is a trademark of SOLUTEX GC.\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"Metagenics SPM Active 10% off RRP | HealthMasters\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_SPM_Active_10_off_RRP_-_HealthMasters_large.jpg?v=1560312341\"\u003e\u003c\/p\u003e\n\u003cp\u003ePatients:\u003c\/p\u003e\n\u003cp\u003eAustralia\/AU 2013259503\u003c\/p\u003e\n\u003cp\u003eNew Zealand\/NZ 702325\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics SPM Active\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eEach Metagenics SPM Active capsule contains:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eConcentrated fish Omega-3 triglycerides (LIPINOVA-11TG\u003csup\u003eTM\u003c\/sup\u003e)\u003c\/td\u003e\n\u003ctd\u003e498mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Eicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Docosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eContains active SPMs 17-HDHA and 18-HEPE\u003c\/p\u003e\n\u003cp\u003eMetagenics SPM Active is free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and starches. Metagenics SPM Active is free from artificial colours and flavours.\u003c\/p\u003e\n\u003ch5\u003eCautions and Contraindications\u003c\/h5\u003e\n\u003ch2\u003eCautions and Contraindications: Metagenics SPM Active\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergies and Sensitivities\u003c\/strong\u003e: Avoid in people allergic to fish. Although fish oil is highly purified, those with extreme fish allergy (anaphylaxis) would be advised to avoid it.82\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eModerate Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticoagulant\/antiplatelet drugs\u003c\/strong\u003e: Clinical trials have shown high-dose fish oil omega-3 fatty acid consumption to be safe, even when concurrently administered with other agents that may increase bleeding (i.e. antiplatelet or antithrombotic medications such as aspirin and warfarin). The clinical trial evidence suggests that if such an increased bleeding risk exists, the risk is very small and not of clinical significance. For example, 6.8 g of EPA\/DHA daily for 6 months showed no adverse effects. However, it is reasonable to monitor patients treated with fish oils and anticoagulants for international normalised ratio (INR) as well as potential adverse bleeding experiences.83,84\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBleeding disorders\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils during acute bleeding episodes, such as during and immediately after a haemorrhagic stroke, or in patients who are at high risk for haemorrhagic stroke.85,86\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils 4-7 days before elective procedures which have a high risk for bleeding complications. However, consider fish oil supplementation postoperatively if there are no bleeding complications, given that supplementation may reduce the risk of thrombotic and cardiovascular events which could occur following major surgery.87,88\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eLow Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNone of note.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003ePregnancy and Breastfeeding\u003c\/h5\u003e\n\u003ch2\u003ePregnancy and Breastfeeding: Metagenics SPM Active\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSafe to use in pregnancy and breastfeeding\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003e82 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003c\/p\u003e\n\u003cp\u003e83 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e84 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e85 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e86 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e87 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e88 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e89 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2019-06-12T13:51:28+10:00","created_at":"2019-06-12T14:10:18+10:00","vendor":"Metagenics","type":"Metagenics Naturopathic Medicines","tags":["Fish Oil","Metagenics","Naturopathic","Pain and Inflammation"],"price":6795,"price_min":6795,"price_max":6795,"available":true,"price_varies":false,"compare_at_price":7550,"compare_at_price_min":7550,"compare_at_price_max":7550,"compare_at_price_varies":false,"variants":[{"id":21109952741435,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"SPMActive60caps","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Metagenics SPM Active 60 Capsules","public_title":null,"options":["Default Title"],"price":6795,"weight":150,"compare_at_price":7550,"inventory_quantity":9409,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9315771011119"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics.jpg?v=1640754654","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics3.jpg?v=1640754654","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics2.jpg?v=1640754654","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_SPM_Active_60_caps_10_off_RRP_-_HealthMasters.jpg?v=1640754654"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics.jpg?v=1640754654","options":["Title"],"media":[{"alt":"Metagenics SPM Active 60 Capsules 10% off RRP | HealthMasters 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Directions","id":29000735490278,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics3.jpg?v=1640754654"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics3.jpg?v=1640754654","width":1200},{"alt":"Metagenics SPM Active 60 Capsules 10% off RRP | HealthMasters Metagenics Information","id":29000735555814,"position":3,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics2.jpg?v=1640754654"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsSPMActive60Caps10_offRRPatHealthMastersMetagenics2.jpg?v=1640754654","width":1200},{"alt":"Metagenics SPM Active 60 Capsules 10% off RRP | HealthMasters Metagenics Logo","id":2774603694139,"position":4,"preview_image":{"aspect_ratio":0.966,"height":500,"width":483,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_SPM_Active_60_caps_10_off_RRP_-_HealthMasters.jpg?v=1640754654"},"aspect_ratio":0.966,"height":500,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_SPM_Active_60_caps_10_off_RRP_-_HealthMasters.jpg?v=1640754654","width":483}],"content":"\u003ch3\u003e\u003cem\u003eSpecialised Pro-Resolving Mediators\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics SPM Active 60 Capsules\u003c\/h2\u003e\n\u003cp\u003eMetagenics SPM Active has been shown to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStimulate resolution of inflammation.\u003c\/li\u003e\n\u003cli\u003eAssist unresolved and chronic inflammatory processes by actively helping the body naturally restore homeostasis.\u003c\/li\u003e\n\u003cli\u003eSPM Active contains standardised and concentrated specialised proresolving mediators (SPMs) exclusive to Metagenics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics SPM Active is free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and starches.\u003c\/p\u003e\n\u003cp\u003eMetagenics SPM Active is free from artificial colours and flavours.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff0000;\"\u003e\u003cimg alt=\"Metagenics SPM Active 10% off RRP | HealthMasters\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_SPM_Active_Image_2_large.jpg?v=1560318694\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics SPM Active AUST L 313959\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule twice daily.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSpecialised Pro-Resolving Mediators (SPMs)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPM Active is a specific and targeted approach to facilitate the resolution phase in patients experiencing inflammation which may be failing to resolve in a timely manner.\u003c\/strong\u003e Unresolved inflammation can lead into low-grade, chronic inflammation that may worsen existing disease states, impair recovery and negatively affect healthy ageing.\u003csup\u003e3\u003c\/sup\u003e Chronic disease is an increasing health burden and it is now estimated that 1 in 3 Australians live with at least one chronic inflammatory condition including arthritis and other musculoskeletal disorders, cardiovascular disease and diabetes mellitus.\u003csup\u003e4\u003c\/sup\u003e These health issues are characterised by inflammatory processes disrupting healing and driving chronic states indicating the need for SPMs to help support healthy resolution outcomes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPMs found in SPM Active are lipid mediators that occur naturally in the body and have been found in various human tissue (such as the brain, lymph nodes and synovial fluid).\u003c\/strong\u003e\u003csup\u003e5\u003c\/sup\u003e SPMs orchestrate resolution at the site of inflammation to assist tissue repair, healing, recovery and the return to homeostasis.\u003csup\u003e6\u003c\/sup\u003e These mediators help to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivate the resolution phase.\u003c\/li\u003e\n\u003cli\u003eSignal to, and recruit certain immune cells and inflammatory mediators.\u003c\/li\u003e\n\u003cli\u003eRepair damage and clearance of pathogens.\u003c\/li\u003e\n\u003cli\u003ePrevent further pathological inflammation without immunosuppression.\u003csup\u003e7,8\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDespite omega-3 EPA and DHA being precursors of SPMs, they do not possess significant pro-resolving properties.\u003c\/strong\u003e\u003csup\u003e9\u003c\/sup\u003e Metagenics, in collaboration with SPMs experts and world-renowned leaders in the field of resolution physiology, are the first to set the standard for defining SPMs within a therapeutic supplement. Using a refined, patent pending fractionation process, specific SPM fractions are standardised for consistent dosing and therapeutic patient outcomes. The special fraction and ratio is isolated, concentrated and measured for bioactivity to verify the active SPMs 17-HDHA and 18-HEPE. This process is exclusive to Metagenics, providing an inflammation-specific solution.\u003c\/p\u003e\n\u003cp\u003eLiponva SPM's is a trademark of SOLUTEX GC.\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"Metagenics SPM Active 10% off RRP | HealthMasters\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_SPM_Active_10_off_RRP_-_HealthMasters_large.jpg?v=1560312341\"\u003e\u003c\/p\u003e\n\u003cp\u003ePatients:\u003c\/p\u003e\n\u003cp\u003eAustralia\/AU 2013259503\u003c\/p\u003e\n\u003cp\u003eNew Zealand\/NZ 702325\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics SPM Active\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eEach Metagenics SPM Active capsule contains:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eConcentrated fish Omega-3 triglycerides (LIPINOVA-11TG\u003csup\u003eTM\u003c\/sup\u003e)\u003c\/td\u003e\n\u003ctd\u003e498mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Eicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Docosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e100mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eContains active SPMs 17-HDHA and 18-HEPE\u003c\/p\u003e\n\u003cp\u003eMetagenics SPM Active is free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and starches. Metagenics SPM Active is free from artificial colours and flavours.\u003c\/p\u003e\n\u003ch5\u003eCautions and Contraindications\u003c\/h5\u003e\n\u003ch2\u003eCautions and Contraindications: Metagenics SPM Active\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergies and Sensitivities\u003c\/strong\u003e: Avoid in people allergic to fish. Although fish oil is highly purified, those with extreme fish allergy (anaphylaxis) would be advised to avoid it.82\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eModerate Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticoagulant\/antiplatelet drugs\u003c\/strong\u003e: Clinical trials have shown high-dose fish oil omega-3 fatty acid consumption to be safe, even when concurrently administered with other agents that may increase bleeding (i.e. antiplatelet or antithrombotic medications such as aspirin and warfarin). The clinical trial evidence suggests that if such an increased bleeding risk exists, the risk is very small and not of clinical significance. For example, 6.8 g of EPA\/DHA daily for 6 months showed no adverse effects. However, it is reasonable to monitor patients treated with fish oils and anticoagulants for international normalised ratio (INR) as well as potential adverse bleeding experiences.83,84\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBleeding disorders\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils during acute bleeding episodes, such as during and immediately after a haemorrhagic stroke, or in patients who are at high risk for haemorrhagic stroke.85,86\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils 4-7 days before elective procedures which have a high risk for bleeding complications. However, consider fish oil supplementation postoperatively if there are no bleeding complications, given that supplementation may reduce the risk of thrombotic and cardiovascular events which could occur following major surgery.87,88\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eLow Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNone of note.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003ePregnancy and Breastfeeding\u003c\/h5\u003e\n\u003ch2\u003ePregnancy and Breastfeeding: Metagenics SPM Active\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSafe to use in pregnancy and breastfeeding\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003e82 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003c\/p\u003e\n\u003cp\u003e83 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e84 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e85 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e86 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e87 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e88 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e89 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics SPM Active\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}

Metagenics SPM Active 60 Capsules

Product Details

Specialised Pro-Resolving Mediators

Metagenics SPM Active 60 Capsules

Metagenics SPM Active has been shown to:

  • Stimulate resolution of inflammation.
  • Assist unresolved and chronic inflammatory processes by actively helping the body naturally restore homeostasis.
  • SPM Active contains standardised and concentrated specialised proresolving mediators (SPMs) exclusive to Metagenics.

Metagenics SPM Active is free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and starches.

Metagenics SPM Active is free from artificial colours and flavours.

Metagenics SPM Active 10% off RRP | HealthMasters

Metagenics SPM Active AUST L 313959

Directions: Metagenics SPM Active

Adults: Take 1 capsule twice daily.

Clinical Benefits: Metagenics SPM Active

Specialised Pro-Resolving Mediators (SPMs)

SPM Active is a specific and targeted approach to facilitate the resolution phase in patients experiencing inflammation which may be failing to resolve in a timely manner. Unresolved inflammation can lead into low-grade, chronic inflammation that may worsen existing disease states, impair recovery and negatively affect healthy ageing.3 Chronic disease is an increasing health burden and it is now estimated that 1 in 3 Australians live with at least one chronic inflammatory condition including arthritis and other musculoskeletal disorders, cardiovascular disease and diabetes mellitus.4 These health issues are characterised by inflammatory processes disrupting healing and driving chronic states indicating the need for SPMs to help support healthy resolution outcomes.

SPMs found in SPM Active are lipid mediators that occur naturally in the body and have been found in various human tissue (such as the brain, lymph nodes and synovial fluid).5 SPMs orchestrate resolution at the site of inflammation to assist tissue repair, healing, recovery and the return to homeostasis.6 These mediators help to:

  • Activate the resolution phase.
  • Signal to, and recruit certain immune cells and inflammatory mediators.
  • Repair damage and clearance of pathogens.
  • Prevent further pathological inflammation without immunosuppression.7,8

Despite omega-3 EPA and DHA being precursors of SPMs, they do not possess significant pro-resolving properties.9 Metagenics, in collaboration with SPMs experts and world-renowned leaders in the field of resolution physiology, are the first to set the standard for defining SPMs within a therapeutic supplement. Using a refined, patent pending fractionation process, specific SPM fractions are standardised for consistent dosing and therapeutic patient outcomes. The special fraction and ratio is isolated, concentrated and measured for bioactivity to verify the active SPMs 17-HDHA and 18-HEPE. This process is exclusive to Metagenics, providing an inflammation-specific solution.

Liponva SPM's is a trademark of SOLUTEX GC.

Metagenics SPM Active 10% off RRP | HealthMasters

Patients:

Australia/AU 2013259503

New Zealand/NZ 702325

Ingredients: Metagenics SPM Active

Each Metagenics SPM Active capsule contains:
Concentrated fish Omega-3 triglycerides (LIPINOVA-11TGTM) 498mg
Equivalent Eicosapentaenoic acid (EPA) 50mg
Equivalent Docosahexaenoic acid (DHA) 100mg

Contains active SPMs 17-HDHA and 18-HEPE

Metagenics SPM Active is free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and starches. Metagenics SPM Active is free from artificial colours and flavours.

Cautions and Contraindications: Metagenics SPM Active

Contraindications

  • Allergies and Sensitivities: Avoid in people allergic to fish. Although fish oil is highly purified, those with extreme fish allergy (anaphylaxis) would be advised to avoid it.82

Moderate Level Cautions

  • Anticoagulant/antiplatelet drugs: Clinical trials have shown high-dose fish oil omega-3 fatty acid consumption to be safe, even when concurrently administered with other agents that may increase bleeding (i.e. antiplatelet or antithrombotic medications such as aspirin and warfarin). The clinical trial evidence suggests that if such an increased bleeding risk exists, the risk is very small and not of clinical significance. For example, 6.8 g of EPA/DHA daily for 6 months showed no adverse effects. However, it is reasonable to monitor patients treated with fish oils and anticoagulants for international normalised ratio (INR) as well as potential adverse bleeding experiences.83,84
  • Bleeding disorders: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils during acute bleeding episodes, such as during and immediately after a haemorrhagic stroke, or in patients who are at high risk for haemorrhagic stroke.85,86
  • Surgery: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils 4-7 days before elective procedures which have a high risk for bleeding complications. However, consider fish oil supplementation postoperatively if there are no bleeding complications, given that supplementation may reduce the risk of thrombotic and cardiovascular events which could occur following major surgery.87,88

Low Level Cautions

  • None of note.

Pregnancy and Breastfeeding: Metagenics SPM Active

  • Safe to use in pregnancy and breastfeeding

References: Metagenics SPM Active

82 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http://www.naturaldatabase.com. subscription required to view.

83 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.

84 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.

85 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.

86 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.

87 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.

88 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol 2007;99(6 Suppl 1):44C-46C.

89 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http://www.naturaldatabase.com. subscription required to view.

Storage: Metagenics SPM Active

Store below 30°C

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