{"id":4282806960187,"title":"Metagenics MetaPure Algal Oil 60 capsules","handle":"metagenics-metapure-algal-oil-60-capsules","description":"\u003ch3\u003e\u003cem\u003eHigh Purity, Sustainably Sourced, Vegan DHA and EPA.\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics MetaPure Algal Oil 60 capsules\u003c\/h2\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil Size: 60 tapioca-based softgel capsules (30 days)\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eThis product is currently out of stock. Due in 14th October\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eOrders of Metagenics MetaPure Algal Oil are back ordered to ensure you receive priority\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil is Dairy protein free Lactose free Egg free Gluten free Wheat free Free from Nuts Free from Yeast Free from Soy protein\u003c\/p\u003e\n\u003ch2\u003eMetagenics Allergy \u0026amp; Reactivity Reduction Program:\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-alergenics-powder-202-g?_pos=1\u0026amp;_sid=c6ca6e416\u0026amp;_ss=r\" title=\"Metagenics Alergenics 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Alergenics,\u003c\/a\u003e\u003cspan style=\"font-size: 1.4em;\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/metagenics-practitioner-range\/products\/metagenics-alergeze-60-tablets?_pos=1\u0026amp;_sid=930072260\u0026amp;_ss=r\" title=\"Metagenics Alergeze 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Alergeze,\u003c\/a\u003e\u003cspan style=\"font-size: 1.4em;\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/search?q=Ultra+Flora+Immune+Control\" title=\"Metagenics Ultra Flora Immune Control 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Ultra Flora Immune Control\u003c\/a\u003e\u003cspan style=\"font-size: 1.4em;\"\u003e and \u003c\/span\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/search?q=MetaPure+EPA%2FDHA+Fish+Oil\" title=\"Metagenics EPA\/DHA Fish Oil 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Meta EPA\/DHA Fish Oil\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"Patients Can Buy Naturopathic Medicines 10% off RRP | HealthMasters\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003eMetagenics 10% off RRP\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cbig\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"Patients Can Buy Naturopathic Medicines 10% off RRP | HealthMasters\" style=\"color: #ff2a00;\"\u003eClick Here To Access\u003c\/a\u003e\u003c\/big\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003eIf you have access see below for more on Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eProduct Description\u003c\/h5\u003e\n\u003ch2\u003eProduct Description: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eIngredients in Metagenics MetaPure Algal Oil has been shown to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvide a sustainable and pure source of vegan omega-3 fatty acids for health and wellbeing.\u003c\/li\u003e\n\u003cli\u003eSupport cognitive and mental function.\u003c\/li\u003e\n\u003cli\u003eMaintain a healthy pregnancy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMetagenics Allergy and Reactivity Program\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/266627135\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule twice daily with food\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics MetaPure Algal Oil provides a vegan source of omega-3 essential fatty acids (EFAs) derived from algae, encapsulated in tapioca-based softgels.\u003c\/strong\u003e Algae-rich EFAs exert the same therapeutic benefits as EPA and DHA derived from traditional fish oil. Metagenics MetaPure Algal Oil is sourced from algae grown under closed and controlled conditions ensuring the algae are not exposed to environmental contaminants present in oceans. Metagenics MetaPure Algal Oil is rigorously screened for contaminants such as heavy metals (cadmium, lead, mercury and arsenic) and oxidation (anisidine and peroxide) ensuring purity levels that significantly exceed TGA standards, delivering a fresh and pure product.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics MetaPure Algal Oil contains vegan-friendly DHA, which is required for brain, nervous system and cognitive health.\u003c\/strong\u003e\u003csup\u003e1\u003c\/sup\u003e DHA is integral to neural membrane phospholipid composition in the brain, retina and neural tissues,\u003csup\u003e2\u003c\/sup\u003e making DHA an essential prescription for people affected by memory or vision related conditions. Both EPA and DHA has been shown to improve cognitive function\u003csup\u003e3\u003c\/sup\u003e while EFAs have been shown to regulate mood.\u003csup\u003e4\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHA is essential for prenatal human brain development\u003csup\u003e5\u003c\/sup\u003e with a deficiency having marked consequences for vision, cognition, cerebellar function, and neurological health.\u003c\/strong\u003e\u003csup\u003e6\u003c\/sup\u003e DHA is critical for brain growth, which is especially rapid from the third trimester of pregnancy until 18 months after birth.\u003csup\u003e7,8\u003c\/sup\u003e DHA is conferred to infants via the placenta and breastfeeding, however human milk levels of DHA have shown variations relating to maternal dietary DHA intake.\u003csup\u003e9,10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics MetaPure Algal oil provides a vegan source of EPA and DHA, ideal for those undertaking sustainable or vegan lifestyles looking to maintain general health. \u003c\/strong\u003eUp to 80% of Australians are not meeting the recommended daily intake for omega-3 EFAs.\u003csup\u003e11\u003c\/sup\u003e Omega-3 EFAs play key roles in the body influencing inflammatory mechanisms and the health of cell membranes, the brain and cardiovascular, reproductive, and musculoskeletal systems.\u003csup\u003e12,13,14,15,16,17,18,19,20\u003c\/sup\u003e Although dietary intake is important, enzymatic conversion in the body to yield EPA and DHA is inefficient, reinforcing the importance of omega-3 supplementation.Life's \u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_MetaPure_Algal_Oil_10_off_RRP_at_HealthMasters_Life_s_Omega_Logo_large.JPG?v=1571275305\" alt=\"Metagenics MetaPure Algal Oil 10% off RRP at HealthMasters Life's Omega Logo\"\u003eOmega logolife's® OMEGA is a trademark of DSM\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Metagenics MetaPure Algal Oil capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDHA\/EPA rich Schizochytrium algal oil\u003c\/td\u003e\n\u003ctd\u003e962.7mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Docosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Eicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e150mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_MetaPure_Algal_Oil_10_off_RRP_at_HealthMasters_Life_s_Omega_Logo_large.JPG?v=1571275305\" alt=\"Metagenics MetaPure Algal Oil 10% off RRP at HealthMasters Life's Omega Logo\"\u003eLife's Omega logolife's® OMEGA is a registered trademark of DSM.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eNot all cautions and contraindications are listed. For full details, references or more information contact HealthMasters in Australia by email: reception@healthmasters.com.au.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eCautions and Contraindications\u003c\/h5\u003e\n\u003ch2\u003eCautions and Contraindications: Metagenics MetaPure Algal\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNone of note.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eModerate Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticoagulant\/antiplatelet drugs\u003c\/strong\u003e: Clinical trials have shown high-dose fish oil omega-3 fatty acid consumption to be safe, even when concurrently administered with other agents that may increase bleeding (i.e. antiplatelet or antithrombotic medications such as aspirin and warfarin). The clinical trial evidence suggests that if such an increased bleeding risk exists, the risk is very small and not of clinical significance. For example, 6.8 g of EPA\/DHA daily for 6 months showed no adverse effects. However, it is reasonable to monitor patients treated with fish oils and anticoagulants for international normalised ratio (INR) as well as potential adverse bleeding experiences.\u003csup\u003e83,84\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBleeding disorders\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils during acute bleeding episodes, such as during and immediately after a haemorrhagic stroke, or in patients who are at high risk for haemorrhagic stroke.\u003csup\u003e85,86\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils 4-7 days before elective procedures which have a high risk for bleeding complications. However, consider fish oil supplementation postoperatively if there are no bleeding complications, given that supplementation may reduce the risk of thrombotic and cardiovascular events which could occur following major surgery.\u003csup\u003e87,88\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003e82 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e83 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e84 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e85 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e86 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e87 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e88 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e89 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eLow Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNone of note.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFish Oil Consumption Does Not Increase Bleeding Risk\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eby Lewis Chang, PhD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFish oil is rich in omega-3 fatty acids EPA and DHA. Increased intake of EPA and DHA is beneficial for cardiovascular health, cognitive function, mental health, maternal and child health, immunity and inflammation. EPA and DHA supplements are becoming more and more popular across a wide diversity of people; from healthy individuals to vulnerable populations with impaired health.\u003c\/p\u003e\n\u003cp\u003eHigher omega-3 concentrations may compete with fatty acids such as arachidonic acid for metabolizing enzymes. The interaction results in a decreased production of compounds that induce platelet aggregation and an increased production of compounds with anti-platelet properties, hence the anticoagulation benefits of omega-3. However, for patients who are under antithrombotic therapy (either with platelet aggregation inhibitors such as aspirin or anticoagulant drugs such as warfarin), the potential risk of bleeding due to the concurrent use of omega-3 fatty acids has been a concern by many clinicians, particularly surgeons.\u003csup\u003e1,2\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eMultiple clinical studies have been conducted to investigate whether omega-3 fatty acids pose a clinically significant bleeding risk. So far, the findings have been consistent:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 2004 Cochrane review of 48 randomized controlled trials and 41 epidemiological analyses concludes that 0.4-7 g\/day omega-3 fatty acids \u003cstrong\u003edo not result in any change in clinical bleeding manifestations\u003c\/strong\u003e\u003csup\u003e3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2007 review of 19 clinical studies involving nearly 4400 surgical patients concludes that the \u003cstrong\u003erisk for clinically significant bleeding was virtually nonexistent\u003c\/strong\u003e with the use of 1.4-21 g\/day of omega-3 fatty acid supplements, even with the concurrent use of antiplatelet or antithrombotic medications\u003csup\u003e4\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2013 systematic review of 10 randomized trials involving nearly 1000 adults 60 years or older concludes that there is \u003cstrong\u003eno difference in total adverse event rates\u003c\/strong\u003e between daily use of placebo or 0.03-1.86 g EPA and\/or DHA for 6-52 weeks\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2014 review of 7 randomized controlled trials and 3 epidemiological studies concludes that omega-3 fatty acid treatment \u003cstrong\u003ehas no effect on the risk of clinically significant bleeding\u003c\/strong\u003e in either monotherapy or combination therapy settings and there is \u003cstrong\u003eno support for discontinuing the use of omega-3 fatty acid treatment before invasive procedures\u003c\/strong\u003e\u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2017 systematic review based on 32 publications on healthy subjects and 20 publications on patients undergoing surgery finds that fish oil supplements reduce platelet aggregation in healthy subjects and do not increase intra- or post-operative bleedings in patients, and concludes that \u003cstrong\u003ediscontinuation of fish oils supplements prior to surgery is not recommended\u003c\/strong\u003e\u003csup\u003e7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the accumulating evidence demonstrating the safety of fish oil, the worry seems to persist, especially when at risk patients are involved.\u003c\/p\u003e\n\u003cp\u003eMost recently, researchers from Danone Food Safety Centre (Palaiseau, France) and Nutricia Research (Utrecht, the Netherlands) evaluated the safety data from 8 clinical intervention studies involving over 600 patients, including oncology patients, HIV patients, ICU patients, and patients with Alzheimer’s disease.\u003csup\u003e8\u003c\/sup\u003e The levels of omega-3 fatty acids received by these patients (either via oral consumption or tube feeding) ranged from 1.5-10.2 g\/day with a duration of 8 days to 52 weeks. The outcomes included bleeding-related adverse events, prothrombin time, and partial thromboplastin time. In the end, the researchers found \u003cstrong\u003eno evidence of increased risk of bleeding with the use of omega-3 fatty acid products in these patients, with or without concomitant use of antithrombotic medications.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn summary, the legitimate concern of increased bleeding as a result of omega-3 fatty acid intake has not been supported by numerous randomized controlled trials and epidemiological studies involving a wide range or participants, from healthy young folks to surgical patients to very vulnerable older patients.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003e\u003cstrong\u003eWhy is this Clinically Relevant?\u003c\/strong\u003e\u003c\/em\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eFish oil or EPA\/DHA products are associated with a variety of benefits, from cardiovascular health to cognitive function to anti-inflammation\u003c\/li\u003e\n\u003cli\u003eThe concern of increased risks of bleeding associated with these ingredients has not been validated by a large number of clinical studies and systemic reviews\u003c\/li\u003e\n\u003cli\u003eClinicians should inform patients of the safety of omega-3 fatty acids for the vast majority of the population, and there is no scientific evidence supporting the discontinuation of omega-3 products prior to surgery\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003e1. Bays HE. Safety considerations with omega-3 fatty acid therapy. \u003cem\u003eAm J Cardiol.\u003c\/em\u003e 2007;99(6A):35C-43C.\u003c\/p\u003e\n\u003cp\u003e2. Braga M, Ljungqvist O, Soeters P, et al. ESPEN Guidelines on Parenteral Nutrition: surgery. \u003cem\u003eClin Nutr\u003c\/em\u003e. 2009;28(4):378-386.\u003c\/p\u003e\n\u003cp\u003e3. Hooper L, Thompson RL, Harrison RA, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. \u003cem\u003eCochrane Database Syst\u003c\/em\u003e Rev. 2004(4):CD003177.\u003c\/p\u003e\n\u003cp\u003e4. Harris WS. Expert opinion: omega-3 fatty acids and bleeding-cause for concern? \u003cem\u003eAm J Cardiol\u003c\/em\u003e. 2007;99(6A):44C-46C.\u003c\/p\u003e\n\u003cp\u003e5. Villani AM, Crotty M, Cleland LG, et al. Fish oil administration in older adults: is there potential for adverse events? A systematic review of the literature. \u003cem\u003eBMC Geriatr\u003c\/em\u003e. 2013;13:41.\u003c\/p\u003e\n\u003cp\u003e6. Wachira JK, Larson MK, Harris WS. n-3 Fatty acids affect haemostasis but do not increase the risk of bleeding: clinical observations and mechanistic insights. \u003cem\u003eBr J Nutr\u003c\/em\u003e. 2014;111(9):1652-1662.\u003c\/p\u003e\n\u003cp\u003e7. Begtrup KM, Krag AE, Hvas AM. No impact of fish oil supplements on bleeding risk: a systematic review. \u003cem\u003eDan Med J.\u003c\/em\u003e 2017;64(5).\u003c\/p\u003e\n\u003cp\u003e8. Jeansen S, Witkamp RF, Garthoff JA, van Helvoort A, Calder PC. Fish oil LCPUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition. \u003cem\u003eClin Nutr.\u003c\/em\u003e 2018;37(3):948-957.\u003c\/p\u003e\n\u003ch5\u003ePregnancy and Breastfeeding\u003c\/h5\u003e\n\u003ch2\u003ePregnancy and Breastfeeding: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003ch3\u003ePregnancy and Breastfeeding\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use in pregnancy and breast feeding.82,83.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eBreastfeeding\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use.89\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eStore below 25°C\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2019-10-17T11:59:40+11:00","created_at":"2019-10-17T11:59:40+11:00","vendor":"Metagenics","type":"Buy Naturopathic Products 10% off RRP","tags":["Essential Fatty Acids","Fish Oil","Metagenics","Omega-3","Pain and Inflammation","Postnatal","Preconception","Pregnancy"],"price":5265,"price_min":5265,"price_max":5265,"available":true,"price_varies":false,"compare_at_price":5850,"compare_at_price_min":5850,"compare_at_price_max":5850,"compare_at_price_varies":false,"variants":[{"id":30769889378363,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"MetaPureAlgalOil60caps","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Metagenics MetaPure Algal Oil 60 capsules","public_title":null,"options":["Default Title"],"price":5265,"weight":244,"compare_at_price":5850,"inventory_quantity":9987,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9315771011300"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-1.jpg?v=1593126753","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-2.jpg?v=1593126762","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-3.jpg?v=1593126771","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_MetaPure_Algal_Oil_10_off_RRP_at_HealthMasters_Life_s_Omega_Logo.JPG?v=1593126745","\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_MetaPure_EPA-DHA_Citrus_Berry_100_mL_10_off_RRP_at_HealthMasters_ae0f34a2-de1f-4929-ac2f-a9072b1e4be5.jpg?v=1593126745"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-1.jpg?v=1593126753","options":["Title"],"media":[{"alt":"Metagenics MetaPure Algal Oil 60 Capsules-1","id":9760167067806,"position":1,"preview_image":{"aspect_ratio":1.0,"height":2400,"width":2400,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-1.jpg?v=1593126740"},"aspect_ratio":1.0,"height":2400,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-1.jpg?v=1593126740","width":2400},{"alt":"Metagenics MetaPure Algal Oil 60 Capsules-2","id":9760167100574,"position":2,"preview_image":{"aspect_ratio":1.0,"height":2400,"width":2400,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-2.jpg?v=1593126741"},"aspect_ratio":1.0,"height":2400,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-2.jpg?v=1593126741","width":2400},{"alt":"Metagenics MetaPure Algal Oil 60 Capsules-3","id":9760167133342,"position":3,"preview_image":{"aspect_ratio":1.0,"height":2400,"width":2400,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-3.jpg?v=1593126740"},"aspect_ratio":1.0,"height":2400,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/MetagenicsMetaPureAlgalOil60Capsules-3.jpg?v=1593126740","width":2400},{"alt":"Metagenics MetaPure Algal Oil 10% off RRP at HealthMasters Life's Omega Logo | HealthMasters","id":5360992387131,"position":4,"preview_image":{"aspect_ratio":1.224,"height":49,"width":60,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_MetaPure_Algal_Oil_10_off_RRP_at_HealthMasters_Life_s_Omega_Logo.JPG?v=1571275216"},"aspect_ratio":1.224,"height":49,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_MetaPure_Algal_Oil_10_off_RRP_at_HealthMasters_Life_s_Omega_Logo.JPG?v=1571275216","width":60},{"alt":"Metagenics MetaPure Algal Oil 60 capsules 10% off RRP | HealthMasters","id":5360982687803,"position":5,"preview_image":{"aspect_ratio":1.0,"height":500,"width":500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_MetaPure_EPA-DHA_Citrus_Berry_100_mL_10_off_RRP_at_HealthMasters_ae0f34a2-de1f-4929-ac2f-a9072b1e4be5.jpg?v=1591735328"},"aspect_ratio":1.0,"height":500,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/Metagenics_MetaPure_EPA-DHA_Citrus_Berry_100_mL_10_off_RRP_at_HealthMasters_ae0f34a2-de1f-4929-ac2f-a9072b1e4be5.jpg?v=1591735328","width":500}],"content":"\u003ch3\u003e\u003cem\u003eHigh Purity, Sustainably Sourced, Vegan DHA and EPA.\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics MetaPure Algal Oil 60 capsules\u003c\/h2\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil Size: 60 tapioca-based softgel capsules (30 days)\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eThis product is currently out of stock. Due in 14th October\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003eOrders of Metagenics MetaPure Algal Oil are back ordered to ensure you receive priority\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil is Dairy protein free Lactose free Egg free Gluten free Wheat free Free from Nuts Free from Yeast Free from Soy protein\u003c\/p\u003e\n\u003ch2\u003eMetagenics Allergy \u0026amp; Reactivity Reduction Program:\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-alergenics-powder-202-g?_pos=1\u0026amp;_sid=c6ca6e416\u0026amp;_ss=r\" title=\"Metagenics Alergenics 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Alergenics,\u003c\/a\u003e\u003cspan style=\"font-size: 1.4em;\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/collections\/metagenics-practitioner-range\/products\/metagenics-alergeze-60-tablets?_pos=1\u0026amp;_sid=930072260\u0026amp;_ss=r\" title=\"Metagenics Alergeze 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Alergeze,\u003c\/a\u003e\u003cspan style=\"font-size: 1.4em;\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/search?q=Ultra+Flora+Immune+Control\" title=\"Metagenics Ultra Flora Immune Control 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Ultra Flora Immune Control\u003c\/a\u003e\u003cspan style=\"font-size: 1.4em;\"\u003e and \u003c\/span\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/search?q=MetaPure+EPA%2FDHA+Fish+Oil\" title=\"Metagenics EPA\/DHA Fish Oil 10% off RRP | HealthMasters Metagenics\" style=\"font-size: 1.4em;\"\u003eMetagenics Meta EPA\/DHA Fish Oil\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"Patients Can Buy Naturopathic Medicines 10% off RRP | HealthMasters\"\u003e\u003cbig\u003e\u003cspan style=\"color: #27ae60;\"\u003eMetagenics 10% off RRP\u003c\/span\u003e\u003c\/big\u003e\u003c\/a\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cbig\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/buy-naturopathic-products\" title=\"Patients Can Buy Naturopathic Medicines 10% off RRP | HealthMasters\" style=\"color: #ff2a00;\"\u003eClick Here To Access\u003c\/a\u003e\u003c\/big\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003eIf you have access see below for more on Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eProduct Description\u003c\/h5\u003e\n\u003ch2\u003eProduct Description: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eIngredients in Metagenics MetaPure Algal Oil has been shown to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvide a sustainable and pure source of vegan omega-3 fatty acids for health and wellbeing.\u003c\/li\u003e\n\u003cli\u003eSupport cognitive and mental function.\u003c\/li\u003e\n\u003cli\u003eMaintain a healthy pregnancy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMetagenics Allergy and Reactivity Program\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/266627135\" frameborder=\"0\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule twice daily with food\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics MetaPure Algal Oil provides a vegan source of omega-3 essential fatty acids (EFAs) derived from algae, encapsulated in tapioca-based softgels.\u003c\/strong\u003e Algae-rich EFAs exert the same therapeutic benefits as EPA and DHA derived from traditional fish oil. Metagenics MetaPure Algal Oil is sourced from algae grown under closed and controlled conditions ensuring the algae are not exposed to environmental contaminants present in oceans. Metagenics MetaPure Algal Oil is rigorously screened for contaminants such as heavy metals (cadmium, lead, mercury and arsenic) and oxidation (anisidine and peroxide) ensuring purity levels that significantly exceed TGA standards, delivering a fresh and pure product.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics MetaPure Algal Oil contains vegan-friendly DHA, which is required for brain, nervous system and cognitive health.\u003c\/strong\u003e\u003csup\u003e1\u003c\/sup\u003e DHA is integral to neural membrane phospholipid composition in the brain, retina and neural tissues,\u003csup\u003e2\u003c\/sup\u003e making DHA an essential prescription for people affected by memory or vision related conditions. Both EPA and DHA has been shown to improve cognitive function\u003csup\u003e3\u003c\/sup\u003e while EFAs have been shown to regulate mood.\u003csup\u003e4\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHA is essential for prenatal human brain development\u003csup\u003e5\u003c\/sup\u003e with a deficiency having marked consequences for vision, cognition, cerebellar function, and neurological health.\u003c\/strong\u003e\u003csup\u003e6\u003c\/sup\u003e DHA is critical for brain growth, which is especially rapid from the third trimester of pregnancy until 18 months after birth.\u003csup\u003e7,8\u003c\/sup\u003e DHA is conferred to infants via the placenta and breastfeeding, however human milk levels of DHA have shown variations relating to maternal dietary DHA intake.\u003csup\u003e9,10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics MetaPure Algal oil provides a vegan source of EPA and DHA, ideal for those undertaking sustainable or vegan lifestyles looking to maintain general health. \u003c\/strong\u003eUp to 80% of Australians are not meeting the recommended daily intake for omega-3 EFAs.\u003csup\u003e11\u003c\/sup\u003e Omega-3 EFAs play key roles in the body influencing inflammatory mechanisms and the health of cell membranes, the brain and cardiovascular, reproductive, and musculoskeletal systems.\u003csup\u003e12,13,14,15,16,17,18,19,20\u003c\/sup\u003e Although dietary intake is important, enzymatic conversion in the body to yield EPA and DHA is inefficient, reinforcing the importance of omega-3 supplementation.Life's \u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_MetaPure_Algal_Oil_10_off_RRP_at_HealthMasters_Life_s_Omega_Logo_large.JPG?v=1571275305\" alt=\"Metagenics MetaPure Algal Oil 10% off RRP at HealthMasters Life's Omega Logo\"\u003eOmega logolife's® OMEGA is a trademark of DSM\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Metagenics MetaPure Algal Oil capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDHA\/EPA rich Schizochytrium algal oil\u003c\/td\u003e\n\u003ctd\u003e962.7mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Docosahexaenoic acid (DHA)\u003c\/td\u003e\n\u003ctd\u003e300mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Eicosapentaenoic acid (EPA)\u003c\/td\u003e\n\u003ctd\u003e150mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics MetaPure Algal Oil is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_MetaPure_Algal_Oil_10_off_RRP_at_HealthMasters_Life_s_Omega_Logo_large.JPG?v=1571275305\" alt=\"Metagenics MetaPure Algal Oil 10% off RRP at HealthMasters Life's Omega Logo\"\u003eLife's Omega logolife's® OMEGA is a registered trademark of DSM.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eNot all cautions and contraindications are listed. For full details, references or more information contact HealthMasters in Australia by email: reception@healthmasters.com.au.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch5\u003eCautions and Contraindications\u003c\/h5\u003e\n\u003ch2\u003eCautions and Contraindications: Metagenics MetaPure Algal\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNone of note.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eModerate Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticoagulant\/antiplatelet drugs\u003c\/strong\u003e: Clinical trials have shown high-dose fish oil omega-3 fatty acid consumption to be safe, even when concurrently administered with other agents that may increase bleeding (i.e. antiplatelet or antithrombotic medications such as aspirin and warfarin). The clinical trial evidence suggests that if such an increased bleeding risk exists, the risk is very small and not of clinical significance. For example, 6.8 g of EPA\/DHA daily for 6 months showed no adverse effects. However, it is reasonable to monitor patients treated with fish oils and anticoagulants for international normalised ratio (INR) as well as potential adverse bleeding experiences.\u003csup\u003e83,84\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBleeding disorders\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils during acute bleeding episodes, such as during and immediately after a haemorrhagic stroke, or in patients who are at high risk for haemorrhagic stroke.\u003csup\u003e85,86\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery\u003c\/strong\u003e: Due to the anticoagulant properties of fish oils, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. Although this theoretical possibility is not reflected functionally in human studies, it would still warrant caution in situations which carry a high risk of bleeding such as haemorrhagic stroke and postoperative events. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use of fish oils 4-7 days before elective procedures which have a high risk for bleeding complications. However, consider fish oil supplementation postoperatively if there are no bleeding complications, given that supplementation may reduce the risk of thrombotic and cardiovascular events which could occur following major surgery.\u003csup\u003e87,88\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003e82 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e83 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e84 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e85 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e86 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol. 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e87 Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99(6 Suppl 1):35C-43C.\u003c\/p\u003e\n\u003cp\u003e88 Harris WS. Expert opinion: omega-3 fatty acids and bleeding – cause for concern? Am J Cardiol 2007;99(6 Suppl 1):44C-46C.\u003c\/p\u003e\n\u003cp\u003e89 Fish Oil. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2008 [cited 2017 Feb 21]. Available from: http:\/\/www.naturaldatabase.com. subscription required to view.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eLow Level Cautions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNone of note.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFish Oil Consumption Does Not Increase Bleeding Risk\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eby Lewis Chang, PhD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFish oil is rich in omega-3 fatty acids EPA and DHA. Increased intake of EPA and DHA is beneficial for cardiovascular health, cognitive function, mental health, maternal and child health, immunity and inflammation. EPA and DHA supplements are becoming more and more popular across a wide diversity of people; from healthy individuals to vulnerable populations with impaired health.\u003c\/p\u003e\n\u003cp\u003eHigher omega-3 concentrations may compete with fatty acids such as arachidonic acid for metabolizing enzymes. The interaction results in a decreased production of compounds that induce platelet aggregation and an increased production of compounds with anti-platelet properties, hence the anticoagulation benefits of omega-3. However, for patients who are under antithrombotic therapy (either with platelet aggregation inhibitors such as aspirin or anticoagulant drugs such as warfarin), the potential risk of bleeding due to the concurrent use of omega-3 fatty acids has been a concern by many clinicians, particularly surgeons.\u003csup\u003e1,2\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eMultiple clinical studies have been conducted to investigate whether omega-3 fatty acids pose a clinically significant bleeding risk. So far, the findings have been consistent:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 2004 Cochrane review of 48 randomized controlled trials and 41 epidemiological analyses concludes that 0.4-7 g\/day omega-3 fatty acids \u003cstrong\u003edo not result in any change in clinical bleeding manifestations\u003c\/strong\u003e\u003csup\u003e3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2007 review of 19 clinical studies involving nearly 4400 surgical patients concludes that the \u003cstrong\u003erisk for clinically significant bleeding was virtually nonexistent\u003c\/strong\u003e with the use of 1.4-21 g\/day of omega-3 fatty acid supplements, even with the concurrent use of antiplatelet or antithrombotic medications\u003csup\u003e4\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2013 systematic review of 10 randomized trials involving nearly 1000 adults 60 years or older concludes that there is \u003cstrong\u003eno difference in total adverse event rates\u003c\/strong\u003e between daily use of placebo or 0.03-1.86 g EPA and\/or DHA for 6-52 weeks\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2014 review of 7 randomized controlled trials and 3 epidemiological studies concludes that omega-3 fatty acid treatment \u003cstrong\u003ehas no effect on the risk of clinically significant bleeding\u003c\/strong\u003e in either monotherapy or combination therapy settings and there is \u003cstrong\u003eno support for discontinuing the use of omega-3 fatty acid treatment before invasive procedures\u003c\/strong\u003e\u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eA 2017 systematic review based on 32 publications on healthy subjects and 20 publications on patients undergoing surgery finds that fish oil supplements reduce platelet aggregation in healthy subjects and do not increase intra- or post-operative bleedings in patients, and concludes that \u003cstrong\u003ediscontinuation of fish oils supplements prior to surgery is not recommended\u003c\/strong\u003e\u003csup\u003e7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the accumulating evidence demonstrating the safety of fish oil, the worry seems to persist, especially when at risk patients are involved.\u003c\/p\u003e\n\u003cp\u003eMost recently, researchers from Danone Food Safety Centre (Palaiseau, France) and Nutricia Research (Utrecht, the Netherlands) evaluated the safety data from 8 clinical intervention studies involving over 600 patients, including oncology patients, HIV patients, ICU patients, and patients with Alzheimer’s disease.\u003csup\u003e8\u003c\/sup\u003e The levels of omega-3 fatty acids received by these patients (either via oral consumption or tube feeding) ranged from 1.5-10.2 g\/day with a duration of 8 days to 52 weeks. The outcomes included bleeding-related adverse events, prothrombin time, and partial thromboplastin time. In the end, the researchers found \u003cstrong\u003eno evidence of increased risk of bleeding with the use of omega-3 fatty acid products in these patients, with or without concomitant use of antithrombotic medications.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn summary, the legitimate concern of increased bleeding as a result of omega-3 fatty acid intake has not been supported by numerous randomized controlled trials and epidemiological studies involving a wide range or participants, from healthy young folks to surgical patients to very vulnerable older patients.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003e\u003cstrong\u003eWhy is this Clinically Relevant?\u003c\/strong\u003e\u003c\/em\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eFish oil or EPA\/DHA products are associated with a variety of benefits, from cardiovascular health to cognitive function to anti-inflammation\u003c\/li\u003e\n\u003cli\u003eThe concern of increased risks of bleeding associated with these ingredients has not been validated by a large number of clinical studies and systemic reviews\u003c\/li\u003e\n\u003cli\u003eClinicians should inform patients of the safety of omega-3 fatty acids for the vast majority of the population, and there is no scientific evidence supporting the discontinuation of omega-3 products prior to surgery\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003e1. Bays HE. Safety considerations with omega-3 fatty acid therapy. \u003cem\u003eAm J Cardiol.\u003c\/em\u003e 2007;99(6A):35C-43C.\u003c\/p\u003e\n\u003cp\u003e2. Braga M, Ljungqvist O, Soeters P, et al. ESPEN Guidelines on Parenteral Nutrition: surgery. \u003cem\u003eClin Nutr\u003c\/em\u003e. 2009;28(4):378-386.\u003c\/p\u003e\n\u003cp\u003e3. Hooper L, Thompson RL, Harrison RA, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. \u003cem\u003eCochrane Database Syst\u003c\/em\u003e Rev. 2004(4):CD003177.\u003c\/p\u003e\n\u003cp\u003e4. Harris WS. Expert opinion: omega-3 fatty acids and bleeding-cause for concern? \u003cem\u003eAm J Cardiol\u003c\/em\u003e. 2007;99(6A):44C-46C.\u003c\/p\u003e\n\u003cp\u003e5. Villani AM, Crotty M, Cleland LG, et al. Fish oil administration in older adults: is there potential for adverse events? A systematic review of the literature. \u003cem\u003eBMC Geriatr\u003c\/em\u003e. 2013;13:41.\u003c\/p\u003e\n\u003cp\u003e6. Wachira JK, Larson MK, Harris WS. n-3 Fatty acids affect haemostasis but do not increase the risk of bleeding: clinical observations and mechanistic insights. \u003cem\u003eBr J Nutr\u003c\/em\u003e. 2014;111(9):1652-1662.\u003c\/p\u003e\n\u003cp\u003e7. Begtrup KM, Krag AE, Hvas AM. No impact of fish oil supplements on bleeding risk: a systematic review. \u003cem\u003eDan Med J.\u003c\/em\u003e 2017;64(5).\u003c\/p\u003e\n\u003cp\u003e8. Jeansen S, Witkamp RF, Garthoff JA, van Helvoort A, Calder PC. Fish oil LCPUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition. \u003cem\u003eClin Nutr.\u003c\/em\u003e 2018;37(3):948-957.\u003c\/p\u003e\n\u003ch5\u003ePregnancy and Breastfeeding\u003c\/h5\u003e\n\u003ch2\u003ePregnancy and Breastfeeding: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003ch3\u003ePregnancy and Breastfeeding\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use in pregnancy and breast feeding.82,83.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eBreastfeeding\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use.89\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics MetaPure Algal Oil\u003c\/h2\u003e\n\u003cp\u003eStore below 25°C\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}

Metagenics MetaPure Algal Oil 60 capsules

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High Purity, Sustainably Sourced, Vegan DHA and EPA.

Metagenics MetaPure Algal Oil 60 capsules

Metagenics MetaPure Algal Oil Size: 60 tapioca-based softgel capsules (30 days)

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Metagenics MetaPure Algal Oil is Dairy protein free Lactose free Egg free Gluten free Wheat free Free from Nuts Free from Yeast Free from Soy protein

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