BioCeuticals PepZin Pro 60 caps
Dose: BioCeuticals PepZin Pro
Adults: For symptoms of mild gastritis: Take 3-6 capsules daily. During and after antibiotic use: Take 1-3 capsules daily.
Take as above or as directed by your health professional.
Features: BioCeuticals PepZin Pro
- Contains Polaprezinc (zinc carnosine) PepZinGI a highly bioavailable chelated form of zinc.
- Polaprezinc (zinc carnosine) PepZinGI helps relieve symptoms of mild gastritis including gastrointestinal pain, nausea, abdominal distention and heartburn.
- Formulated with Lacidofil which is a clinically trialled probiotic combination of Lactobacillus helveticus Rosell-52 (R0052) and Lactobacillus rhamnosus Rosell-11 (R0011).
- Lacidofil relieves symptoms of medically diagnosed irritable bowel syndrome including a reduction in abdominal pain.
- Lactobacillus rhamnosus supports beneficial gut flora during antibiotic use and restores beneficial gut flora after antibiotic use.
- Zinc supports wound healing.
- Vegan friendly.
Ingredients: BioCeuticals PepZin Pro
|Each capsule contains:|
|Polaprezinc (zinc carnosine) - PepZin GI||25mg|
|equiv. to carnosine||19.5mg|
|Lactobacillus rhamnosus R0011 (Lacidofil)||3.8 billion CFU|
|Lactobacillus helveticus R0052 (Lacidofil)||200 million CFU|
Ingredient Summary: BioCeuticals PepZin Pro
With roughly 40% of the Australian population over 60 years old infected with a bacteria which can cause gastritis28-29, it is a common clinical presentation. Gastritis is an inflammation of the stomach lining.1,8 Common causes of gastritis include non-steroidal anti-inflammatory medication (NSAIDs), alcohol and bacterial infection.8 Zinc carnosine helps relieve the symptoms of mild gastritis including gastrointestinal pain, nausea, bloating and heartburn.
Polaprezinc (zinc carnosine)
PepZin Pro contains PepZinGI a compound which was developed in 1983 and is a novel chelated crystalline compound combining zinc and L-carnosine (N-beta-alanyl-L-histidine).15 The healing properties of zinc are well established and the use of zinc in combination with carnosine is innovative, due to the synergistic effects and beneficial properties as a combination.4 Combining both zinc and L-carnosine into a molecule, called polaprezinc, has been shown in rats to have a greater effect than each individual nutrient, even when taken together.16-17 For over 20 years, zinc carnosine has been used in Japan for promoting healing of gastric mucosa. In vivo and in vitro studies have shown that zinc carnosine has a particular affinity with the digestive tract.9-14 This is due to zinc carnosine having the ability to be broken down slowly in the digestive juices, allowing it to stay in contact with the gastrointestinal tissues for longer.4 Animal studies show that this extended exposure enables zinc carnosine to aid in wound healing and to exert its beneficial health effects on this area.4,16-17
Zinc assists in wound healing. In vivo and in vitro studies suggest that zinc carnosine prevents gastric mucosal injury.2 The hypothesis behind this is attributed to several mechanisms, including the wound healing properties of zinc. Research on healthy humans alongside in vivo and in vitro models of gut injury and repair has shown that when zinc carnosine was given alongside a medication, there was no increase in gut permeability when compared to taking the medication alone. When the medicine was administered alone, it caused a three-fold increase in gut permeability after five days of treatment suggesting stabilisation of the gut mucosa.9 L
Lacidofil probiotic blend
The beneficial effects of probiotic supplementation are known to maintain beneficial intestinal flora and re-establish it when it is disturbed.24-26 This includes the Lactobacillus rhamnosus strain as it maintains beneficial gut flora during antibiotic use and restores beneficial gut flora after antibiotic use.19, 22 Lacidofil is a probiotic blend consisting of Lactobacillus rhamnosus (L. rhamnosus) Rosell-11, R0011 and Lactobacillus helveticus (L. helveticus) Rosell-52, R0052. Both of these strains have full genome sequencing and can survive in the gastrointestinal tract as they are unaffected by bile and gastric acidity.7 Lacidofil also relieves diarrhoea.22-23
Warnings: BioCeuticals PepZin Pro
- Mineral supplements should not replace a balanced diet.
- If symptoms persist or worsen speak to your medical practitioner.
- Contains zinc which may be dangerous if taken in large amounts or for a long period.
- Contains soy.
- Keep out of reach of children.
- Do not use if seal on cap is broken.
- Store below 25°C.
- If you have any pre-existing conditions, are on any medications, always talk to your health professional before use.
- Some products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.
References: BioCeuticals PepZin Pro
 Miyoshi A, Matsuo H, Miwa T, et al. Clinical Evaluation of Z-103 in the Treatment of Gastritis Ref. 30. A multicentre double-blind dose finding study. Jpn Pharmacol Ther 1997;25(5):1403-1442
 Fuji Y, Matsura T, Kai M, et al. Protection by Polaprezinc, an Anti-ulcer Drug, Against Indomethacin-Induced Apoptosis in Rat Gastric Mucosal Cells. Jpm. J. Pharmacol. 2000;84(1):63-70
 Tan B, Luo HQ, Xu H, et al. Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial. PLoS ONE 12(4): e0175625.
 Matsukura T, Tanaka H. Applicability of Zinc Complex of L-Carnosine for Med-ical Use. Biochemistry (Moscow), Vol 65, No. 7, 2000, pp. 817-823
 Simadibrata M, Ndraha S, Tedjasaputra R, et al. Revealing the effect of probiotic combination: Lactobacillus rhamnosus and Lactobacillus acidophilus (Lacidofil) on acute diarrhea in adult patients. Journal of Clinical Medicine and Research 2013;5:(2):23-28
 Song H. et al. Effect of Probiotic Lactobacillus (Lacidofil Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Mul-ticenter Study. J Korean Med Sci. 2010;25(12):1784–1791.
 Lacidofil Unique combination. Twenty-six clinical studies. Lallemand brochure.
 Better Health Channel. Gastritis. Viewed 16th July 2019 https://www.betterhealth.vic.gov.au/health/ConditionsAndTreatments/gastritis
 Mahmood A, Fitzgerald AJ, Marchbank T, et al. Zinc carnosine, a health food sup-plement that stabilises small bowel integrity and stimulates gut repair processes. Gut 2007;56(2):168-175
 Shimada T, Watanabe N, Ohtsuka Y, et al. Polaprezinc down-regulates proinflamma-tory cytokine-induced nuclear factor-kappB activation and interleukin-8 expression in gastric epithelial cells. J Pharmacol Exp Ther 1999;291(1):345-352.
 Hiraishi H, Sasai T, Oinuma T, et al. Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. Aliment Pharmacol Ther 1999;13(2):261.
 Handa O, Yoshida N, Tanaka Y, et al. Inhibitory effect of polaprezinc on the inflamma-tory response to Helicobacter pylori. Can J Gastroenterol 2002;16(11):785-789.
 Cho CH, Luk CT, Ogle CW. The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats. Life Sci 1991;49(23):PL189-194.
 Ueki S, Seiki M, Yoneta T, et al. Effect of Z-103 on compound 48/80-induced gastric lesions in rats. Scand J Gastroenterol Suppl 1989;162:202-205.
 PepZinGI. Scientific Literature for PepZinGI. Viewed 16th July 2019 https://www.pepzingi.com/health_claims.php
 Opoka W, Adamek D, Plonka M, et al. Importance of luminal and mucosal zinc in the mechanism of experimental gastric ulcer healing. J Physiology Pharmacol 2010;61(5):581-591.
 Furuta S, Toyama S, Miwa M, et al. Residence time of polaprezinc (zinc L-carnosine complex) in the rat stomach and adhesiveness to ulcerous sites. Jpn J Pharmacol 1995;67(4):271-278.
 Drake VJ. Zinc. Micronutrient information center, Linus Pauling Institute 2013. Viewed 10 June 2014, http://lpi.oregonstate.edu/infocenter/minerals/zinc/
 Braun L, Cohen M. Herbs & Natural Supplements: An evidence-based guide, Volume 2, 4th ed. Sydney: Churchill Livingstone Elsevier, 2015.
 Therapeutic Research Center. Natural Medicines Database 2019. Professional Mon-ograph, Zinc. Viewed 30 July 2019. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=982
 Foster LM, Tompkins TA, Dahl WJ. A comprehensive post-market review of studies on a probiotic prod-uct containing Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011. Beneficial Microbes. 2011;2(4):319-334
 Evans M, Salewski RP, Christman MC, et al. Effectiveness of Lactobacillus helveticus and Lactobacillus rhamno-sus for the management of antibiotic-associated diarrhoea in healthy adults: a random-ized, double-blind, placebo-controlled trial. Br J Nutr. 2016;116(1):94-103
 Simadibrata M, Ndraha S, Tedjasaputra R, et al. Revealing the effect of probiotic combination: Lactobacillus rhamnosus and Lactobacillus acidophilus (Lacidofil®) on acute diarrhea in adult patients. Journal of Clinical Medicine and Research 2013;5(2):23-28
 Health Canada. Probiotics. Viewed 2nd August 2019. http://webprod.hc-sc.gc.ca/nhpid-bdipsn/atReq.do?atid=probio&lang=eng#t2fn1
 Hendler, PDR for Nutritional Supplements p. 517
 Linares DM, Ross P, Stanton C. Beneficial Microbes: The pharmacy in the gut. Bio-engineered. 2016;7(1):1-20
 Therapeutic Research Center. Natural Medicines Database 2019. Professional Monograph, Carnosine. Viewed 9th August 2019. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1038
 GESA Gastroentrological Society of Australia. Helicobacter Pylori. Viewed 14th Au-gust 2019. https://www.gesa.org.au/index.cfm//resources/patients/helicobacter-pylori/
 dhf. Digestive Health Foundation. GESA Gastroenteological Society of Australia. In-formation about Helicobacter Pylori (H. pylori). Third edition 2010. Viewed 14th August 2019. http://cart.gesa.org.au/membes/files/Consumer%20Information/H_Pylori.pdf