Activated Probiotics Biome Daily Probiotic

Ailments

• General immune health
• Upper respiratory tract infections
• Common colds
• General digestive health

Instructions For Use

Adults and children over 12 years:

Take 1 capsule daily (with or without food), or as directed by your healthcare practitioner.

If you are pregnant or breastfeeding seek the advice of a healthcare practitioner before using.

Ingredients

*BLB = Billion Live Bacteria" No Refrigeration Required

No Added

GMOs, wheat, gluten, dairy, lactose, fructose, yeast, nuts, seeds, peanut, soy, egg, fish, shellfish, or animal derivatives. No artificial colours, flavours, sweeteners, or preservatives.

Warnings and Cautions

Drink plenty of water. Do not use when abdominal pain, nausea or vomiting are present, or if you develop diarrhoea

Storage Conditions

Refrigeration Not Required

Technical Information

BENEFIT OF PROBIOTICS FOR GASTROINTESTINAL HEALTH

There is increasing evidence that the microbial composition of the gut is fundamental to many aspects of human health. Collectively referred to as the gut microbiome, this community of microorganisms is of such importance to our health and wellbeing that it is now considered akin to an additional organ of the body1. One way to support the health of the gut microbiome is through supplementation with probiotics, which are
defined as ‘live microorganisms which, when administered in adequate amounts, confer a health benefit on the host’2.

Probiotics have numerous beneficial effects on the gut microbiome, such as inhibiting the growth and proliferation of pathogenic microorganisms, which helps to maintain microbial balance in favour of beneficial bacteria2. In the gut, probiotics can also improve gut barrier function (reducing intestinal permeability), enhance the local immune system, and produce a number of beneficial metabolites, such as short-chain fatty acids (SCFAs), which exert both local and systemic effects2.

ACUTE RESPIRATORY TRACT INFECTIONS

Acute respiratory infections are one of the most commonly encountered conditions by GPs in Australia3. Common colds, which are an upper respiratory tract infection, are one of the most commonly occurring acute respiratory infections seen in adults. Common colds and are responsible for significant productivity and economic losses, due to their high prevalence among working-age adults4.

While it is increasingly recognised that the benefits of prescribing antibiotics for acute respiratory infections are often outweighed by potential harms - including concerns about rising antibiotic resistance - the rates of antibiotic prescribing for these conditions are 4-9 times as high as those recommended by evidence-based guidelines3. As a result, there is great interest in the potential for therapeutic alternatives for the management – and prevention - of acute respiratory tract infections.

PROBIOTICS FOR ACUTE RESPIRATORY TRACT INFECTIONS

As probiotics are known to enhance the function of the immune system5, there has been a wealth of research investigating the effect of probiotic supplementation on the occurrence, duration and severity of common colds. A recent systematic review and meta-analysis published in the British Journal of Nutrition found that interventions with probiotic products significantly reduce the duration of common colds, and absenteeism from child care, school or work6.

Biome Daily™ Probiotic contains two exclusive probiotic strains: Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2, which have been clinically proven to reduce the frequency, severity, and duration of common colds7, 8.

CLINICAL TRIALS: L. PLANTARUM HEAL9 AND L. PARACASEI 8700:2

A randomised, parallel, double-blind, placebo-controlled trial conducted in 272 adults-found a statistically significant reduction in the incidence and duration of common colds in the group who received a daily dose (109 cfu) of L. plantarum HEAL9 and L. paracasei 8700:2 for 12 weeks, compared to placebo (p<0.05)7 (Figure 1).

A second randomised, double-blind, placebo-controlled trial conducted in 310 adults found a significant reduction in the symptoms of common cold in the group who received a daily dose (109 cfu) of L. plantarum HEAL9 and L. paracasei 8700:2 for 12 weeks, compared to placebo (p < 0.001)8 (Figure 2).

References

1. Marchesi JR, Adams DH, Fava F, Hermes GDA, Hirschfield GM, Hold G, et al. The gut microbiota and host health: a new clinical frontier. Gut. 2016 Feb;65(2):330–9.

2. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506–14.

3. McCullough AR, Pollack AJ, Plejdrup Hansen M, Glasziou PP, Looke DF, Britt HC, et al. Antibiotics for acute respiratory infections in general practice: comparison of prescribing rates with guideline recommendations. Med J Aust. 2017 Jul;207(2):65–9.

4. Bramley TJ, Lerner D, Sames M. Productivity losses related to the common cold. J Occup Environ Med. 2002 Sep;44(9):822–9.

5. Rask C, Adlerberth I, Berggren A, Ahrén IL, Wold AE. Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli. Clin Exp Immunol. 2013;172(2):321–32.

6. King S, Glanville J, Sanders ME, Fitzgerald A, Varley D. Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis. Br J Nutr. 2014 Jul;112(1):41–54.

7. Berggren A, Lazou Ahrén I, Larsson N, Önning G. Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections. Eur J Nutr. 2011 Apr;50(3):203–10.

8. Busch R, Gruenwald J, Dudek S. Randomized, Double Blind and Placebo Controlled Study Using a Combination of Two Probiotic Lactobacilli to Alleviate Symptoms and Frequency of Common Cold. Food Nutr Sci. 2013;04(11):13–20.