{"id":2288394108987,"title":"BioCeuticals Folinic Acid 120 caps","handle":"bioceuticals-folinic-acid-120-caps","description":"\u003ch3\u003e\u003cem\u003eBioactivated B9\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eBioCeuticals Folinic Acid 120 caps\u003c\/h2\u003e\n\u003cp\u003eSizes: 120 capsules\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Folinic Acid Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Folinic acid is an alternative form of folic acid that bypasses some of the steps in the conversion of folic acid to the active form, 5-methyltetrahydrofolate (5-MTHF).\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eBioCeuticals \u003c\/span\u003eFolinic acid supports healthy methylation pathways, homocysteine metabolism, DNA replication and foetal development.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Folinic Acid has No Added Dairy, No Added Gluten, No Added Shellfish, No Added Soy Protein\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePregnancy Friendly, Vegan Friendly, Vegetarian Friendly\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Folinic Acid AUST L 233205\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdults\u003c\/strong\u003e: Take 1 capsule once daily or as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports healthy methylation pathways in the body.\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine metabolism.\u003c\/li\u003e\n\u003cli\u003eInvolved in the synthesis of S-adenosylmethionine (SAMe).\u003c\/li\u003e\n\u003cli\u003eHelps form red blood cells.\u003c\/li\u003e\n\u003cli\u003eSupports a healthy brain and nervous system function.\u003c\/li\u003e\n\u003cli\u003eHelps support cognitive health, with healthy neural development, growth and repair.\u003c\/li\u003e\n\u003cli\u003eInvolved in growth and cellular replication, and contributes to normal growth of the foetus.\u003c\/li\u003e\n\u003cli\u003eVegetarian and vegan friendly.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach BioCeuticals Folinic Acid capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium folinate\u003c\/td\u003e\n\u003ctd\u003e694mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. folinic acid (activated vitamin B9)\u003c\/td\u003e\n\u003ctd\u003e500mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eMethylation pathways and homocysteine metabolism\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eFolinic acid is an active metabolite of folic acid and does not require the enzyme dihydrofolate reductase (DHFR) to participate in reactions utilising folates.\u003c\/p\u003e\n\u003cp\u003eThe remethylation pathway of the methylation cycle actually involves methylation, re-methylation and de-methylation reactions involving folate, B12 and B2. By supplementing with folinic acid (5-formyl-THF), a number of reduction steps can be bypassed to convert directly to 5,10-methylene-THF, alleviating the need for the DHFR enzyme.\u003c\/p\u003e\n\u003cp\u003eSupplementing with folinic acid, therefore, assists 5,10-methylene-tetrahydrofolate reductase (MTHFR) enzyme to produce active folate (5-MTHF) which then methylates homocysteine; helping to convert homocysteine to methionine and then SAMe, rather than elevating.\u003c\/p\u003e\n\u003cp\u003eLow serum folate and elevated levels of homocysteine are associated with increased risk of developing a number of conditions.[1-10]\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eCognitive health\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eLow folate is associated with a degree of cognitive decline.[6-8] A randomised, double-blind, placebo-controlled study of 818 participants found that folic acid supplementation for three years significantly improved domains of cognitive function that tend to decline with age. Serum folate increased by 576% and plasma total homocysteine decreased by 26% in the folic acid group. The three-year change in memory, information processing speed and sensorimotor speed were also significantly better in the folic acid group.[9]\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eDNA replication and foetal development\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eFolic acid is involved in intracellular metabolism and DNA synthesis.[10]\u003c\/p\u003e\n\u003cp\u003eThe need for folate is higher when cell turnover is increased, such as in pregnancy and foetal development. A daily dose of 500mcg of folinic acid or folate taken one month before conception and during pregnancy may reduce the risk of women having a child with birth defects of the brain or neural tube defects such as spina bifida and anencephaly.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMethylation\/remethylation and transsulfuration\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cimg alt=\"BioCeuticals Folinic Acid 120 caps Methylation 10% off RRP | HealthMasters BioCeuticals\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticals_Folinic_Acid_120_caps_Methylation_10_off_RRP_at_HealthMasters_BioCeuticals_600x600.jpg?v=1598489527\"\u003e\u003c\/h3\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIf symptoms persist talk to your health professional.\u003c\/li\u003e\n\u003cli\u003eDo not exceed the stated dose except on medical advice.\u003c\/li\u003e\n\u003cli\u003eIf you have had a baby with neural tube defect\/spina bifida – seek specific medical advice.\u003c\/li\u003e\n\u003cli\u003eIf you have any pre-existing conditions, are on any medications, always talk to your health professional before use.\u003c\/li\u003e\n\u003cli\u003eSome products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.\u003c\/li\u003e\n\u003cli\u003eVitamin supplements should not replace a balanced diet.\u003c\/li\u003e\n\u003cli\u003eAlways read the label. Use only as directed.\u003c\/li\u003e\n\u003cli\u003eIf you have any pre-existing conditions, are on any medications, always talk to your health professional before use.\u003c\/li\u003e\n\u003cli\u003eSome products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eCompanion Products\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals CardioNutrients Forte\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals CardioPack\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Methyl-Max\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals InNatal\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cp\u003e[1] Refsum H, Ueland PM, Nygard O, et al. Homocysteine and cardiovascular disease. Ann Rev Medicine 1998;49:31-62.\u003c\/p\u003e\n\u003cp\u003e[2] Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med 2002;346(7):476-483.\u003c\/p\u003e\n\u003cp\u003e[3] Moschiano F, D’Amico D, Usai S, et al. Homocysteine plasma levels in patients with migraine with aura. Neurol Sci 2008;29 Suppl 1:S173-S175.\u003c\/p\u003e\n\u003cp\u003e[4] Rochtchina E, Wang JJ, Flood VM, et al. Elevated serum homocysteine, low serum vitamin B12, folate and age related macular degeneration: the Blue Mountains eye study. Am J Ophthalmol 2007;143(2):344-346.\u003c\/p\u003e\n\u003cp\u003e[5] van Wijingaarden JP, Doets EL, Szczecinska A, et al. Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review and meta-analysis. J Nutr Metab 2013;2013:486186.\u003c\/p\u003e\n\u003cp\u003e[6] Gallucci M, Zanardo A, Bendini M, et al. Serum folate, homocysteine, brain atrophy, and auto-CM system: the Treviso Dementia (TREDEM) study. J Alzheimers Dis 2013:PMID 24028866 [Epub ahead of print].\u003c\/p\u003e\n\u003cp\u003e[7] Tucker K, Qiao N, Scott T, et al. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs normative aging study. Am J Clin Nutr 2005;82:627-635.\u003c\/p\u003e\n\u003cp\u003e[8] Herrmann W, Obeid R. Homocysteine: a biomarker in neurodegenerative diseases. Clin Chem Lab Med 2011;49(3):435-441.\u003c\/p\u003e\n\u003cp\u003e[9] Durga J, van Boxtel MPJ, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369: 208-216.\u003c\/p\u003e\n\u003cp\u003e[10] Higdon J. An evidenced-based approach to vitamins and minerals. New York: Thieme, 2003.\u003c\/p\u003e\n\u003cp\u003e[11] Folic acid\/folinic acid. Natural Medicines Comprehensive Database. Viewed 22 Nov 2013, www.naturaldatabase.com\u003c\/p\u003e\n\u003cp\u003e[12] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2019-07-09T17:20:39+10:00","created_at":"2019-07-09T17:20:41+10:00","vendor":"BioCeuticals","type":"BioCeuticals Naturopathic Products","tags":["BioCeuticals","Methylation","Naturopathic"],"price":3065,"price_min":3065,"price_max":3065,"available":true,"price_varies":false,"compare_at_price":3405,"compare_at_price_min":3405,"compare_at_price_max":3405,"compare_at_price_varies":false,"variants":[{"id":21199235809339,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"BioCeuticals Folinic Acid 120 caps","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"BioCeuticals Folinic Acid 120 caps","public_title":null,"options":["Default Title"],"price":3065,"weight":80,"compare_at_price":3405,"inventory_quantity":9988,"inventory_management":"shopify","inventory_policy":"deny","barcode":"9328727007074"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsFolinicAcid120caps10_offRRPatHealthMastersBioCeuticals.jpg?v=1598490199"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsFolinicAcid120caps10_offRRPatHealthMastersBioCeuticals.jpg?v=1598490199","options":["Title"],"media":[{"alt":"BioCeuticals Folinic Acid 120 caps 10% off RRP at HealthMasters BioCeuticals","id":10838951723166,"position":1,"preview_image":{"aspect_ratio":0.525,"height":971,"width":510,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsFolinicAcid120caps10_offRRPatHealthMastersBioCeuticals.jpg?v=1598490199"},"aspect_ratio":0.525,"height":971,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/BioCeuticalsFolinicAcid120caps10_offRRPatHealthMastersBioCeuticals.jpg?v=1598490199","width":510}],"content":"\u003ch3\u003e\u003cem\u003eBioactivated B9\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eBioCeuticals Folinic Acid 120 caps\u003c\/h2\u003e\n\u003cp\u003eSizes: 120 capsules\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Folinic Acid Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBioCeuticals Folinic acid is an alternative form of folic acid that bypasses some of the steps in the conversion of folic acid to the active form, 5-methyltetrahydrofolate (5-MTHF).\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eBioCeuticals \u003c\/span\u003eFolinic acid supports healthy methylation pathways, homocysteine metabolism, DNA replication and foetal development.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Folinic Acid has No Added Dairy, No Added Gluten, No Added Shellfish, No Added Soy Protein\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePregnancy Friendly, Vegan Friendly, Vegetarian Friendly\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Folinic Acid AUST L 233205\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdults\u003c\/strong\u003e: Take 1 capsule once daily or as directed by your health professional.\u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports healthy methylation pathways in the body.\u003c\/li\u003e\n\u003cli\u003eSupports healthy homocysteine metabolism.\u003c\/li\u003e\n\u003cli\u003eInvolved in the synthesis of S-adenosylmethionine (SAMe).\u003c\/li\u003e\n\u003cli\u003eHelps form red blood cells.\u003c\/li\u003e\n\u003cli\u003eSupports a healthy brain and nervous system function.\u003c\/li\u003e\n\u003cli\u003eHelps support cognitive health, with healthy neural development, growth and repair.\u003c\/li\u003e\n\u003cli\u003eInvolved in growth and cellular replication, and contributes to normal growth of the foetus.\u003c\/li\u003e\n\u003cli\u003eVegetarian and vegan friendly.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach BioCeuticals Folinic Acid capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium folinate\u003c\/td\u003e\n\u003ctd\u003e694mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eequiv. folinic acid (activated vitamin B9)\u003c\/td\u003e\n\u003ctd\u003e500mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eMethylation pathways and homocysteine metabolism\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eFolinic acid is an active metabolite of folic acid and does not require the enzyme dihydrofolate reductase (DHFR) to participate in reactions utilising folates.\u003c\/p\u003e\n\u003cp\u003eThe remethylation pathway of the methylation cycle actually involves methylation, re-methylation and de-methylation reactions involving folate, B12 and B2. By supplementing with folinic acid (5-formyl-THF), a number of reduction steps can be bypassed to convert directly to 5,10-methylene-THF, alleviating the need for the DHFR enzyme.\u003c\/p\u003e\n\u003cp\u003eSupplementing with folinic acid, therefore, assists 5,10-methylene-tetrahydrofolate reductase (MTHFR) enzyme to produce active folate (5-MTHF) which then methylates homocysteine; helping to convert homocysteine to methionine and then SAMe, rather than elevating.\u003c\/p\u003e\n\u003cp\u003eLow serum folate and elevated levels of homocysteine are associated with increased risk of developing a number of conditions.[1-10]\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eCognitive health\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eLow folate is associated with a degree of cognitive decline.[6-8] A randomised, double-blind, placebo-controlled study of 818 participants found that folic acid supplementation for three years significantly improved domains of cognitive function that tend to decline with age. Serum folate increased by 576% and plasma total homocysteine decreased by 26% in the folic acid group. The three-year change in memory, information processing speed and sensorimotor speed were also significantly better in the folic acid group.[9]\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eDNA replication and foetal development\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eFolic acid is involved in intracellular metabolism and DNA synthesis.[10]\u003c\/p\u003e\n\u003cp\u003eThe need for folate is higher when cell turnover is increased, such as in pregnancy and foetal development. A daily dose of 500mcg of folinic acid or folate taken one month before conception and during pregnancy may reduce the risk of women having a child with birth defects of the brain or neural tube defects such as spina bifida and anencephaly.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMethylation\/remethylation and transsulfuration\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch3\u003e\u003cimg alt=\"BioCeuticals Folinic Acid 120 caps Methylation 10% off RRP | HealthMasters BioCeuticals\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticals_Folinic_Acid_120_caps_Methylation_10_off_RRP_at_HealthMasters_BioCeuticals_600x600.jpg?v=1598489527\"\u003e\u003c\/h3\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eIf symptoms persist talk to your health professional.\u003c\/li\u003e\n\u003cli\u003eDo not exceed the stated dose except on medical advice.\u003c\/li\u003e\n\u003cli\u003eIf you have had a baby with neural tube defect\/spina bifida – seek specific medical advice.\u003c\/li\u003e\n\u003cli\u003eIf you have any pre-existing conditions, are on any medications, always talk to your health professional before use.\u003c\/li\u003e\n\u003cli\u003eSome products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.\u003c\/li\u003e\n\u003cli\u003eVitamin supplements should not replace a balanced diet.\u003c\/li\u003e\n\u003cli\u003eAlways read the label. Use only as directed.\u003c\/li\u003e\n\u003cli\u003eIf you have any pre-existing conditions, are on any medications, always talk to your health professional before use.\u003c\/li\u003e\n\u003cli\u003eSome products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eCompanion Products\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals CardioNutrients Forte\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals CardioPack\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Methyl-Max\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals InNatal\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Folinic Acid \u003c\/h2\u003e\n\u003cp\u003e[1] Refsum H, Ueland PM, Nygard O, et al. Homocysteine and cardiovascular disease. Ann Rev Medicine 1998;49:31-62.\u003c\/p\u003e\n\u003cp\u003e[2] Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med 2002;346(7):476-483.\u003c\/p\u003e\n\u003cp\u003e[3] Moschiano F, D’Amico D, Usai S, et al. Homocysteine plasma levels in patients with migraine with aura. Neurol Sci 2008;29 Suppl 1:S173-S175.\u003c\/p\u003e\n\u003cp\u003e[4] Rochtchina E, Wang JJ, Flood VM, et al. Elevated serum homocysteine, low serum vitamin B12, folate and age related macular degeneration: the Blue Mountains eye study. Am J Ophthalmol 2007;143(2):344-346.\u003c\/p\u003e\n\u003cp\u003e[5] van Wijingaarden JP, Doets EL, Szczecinska A, et al. Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review and meta-analysis. J Nutr Metab 2013;2013:486186.\u003c\/p\u003e\n\u003cp\u003e[6] Gallucci M, Zanardo A, Bendini M, et al. Serum folate, homocysteine, brain atrophy, and auto-CM system: the Treviso Dementia (TREDEM) study. J Alzheimers Dis 2013:PMID 24028866 [Epub ahead of print].\u003c\/p\u003e\n\u003cp\u003e[7] Tucker K, Qiao N, Scott T, et al. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs normative aging study. Am J Clin Nutr 2005;82:627-635.\u003c\/p\u003e\n\u003cp\u003e[8] Herrmann W, Obeid R. Homocysteine: a biomarker in neurodegenerative diseases. Clin Chem Lab Med 2011;49(3):435-441.\u003c\/p\u003e\n\u003cp\u003e[9] Durga J, van Boxtel MPJ, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369: 208-216.\u003c\/p\u003e\n\u003cp\u003e[10] Higdon J. An evidenced-based approach to vitamins and minerals. New York: Thieme, 2003.\u003c\/p\u003e\n\u003cp\u003e[11] Folic acid\/folinic acid. 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