{"id":4450261598267,"title":"Metagenics Immunogenics 60 capsules","handle":"metagenics-immunogenics-60-capsules","description":"\u003ch3\u003e\u003cem\u003eAHCC And Ginger To Support Healthy Immune Function And Reduce Nausea\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics Immunogenics 60 capsules\u003c\/h2\u003e\n\u003cp\u003eSize: 60 capsules\u003c\/p\u003e\n\u003cp\u003eMetagenics Immunogenics shown to or may:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupport patients with an impaired immune response.\u003c\/li\u003e\n\u003cli\u003eContains Active hexose correlated compound (AHCC) and ginger.\u003c\/li\u003e\n\u003cli\u003eClinically trialed AHCC with an extensive safety and tolerance profile.\u003c\/li\u003e\n\u003cli\u003eContains ginger to address nausea, vomiting and appetite, and to protect intestinal mucosa.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics Immunogenics is Free from Animal Products, Dairy protein free, Lactose free, Egg free, Gluten free, Wheat free, Free from Yeast, Free from Soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics Immunogenics AUST L 324273\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/biomedica-ribraxx-30-sachets\" title=\"BioMedica Ribraxx 30 Sachets 10% off RRP | HealthMasters BioMedica\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/products\/biomedica-ribraxx-30-sachets\" target=\"_blank\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eBioMedica Ribraxx 30 Sachets\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/biomedica-ribraxx-90-sachets\" target=\"_blank\" title=\"BioMedica Ribraxx 90 Sachets 10% off RRP | HealthMasters BioMedica\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eBioMedica Ribraxx 90 Sachets\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-super-mushroom-with-astragalus-30-tablets\" title=\"Metagenics Super Mushroom with Astragalus 10% off RRP | HealthMasters Metagenics\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-super-mushroom-with-astragalus-30-tablets\" target=\"_blank\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eMetagenics Super Mushroom with Astragalus\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-ultra-flora-immune-enhance-60-vegecaps\" title=\"Metagenics Ultra Flora Immune Enhance 10% off RRP | HealthMasters Metagenics\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-ultra-flora-immune-enhance-60-vegecaps\" target=\"_blank\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eMetagenics Ultra Flora Immune Enhance\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca title=\"Contact HealthMasters For Assistance\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 2 capsules twice daily.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing suggestion:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCapsules may be opened and the powder mixed into a liquid of choice.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics Immunogenics supports patients with an impaired immune response, assisting with immune system surveillance and modulation.\u003c\/strong\u003e Research into AHCC reveals positive effects on both innate and adaptive immunity. Specifically, AHCC has been shown to enhance natural killer (NK) cell activity, cytokine production, whilst promoting macrophage activity and increasing the number and activity of dendritic cells.\u003csup\u003e1,2,3,4\u003c\/sup\u003e Furthermore, research also indicates benefits for the adaptive immune response pertaining to both B and T cell lymphocytes.\u003csup\u003e5,6,7,8\u003c\/sup\u003e AHCC is well tolerated, making it suitable as an adjunct for immunosuppressed patients during and in between treatments to reduce possible side effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGinger assists with nausea, vomiting, gut barrier function, and also exerts anti-ulcer, anti-inflammatory and immunomodulatory effects.\u003csup\u003e9,10\u003c\/sup\u003e\u003c\/strong\u003e Supporting gastrointestinal health is paramount to optimal functioning of the immune system. Ginger provides a protective action on the intestinal mucosa\u003csup\u003e11\u003c\/sup\u003e and has been shown to ameliorate intestinal damage by reducing neutrophil infiltration and the pro-inflammatory response, while reducing oxidant stress and lipid peroxidation.\u003csup\u003e12\u003c\/sup\u003e Ginger compounds are also able to elicit an anti-inflammatory effect via inhibition of key inflammatory response mediators, such as Nuclear factor kappa B (NFkB), Cyclooxygenase (COX) enzymes, and 5-Lipoxygenase (5-Lox).13 Furthermore, Ginger is able to support a healthy appetite thereby supporting energy production and reduce fatigue.\u003csup\u003e14,15\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHaving been studied in hundreds of clinical trials, AHCC is used in more than 600 international hospitals and institutions for an array of medical conditions.\u003csup\u003e16,17\u003c\/sup\u003e\u003c\/strong\u003e Immunogenics has been formulated to match the amount of AHCC used in human clinical trials. AHCC itself is a mixture of amino acids, lipids, and minerals extracted from a culture of Shiitake mushroom (Lentinula edodes), with polysaccharides being an active component. AHCC research in human populations has also shown improved immune parameters in immunocompromised people. AHCC has demonstrable safety and a history of being well tolerated since it was launched in 1989, with hundreds of thousands of users reporting no serious side effects.\u003csup\u003e19\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAHCC is a registered trademark of Amino Up Chemical Co. Ltd Japan.\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"Metagenics Immunogenics 60 capsules 10% off RRP at HealthMasters AHCC logo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_Immunogenics_60_capsules_10_off_RRP_at_HealthMasters_AHCC_logo_480x480.JPG?v=1579398794\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_Immunogenics_60_capsules_10_off_RRP_at_HealthMasters_AHCC_logo_480x480.JPG?v=1579398794\"\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics Immunogenics\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Metagenics Immunogenics capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDry herbal extracts:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLentinula edodes, (Shiitake) (AHCC) hyphae\u003c\/td\u003e\n\u003ctd\u003e338mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding-left: 30px;\" data-mce-style=\"padding-left: 30px;\"\u003eDerived from fresh hyphae\u003c\/td\u003e\n\u003ctd\u003e3.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZingiber officinale, (Ginger) rhizome\u003c\/td\u003e\n\u003ctd\u003e38.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding-left: 30px;\" data-mce-style=\"padding-left: 30px;\"\u003eDerived from dry rhizome\u003c\/td\u003e\n\u003ctd\u003e1.6g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eMetagenics Immunogenics\u003c\/strong\u003e is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMetagenics Immunogenics\u003c\/strong\u003e is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003cp\u003eAHCC is a registered trademark of Amino Up Chemical Co. Ltd Japan.\u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eHypromellose, Gellan gum, Water, Potassium acetate and Disodium edetate. Calcium hydrogen phosphate, Calcium hydroxide, Corn alfadex (fibre), Magnesium stearate, Microcrystalline cellulose, Silicon dioxide, Sunflower lecithin and Tapioca maltodextrin.\u003c\/p\u003e\n\u003cp\u003eFor more information about excipients used in this product, see the full excipient list \u003ca href=\"https:\/\/www.metagenics.com.au\/TruQuality#excipient\" data-mce-href=\"https:\/\/www.metagenics.com.au\/TruQuality#excipient\"\u003ehere\u003c\/a\u003e.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eQuality Information\u003c\/h5\u003e\n\u003ch2\u003eQuality Information: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eThere are two grades available from the original developer and supplier of the AHCC compound (AHCC) is a registered trademark of Amino Up Chemical Co. Ltd Japan).\u003c\/p\u003e\n\u003cp\u003eThe \u003cstrong\u003eOriginal\u003c\/strong\u003e grade is in a lipid base at a low concentration of 45% (55% carrier excipients, 45% actual AHCC). This happens to be the most prolific form used in studies.\u003c\/p\u003e\n\u003cp\u003eMetagenics R\u0026amp;D and procurement teams weren't happy with this original compound and actually passed on its incorporation into the Metagenics range.\u003c\/p\u003e\n\u003cp\u003eThe suppliers then alerted Metagenics to their \u003cstrong\u003ePremium\u003c\/strong\u003e compound which is a 75% concentration (75% AHCC, 25% carrier).\u003c\/p\u003e\n\u003cp\u003eThis is the compound Metagenics chose - it results in the same dose of actual AHCC in the final product, ie: 1.35g of Metagenics AHCC equates to the quantities used in the official clinical trials.\u003c\/p\u003e\n\u003cp\u003eSee the below graphic for further explanation:\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e\u003cstrong\u003eOriginal\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e\u003cstrong\u003ePremium\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e45% concentration\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e75% concentration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e\n\u003ctd\u003eOf 3 grams\u003c\/td\u003e\n\u003ctd\u003eOf 1.9 grams\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e= 1.35 g of actual AHCC\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e= 1.35 g of actual AHCC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics uses the \u003cstrong\u003ePremium\u003c\/strong\u003e grade to provide the correct daily dose of AHCC (1.35g) based on official clinical trials and has fewer excipients.\u003c\/p\u003e\n\u003cp\u003eSome products containing AHCC commonly use the \u003cstrong\u003eOriginal\u003c\/strong\u003e grade described as a 'proprietary blend' with 45% AHCC and containing more excipients. These products may recommend a dose of one capsule\/tablet per day which is below the dose required based on the official studies. This results in an inferior product at a dose below the dose required for therapeutic benefits. These products can be more expensive when the correct dose is taken.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch3\u003eContraindications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergies and sensitivities:\u003c\/strong\u003e Most allergic reactions occur after ingestion of raw or partially cooked shiitakes, or after physically handling them. Avoid with known allergy or hypersensitivity to mushrooms or derivatives thereof.[236],[237],[238],[239] Note that this product uses shiitake mushrooms that have been processed using heat above 100 degrees Celsius, reducing the risk of reactions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGallstones:\u003c\/strong\u003e Ginger can stimulate gall bladder contractions and is therefore contraindicated in patients with gallstones. It is recommended to only use after consultation with a physician if the patients has gallstones.[240],[241],[242],[243]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eModerate Level Cautions\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastric ulcers:\u003c\/strong\u003e Because of ginger’s effect on the gastric mucosa, it may worsen discomfort in patients with gastric ulcers.[244], [245] Use with caution, inform patients of potential effect and cease use if required.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunosuppressant drugs:\u003c\/strong\u003e \u003cem\u003eIn vitro\u003c\/em\u003e evidence suggests shiitake mushroom extracts may stimulate immune function, which may reduce the effects of immunosuppressive therapy.[246],[247] Use with caution and under medical supervision in patients on these medications undergoing organ transplant.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eLow Level Cautions\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticoagulant\/Antiplatelet medications:\u003c\/strong\u003e Ginger is thought to inhibit thromboxane synthetase and decrease platelet aggregation,[248],[249] affecting lipoxygenase and cyclooxygenase,[250],[251] particularly in doses that exceed 10 g\/d.[252] Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant\/antiplatelet drugs.[253],[254],[255],[256] Shiitake mushrooms may also decrease the effectiveness of blood platelets in initiating coagulation.[257],[258],[259] Use with caution in patients taking antiplatelet and\/or anticoagulant medications (e.g. aspirin or warfarin) and monitor international normalised ratio (INR) as well as potential adverse bleeding experiences. Consider combined supplemental and dietary ginger intake.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAutoimmune disease:\u003c\/strong\u003e It has been suggested that this mushroom should be avoided in individuals where immune suppression is desired.[260] However, due to the emerging role of infection in the pathogenesis of autoimmune disease,[261] and the anti-inflammatory and immunomodulatory actions of Lentinula edodes,[262] it may in fact be useful in the management of certain cases of autoimmune disease. Practitioners are advised to use their discretion when treating patients with autoimmune conditions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery:\u003c\/strong\u003e Due to the anticoagulant properties of ginger, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use one to two weeks prior surgery.[263],[264]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003ePregnancy and Breastfeeding\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePregnancy\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAvoid use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e It is advised that a daily dose of 2 g\/d of ginger should not be exceeded during pregnancy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBreastfeeding\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e A review did not identify any concerns for use during breast feeding, however safety has not been conclusively established in humans.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eChildren\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use.[265],[266]\u003c\/li\u003e\n\u003cli\u003eNo information available for AHCC.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e[*] In patients with COMT variants, AHCC may cause a reduction in Letrozole activity, possibly due to the aromatase induction activity of AHCC. Avoid this combination in patients with COMT variants\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003e[236] Skidmore-Roth L. Mosby’s handbook of herbs \u0026amp; natural supplements. 4th ed. St Louis (MO): Mosby Elsevier; 2010. p. 393-5. \u003c\/p\u003e\n\u003cp\u003e[237] Health Canada. Monograph Mushrooms. [Internet]. Ottawa (CA): Government of Canada. 2019 Mar. [cited 2016 Sept 29]. Available from: http:\/\/webprod.hc-sc.gc.ca\/nhpid-bdipsn\/atReq.do?atid=mushrooms.champignons\u0026amp;lang=eng#rsk4. \u003c\/p\u003e\n\u003cp\u003e[238] Gardner Z, McGuffin M. Botanical safety handbook. 2nd ed. Boca Raton (FL): CRC Press; 2013. P 509-11. \u003c\/p\u003e\n\u003cp\u003e[239] Levy AM, Kita H, Phillips SF, Schkade PA, Dyer PD, Gleich GJ, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol. 1998 May;101(5):613-20. PMID: 9600497. \u003c\/p\u003e\n\u003cp\u003e[240] Skidmore-Roth L. Mosby’s handbook of herbs \u0026amp; natural supplements. 4th ed. St Louis (MO): Mosby Elsevier; 2010. p. 287-90. \u003c\/p\u003e\n\u003cp\u003e[241] Mills S, Bone K. Principles and practice of phytotherapy: modern herbal medicine. 2nd ed. Edinburgh (UK): Elsevier\/Churchill Livingstone; 2013. p. 394-403. \u003c\/p\u003e\n\u003cp\u003e[242] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[243] Gardner Z, McGuffin M. Botanical safety handbook. 2nd ed. Botan Raton (FL): CRC Press; 2013. p. 948-51. \u003c\/p\u003e\n\u003cp\u003e[244] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[245] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[246] Shiitake Mushroom. In: Natural Medicines Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2019 [2015; cited 2017 May 4]. Available from: URL. Subscription required to view. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=680#scientificName. \u003c\/p\u003e\n\u003cp\u003e[247] Gardner Z, McGuffin M. Botanical safety handbook. 2nd ed. Boca Raton (FL): CRC Press; 2013. P 509-11. \u003c\/p\u003e\n\u003cp\u003e[248] Ginger. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2018 Mar 13; cited 2018 Aug 13]. Available from: http:\/\/www.naturaldatabase.com. \u003c\/p\u003e\n\u003cp\u003e[249] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[250] Stargrove MB, Treasure J, McKee DL. Herb, nutrient, and drug interactions. St Louis (MO): Mosby Elsevier; 2010. p. 62-8. \u003c\/p\u003e\n\u003cp\u003e[251] Wang CZ, Moss J, Yuan CS. Commonly used dietary supplements on coagulation function during surgery. Medicines. 2015;2(3):157-185. doi:10.3390\/medicines2030157. \u003c\/p\u003e\n\u003cp\u003e[252] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[253] Ginger. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2018 Mar 13; cited 2018 Aug 13]. Available from: http:\/\/www.naturaldatabase.com. \u003c\/p\u003e\n\u003cp\u003e[254] Mills S, Bone K. Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[255] Fetrow CW, Avila JR. Professionals handbook of complementary and alternative medicines. 3rd ed. Philadelphia (PA): Lippincott Williams \u0026amp; Wilkins; 2004. p. 352-8. \u003c\/p\u003e\n\u003cp\u003e[256] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[257] Bisen PS, Baghel RK, Sanodiya BS, et al. Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem. 2010;17(22):2419-30. Review. \u003c\/p\u003e\n\u003cp\u003e[258] Shimada S, Komamura K, Kumagai H, et al. Inhibitory activity of shiitake flavor against platelet aggregation. Biofactors. 2004;22(1-4):177-9. \u003c\/p\u003e\n\u003cp\u003e[259] Odani S, Tominaga K, Kondou S, et al. The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes. Eur J Biochem. 1999 Jun;262(3):915-23. \u003c\/p\u003e\n\u003cp\u003e[260] Shiitake Mushroom. In: Natural Medicines Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2019 [2015; cited 2017 May 4]. Available from: URL. Subscription required to view. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=680#scientificName. \u003c\/p\u003e\n\u003cp\u003e[261] Root-Bernstein R, Fairweather D. Complexities in the relationship between Infection and autoimmunity. Curr Allergy Asthma Rep. 2014 Jan;14(1):407. \u003c\/p\u003e\n\u003cp\u003e[262] Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, et al. Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity: A randomized dietary intervention in healthy young ddults. J Am Coll Nutr. 2015;34(6):478-87. \u003c\/p\u003e\n\u003cp\u003e[263] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[264] Wang CZ, Moss J, Yuan CS. Commonly used dietary supplements on coagulation function during surgery. Medicines. 2015;2(3):157-185. doi:10.3390\/medicines2030157. \u003c\/p\u003e\n\u003cp\u003e[265] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[266] Ginger. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2018 Mar 13; cited 2018 Aug 13]. Available from: http:\/\/www.naturaldatabase.com.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T14:14:52+11:00","created_at":"2020-01-19T12:25:42+11:00","vendor":"Metagenics","type":"Metagenics Naturopathic Medicines","tags":["1200px","Immunity","Metagenics","Naturopathic","PB"],"price":12146,"price_min":12146,"price_max":12146,"available":true,"price_varies":false,"compare_at_price":13495,"compare_at_price_min":13495,"compare_at_price_max":13495,"compare_at_price_varies":false,"variants":[{"id":31665762304059,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"Immunogenics60C","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Metagenics Immunogenics 60 capsules","public_title":null,"options":["Default Title"],"price":12146,"weight":0,"compare_at_price":13495,"inventory_quantity":9957,"inventory_management":"shopify","inventory_policy":"continue","barcode":"9315771011485","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-1.jpg?v=1621645074","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-2.jpg?v=1621645174","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-3.jpg?v=1621645209","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_Immunogenics_60_capsules_10_off_RRP_at_HealthMasters_AHCC_logo.jpg?v=1621645508","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_500-C_Methoxyflavone_90_tabs_10_off_RRP_-_HealthMasters_5c47a5a3-091a-45d6-a2f2-3b7162a84f9d.jpg?v=1621645272"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-1.jpg?v=1621645074","options":["Title"],"media":[{"alt":"Metagenics Immunogenics 60 capsules 10% off RRP at HealthMasters Metagenics","id":21558807232670,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-1.jpg?v=1621645074"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-1.jpg?v=1621645074","width":1200},{"alt":"Metagenics Immunogenics 60 capsules 10% off RRP at HealthMasters Metagenics Ingredients","id":21558807265438,"position":2,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-2.jpg?v=1621645174"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-2.jpg?v=1621645174","width":1200},{"alt":"Metagenics Immunogenics 60 capsules 10% off RRP at HealthMasters Metagenics Information","id":21558807298206,"position":3,"preview_image":{"aspect_ratio":1.0,"height":1200,"width":1200,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-3.jpg?v=1621645209"},"aspect_ratio":1.0,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/MetagenicsImmunogenics60Capsules-3.jpg?v=1621645209","width":1200},{"alt":"Metagenics Immunogenics 60 capsules 10% off RRP at HealthMasters Metagenics AHCC Authentic","id":6021066620987,"position":4,"preview_image":{"aspect_ratio":1.187,"height":150,"width":178,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_Immunogenics_60_capsules_10_off_RRP_at_HealthMasters_AHCC_logo.jpg?v=1621645508"},"aspect_ratio":1.187,"height":150,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_Immunogenics_60_capsules_10_off_RRP_at_HealthMasters_AHCC_logo.jpg?v=1621645508","width":178},{"alt":"Metagenics Immunogenics 10% off RRP at HealthMasters Metagenics","id":6020845633595,"position":5,"preview_image":{"aspect_ratio":1.0,"height":500,"width":500,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_500-C_Methoxyflavone_90_tabs_10_off_RRP_-_HealthMasters_5c47a5a3-091a-45d6-a2f2-3b7162a84f9d.jpg?v=1621645272"},"aspect_ratio":1.0,"height":500,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Metagenics_500-C_Methoxyflavone_90_tabs_10_off_RRP_-_HealthMasters_5c47a5a3-091a-45d6-a2f2-3b7162a84f9d.jpg?v=1621645272","width":500}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch3\u003e\u003cem\u003eAHCC And Ginger To Support Healthy Immune Function And Reduce Nausea\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics Immunogenics 60 capsules\u003c\/h2\u003e\n\u003cp\u003eSize: 60 capsules\u003c\/p\u003e\n\u003cp\u003eMetagenics Immunogenics shown to or may:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupport patients with an impaired immune response.\u003c\/li\u003e\n\u003cli\u003eContains Active hexose correlated compound (AHCC) and ginger.\u003c\/li\u003e\n\u003cli\u003eClinically trialed AHCC with an extensive safety and tolerance profile.\u003c\/li\u003e\n\u003cli\u003eContains ginger to address nausea, vomiting and appetite, and to protect intestinal mucosa.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics Immunogenics is Free from Animal Products, Dairy protein free, Lactose free, Egg free, Gluten free, Wheat free, Free from Yeast, Free from Soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics Immunogenics AUST L 324273\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/biomedica-ribraxx-30-sachets\" title=\"BioMedica Ribraxx 30 Sachets 10% off RRP | HealthMasters BioMedica\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/products\/biomedica-ribraxx-30-sachets\" target=\"_blank\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eBioMedica Ribraxx 30 Sachets\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/biomedica-ribraxx-90-sachets\" target=\"_blank\" title=\"BioMedica Ribraxx 90 Sachets 10% off RRP | HealthMasters BioMedica\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eBioMedica Ribraxx 90 Sachets\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-super-mushroom-with-astragalus-30-tablets\" title=\"Metagenics Super Mushroom with Astragalus 10% off RRP | HealthMasters Metagenics\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-super-mushroom-with-astragalus-30-tablets\" target=\"_blank\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eMetagenics Super Mushroom with Astragalus\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-ultra-flora-immune-enhance-60-vegecaps\" title=\"Metagenics Ultra Flora Immune Enhance 10% off RRP | HealthMasters Metagenics\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-ultra-flora-immune-enhance-60-vegecaps\" target=\"_blank\"\u003e\u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003eMetagenics Ultra Flora Immune Enhance\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca title=\"Contact HealthMasters For Assistance\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" data-mce-href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 2 capsules twice daily.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing suggestion:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCapsules may be opened and the powder mixed into a liquid of choice.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetagenics Immunogenics supports patients with an impaired immune response, assisting with immune system surveillance and modulation.\u003c\/strong\u003e Research into AHCC reveals positive effects on both innate and adaptive immunity. Specifically, AHCC has been shown to enhance natural killer (NK) cell activity, cytokine production, whilst promoting macrophage activity and increasing the number and activity of dendritic cells.\u003csup\u003e1,2,3,4\u003c\/sup\u003e Furthermore, research also indicates benefits for the adaptive immune response pertaining to both B and T cell lymphocytes.\u003csup\u003e5,6,7,8\u003c\/sup\u003e AHCC is well tolerated, making it suitable as an adjunct for immunosuppressed patients during and in between treatments to reduce possible side effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGinger assists with nausea, vomiting, gut barrier function, and also exerts anti-ulcer, anti-inflammatory and immunomodulatory effects.\u003csup\u003e9,10\u003c\/sup\u003e\u003c\/strong\u003e Supporting gastrointestinal health is paramount to optimal functioning of the immune system. Ginger provides a protective action on the intestinal mucosa\u003csup\u003e11\u003c\/sup\u003e and has been shown to ameliorate intestinal damage by reducing neutrophil infiltration and the pro-inflammatory response, while reducing oxidant stress and lipid peroxidation.\u003csup\u003e12\u003c\/sup\u003e Ginger compounds are also able to elicit an anti-inflammatory effect via inhibition of key inflammatory response mediators, such as Nuclear factor kappa B (NFkB), Cyclooxygenase (COX) enzymes, and 5-Lipoxygenase (5-Lox).13 Furthermore, Ginger is able to support a healthy appetite thereby supporting energy production and reduce fatigue.\u003csup\u003e14,15\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHaving been studied in hundreds of clinical trials, AHCC is used in more than 600 international hospitals and institutions for an array of medical conditions.\u003csup\u003e16,17\u003c\/sup\u003e\u003c\/strong\u003e Immunogenics has been formulated to match the amount of AHCC used in human clinical trials. AHCC itself is a mixture of amino acids, lipids, and minerals extracted from a culture of Shiitake mushroom (Lentinula edodes), with polysaccharides being an active component. AHCC research in human populations has also shown improved immune parameters in immunocompromised people. AHCC has demonstrable safety and a history of being well tolerated since it was launched in 1989, with hundreds of thousands of users reporting no serious side effects.\u003csup\u003e19\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAHCC is a registered trademark of Amino Up Chemical Co. Ltd Japan.\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"Metagenics Immunogenics 60 capsules 10% off RRP at HealthMasters AHCC logo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_Immunogenics_60_capsules_10_off_RRP_at_HealthMasters_AHCC_logo_480x480.JPG?v=1579398794\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_Immunogenics_60_capsules_10_off_RRP_at_HealthMasters_AHCC_logo_480x480.JPG?v=1579398794\"\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics Immunogenics\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach Metagenics Immunogenics capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDry herbal extracts:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLentinula edodes, (Shiitake) (AHCC) hyphae\u003c\/td\u003e\n\u003ctd\u003e338mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding-left: 30px;\" data-mce-style=\"padding-left: 30px;\"\u003eDerived from fresh hyphae\u003c\/td\u003e\n\u003ctd\u003e3.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZingiber officinale, (Ginger) rhizome\u003c\/td\u003e\n\u003ctd\u003e38.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding-left: 30px;\" data-mce-style=\"padding-left: 30px;\"\u003eDerived from dry rhizome\u003c\/td\u003e\n\u003ctd\u003e1.6g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eMetagenics Immunogenics\u003c\/strong\u003e is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMetagenics Immunogenics\u003c\/strong\u003e is free from artificial colours, flavours and preservatives.\u003c\/p\u003e\n\u003cp\u003eAHCC is a registered trademark of Amino Up Chemical Co. Ltd Japan.\u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eHypromellose, Gellan gum, Water, Potassium acetate and Disodium edetate. Calcium hydrogen phosphate, Calcium hydroxide, Corn alfadex (fibre), Magnesium stearate, Microcrystalline cellulose, Silicon dioxide, Sunflower lecithin and Tapioca maltodextrin.\u003c\/p\u003e\n\u003cp\u003eFor more information about excipients used in this product, see the full excipient list \u003ca href=\"https:\/\/www.metagenics.com.au\/TruQuality#excipient\" data-mce-href=\"https:\/\/www.metagenics.com.au\/TruQuality#excipient\"\u003ehere\u003c\/a\u003e.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eQuality Information\u003c\/h5\u003e\n\u003ch2\u003eQuality Information: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eThere are two grades available from the original developer and supplier of the AHCC compound (AHCC) is a registered trademark of Amino Up Chemical Co. Ltd Japan).\u003c\/p\u003e\n\u003cp\u003eThe \u003cstrong\u003eOriginal\u003c\/strong\u003e grade is in a lipid base at a low concentration of 45% (55% carrier excipients, 45% actual AHCC). This happens to be the most prolific form used in studies.\u003c\/p\u003e\n\u003cp\u003eMetagenics R\u0026amp;D and procurement teams weren't happy with this original compound and actually passed on its incorporation into the Metagenics range.\u003c\/p\u003e\n\u003cp\u003eThe suppliers then alerted Metagenics to their \u003cstrong\u003ePremium\u003c\/strong\u003e compound which is a 75% concentration (75% AHCC, 25% carrier).\u003c\/p\u003e\n\u003cp\u003eThis is the compound Metagenics chose - it results in the same dose of actual AHCC in the final product, ie: 1.35g of Metagenics AHCC equates to the quantities used in the official clinical trials.\u003c\/p\u003e\n\u003cp\u003eSee the below graphic for further explanation:\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e\u003cstrong\u003eOriginal\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e\u003cstrong\u003ePremium\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e45% concentration\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e75% concentration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e\n\u003ctd\u003eOf 3 grams\u003c\/td\u003e\n\u003ctd\u003eOf 1.9 grams\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e= 1.35 g of actual AHCC\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\" data-mce-style=\"text-align: center;\"\u003e= 1.35 g of actual AHCC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics uses the \u003cstrong\u003ePremium\u003c\/strong\u003e grade to provide the correct daily dose of AHCC (1.35g) based on official clinical trials and has fewer excipients.\u003c\/p\u003e\n\u003cp\u003eSome products containing AHCC commonly use the \u003cstrong\u003eOriginal\u003c\/strong\u003e grade described as a 'proprietary blend' with 45% AHCC and containing more excipients. These products may recommend a dose of one capsule\/tablet per day which is below the dose required based on the official studies. This results in an inferior product at a dose below the dose required for therapeutic benefits. These products can be more expensive when the correct dose is taken.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eAlways read the label. Use only as directed. If symptoms persist consult your healthcare professional.\u003c\/p\u003e\n\u003ch3\u003eContraindications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergies and sensitivities:\u003c\/strong\u003e Most allergic reactions occur after ingestion of raw or partially cooked shiitakes, or after physically handling them. Avoid with known allergy or hypersensitivity to mushrooms or derivatives thereof.[236],[237],[238],[239] Note that this product uses shiitake mushrooms that have been processed using heat above 100 degrees Celsius, reducing the risk of reactions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGallstones:\u003c\/strong\u003e Ginger can stimulate gall bladder contractions and is therefore contraindicated in patients with gallstones. It is recommended to only use after consultation with a physician if the patients has gallstones.[240],[241],[242],[243]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eModerate Level Cautions\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastric ulcers:\u003c\/strong\u003e Because of ginger’s effect on the gastric mucosa, it may worsen discomfort in patients with gastric ulcers.[244], [245] Use with caution, inform patients of potential effect and cease use if required.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunosuppressant drugs:\u003c\/strong\u003e \u003cem\u003eIn vitro\u003c\/em\u003e evidence suggests shiitake mushroom extracts may stimulate immune function, which may reduce the effects of immunosuppressive therapy.[246],[247] Use with caution and under medical supervision in patients on these medications undergoing organ transplant.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eLow Level Cautions\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticoagulant\/Antiplatelet medications:\u003c\/strong\u003e Ginger is thought to inhibit thromboxane synthetase and decrease platelet aggregation,[248],[249] affecting lipoxygenase and cyclooxygenase,[250],[251] particularly in doses that exceed 10 g\/d.[252] Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant\/antiplatelet drugs.[253],[254],[255],[256] Shiitake mushrooms may also decrease the effectiveness of blood platelets in initiating coagulation.[257],[258],[259] Use with caution in patients taking antiplatelet and\/or anticoagulant medications (e.g. aspirin or warfarin) and monitor international normalised ratio (INR) as well as potential adverse bleeding experiences. Consider combined supplemental and dietary ginger intake.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAutoimmune disease:\u003c\/strong\u003e It has been suggested that this mushroom should be avoided in individuals where immune suppression is desired.[260] However, due to the emerging role of infection in the pathogenesis of autoimmune disease,[261] and the anti-inflammatory and immunomodulatory actions of Lentinula edodes,[262] it may in fact be useful in the management of certain cases of autoimmune disease. Practitioners are advised to use their discretion when treating patients with autoimmune conditions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgery:\u003c\/strong\u003e Due to the anticoagulant properties of ginger, there have been safety concerns in regards to the risk of increased bleeding tendency and postoperative bleeding. To minimise the risk of exacerbation of these bleeding events it is recommended to discontinue use one to two weeks prior surgery.[263],[264]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003ePregnancy and Breastfeeding\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePregnancy\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAvoid use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e It is advised that a daily dose of 2 g\/d of ginger should not be exceeded during pregnancy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBreastfeeding\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e A review did not identify any concerns for use during breast feeding, however safety has not been conclusively established in humans.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eChildren\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAppropriate for use.[265],[266]\u003c\/li\u003e\n\u003cli\u003eNo information available for AHCC.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e[*] In patients with COMT variants, AHCC may cause a reduction in Letrozole activity, possibly due to the aromatase induction activity of AHCC. Avoid this combination in patients with COMT variants\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003eStore below 30°C\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: Metagenics Immunogenics\u003c\/h2\u003e\n\u003cp\u003e[236] Skidmore-Roth L. Mosby’s handbook of herbs \u0026amp; natural supplements. 4th ed. St Louis (MO): Mosby Elsevier; 2010. p. 393-5. \u003c\/p\u003e\n\u003cp\u003e[237] Health Canada. Monograph Mushrooms. [Internet]. Ottawa (CA): Government of Canada. 2019 Mar. [cited 2016 Sept 29]. Available from: http:\/\/webprod.hc-sc.gc.ca\/nhpid-bdipsn\/atReq.do?atid=mushrooms.champignons\u0026amp;lang=eng#rsk4. \u003c\/p\u003e\n\u003cp\u003e[238] Gardner Z, McGuffin M. Botanical safety handbook. 2nd ed. Boca Raton (FL): CRC Press; 2013. P 509-11. \u003c\/p\u003e\n\u003cp\u003e[239] Levy AM, Kita H, Phillips SF, Schkade PA, Dyer PD, Gleich GJ, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol. 1998 May;101(5):613-20. PMID: 9600497. \u003c\/p\u003e\n\u003cp\u003e[240] Skidmore-Roth L. Mosby’s handbook of herbs \u0026amp; natural supplements. 4th ed. St Louis (MO): Mosby Elsevier; 2010. p. 287-90. \u003c\/p\u003e\n\u003cp\u003e[241] Mills S, Bone K. Principles and practice of phytotherapy: modern herbal medicine. 2nd ed. Edinburgh (UK): Elsevier\/Churchill Livingstone; 2013. p. 394-403. \u003c\/p\u003e\n\u003cp\u003e[242] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[243] Gardner Z, McGuffin M. Botanical safety handbook. 2nd ed. Botan Raton (FL): CRC Press; 2013. p. 948-51. \u003c\/p\u003e\n\u003cp\u003e[244] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[245] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[246] Shiitake Mushroom. In: Natural Medicines Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2019 [2015; cited 2017 May 4]. Available from: URL. Subscription required to view. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=680#scientificName. \u003c\/p\u003e\n\u003cp\u003e[247] Gardner Z, McGuffin M. Botanical safety handbook. 2nd ed. Boca Raton (FL): CRC Press; 2013. P 509-11. \u003c\/p\u003e\n\u003cp\u003e[248] Ginger. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2018 Mar 13; cited 2018 Aug 13]. Available from: http:\/\/www.naturaldatabase.com. \u003c\/p\u003e\n\u003cp\u003e[249] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[250] Stargrove MB, Treasure J, McKee DL. Herb, nutrient, and drug interactions. St Louis (MO): Mosby Elsevier; 2010. p. 62-8. \u003c\/p\u003e\n\u003cp\u003e[251] Wang CZ, Moss J, Yuan CS. Commonly used dietary supplements on coagulation function during surgery. Medicines. 2015;2(3):157-185. doi:10.3390\/medicines2030157. \u003c\/p\u003e\n\u003cp\u003e[252] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[253] Ginger. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2018 Mar 13; cited 2018 Aug 13]. Available from: http:\/\/www.naturaldatabase.com. \u003c\/p\u003e\n\u003cp\u003e[254] Mills S, Bone K. Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[255] Fetrow CW, Avila JR. Professionals handbook of complementary and alternative medicines. 3rd ed. Philadelphia (PA): Lippincott Williams \u0026amp; Wilkins; 2004. p. 352-8. \u003c\/p\u003e\n\u003cp\u003e[256] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[257] Bisen PS, Baghel RK, Sanodiya BS, et al. Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem. 2010;17(22):2419-30. Review. \u003c\/p\u003e\n\u003cp\u003e[258] Shimada S, Komamura K, Kumagai H, et al. Inhibitory activity of shiitake flavor against platelet aggregation. Biofactors. 2004;22(1-4):177-9. \u003c\/p\u003e\n\u003cp\u003e[259] Odani S, Tominaga K, Kondou S, et al. The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes. Eur J Biochem. 1999 Jun;262(3):915-23. \u003c\/p\u003e\n\u003cp\u003e[260] Shiitake Mushroom. In: Natural Medicines Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2019 [2015; cited 2017 May 4]. Available from: URL. Subscription required to view. Available from: https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food,-herbs-supplements\/professional.aspx?productid=680#scientificName. \u003c\/p\u003e\n\u003cp\u003e[261] Root-Bernstein R, Fairweather D. Complexities in the relationship between Infection and autoimmunity. Curr Allergy Asthma Rep. 2014 Jan;14(1):407. \u003c\/p\u003e\n\u003cp\u003e[262] Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, et al. Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity: A randomized dietary intervention in healthy young ddults. J Am Coll Nutr. 2015;34(6):478-87. \u003c\/p\u003e\n\u003cp\u003e[263] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide. 4th ed. Vol 2. Sydney (AU): Elsevier\/Churchill Livingstone; 2015. p. 400-15. \u003c\/p\u003e\n\u003cp\u003e[264] Wang CZ, Moss J, Yuan CS. Commonly used dietary supplements on coagulation function during surgery. Medicines. 2015;2(3):157-185. doi:10.3390\/medicines2030157. \u003c\/p\u003e\n\u003cp\u003e[265] Mills S, Bone K. The essential guide to herbal safety. Philadelphia (PA): Elsevier\/Churchill Livingstone; 2005. p. 420-4. \u003c\/p\u003e\n\u003cp\u003e[266] Ginger. In: Natural Medicines Comprehensive Database [database on the Internet]. Stockton (CA): Therapeutic Research Faculty; 1995-2018 [updated 2018 Mar 13; cited 2018 Aug 13]. Available from: http:\/\/www.naturaldatabase.com.\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}