{"id":6051797926046,"title":"Metagenics CalmX","handle":"metagenics-calmx","description":"\u003ch3\u003e\u003cem\u003eMagnesium Combination For A Healthy Stress Response\u003c\/em\u003e\u003c\/h3\u003e\n\u003ch2\u003eMetagenics CalmX Raspberry or Tropical Powder\u003c\/h2\u003e\n\u003cp\u003eMetagenics CalmX Summary:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupport a healthy stress response.\u003c\/li\u003e\n\u003cli\u003eAssist metabolism and synthesis of some neurotransmitters including the calming neurotransmitter GABA.\u003c\/li\u003e\n\u003cli\u003e350 mg Meta Mag magnesium for extra replenishment during times of stress.\u003c\/li\u003e\n\u003cli\u003eMagnesium, taurine, glutamine, B vitamins, vitamin C and zinc for stress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics CalmX is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX is free from artificial colours, sweeteners, flavours and preservatives. Sweetened with steviol glycosides. Contains 362 mg of potassium per 11.9 g dose.\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX Raspberry AUST L 343133 or Tropical AUST L 273906\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eImages of fruit are for flavour representation purposes only.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca rel=\"noopener\" title=\"Metagenics Fibroplex MagActive 10% off RRP | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/collections\/metagenics-fibroplex-magactive\" target=\"_blank\"\u003eMetagenics Fibroplex MagActive Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/search?q=Metagenics+SleepX\" target=\"_blank\" title=\"Metagenics SleepX 10% off RRP | HealthMasters Metagenics\" rel=\"noopener\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eMetagenics SleepX Powder\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"BioCeuticals Ultra Muscleze Night 10% off RRP \\ HealthMasters BioCeuticals\" href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioceuticals-products\/products\/bioceuticals-ultra-muscleze-night-400g\" target=\"_blank\"\u003eBioCeuticals Ultra Muscleze Night Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"Designs For Health Tri-Mag Supreme Night Powder 10% off RRP | HealthMasters Designs For Health\" href=\"https:\/\/shop.healthmasters.com.au\/products\/designs-for-health-tri-mag-supreme-night-powder\" target=\"_blank\"\u003eDesigns For Health Tri-Mag Supreme Night Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/ethical-nutrients-megazorb-mega-magnesium-night\" title=\"Ethical Nutrients Mega Magnesium Night 20% off RR{ \\ HealthMasters Ethical Nutrients\" target=\"_blank\"\u003eEthical Nutrients Mega Magnesium Night Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/mediherb-medimag-calm-powder-480g\" title=\"MediHerb MediMag Calm 10% off RRP | HealthMasters MediHerb\" target=\"_blank\"\u003eMediHerb MediMag Calm Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-calm-care-for-kids-120gm\" title=\"Metagenics Calm Care for Kids 10% off RRP | HealthMasters Metagenics\"\u003eMetagenics Calm Care for Kids Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/orthoplex-white-alkamin-calm-260g\" title=\"Orthoplex AlkaMin Calm 10% off RRP | HealthMasters Orthoplex White\" target=\"_blank\"\u003eOrthoplex AlkaMin Calm Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eProduct Video\u003c\/h5\u003e\n\u003ch2\u003eProduct Video: Metagenics CalmX\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/283828625\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003eAdd 2 level scoops (12.7g) to 200 mL of water, twice daily.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics CalmX\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eProvides 350 mg of highly bioavailable Meta Mag magnesium to be of benefit during stress.\u003c\/strong\u003e Magnesium, B vitamins, vitamin C and zinc are all nutrients required to be able to cope with stress effectively and may be depleted in chronic stress.\u003csup\u003e4\u003c\/sup\u003e The adrenergic effects of stress induce a shift of magnesium to the extracellular space, increasing urinary excretion and depleting body stores (Figure One). Magnesium deficiency adversely affects excitatory neurotransmitters such as serotonin and acetylcholine and is associated with stress.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA double-blind, placebo controlled trial using 6.0 g of taurine per day investigated its impact on stress symptoms and biochemistry.\u003c\/strong\u003e This study showed taurine to inhibit the stress-induced release of adrenaline.\u003csup\u003e8\u003c\/sup\u003e Magnesium, B vitamins, vitamin C and zinc are required to regulate the stress response as co-factors in neurotransmitter synthesis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eZinc is essential in modulating the stress response.\u003c\/strong\u003e\u003csup\u003e9\u003c\/sup\u003e Zinc levels have been found to be deficient in people with generalised anxiety disorder.\u003csup\u003e10\u003c\/sup\u003e Exposure to acute stress increases serum glycocorticoids and induces metallothionein synthesis which consequently decreases serum zinc.\u003csup\u003e11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\n\u003cp\u003e\u003csup\u003e\u003cimg alt=\"Metagenics CalmX | HealthMasters\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_CalmX_figure-1_large.jpg?v=1554257593\"\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eFigure One: Magnesium and the Stress Response.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics CalmX\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eEach 12.7 g dose contains:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium amino acid chelate (Meta Mag® - Magnesium bisglycinate)\u003c\/td\u003e\n\u003ctd\u003e3.5g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Magnesium\u003c\/td\u003e\n\u003ctd\u003e350mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTaurine\u003c\/td\u003e\n\u003ctd\u003e3.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlutamine\u003c\/td\u003e\n\u003ctd\u003e2.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePotassium citrate\u003c\/td\u003e\n\u003ctd\u003e1.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Potassium\u003c\/td\u003e\n\u003ctd\u003e362mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium ascorbate dihydrate\u003c\/td\u003e\n\u003ctd\u003e605mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Ascorbic acid (Vitamin C)\u003c\/td\u003e\n\u003ctd\u003e500mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThiamine hydrochloride (Vitamin B1)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Riboflavin sodium phosphate\u003c\/td\u003e\n\u003ctd\u003e34mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRiboflavin (Vitamin B2)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide (Vitamin B3)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium pantothenate (Vitamin B5)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyidoxal 5-phosphate monohydrate (Vitamin B6)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc amino acid chelate (Meta Zn® - Zinc bisglycinate)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Zinc\u003c\/td\u003e\n\u003ctd\u003e10mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eMetagenics CalmX is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX is free from artificial colours, sweeteners, flavours and preservatives. Sweetened with steviol glycosides. Contains 362 mg of potassium per 11.9 g dose.\u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eCitric acid, Colloidal anhydrous silica, Flavour, Hypromellose, Malic acid, Silicon dioxide, Steviol glycosides and Tartaric acid.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eNot all cautions and contraindications are listed. For full details, references or more information contact HealthMasters in Australia by email: \u003ca href=\"mailto:reception@healthmasters.com.au\"\u003ereception@healthmasters.com.au\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eStore below 30° C\u003c\/p\u003e\n\u003ch5\u003eMagnesium Bisglycinate\u003c\/h5\u003e\n\u003ch2\u003eMagnesium Bisglycinate: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMAGNESIUM BISGLYCINATE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX contains evidenced-based ingredients to support the natural metabolic pathways for gamma-aminobutyric acid (GABA) production and activity, indicated to promote relaxation during times of stress. MetaMag Magnesium bisglycinate is scientifically designed to provide a highly bioavailable form of magnesium. Magnesium may act as a GABA receptor agonist and also has a binding site on the glutamate receptors helping to regulate the activity of this main excitatory neurotransmitter.1 Glycine functions as an inhibitory neurotransmitter in the nervous system while glutamine is a precursor to GABA production.2 Pyridoxal (vitamin B6) is a cofactor for the enzyme Glutamate decarboxylase that synthesises GABA from glutamate.4 Zinc also has a binding site on the glutamate receptor and may act as a modulator for both excitatory and inhibitory neurotransmission.5\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMagnesium is predominantly located intra-cellular in bone, muscles and non-muscular soft tissues while only 1% of total magnesium is found in serum and red blood cells. Magnesium needs to be consumed in the diet regularly to prevent the risk of magnesium deficiency and due to the increased consumption of processed foods; magnesium intake in the western world is decreasing. Magnesium is a cofactor in more than 300 enzymatic reactions, critically stabilising enzymes, including many ATP-generating reactions. ATP metabolism, muscle contraction and relaxation, normal neurological function and release of neurotransmitters are all magnesium dependent.6 While evidence generally does not support the use of magnesium for skeletal muscle cramps with many studies producing null effect7,8, there is evidence to suggest oral magnesium supplementation can improve anaerobic metabolism in athletes, decreasing lactate production9 and improving physical performance in healthy elderly women involved in an exercise program.10\u003c\/p\u003e\n\u003cp\u003eMagnesium may function as a GABA receptor agonist promoting the effects of GABA. Further, in the central nervous system (CNS), magnesium ions block NMDAR channels at resting membrane potentials. The binding site for magnesium ions is deep within the channel. This block is voltage-dependent but ion flux occurs when the membrane potential is depolarized. NMDAR receptors are glutamate-binding sites, being the major excitatory neurotransmitter in the CNS.11 See Figure 1.\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Medlab Mg Optima Relax GABA Glutamate fig1 at HealthMasters\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Medlab_Mg_Optima_Relax_GABA_Glutamate_fig1_10_off_RRP_at_HealthMasters_600x600.jpg?v=1590698994\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1.\u003c\/strong\u003e Neurotransmitter signalling12\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlycine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlycine functions as one of the major inhibitory neurotransmitters in the CNS with a high density of glycine containing neurons being found in spinal cord and brain stem. When glycine binds to its receptor it opens the anion channel allowing an influx of chloride ions into the postsynaptic neuron causing hyperpolarization that raises the threshold for neuronal firing and thereby inhibits the postsynaptic neuron.2,13\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlutamine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlutamine and glutamate are amino acids. Several studies show that concentrations of serum glutamine in the body are diminished during times of physical or psychological stress and further that patients presenting with exhaustion, anxiety, sleeplessness and lack of concentration have low serum glutamate concentration. Glutamine and glutamate synthesis occur interchangeably (see figure 2). Glutamine converts to glutamate using NADPH as a cofactor and glutamate is a precursor for GABA production using vitamin B6 as a cofactor.15-19\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Medlab Mg Optima Relax GABA Glutamate fig2 at HealthMasters\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Medlab_Mg_Optima_Relax_GABA_Glutamate_fig2_10_off_RRP_at_HealthMasters_600x600.jpg?v=1590699060\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2.\u003c\/strong\u003e GABA is synthesized from Glutamine and Glutamate20\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePyridoxal 5-Phosphate (Vitamin B6)\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003ePyridoxine is the cofactor required by Glutamate decarboxylase to convert glutamate to GABA in the CNS.4 See Figure 2.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eApproximately 10% of total zinc in the brain is located in synaptic vesicles of certain glutamatergic neurons.5 Zinc may modulate neurotransmission mediated via both excitatory and inhibitory amino acid receptors at specific synapses for example the NMDA glutamate receptor is directly inhibited by zinc whereas GABA release from the presynapse can be potentiated (see Figure 1).28\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTo naturally increase GABA production to induce relaxation\u003c\/li\u003e\n\u003cli\u003eHelps relieve symptoms of nervous tension, stress and mild anxiety\u003c\/li\u003e\n\u003cli\u003eFor the symptomatic relief of stress disorders.\u003c\/li\u003e\n\u003cli\u003eHerbal blend which helps relieve stress of study or work\u003c\/li\u003e\n\u003cli\u003eMay help reduce the frequency of migraines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWho will benefit:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThose with symptoms of anxiety and nervous tension\u003c\/li\u003e\n\u003cli\u003eThose who are experiencing mild stress and associated disorders\u003c\/li\u003e\n\u003cli\u003eThose who are experiencing stress associated with work and\/or study\u003c\/li\u003e\n\u003cli\u003eThose with magnesium deficiency\u003c\/li\u003e\n\u003cli\u003eThose who are experiencing frequent migraines\u003c\/li\u003e\n\u003cli\u003eThose who wish to improve their cognitive performance and mood.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eHeld K, Antonijevic IA, Künzel H, et al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry 2002;35(4):135-143\u003c\/li\u003e\n\u003cli\u003eLegendre P. The glycinergic inhibitory synapse. Cell. Mol. Life Sci 2001;58:760–793\u003c\/li\u003e\n\u003cli\u003eKimura K1, Ozeki M, Juneja LR, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol 2007;74(1):39-45\u003c\/li\u003e\n\u003cli\u003eQu K, Martin DL, Lawrence C. Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase. Protein Sci 1998;7:1092-1105.\u003c\/li\u003e\n\u003cli\u003eTakeda A, Minami A, Seki Y, et al. Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. J Neurosci Res 2004; 15;75(2):225-9.\u003c\/li\u003e\n\u003cli\u003eJahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J 2012;5 (1);i3–i14.\u003c\/li\u003e\n\u003cli\u003eNygaard IH, Valbo A, Oethick SV, et al. Does oral magnesium substitution relieve pregnancy-inducede leg cramps? Eur J Obstet Gynecol Reprod Biol 2008;141:23-6.\u003c\/li\u003e\n\u003cli\u003eGarrison SR, Birmingham CL, Koehler BE, et al. The effect of magnesium infusion on rest cramps: a randomized controlled trial. J Gerontol A Biol Sci Med Sci 2011;66:661-6.\u003c\/li\u003e\n\u003cli\u003eSetaro L, Santos-Silva PR, Nakano EY, et al. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation. J Sports Sci 2014;32:438-45.\u003c\/li\u003e\n\u003cli\u003eVeronese N, Berton L, Carraro S, et al. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Nutr 2014;100:974-81.\u003c\/li\u003e\n\u003cli\u003eMonaghan DT, Jane DE. Pharmacology of NMDA receptors. In: Van Dongen AM, editor. Biology of the NMDA receptor. Boca Raton (FL): CRC Press\/Taylor \u0026amp; Francis; 2009. Chapter 12.\u003c\/li\u003e\n\u003cli\u003eGecz, J. Glutamate receptors and learning and memory. Nat. Genet 2010;42:925\u003c\/li\u003e\n\u003cli\u003eBerger AJ, Dieudonne S, Ascher P. Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol 1998;80: 3336–3340.\u003c\/li\u003e\n\u003cli\u003eHubner CA, Stein V, Hermans-Borgmeyer I, et al. Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron 2001;30:515–524.\u003c\/li\u003e\n\u003cli\u003eChen SW, Kong WX, Zhang YJ, et al. Possible anxiolytic effects of taurine in the mouse elevated plus-maze. Life Sci 2004;75(12):1503-1511.\u003c\/li\u003e\n\u003cli\u003eHertz L, Kvamme E, McGeer, EG, et al. Glutamine, Glutamate, and Gaba in the Central Nervous System. Alan R Liss Inc. New York; 1983.\u003c\/li\u003e\n\u003cli\u003eBowtell JL, Gelly K, Jackman ML, et al. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. J.Appl Physiol 1999:1770-1777.\u003c\/li\u003e\n\u003cli\u003eWelbourne TC. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr 1995;61(5):1058-1061.\u003c\/li\u003e\n\u003cli\u003eHasler G, Van der Veen JW, Tumonis, T, et al. Reduced Prefrontal Glutamate\/Glutamine and Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy. Arch Gen Psych 2007;64 (2):193-200.\u003c\/li\u003e\n\u003cli\u003eOwens DF, Krieg Stein AR. Is there more to GABA than synaptic inhibition? Nat. Rev. Neurosci 2002;3:715\u003c\/li\u003e\n\u003cli\u003eKakuda T, Nozawa A, Sugimoto A, et al. Inhibition by Theanine of binding of [3H]AMPA, [3H]Kainate and [3H]MDL 105,519 to glutamate receptors. Biosci Biotechnol Biochem 2002;66:2683-86.\u003c\/li\u003e\n\u003cli\u003eKimura R, Murata T. Influence of alkylamides of glutamic acid and related compounds on the central nervous system I. Central depressant effect of theanine. Chem Pharm Bull 1971;19:1257–1261.\u003c\/li\u003e\n\u003cli\u003eNathan PJ, Lu K, Gray M, et al.; The neuropharmacology of L-theanine (N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother 2006;6(2):21-30.\u003c\/li\u003e\n\u003cli\u003eHeese T, Jenkinson J, Love C, et al.\u0026amp; Anxiolytic effects of L-theanine - a component of green tea - when combined with midazolam, in the male Sprague-Dawley rat. AANA J 2009;77(6):445-449.\u003c\/li\u003e\n\u003cli\u003eIto K, Nagato Y, Aoi N, et al. Effects of L-theanine on the release of alpha brain waves in human volunteers. Nippon Nogeikagaku Kaishi 1998;72:153-157.\u003c\/li\u003e\n\u003cli\u003eLu K., Gray MA, Oliver C, et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol 2004;19(7):457-465.\u003c\/li\u003e\n\u003cli\u003eLardner AL. Neurobiological effects of the green tea constituent Theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutr Neurosci 2014;17:145-55.\u003c\/li\u003e\n\u003cli\u003eSmart TG, Hosie AM, Miller PS. Zn2+ ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist 2004;10(5):432-42.\u003c\/li\u003e\n\u003cli\u003eGröber U. Magnesium. In: Gröber U., editor. Micronutrients: Metabolic Tuning-Prevention-Therapy. 1st ed. MedPharm Scientific Publishers; Stuttgart, Germany: 2009:159–166.\u003c\/li\u003e\n\u003cli\u003eFoca FJ. Motor and sensory neuropathy secondary to excessive pyridoxine ingestion. Arch Phys Med Rehabil 1985;66(9):634-6.\u003c\/li\u003e\n\u003cli\u003eDalton K, Dalton MJ. Characteristics of pyridoxine overdose neuropathy syndrome. 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GABA.\u003c\/li\u003e\n\u003cli\u003e350 mg Meta Mag magnesium for extra replenishment during times of stress.\u003c\/li\u003e\n\u003cli\u003eMagnesium, taurine, glutamine, B vitamins, vitamin C and zinc for stress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMetagenics CalmX is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX is free from artificial colours, sweeteners, flavours and preservatives. Sweetened with steviol glycosides. Contains 362 mg of potassium per 11.9 g dose.\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX Raspberry AUST L 343133 or Tropical AUST L 273906\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eImages of fruit are for flavour representation purposes only.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch4\u003eSimilar Products\u003c\/h4\u003e\n\u003cp\u003eThe products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca rel=\"noopener\" title=\"Metagenics Fibroplex MagActive 10% off RRP | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/collections\/metagenics-fibroplex-magactive\" target=\"_blank\"\u003eMetagenics Fibroplex MagActive Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/search?q=Metagenics+SleepX\" target=\"_blank\" title=\"Metagenics SleepX 10% off RRP | HealthMasters Metagenics\" rel=\"noopener\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eMetagenics SleepX Powder\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"BioCeuticals Ultra Muscleze Night 10% off RRP \\ HealthMasters BioCeuticals\" href=\"https:\/\/shop.healthmasters.com.au\/collections\/bioceuticals-products\/products\/bioceuticals-ultra-muscleze-night-400g\" target=\"_blank\"\u003eBioCeuticals Ultra Muscleze Night Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca title=\"Designs For Health Tri-Mag Supreme Night Powder 10% off RRP | HealthMasters Designs For Health\" href=\"https:\/\/shop.healthmasters.com.au\/products\/designs-for-health-tri-mag-supreme-night-powder\" target=\"_blank\"\u003eDesigns For Health Tri-Mag Supreme Night Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/ethical-nutrients-megazorb-mega-magnesium-night\" title=\"Ethical Nutrients Mega Magnesium Night 20% off RR{ \\ HealthMasters Ethical Nutrients\" target=\"_blank\"\u003eEthical Nutrients Mega Magnesium Night Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/mediherb-medimag-calm-powder-480g\" title=\"MediHerb MediMag Calm 10% off RRP | HealthMasters MediHerb\" target=\"_blank\"\u003eMediHerb MediMag Calm Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/metagenics-calm-care-for-kids-120gm\" title=\"Metagenics Calm Care for Kids 10% off RRP | HealthMasters Metagenics\"\u003eMetagenics Calm Care for Kids Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/products\/orthoplex-white-alkamin-calm-260g\" title=\"Orthoplex AlkaMin Calm 10% off RRP | HealthMasters Orthoplex White\" target=\"_blank\"\u003eOrthoplex AlkaMin Calm Powder\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCan't see an appropriate product, or have any other questions?\u003c\/p\u003e\n\u003cp\u003eYou can contact HealthMasters for assistance \u003cspan style=\"text-decoration: underline;\" data-mce-style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/shop.healthmasters.com.au\/pages\/healthmasters-contact\" title=\"Contact HealthMasters For Assistance\" target=\"_blank\"\u003eHERE\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eProduct Video\u003c\/h5\u003e\n\u003ch2\u003eProduct Video: Metagenics CalmX\u003c\/h2\u003e\n\u003cstyle\u003e\u003c!--\n.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }\n--\u003e\u003c\/style\u003e\n\u003cdiv class=\"embed-container\"\u003e\u003ciframe src=\"https:\/\/player.vimeo.com\/video\/283828625\" webkitallowfullscreen=\"\" mozallowfullscreen=\"\" allowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003ch5\u003eDirections\u003c\/h5\u003e\n\u003ch2\u003eDirections: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003eAdd 2 level scoops (12.7g) to 200 mL of water, twice daily.\u003c\/p\u003e\n\u003ch5\u003eBenefits\u003c\/h5\u003e\n\u003ch2\u003eClinical Benefits: Metagenics CalmX\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eProvides 350 mg of highly bioavailable Meta Mag magnesium to be of benefit during stress.\u003c\/strong\u003e Magnesium, B vitamins, vitamin C and zinc are all nutrients required to be able to cope with stress effectively and may be depleted in chronic stress.\u003csup\u003e4\u003c\/sup\u003e The adrenergic effects of stress induce a shift of magnesium to the extracellular space, increasing urinary excretion and depleting body stores (Figure One). Magnesium deficiency adversely affects excitatory neurotransmitters such as serotonin and acetylcholine and is associated with stress.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA double-blind, placebo controlled trial using 6.0 g of taurine per day investigated its impact on stress symptoms and biochemistry.\u003c\/strong\u003e This study showed taurine to inhibit the stress-induced release of adrenaline.\u003csup\u003e8\u003c\/sup\u003e Magnesium, B vitamins, vitamin C and zinc are required to regulate the stress response as co-factors in neurotransmitter synthesis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eZinc is essential in modulating the stress response.\u003c\/strong\u003e\u003csup\u003e9\u003c\/sup\u003e Zinc levels have been found to be deficient in people with generalised anxiety disorder.\u003csup\u003e10\u003c\/sup\u003e Exposure to acute stress increases serum glycocorticoids and induces metallothionein synthesis which consequently decreases serum zinc.\u003csup\u003e11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\n\u003cp\u003e\u003csup\u003e\u003cimg alt=\"Metagenics CalmX | HealthMasters\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Metagenics_CalmX_figure-1_large.jpg?v=1554257593\"\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eFigure One: Magnesium and the Stress Response.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Metagenics CalmX\u003c\/h2\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eEach 12.7 g dose contains:\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMagnesium amino acid chelate (Meta Mag® - Magnesium bisglycinate)\u003c\/td\u003e\n\u003ctd\u003e3.5g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Magnesium\u003c\/td\u003e\n\u003ctd\u003e350mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTaurine\u003c\/td\u003e\n\u003ctd\u003e3.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlutamine\u003c\/td\u003e\n\u003ctd\u003e2.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePotassium citrate\u003c\/td\u003e\n\u003ctd\u003e1.0g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Potassium\u003c\/td\u003e\n\u003ctd\u003e362mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium ascorbate dihydrate\u003c\/td\u003e\n\u003ctd\u003e605mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Ascorbic acid (Vitamin C)\u003c\/td\u003e\n\u003ctd\u003e500mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThiamine hydrochloride (Vitamin B1)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Riboflavin sodium phosphate\u003c\/td\u003e\n\u003ctd\u003e34mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRiboflavin (Vitamin B2)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNicotinamide (Vitamin B3)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCalcium pantothenate (Vitamin B5)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyidoxal 5-phosphate monohydrate (Vitamin B6)\u003c\/td\u003e\n\u003ctd\u003e25mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc amino acid chelate (Meta Zn® - Zinc bisglycinate)\u003c\/td\u003e\n\u003ctd\u003e50mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEquivalent Zinc\u003c\/td\u003e\n\u003ctd\u003e10mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eMetagenics CalmX is free from animal products, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast and soy protein.\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX is free from artificial colours, sweeteners, flavours and preservatives. Sweetened with steviol glycosides. Contains 362 mg of potassium per 11.9 g dose.\u003c\/p\u003e\n\u003ch5\u003eExcipients\u003c\/h5\u003e\n\u003ch2\u003eExcipients: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eCitric acid, Colloidal anhydrous silica, Flavour, Hypromellose, Malic acid, Silicon dioxide, Steviol glycosides and Tartaric acid.\u003c\/p\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eNot all cautions and contraindications are listed. For full details, references or more information contact HealthMasters in Australia by email: \u003ca href=\"mailto:reception@healthmasters.com.au\"\u003ereception@healthmasters.com.au\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003eStore below 30° C\u003c\/p\u003e\n\u003ch5\u003eMagnesium Bisglycinate\u003c\/h5\u003e\n\u003ch2\u003eMagnesium Bisglycinate: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eMAGNESIUM BISGLYCINATE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMetagenics CalmX contains evidenced-based ingredients to support the natural metabolic pathways for gamma-aminobutyric acid (GABA) production and activity, indicated to promote relaxation during times of stress. MetaMag Magnesium bisglycinate is scientifically designed to provide a highly bioavailable form of magnesium. Magnesium may act as a GABA receptor agonist and also has a binding site on the glutamate receptors helping to regulate the activity of this main excitatory neurotransmitter.1 Glycine functions as an inhibitory neurotransmitter in the nervous system while glutamine is a precursor to GABA production.2 Pyridoxal (vitamin B6) is a cofactor for the enzyme Glutamate decarboxylase that synthesises GABA from glutamate.4 Zinc also has a binding site on the glutamate receptor and may act as a modulator for both excitatory and inhibitory neurotransmission.5\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMagnesium is predominantly located intra-cellular in bone, muscles and non-muscular soft tissues while only 1% of total magnesium is found in serum and red blood cells. Magnesium needs to be consumed in the diet regularly to prevent the risk of magnesium deficiency and due to the increased consumption of processed foods; magnesium intake in the western world is decreasing. Magnesium is a cofactor in more than 300 enzymatic reactions, critically stabilising enzymes, including many ATP-generating reactions. ATP metabolism, muscle contraction and relaxation, normal neurological function and release of neurotransmitters are all magnesium dependent.6 While evidence generally does not support the use of magnesium for skeletal muscle cramps with many studies producing null effect7,8, there is evidence to suggest oral magnesium supplementation can improve anaerobic metabolism in athletes, decreasing lactate production9 and improving physical performance in healthy elderly women involved in an exercise program.10\u003c\/p\u003e\n\u003cp\u003eMagnesium may function as a GABA receptor agonist promoting the effects of GABA. Further, in the central nervous system (CNS), magnesium ions block NMDAR channels at resting membrane potentials. The binding site for magnesium ions is deep within the channel. This block is voltage-dependent but ion flux occurs when the membrane potential is depolarized. NMDAR receptors are glutamate-binding sites, being the major excitatory neurotransmitter in the CNS.11 See Figure 1.\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Medlab Mg Optima Relax GABA Glutamate fig1 at HealthMasters\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Medlab_Mg_Optima_Relax_GABA_Glutamate_fig1_10_off_RRP_at_HealthMasters_600x600.jpg?v=1590698994\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 1.\u003c\/strong\u003e Neurotransmitter signalling12\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlycine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlycine functions as one of the major inhibitory neurotransmitters in the CNS with a high density of glycine containing neurons being found in spinal cord and brain stem. When glycine binds to its receptor it opens the anion channel allowing an influx of chloride ions into the postsynaptic neuron causing hyperpolarization that raises the threshold for neuronal firing and thereby inhibits the postsynaptic neuron.2,13\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlutamine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlutamine and glutamate are amino acids. Several studies show that concentrations of serum glutamine in the body are diminished during times of physical or psychological stress and further that patients presenting with exhaustion, anxiety, sleeplessness and lack of concentration have low serum glutamate concentration. Glutamine and glutamate synthesis occur interchangeably (see figure 2). Glutamine converts to glutamate using NADPH as a cofactor and glutamate is a precursor for GABA production using vitamin B6 as a cofactor.15-19\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" alt=\"Medlab Mg Optima Relax GABA Glutamate fig2 at HealthMasters\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/Medlab_Mg_Optima_Relax_GABA_Glutamate_fig2_10_off_RRP_at_HealthMasters_600x600.jpg?v=1590699060\"\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003eFigure 2.\u003c\/strong\u003e GABA is synthesized from Glutamine and Glutamate20\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePyridoxal 5-Phosphate (Vitamin B6)\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003ePyridoxine is the cofactor required by Glutamate decarboxylase to convert glutamate to GABA in the CNS.4 See Figure 2.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eApproximately 10% of total zinc in the brain is located in synaptic vesicles of certain glutamatergic neurons.5 Zinc may modulate neurotransmission mediated via both excitatory and inhibitory amino acid receptors at specific synapses for example the NMDA glutamate receptor is directly inhibited by zinc whereas GABA release from the presynapse can be potentiated (see Figure 1).28\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTo naturally increase GABA production to induce relaxation\u003c\/li\u003e\n\u003cli\u003eHelps relieve symptoms of nervous tension, stress and mild anxiety\u003c\/li\u003e\n\u003cli\u003eFor the symptomatic relief of stress disorders.\u003c\/li\u003e\n\u003cli\u003eHerbal blend which helps relieve stress of study or work\u003c\/li\u003e\n\u003cli\u003eMay help reduce the frequency of migraines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWho will benefit:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThose with symptoms of anxiety and nervous tension\u003c\/li\u003e\n\u003cli\u003eThose who are experiencing mild stress and associated disorders\u003c\/li\u003e\n\u003cli\u003eThose who are experiencing stress associated with work and\/or study\u003c\/li\u003e\n\u003cli\u003eThose with magnesium deficiency\u003c\/li\u003e\n\u003cli\u003eThose who are experiencing frequent migraines\u003c\/li\u003e\n\u003cli\u003eThose who wish to improve their cognitive performance and mood.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eHeld K, Antonijevic IA, Künzel H, et al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry 2002;35(4):135-143\u003c\/li\u003e\n\u003cli\u003eLegendre P. The glycinergic inhibitory synapse. Cell. Mol. Life Sci 2001;58:760–793\u003c\/li\u003e\n\u003cli\u003eKimura K1, Ozeki M, Juneja LR, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol 2007;74(1):39-45\u003c\/li\u003e\n\u003cli\u003eQu K, Martin DL, Lawrence C. Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase. Protein Sci 1998;7:1092-1105.\u003c\/li\u003e\n\u003cli\u003eTakeda A, Minami A, Seki Y, et al. Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. J Neurosci Res 2004; 15;75(2):225-9.\u003c\/li\u003e\n\u003cli\u003eJahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J 2012;5 (1);i3–i14.\u003c\/li\u003e\n\u003cli\u003eNygaard IH, Valbo A, Oethick SV, et al. Does oral magnesium substitution relieve pregnancy-inducede leg cramps? Eur J Obstet Gynecol Reprod Biol 2008;141:23-6.\u003c\/li\u003e\n\u003cli\u003eGarrison SR, Birmingham CL, Koehler BE, et al. The effect of magnesium infusion on rest cramps: a randomized controlled trial. J Gerontol A Biol Sci Med Sci 2011;66:661-6.\u003c\/li\u003e\n\u003cli\u003eSetaro L, Santos-Silva PR, Nakano EY, et al. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation. J Sports Sci 2014;32:438-45.\u003c\/li\u003e\n\u003cli\u003eVeronese N, Berton L, Carraro S, et al. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Nutr 2014;100:974-81.\u003c\/li\u003e\n\u003cli\u003eMonaghan DT, Jane DE. Pharmacology of NMDA receptors. In: Van Dongen AM, editor. Biology of the NMDA receptor. Boca Raton (FL): CRC Press\/Taylor \u0026amp; Francis; 2009. Chapter 12.\u003c\/li\u003e\n\u003cli\u003eGecz, J. Glutamate receptors and learning and memory. Nat. Genet 2010;42:925\u003c\/li\u003e\n\u003cli\u003eBerger AJ, Dieudonne S, Ascher P. Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol 1998;80: 3336–3340.\u003c\/li\u003e\n\u003cli\u003eHubner CA, Stein V, Hermans-Borgmeyer I, et al. Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron 2001;30:515–524.\u003c\/li\u003e\n\u003cli\u003eChen SW, Kong WX, Zhang YJ, et al. Possible anxiolytic effects of taurine in the mouse elevated plus-maze. Life Sci 2004;75(12):1503-1511.\u003c\/li\u003e\n\u003cli\u003eHertz L, Kvamme E, McGeer, EG, et al. Glutamine, Glutamate, and Gaba in the Central Nervous System. Alan R Liss Inc. New York; 1983.\u003c\/li\u003e\n\u003cli\u003eBowtell JL, Gelly K, Jackman ML, et al. 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Acta Neurol Scand 1987;76(1):8-11.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch5\u003eTechnical Information\u003c\/h5\u003e\n\u003ch2\u003eTechnical Information: Metagenics CalmX\u003c\/h2\u003e\n\u003cp\u003e\u003ca title=\"Metagenics CalmX Technical Information | HealthMasters Metagenics\" href=\"https:\/\/shop.healthmasters.com.au\/pages\/metagenics-calmx-technical-information\" target=\"_blank\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eMetagenics CalmX Technical Information - Click Here\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c!-- \/TABS --\u003e"}