{"id":6689301921950,"title":"Integra Nutritionals Gemmune I.B. ImmunoBiotic 56vc","handle":"integra-nutritionals-gemmune-i-b-immunobiotic-56vc","description":"\u003ch2\u003eIntegra Nutritionals Gemmune I.B. ImmunoBiotic 56vc\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eGemmune I.B. ImmunoBiotic\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eServing Type: Vegetable Cellulose Size ’00’ Capsule (suitable for vegetarians)\u003c\/p\u003e\n\u003cp\u003eAvailable in 56 Capsules\u003c\/p\u003e\n\u003cp\u003eIntegra Nutritionals Gemmune I.B. ImmunoBiotic AUST L 307048\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDescription\u003c\/h5\u003e\n\u003ch2\u003eDescription: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eThe GEMM Protocol - Gut Ecology \u0026amp; Metabolic Modulation:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe GEMM Protocol is a clinical strategy to prevent and treat acute and chronic disease at its cellular origins and aims to re-establish each patient’s unique gut ecology, by supporting the growth, development and diversity of the microbiota.\u003c\/p\u003e\n\u003cp\u003eThe gut is now widely considered to function as a metabolic organ which plays a primary role in human immunity. A major contributor is the close interrelationships among five key elements – the Intestinal Epithelium and its overlying mucous membranes (IEFC), its underlying Immune cells, the Gut microbiota, the Capillary bed and the Neural networks that enable communication from the gut to other body systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune IB ImmunoBiotic \u003c\/strong\u003e simultaneously enhances immune, digestive and metabolic functions by targeting the gut immune interface.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnhances immune defences\u003c\/li\u003e\n\u003cli\u003eRelieves inflammation and maintains blood vessel health\u003c\/li\u003e\n\u003cli\u003eMaintains circulation and increases cognitive performance\u003c\/li\u003e\n\u003cli\u003eRelieves aching, swollen legs due to mild varicose veins\u003c\/li\u003e\n\u003cli\u003eAids in carbohydrate metabolism\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune I.B\u003c\/strong\u003e is comprehensively supported by \u003cstrong\u003eIntegra Nutritionals GFD\u003c\/strong\u003e and \u003cstrong\u003eIntegra Nutritionals FloraGenex. \u003c\/strong\u003e \u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune I.B. – the Concept of the Immunobiotic\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe healthy microbiome represents a diverse array of over 1000 unique commensal microbial species; by contrast, a probiotic supplement provides just a few.\u003c\/p\u003e\n\u003cp\u003eOn the other hand, an Immunbiotic is a modified probiotic standardised for its content of immune-signalling molecules and is typically heat-killed at the peak of its bioactivity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune I.B.\u003c\/strong\u003e \u003cstrong\u003eImmunoBiotic\u003c\/strong\u003e is an immunobiotic derived from Lactobacillus plantarum HKL-137, a heat-killed, stabilised strain, standardised for its high content of Lipoteichoic Acid (LTA).\u003c\/p\u003e\n\u003cp\u003eWhen LTA binds to the toll-like receptor (TLR2), it initiates a signalling cascade that activates a significant immune response (Figure 2). Modifying the gut environment in this way to foster the growth of the commensals allows an individual’s gut ecology to be restored using the same principles employed by Nature.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus plantaram HKL137 (LP20) (50 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePotent source of Lipoteichoic acid (LTA)\u003c\/li\u003e\n\u003cli\u003eStimulates TLR2, modulating tight junctions\u003c\/li\u003e\n\u003cli\u003eInduces IL-12 to induce Th1 response\u003c\/li\u003e\n\u003cli\u003eEnhances both INNATE and ADAPTIVE immunity\u003c\/li\u003e\n\u003cli\u003eReduces Upper respiratory tract infection\u003c\/li\u003e\n\u003cli\u003eReduces periodontal probing depth\u003c\/li\u003e\n\u003cli\u003eDownregulates inflammation and undesirable responses to allergens\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFucus Vesiculosis extract (deiodinated) (117 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases synthesis of secretory IgA\u003c\/li\u003e\n\u003cli\u003eDownregulates gut and systemic pro-inflammatory cytokines IL-8 and TNF-a\u003c\/li\u003e\n\u003cli\u003eEnhances gut barrier by upregulating tight junction protein, Claudin-1\u003c\/li\u003e\n\u003cli\u003eInhibits adherence of H.pylori\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eGrape Seed polyphenols (90%) (600 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSource of prebiotic nutrition for commensals\u003c\/li\u003e\n\u003cli\u003eReduce oxidant burden of food\u003c\/li\u003e\n\u003cli\u003eDownregulate pro-inflammatory cytokines\u003c\/li\u003e\n\u003cli\u003eIncrease mucin synthesis and sigA\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNOTE:  Polyphenol metabolites promote metabolic health\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCitrus reticulata (40% bioflavonoids) (500 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe peel is uniquely rich in polymethoxylated flavones\u003c\/li\u003e\n\u003cli\u003eQuenches ROS in gut lumen\u003c\/li\u003e\n\u003cli\u003eReduces inflammation markers\u003c\/li\u003e\n\u003cli\u003eConversion of naringenin to naringin enhances gut barrier\u003c\/li\u003e\n\u003cli\u003eBeneficially promotes gut T reg cells\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003eThe standard dose of Gemmune I.B. is 1 capsule twice daily with meals.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eAcute illness:\u003c\/strong\u003e In acute states associated with infection, inflammation and allergy, Gemmune I.B. may be taken in divided doses up to 8 capsules daily, supported with the standard dose of Integra Nutritionals GFD at 2 capsules b.d.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: \u003c\/h2\u003e\n\u003cp\u003eStore below 30°C away from light and moisture. May be refrigerated.\u003c\/p\u003e\n\u003ch5\u003eEvidence\u003c\/h5\u003e\n\u003ch2\u003eEvidence: \u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eFujiki T, Hirose Y, Yamamoto Y, Murosaki S. Enhanced immunomodulatory activity and stability in simulated digestive juices of Lactobacillus plantarum L-137 by heat treatment. Biosci Biotechnol Biochem. 2012;76(5):918-922.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Yamamoto Y, Yoshikai Y, Murosaki S. Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress. Journal of nutritional science. 2013;2:e39.\u003c\/li\u003e\n\u003cli\u003eSashihara T, Sueki N, Ikegami S. An analysis of the effectiveness of heat-killed lactic acid bacteria in alleviating allergic diseases. J Dairy Sci. 2006;89(8):2846-2855.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Murosaki S, Fujiki T, Yamamoto Y, Yoshikai Y, Yamashita M. Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production. Microbiol Immunol. 2010;54(3):143-151.\u003c\/li\u003e\n\u003cli\u003eRyu YH, Baik JE, Yang JS, et al. Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids. Int Immunopharmacol. 2009;9(1):127-133.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Murosaki S, Yamamoto Y, et al. Safety studies of LP20 powder produced from heat-killed Lactobacillus plantarum L-137. Regul Toxicol Pharmacol. 2009;54(3):214-220.\u003c\/li\u003e\n\u003cli\u003eAhn KB, Baik JE, Yun CH, Han SH. Lipoteichoic Acid Inhibits Staphylococcus aureus Biofilm Formation. Front Microbiol. 2018;9:327.\u003c\/li\u003e\n\u003cli\u003eAhn KB, Baik JE, Park OJ, Yun CH, Han SH. Lactobacillus plantarum lipoteichoic acid inhibits biofilm formation of Streptococcus mutans. PLoS One. 2018;13(2):e0192694.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Murosaki S, Yamamoto Y, Yoshikai Y, Tsuru T. Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults. J Nutr. 2006;136(12):3069-3073.\u003c\/li\u003e\n\u003cli\u003eAhrne S, Hagslatt ML. Effect of lactobacilli on paracellular permeability in the gut. Nutrients. 2011;3(1):104-117.\u003c\/li\u003e\n\u003cli\u003eMathew L, Burney M, Gaikwad A, et al. Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment. Integrative Cancer Therapies. 2017;16(4):572-584.\u003c\/li\u003e\n\u003cli\u003eZuo T, Li X, Chang Y, et al. Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice. Food Funct. 2015;6(2):415-422.\u003c\/li\u003e\n\u003cli\u003eShang Q, Shan X, Cai C, Hao J, Li G, Yu G. Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae. Food Funct. 2016;7(7):3224-3232.\u003c\/li\u003e\n\u003cli\u003eWalsh AM, Sweeney T, O’Shea CJ, Doyle DN, O’Doherty JV. Effect of dietary laminarin and fucoidan on selected microbiota, intestinal morphology and immune status of the newly weaned pig. Br J Nutr. 2013;110(9):1630-1638.\u003c\/li\u003e\n\u003cli\u003eIraha A, Chinen H, Hokama A, et al. Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1. World J Gastroenterol. 2013;19(33):5500-5507.\u003c\/li\u003e\n\u003cli\u003eXue M, Ji X, Liang H, et al. The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer. Food Funct. 2018;9(2):1214-1223.\u003c\/li\u003e\n\u003cli\u003eTanoue T, Nishitani Y, Kanazawa K, Hashimoto T, Mizuno M. In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells. Biochem Biophys Res Commun. 2008;374(3):565-569.\u003c\/li\u003e\n\u003cli\u003eBesednova NN, Zaporozhets TS, Somova LM, Kuznetsova TA. Review: prospects for the use of extracts and polysaccharides from marine algae to prevent and treat the diseases caused by Helicobacter pylori. Helicobacter. 2015;20(2):89-97.\u003c\/li\u003e\n\u003cli\u003eIwamoto K, Hiragun T, Takahagi S, et al. Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis. Archives of dermatological research. 2011;303(6):425-431.\u003c\/li\u003e\n\u003cli\u003eChua EG, Verbrugghe P, Perkins TT, Tay CY. Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. Evid Based Complement Alternat Med. 2015;2015:120981.\u003c\/li\u003e\n\u003cli\u003eMori N, Nakasone K, Tomimori K, Ishikawa C. Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection. World J Gastroenterol. 2012;18(18):2225-2230.\u003c\/li\u003e\n\u003cli\u003eLean QY, Eri RD, Fitton JH, Patel RP, Gueven N. Fucoidan Extracts Ameliorate Acute Colitis. PLoS One. 2015;10(6):e0128453.\u003c\/li\u003e\n\u003cli\u003eZhang J, Riby JE, Conde L, Grizzle WE, Cui X, Skibola CF. A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines. BMC complementary and alternative medicine. 2016;16:151.\u003c\/li\u003e\n\u003cli\u003eSkibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report. BMC complementary and alternative medicine. 2004;4:10-10.\u003c\/li\u003e\n\u003cli\u003eMyers SP, O’Connor J, Fitton JH, et al. A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis. Biologics : targets \u0026amp; therapy. 2010;4:33-44.\u003c\/li\u003e\n\u003cli\u003eMyers SP, O’Connor J, Fitton JH, et al. A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex. Biologics : targets \u0026amp; therapy. 2011;5:45-60.\u003c\/li\u003e\n\u003cli\u003eHernandez-Corona DM, Martinez-Abundis E, Gonzalez-Ortiz M. Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults. J Med Food. 2014;17(7):830-832.\u003c\/li\u003e\n\u003cli\u003eNegishi H, Mori M, Mori H, Yamori Y. Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination. J Nutr. 2013;143(11):1794-1798.\u003c\/li\u003e\n\u003cli\u003eHermsdorff HH, Zulet MA, Puchau B, Martinez JA. Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metab (Lond). 2010;7:42.\u003c\/li\u003e\n\u003cli\u003eKanner J. Dietary advanced lipid oxidation endproducts are risk factors to human health. Mol Nutr Food Res. 2007;51(9):1094-1101.\u003c\/li\u003e\n\u003cli\u003eKanner J, Lapidot T. The stomach as a bioreactor: dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants. Free Radic Biol Med. 2001;31(11):1388-1395.\u003c\/li\u003e\n\u003cli\u003eGorelik S, Ligumsky M, Kohen R, Kanner J. A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products. Faseb j. 2008;22(1):41-46.\u003c\/li\u003e\n\u003cli\u003eShimizu M. Multifunctions of dietary polyphenols in the regulation of intestinal inflammation. J Food Drug Anal. 2017;25(1):93-99.\u003c\/li\u003e\n\u003cli\u003eYoun HS, Kim YS, Park ZY, et al. Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. Journal of immunology (Baltimore, Md : 1950). 2010;184(1):411-419.\u003c\/li\u003e\n\u003cli\u003eSuzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci. 2013;70(4):631-659.\u003c\/li\u003e\n\u003cli\u003eYang G, Bibi S, Du M, Suzuki T, Zhu MJ. Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective. Crit Rev Food Sci Nutr. 2017;57(18):3830-3839.\u003c\/li\u003e\n\u003cli\u003eSuzuki T, Hara H. Role of flavonoids in intestinal tight junction regulation. J Nutr Biochem. 2011;22(5):401-408.\u003c\/li\u003e\n\u003cli\u003eCheah KY, Bastian SE, Acott TM, Abimosleh SM, Lymn KA, Howarth GS. Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats. Dig Dis Sci. 2013;58(4):970-977.\u003c\/li\u003e\n\u003cli\u003eWang H, Xue Y, Zhang H, et al. Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Mol Nutr Food Res. 2013;57(12):2253-2257.\u003c\/li\u003e\n\u003cli\u003eEspin JC, Gonzalez-Sarrias A, Tomas-Barberan FA. The gut microbiota: A key factor in the therapeutic effects of (poly)phenols. Biochem Pharmacol. 2017;139:82-93.\u003c\/li\u003e\n\u003cli\u003eDuda-Chodak A, Tarko T, Satora P, Sroka P. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. Eur J Nutr. 2015;54(3):325-341.\u003c\/li\u003e\n\u003cli\u003eEsteban-Torres M, Landete JM, Reveron I, Santamaria L, de las Rivas B, Munoz R. A Lactobacillus plantarum esterase active on a broad range of phenolic esters. Appl Environ Microbiol. 2015;81(9):3235-3242.\u003c\/li\u003e\n\u003cli\u003eKar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009;26(5):526-531.\u003c\/li\u003e\n\u003cli\u003eBenavente-Garcia O, Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem. 2008;56(15):6185-6205.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2021-05-03T13:38:15+10:00","created_at":"2021-05-03T13:00:37+10:00","vendor":"Integra Nutritionals Naturopathic Medicines","type":"Integra Nutritionals Naturopathic Medicines","tags":["Integra Nutritionals"],"price":4496,"price_min":4496,"price_max":4496,"available":true,"price_varies":false,"compare_at_price":4995,"compare_at_price_min":4995,"compare_at_price_max":4995,"compare_at_price_varies":false,"variants":[{"id":39796665090206,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"IntegraNutritionalsGemmuneI.B.ImmunoBiotic56vc","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Integra Nutritionals Gemmune I.B. 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ImmunoBiotic 56vc 10% off RRP - HealthMasters Integra Nutritionals","id":21291538677918,"position":2,"preview_image":{"aspect_ratio":0.544,"height":1200,"width":653,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/IntegraNutritionalsGemmuneI.B.ImmunoBiotic56vc10_offRRP-HealthMastersIntegraNutritionals.jpg?v=1620012905"},"aspect_ratio":0.544,"height":1200,"media_type":"image","src":"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/products\/IntegraNutritionalsGemmuneI.B.ImmunoBiotic56vc10_offRRP-HealthMastersIntegraNutritionals.jpg?v=1620012905","width":653}],"content":"\u003ch2\u003eIntegra Nutritionals Gemmune I.B. ImmunoBiotic 56vc\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eGemmune I.B. ImmunoBiotic\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eServing Type: Vegetable Cellulose Size ’00’ Capsule (suitable for vegetarians)\u003c\/p\u003e\n\u003cp\u003eAvailable in 56 Capsules\u003c\/p\u003e\n\u003cp\u003eIntegra Nutritionals Gemmune I.B. ImmunoBiotic AUST L 307048\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDescription\u003c\/h5\u003e\n\u003ch2\u003eDescription: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eThe GEMM Protocol - Gut Ecology \u0026amp; Metabolic Modulation:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe GEMM Protocol is a clinical strategy to prevent and treat acute and chronic disease at its cellular origins and aims to re-establish each patient’s unique gut ecology, by supporting the growth, development and diversity of the microbiota.\u003c\/p\u003e\n\u003cp\u003eThe gut is now widely considered to function as a metabolic organ which plays a primary role in human immunity. A major contributor is the close interrelationships among five key elements – the Intestinal Epithelium and its overlying mucous membranes (IEFC), its underlying Immune cells, the Gut microbiota, the Capillary bed and the Neural networks that enable communication from the gut to other body systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune IB ImmunoBiotic \u003c\/strong\u003e simultaneously enhances immune, digestive and metabolic functions by targeting the gut immune interface.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnhances immune defences\u003c\/li\u003e\n\u003cli\u003eRelieves inflammation and maintains blood vessel health\u003c\/li\u003e\n\u003cli\u003eMaintains circulation and increases cognitive performance\u003c\/li\u003e\n\u003cli\u003eRelieves aching, swollen legs due to mild varicose veins\u003c\/li\u003e\n\u003cli\u003eAids in carbohydrate metabolism\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune I.B\u003c\/strong\u003e is comprehensively supported by \u003cstrong\u003eIntegra Nutritionals GFD\u003c\/strong\u003e and \u003cstrong\u003eIntegra Nutritionals FloraGenex. \u003c\/strong\u003e \u003c\/p\u003e\n\u003ch5\u003eFeatures\u003c\/h5\u003e\n\u003ch2\u003eFeatures: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune I.B. – the Concept of the Immunobiotic\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe healthy microbiome represents a diverse array of over 1000 unique commensal microbial species; by contrast, a probiotic supplement provides just a few.\u003c\/p\u003e\n\u003cp\u003eOn the other hand, an Immunbiotic is a modified probiotic standardised for its content of immune-signalling molecules and is typically heat-killed at the peak of its bioactivity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntegra Nutritionals Gemmune I.B.\u003c\/strong\u003e \u003cstrong\u003eImmunoBiotic\u003c\/strong\u003e is an immunobiotic derived from Lactobacillus plantarum HKL-137, a heat-killed, stabilised strain, standardised for its high content of Lipoteichoic Acid (LTA).\u003c\/p\u003e\n\u003cp\u003eWhen LTA binds to the toll-like receptor (TLR2), it initiates a signalling cascade that activates a significant immune response (Figure 2). Modifying the gut environment in this way to foster the growth of the commensals allows an individual’s gut ecology to be restored using the same principles employed by Nature.\u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus plantaram HKL137 (LP20) (50 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePotent source of Lipoteichoic acid (LTA)\u003c\/li\u003e\n\u003cli\u003eStimulates TLR2, modulating tight junctions\u003c\/li\u003e\n\u003cli\u003eInduces IL-12 to induce Th1 response\u003c\/li\u003e\n\u003cli\u003eEnhances both INNATE and ADAPTIVE immunity\u003c\/li\u003e\n\u003cli\u003eReduces Upper respiratory tract infection\u003c\/li\u003e\n\u003cli\u003eReduces periodontal probing depth\u003c\/li\u003e\n\u003cli\u003eDownregulates inflammation and undesirable responses to allergens\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFucus Vesiculosis extract (deiodinated) (117 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases synthesis of secretory IgA\u003c\/li\u003e\n\u003cli\u003eDownregulates gut and systemic pro-inflammatory cytokines IL-8 and TNF-a\u003c\/li\u003e\n\u003cli\u003eEnhances gut barrier by upregulating tight junction protein, Claudin-1\u003c\/li\u003e\n\u003cli\u003eInhibits adherence of H.pylori\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eGrape Seed polyphenols (90%) (600 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSource of prebiotic nutrition for commensals\u003c\/li\u003e\n\u003cli\u003eReduce oxidant burden of food\u003c\/li\u003e\n\u003cli\u003eDownregulate pro-inflammatory cytokines\u003c\/li\u003e\n\u003cli\u003eIncrease mucin synthesis and sigA\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNOTE:  Polyphenol metabolites promote metabolic health\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCitrus reticulata (40% bioflavonoids) (500 mg\/day)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe peel is uniquely rich in polymethoxylated flavones\u003c\/li\u003e\n\u003cli\u003eQuenches ROS in gut lumen\u003c\/li\u003e\n\u003cli\u003eReduces inflammation markers\u003c\/li\u003e\n\u003cli\u003eConversion of naringenin to naringin enhances gut barrier\u003c\/li\u003e\n\u003cli\u003eBeneficially promotes gut T reg cells\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eDosage\u003c\/h5\u003e\n\u003ch2\u003eDosage: Integra Nutritionals Gemmune I.B. ImmunoBiotic\u003c\/h2\u003e\n\u003cp\u003eThe standard dose of Gemmune I.B. is 1 capsule twice daily with meals.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eAcute illness:\u003c\/strong\u003e In acute states associated with infection, inflammation and allergy, Gemmune I.B. may be taken in divided doses up to 8 capsules daily, supported with the standard dose of Integra Nutritionals GFD at 2 capsules b.d.\u003c\/p\u003e\n\u003ch5\u003eStorage\u003c\/h5\u003e\n\u003ch2\u003eStorage: \u003c\/h2\u003e\n\u003cp\u003eStore below 30°C away from light and moisture. May be refrigerated.\u003c\/p\u003e\n\u003ch5\u003eEvidence\u003c\/h5\u003e\n\u003ch2\u003eEvidence: \u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eFujiki T, Hirose Y, Yamamoto Y, Murosaki S. Enhanced immunomodulatory activity and stability in simulated digestive juices of Lactobacillus plantarum L-137 by heat treatment. Biosci Biotechnol Biochem. 2012;76(5):918-922.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Yamamoto Y, Yoshikai Y, Murosaki S. Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress. Journal of nutritional science. 2013;2:e39.\u003c\/li\u003e\n\u003cli\u003eSashihara T, Sueki N, Ikegami S. An analysis of the effectiveness of heat-killed lactic acid bacteria in alleviating allergic diseases. J Dairy Sci. 2006;89(8):2846-2855.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Murosaki S, Fujiki T, Yamamoto Y, Yoshikai Y, Yamashita M. Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production. Microbiol Immunol. 2010;54(3):143-151.\u003c\/li\u003e\n\u003cli\u003eRyu YH, Baik JE, Yang JS, et al. Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids. Int Immunopharmacol. 2009;9(1):127-133.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Murosaki S, Yamamoto Y, et al. Safety studies of LP20 powder produced from heat-killed Lactobacillus plantarum L-137. Regul Toxicol Pharmacol. 2009;54(3):214-220.\u003c\/li\u003e\n\u003cli\u003eAhn KB, Baik JE, Yun CH, Han SH. Lipoteichoic Acid Inhibits Staphylococcus aureus Biofilm Formation. Front Microbiol. 2018;9:327.\u003c\/li\u003e\n\u003cli\u003eAhn KB, Baik JE, Park OJ, Yun CH, Han SH. Lactobacillus plantarum lipoteichoic acid inhibits biofilm formation of Streptococcus mutans. PLoS One. 2018;13(2):e0192694.\u003c\/li\u003e\n\u003cli\u003eHirose Y, Murosaki S, Yamamoto Y, Yoshikai Y, Tsuru T. Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults. J Nutr. 2006;136(12):3069-3073.\u003c\/li\u003e\n\u003cli\u003eAhrne S, Hagslatt ML. Effect of lactobacilli on paracellular permeability in the gut. Nutrients. 2011;3(1):104-117.\u003c\/li\u003e\n\u003cli\u003eMathew L, Burney M, Gaikwad A, et al. Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment. Integrative Cancer Therapies. 2017;16(4):572-584.\u003c\/li\u003e\n\u003cli\u003eZuo T, Li X, Chang Y, et al. Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice. Food Funct. 2015;6(2):415-422.\u003c\/li\u003e\n\u003cli\u003eShang Q, Shan X, Cai C, Hao J, Li G, Yu G. Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae. Food Funct. 2016;7(7):3224-3232.\u003c\/li\u003e\n\u003cli\u003eWalsh AM, Sweeney T, O’Shea CJ, Doyle DN, O’Doherty JV. Effect of dietary laminarin and fucoidan on selected microbiota, intestinal morphology and immune status of the newly weaned pig. Br J Nutr. 2013;110(9):1630-1638.\u003c\/li\u003e\n\u003cli\u003eIraha A, Chinen H, Hokama A, et al. Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1. World J Gastroenterol. 2013;19(33):5500-5507.\u003c\/li\u003e\n\u003cli\u003eXue M, Ji X, Liang H, et al. The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer. Food Funct. 2018;9(2):1214-1223.\u003c\/li\u003e\n\u003cli\u003eTanoue T, Nishitani Y, Kanazawa K, Hashimoto T, Mizuno M. In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells. Biochem Biophys Res Commun. 2008;374(3):565-569.\u003c\/li\u003e\n\u003cli\u003eBesednova NN, Zaporozhets TS, Somova LM, Kuznetsova TA. Review: prospects for the use of extracts and polysaccharides from marine algae to prevent and treat the diseases caused by Helicobacter pylori. Helicobacter. 2015;20(2):89-97.\u003c\/li\u003e\n\u003cli\u003eIwamoto K, Hiragun T, Takahagi S, et al. Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis. Archives of dermatological research. 2011;303(6):425-431.\u003c\/li\u003e\n\u003cli\u003eChua EG, Verbrugghe P, Perkins TT, Tay CY. Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. Evid Based Complement Alternat Med. 2015;2015:120981.\u003c\/li\u003e\n\u003cli\u003eMori N, Nakasone K, Tomimori K, Ishikawa C. Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection. World J Gastroenterol. 2012;18(18):2225-2230.\u003c\/li\u003e\n\u003cli\u003eLean QY, Eri RD, Fitton JH, Patel RP, Gueven N. Fucoidan Extracts Ameliorate Acute Colitis. PLoS One. 2015;10(6):e0128453.\u003c\/li\u003e\n\u003cli\u003eZhang J, Riby JE, Conde L, Grizzle WE, Cui X, Skibola CF. A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines. BMC complementary and alternative medicine. 2016;16:151.\u003c\/li\u003e\n\u003cli\u003eSkibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report. BMC complementary and alternative medicine. 2004;4:10-10.\u003c\/li\u003e\n\u003cli\u003eMyers SP, O’Connor J, Fitton JH, et al. A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis. Biologics : targets \u0026amp; therapy. 2010;4:33-44.\u003c\/li\u003e\n\u003cli\u003eMyers SP, O’Connor J, Fitton JH, et al. A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex. Biologics : targets \u0026amp; therapy. 2011;5:45-60.\u003c\/li\u003e\n\u003cli\u003eHernandez-Corona DM, Martinez-Abundis E, Gonzalez-Ortiz M. Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults. J Med Food. 2014;17(7):830-832.\u003c\/li\u003e\n\u003cli\u003eNegishi H, Mori M, Mori H, Yamori Y. Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination. J Nutr. 2013;143(11):1794-1798.\u003c\/li\u003e\n\u003cli\u003eHermsdorff HH, Zulet MA, Puchau B, Martinez JA. Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metab (Lond). 2010;7:42.\u003c\/li\u003e\n\u003cli\u003eKanner J. Dietary advanced lipid oxidation endproducts are risk factors to human health. Mol Nutr Food Res. 2007;51(9):1094-1101.\u003c\/li\u003e\n\u003cli\u003eKanner J, Lapidot T. The stomach as a bioreactor: dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants. Free Radic Biol Med. 2001;31(11):1388-1395.\u003c\/li\u003e\n\u003cli\u003eGorelik S, Ligumsky M, Kohen R, Kanner J. A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products. Faseb j. 2008;22(1):41-46.\u003c\/li\u003e\n\u003cli\u003eShimizu M. Multifunctions of dietary polyphenols in the regulation of intestinal inflammation. J Food Drug Anal. 2017;25(1):93-99.\u003c\/li\u003e\n\u003cli\u003eYoun HS, Kim YS, Park ZY, et al. Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. Journal of immunology (Baltimore, Md : 1950). 2010;184(1):411-419.\u003c\/li\u003e\n\u003cli\u003eSuzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci. 2013;70(4):631-659.\u003c\/li\u003e\n\u003cli\u003eYang G, Bibi S, Du M, Suzuki T, Zhu MJ. Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective. Crit Rev Food Sci Nutr. 2017;57(18):3830-3839.\u003c\/li\u003e\n\u003cli\u003eSuzuki T, Hara H. Role of flavonoids in intestinal tight junction regulation. J Nutr Biochem. 2011;22(5):401-408.\u003c\/li\u003e\n\u003cli\u003eCheah KY, Bastian SE, Acott TM, Abimosleh SM, Lymn KA, Howarth GS. Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats. Dig Dis Sci. 2013;58(4):970-977.\u003c\/li\u003e\n\u003cli\u003eWang H, Xue Y, Zhang H, et al. Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Mol Nutr Food Res. 2013;57(12):2253-2257.\u003c\/li\u003e\n\u003cli\u003eEspin JC, Gonzalez-Sarrias A, Tomas-Barberan FA. The gut microbiota: A key factor in the therapeutic effects of (poly)phenols. Biochem Pharmacol. 2017;139:82-93.\u003c\/li\u003e\n\u003cli\u003eDuda-Chodak A, Tarko T, Satora P, Sroka P. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. Eur J Nutr. 2015;54(3):325-341.\u003c\/li\u003e\n\u003cli\u003eEsteban-Torres M, Landete JM, Reveron I, Santamaria L, de las Rivas B, Munoz R. A Lactobacillus plantarum esterase active on a broad range of phenolic esters. Appl Environ Microbiol. 2015;81(9):3235-3242.\u003c\/li\u003e\n\u003cli\u003eKar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009;26(5):526-531.\u003c\/li\u003e\n\u003cli\u003eBenavente-Garcia O, Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem. 2008;56(15):6185-6205.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e"}

Integra Nutritionals Gemmune I.B. ImmunoBiotic 56vc

Product Description

Integra Nutritionals Gemmune I.B. ImmunoBiotic 56vc

Gemmune I.B. ImmunoBiotic

Serving Type: Vegetable Cellulose Size ’00’ Capsule (suitable for vegetarians)

Available in 56 Capsules

Integra Nutritionals Gemmune I.B. ImmunoBiotic AUST L 307048

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