Blackmores Professional Bio-Chromium Plus 120's
Dose: Blackmores Professional Bio-Chromium Plus
Adults: Take 1 tablet a day with food or as professionally prescribed.
Children under 18 years: Only as professionally prescribed.
Features: Blackmores Professional Bio-Chromium Plus
- Bio-Chromium Plus contains chromium and magnesium which are important for diets high in carbohydrates and sugar.
- Nutrients chromium and manganese aid in normal healthy carbohydrate metabolism.
- Chromium can further assist in the breakdown of dietary fat.
- Manganese is an antioxidant that can reduce free radicals formed in the body.
- Vitamins B5 and B6 help to convert nutrients from food into energy.
- Vitamin B6 supports nervous system function.
Ingredients: Blackmores Professional Bio-Chromium Plus
|Chromium picolinate (equiv. to chromium 50micrograms)||402micrograms|
|Chromic chloride hexahydrate (equiv. to chromium 150micrograms)||768micrograms|
|Total elemental chromium||200micrograms|
|Manganese amino acid chelate (equiv. to manganese 2mg)||20mg|
|Magnesium phosphate pentahydrate (equiv. to magnesium 13.4mg)||65mg|
|Potassium phosphate-dibasic (equiv. to potassium 14.8mg)||33mg|
|Zinc amino acid chelate (equiv. to zinc 5mg)||25mg|
|Calcium pantothenate (equiv. to pantothenic acid (vitamin B5) 229mg)||25mg|
|Pyridoxine hydrochloride (equiv. to pyridoxine (vitamin B6) 20.57mg)||25mg|
|Cyanocobalamin (vitamin B12)||300micrograms|
Ingredient Summary: Blackmores Professional Bio-Chromium Plus
Chromium is required by the body for normal insulin function1 and plays a role in regulating carbohydrate and lipid metabolism by enhancing the efficacy of insulin.2 Chromium may improve insulin sensitivity and facilitate glucose utilisation.3 It is maintained in the bloodstream bound to the protein transferrin.2 Chromium is involved in carbohydrate, fat and protein metabolism and is a fundamental component in healthy glucose utilisation and glycaemic control by aiding cellular glucose uptake. People with high intake of dietary sugar and refined carbohydrates have an increased requirement for chromium. Both picolinate and chloride forms are supported in clinical trials, and using a mix maximises availability and allows for higher dosages. 4,5
Manganese is an essential nutrient required for a variety of metabolic functions including the functioning of antioxidant enzymes involved in reducing free radicals formed in the body. Inadequate intake of manganese can lead to the impaired metabolism of carbohydrates. 6 Manganese superoxide dismutase (MnSOD) is the main antioxidant enzyme found in the mitochondria. The mitochondria is particularly vulnerable to oxidative stress. During ATP production in the mitochondria, the superoxide radicals – a reactive oxygen species (ROS) – are created. MnSOD provides the catalyst for the conversion of superoxide radicals to hydrogen pyroxide, which then allows other antioxidant enzymes to reduce it to water for easy excretion.7
Vitamins B3 and B5
Vitamins B3 and B5 act as coenzymes in the enzymatic processes involved in mitochondrial energy production. Pantothenic acid (B5) provides the main substrate for the citric acid cycle through the formation of Acetyl-CoA. Both B3 and B5 are precursors of the enzymatic reactions to form NADH and FADH which transfers the energy created by the citric acid cycle to the electron transport chain resulting in the production of ATP and energy for cells.8
Pyridoxine hydrochloride (vitamin B6)
Vitamin B6 is a cofactor in the synthesis of neurotransmitters such as dopamine, serotonin and melatonin. Even mild deficiency can result in low mood, disordered sleep and reduced hypothalamus-pituitary control of hormone excretion.8 Pyridoxal phosphate (PLP) is the biologically active form of the vitamin that functions as an enzyme cofactor. In energy metabolism, PLP plays a role in generating glucose from amino acids, a process known as gluconeogenesis.
Warnings: Blackmores Professional Bio-Chromium Plus
Vitamins and minerals can only be of assistance if dietary intake is inadequate. Always read the label. Use only as directed. If symptoms persist, talk to your health professional.
Blackmores Bio-Chromium Plus may interfere with certain other medications your patients may be taking. Magnesium and zinc may decrease the absorption and efficacy of tetracycline and quinolone antibiotics. Administer Blackmores Bio-Chromium Plus at least two hours apart from these medications. Absorption of vitamin B12 may be decreased by clofibrate, sulphonamides, PABA, colchicine, neomycin, metformin, phenformin, primidone, pyrimethamine, ranitidine and sodium nitroprusside. Folic acid may decrease the efficacy of methotrexate and other folic acid antagonists. The efficacy of folic acid may be decreased by co-trimoxazole, sulphasalazine, phenytoin, phenobarbitone, primidon and methotrexate
References: Blackmores Professional Bio-Chromium Plus
- Liu, L., Cui, W. M., Zhang, S. W., Kong, F. H., Pedersen, M. A., Wen, Y. and Lv, J. P. (2015) Effect of glucose tolerance factor (GTF) from high chromium yeast on glucose metabolism in insulin-resistant 3T3-L1 adipocytes. RSC Advances, Issue 5. https://pubs.rsc.org/en/content/articlelanding/2015/RA/C4RA10343B#!divCitation
- Vincent, J. B., & Lukaski, H. C. (2018). Chromium. Advances in nutrition (Bethesda, Md.), 9(4), 505–506. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054252/
- Ngala, R. A., Awe, M. A., & Nsiah, P. (2018). The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case - control study. PloS one, 13(7), e0197977. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033385/
- Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67(6):1250-1255.
- Higdon J. An evidence-based approach to vitamins and minerals. New York: Thieme Medical Publishers, 2003.
- Avila DS, Puntel RL, Aschner M. Manganese in health and disease. Met Ions Life Sci. 2013;13:199–227. doi:10.1007/978-94-007-7500-8_7
- Higdon J. Manganese. Micronutrient information center, Linus Pauling Institute 2003. Viewed 3 Jan 2020, https://lpi.oregonstate.edu/mic/minerals/manganese
- Kennedy, David O. (2016) B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients 2016, 8(2), 68. https://www.mdpi.com/2072-6643/8/2/68
- Bunner SP, McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299.