Dose: BioCeuticals MoodBalance
Adults: Take 1 capsule with breakfast and 1 capsule with dinner or as directed by your healthcare practitioner.
Features: BioCeuticals MoodBalance
- Crocus sativus (saffron) has been used in traditional Persian medicine to support healthy mood balance. MoodBalance contains affron®, a standardised saffron extract.
- Includes clinically trialled Lactobacillus helveticus R0052 and Bifidobacterium longum R0175, which reduce the stress-related gastrointestinal symptoms of nausea and abdominal pain.
- B vitamins contribute to supporting a healthy mood balance.
- Vitamins B6, B9 and B12 are essential for processes involved in the synthesis of neurotransmitters, and zinc supports healthy neurotransmitter system activity.
- Vitamin B6 and zinc contribute to normal functioning of the immune system.
- The lactobacilli strain helps to support a healthy gastrointestinal system and immune function.
- Folate contributes to the reduction of tiredness and fatigue.
- Shelf-stable probiotic strains.
Ingredients: BioCeuticals MoodBalance
|Each capsule contains:|
|Herbal extract equiv. to dry:|
|Crocus sativus (saffron) stigma (affron)||42mg|
|equiv. folinic acid||125mg|
|Hydroxocobalamin (vitamin B12)||125mcg|
|equiv. pyridoxine (vitamine B6)||2.5mg|
|Zinc amino acid chelate||62.5mg|
|Lactobacillus helveticus (Rosell-52)||1 billion CFU*|
|Bifidobacterium longum (Rosell-175)||500 million CFU*|
*CFU = colony forming units
Excipients: BioCeuticals MoodBalance
No Added Gluten, No added Shellfish, Vegetarian Friendly, No added Yeast
Ingredient Summary: BioCeuticals MoodBalance
Crocus sativus (saffron)
In clinical trials, the administration of a standardised saffron extract supported healthy mood to a greater degree than placebo or alternative treatment in a variety of cohorts. A standardised saffron extract administered at 28mg/day significantly impacted mood and decreased somatisation compared with placebo, with no differences in reported adverse events compared with traditional treatment.[1,2] These findings were recently confirmed in a systematic review of herbal medicines which concluded that the weight of evidence was in favour of saffron for supporting a healthy mood.
Animal models suggest that compounds found in saffron increase levels of brain-derived neurotrophic factor (BDNF).
BioCeuticals MoodBalance contains affron®, a clinically trialled saffron extract standardised to >3.5% Lepticrosalides®, which includes the bioactive compounds safranal and crocin.
The combination of L. helveticus R0052 and B. longum R0175 has been shown in clinical trials to reduce the stress-related gastrointestinal symptoms of nausea and abdominal pain at a dose of 3 billion CFU per day.[5,6]
Additional support from B vitamins and zinc
Vitamin B6 is required to assist in neurotransmitter synthesis, including serotonin, gamma-aminobutyric acid (GABA) and dopamine. Folate and B12 are essential cofactors in helping the remethylation of homocysteine to methionine which is then synthesised into S-adenosylmethionine (SAMe), one of the important roles of which is in the metabolism of neurotransmitters including serotonin.7 Reduced levels of vitamins B6, B12 and folate have been shown to impact mood.
Zinc supports healthy neurotransmitter system activity and nervous system function, as well as supporting normal immune system function.[8,9]
Warnings: BioCeuticals MoodBalance
If symptoms persist, consult your healthcare practitioner.
Companion Products: BioCeuticals MoodBalance
Content for Companion Products
References: BioCeuticals MoodBalance
 Lopresti AL, Drummond PD, Inarejos-García AM, et al. Affron?, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: a randomised, double-blind, placebo-controlled study. J Affect Disord 2018;232:349-357.
 Kell G, Rao A, Beccaria G, et al. Affron?, a novel saffron extract (Crocus sativus L.) im-proves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med 2017;33:58-64.
 Sarris J. Herbal medicines in the treatment of psychiatric disorders: 10-year updated re-view. Phytother Res 2018;32(7):1147-1162.
 Hassani FV, Naseri V, Razavi BM, et al. Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. Daru 2014;22(1):16.
 Diop L, Guillou S, Durand H. Probiotic food supplement reduces stress-induced gastrointes-tinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Nutr Res 2008;28(1):1-5.
 Messaoudi M, Lalonde R, Violle N, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 2011;105(5):755-764.
 Braun L and Cohen M. Herbs and natural supplements: an evidence based guide, 3rd ed, 2010. Sydney: Churchill Livingstone Elsevier.
 Gropper SS, Smith JL. Advanced nutrition and human metabolism, 7th ed, 2017. Boston: Cengage Learning.
 EUR-Lex. Commission regulation (EU) no 432/2012, 2012. Viewed 3rd August 2018, https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32012R0432
 Saffron, 2014. Natural Medicines Comprehensive Database. Viewed 16th July 2018, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=844